iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065925

Ensembl Protein ID

ENSMPUP00000008907.1

UniProt Accession

M3YC50; M3YC50_MUSPF

Genbank Protein ID

ENSMPUP00000008907

Protein Name

Probable cytosolic iron-sulfur protein assembly protein CIAO1; WD repeat-containing protein 39

Genbank Nucleotide ID

AEYP01076405

Gene Name

CIAO1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000008980.1	ENSMPUT00000009054.1	ENSMPUP00000008907.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.90e-45	149.1	192	222
UBD/Beta-Prp	8.90e-54	182.7	13	179

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH++ v++laf ++  +l+s+sdD t+++W+
   Q: 192  GHESTVWSLAFdPSgQRLASCSDDRTVRIWR 222
           8***********6669**************8 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrsl.sgheaevtavkfspdgkilvtgseDrtikvw..dlstgkcvhtl 90
           +h++s++  +++ p ++lla+ + d+++++w ++ ++    + l +gh+ +v+ v +sp g++l+++s D+t ++w  + ++++cv tl
   Q: 13   AHPDSRCWFLAWNPAGTLLASCGGDRRVRIWGTEGESWicKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNQDDFECVTTL 101
           688999999999*********************9988754566689******************************99999******** PP
   S: 91   kghedsvlslsfspsgdklvsGshdrtirvwdletgqclee..tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl 166
           +ghe++v s+++ psg+ l++ s+d+ + vw+++++ ++e   +l+ h++ v +vv+hp++ ll+s+s+D tv+l++ 
   Q: 102  EGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECvsVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYRE 179
           *********************************9987776566********************************975 PP

Organism

Mustela putorius furo

Functional Description
(View)

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Protein Sequence
(Fasta)

MKDSLVLLAR VPAHPDSRCW FLAWNPAGTL LASCGGDRRV RIWGTEGESW ICKSVLSEGH 60
QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT LEGHENEVKS VAWAPSGNLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGGACT CGCTGGTGCT GCTGGCTCGT GTCCCGGCGC ATCCGGACTC CCGCTGCTGG 60
TTCTTGGCCT GGAACCCTGC GGGAACCCTC CTGGCGTCGT GCGGTGGTGA CCGTAGAGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR028608--CIAO1/Cia1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097361--C:CIA complex
GO:0071817--C:MMXD complex
GO:0007059--P:chromosome segregation
GO:0016226--P:iron-sulfur cluster assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000874	Aegilops tauschii	49.45	6.00e-68	251.00
IUUC-Aml-001317	Ailuropoda melanoleuca	98.23	0.00e+00	642.00
IUUC-Atr-003029	Amborella trichopoda	52.19	4.00e-94	337.00
IUUC-Apl-004042	Anas platyrhynchos	77.27	2.00e-55	207.00
IUUC-Aly-006458	Arabidopsis lyrata	48.41	2.00e-85	309.00
IUUC-Ath-006671	Arabidopsis thaliana	48.26	7.00e-86	310.00
IUUC-Ago-007820	Ashbya gossypii	40.88	7.00e-61	227.00
IUUC-Acl-008042	Aspergillus clavatus	32.26	2.00e-51	196.00
IUUC-Afl-008639	Aspergillus flavus	33.57	3.00e-55	209.00
IUUC-Afu-008899	Aspergillus fumigatus	32.42	4.00e-50	192.00
IUUC-Ani-009453	Aspergillus nidulans	32.78	2.00e-51	196.00
IUUC-Ang-009758	Aspergillus niger	35.66	2.00e-53	202.00
IUUC-Aor-010212	Aspergillus oryzae	33.57	3.00e-55	209.00
IUUC-Ate-010314	Aspergillus terreus	33.09	8.00e-54	204.00
IUUC-Ame-010676	Astyanax mexicanus	77.54	3.00e-158	550.00
IUUC-Bgr-012095	Blumeria graminis	30.19	1.00e-38	153.00
IUUC-Bta-012884	Bos taurus	94.10	1.00e-177	615.00
IUUC-Bci-013622	Botrytis cinerea	32.87	3.00e-37	149.00
IUUC-Bdi-014614	Brachypodium distachyon	49.70	2.00e-85	309.00
IUUC-Bol-016439	Brassica oleracea	47.94	4.00e-84	304.00
IUUC-Bra-016830	Brassica rapa	46.90	2.00e-82	299.00
IUUC-Cel-018709	Caenorhabditis elegans	40.37	6.00e-64	237.00
IUUC-Cja-019822	Callithrix jacchus	95.87	0.00e+00	628.00
IUUC-Cfa-020823	Canis familiaris	98.82	0.00e+00	645.00
IUUC-Cre-022811	Chlamydomonas reinhardtii	49.11	1.00e-80	293.00
IUUC-Csa-023754	Chlorocebus sabaeus	96.76	0.00e+00	634.00
IUUC-Cin-025395	Ciona intestinalis	57.01	2.00e-115	408.00
IUUC-Csv-025943	Ciona savignyi	55.26	9.00e-112	396.00
IUUC-Cgl-026435	Colletotrichum gloeosporioides	31.13	2.00e-38	153.00
IUUC-Cne-026939	Cryptococcus neoformans	31.79	2.00e-48	186.00
IUUC-Cme-027239	Cyanidioschyzon merolae	40.93	2.00e-43	170.00
IUUC-Dre-028172	Danio rerio	76.35	7.00e-156	542.00
IUUC-Dno-029472	Dasypus novemcinctus	95.88	2.00e-152	531.00
IUUC-Dor-031134	Dipodomys ordii	84.37	2.00e-151	527.00
IUUC-Dse-031535	Dothistroma septosporum	30.57	6.00e-47	181.00
IUUC-Dme-032020	Drosophila melanogaster	58.79	7.00e-117	413.00
IUUC-Eca-033700	Equus caballus	97.64	0.00e+00	635.00
IUUC-Eeu-035010	Erinaceus europaeus	94.69	3.00e-178	617.00
IUUC-Fca-036309	Felis catus	91.18	4.00e-177	613.00
IUUC-Fal-037243	Ficedula albicollis	73.49	9.00e-85	305.00
IUUC-Fox-038058	Fusarium oxysporum	33.16	1.00e-45	177.00
IUUC-Fso-038459	Fusarium solani	33.25	6.00e-41	161.00
IUUC-Gmo-039375	Gadus morhua	74.85	1.00e-140	492.00
IUUC-Ggr-040002	Gaeumannomyces graminis	36.24	6.00e-42	165.00
IUUC-Gga-040294	Gallus gallus	79.37	8.00e-129	452.00
IUUC-Gac-042499	Gasterosteus aculeatus	73.89	5.00e-139	486.00
IUUC-Gma-043543	Glycine max	49.26	4.00e-87	314.00
IUUC-Ggo-045181	Gorilla gorilla	96.76	0.00e+00	634.00
IUUC-Hsa-046528	Homo sapiens	96.76	0.00e+00	634.00
IUUC-Hvu-047341	Hordeum vulgare	57.45	1.00e-55	209.00
IUUC-Itr-048790	Ictidomys tridecemlineatus	97.35	0.00e+00	634.00
IUUC-Kpa-049353	Komagataella pastoris	37.01	4.00e-57	215.00
IUUC-Lch-049763	Latimeria chalumnae	79.64	1.00e-161	561.00
IUUC-Lpe-051500	Leersia perrieri	45.28	7.00e-81	294.00
IUUC-Loc-052021	Lepisosteus oculatus	79.94	3.00e-153	533.00
IUUC-Lma-053331	Leptosphaeria maculans	36.00	7.00e-57	215.00
IUUC-Laf-054558	Loxodonta africana	94.40	4.00e-179	620.00
IUUC-Mcc-055374	Macaca mulatta	97.05	0.00e+00	637.00
IUUC-Meu-056042	Macropus eugenii	77.24	2.00e-112	398.00
IUUC-Mor-057187	Magnaporthe oryzae	31.19	3.00e-40	159.00
IUUC-Mtr-058072	Medicago truncatula	48.52	1.00e-86	313.00
IUUC-Mla-059108	Melampsora laricipopulina	31.29	1.00e-50	194.00
IUUC-Mga-059370	Meleagris gallopavo	64.04	2.00e-100	358.00
IUUC-Mvi-060495	Microbotryum violaceum	37.10	2.00e-57	216.00
IUUC-Mmr-060902	Microcebus murinus	97.05	0.00e+00	634.00
IUUC-Mdo-062510	Monodelphis domestica	93.22	9.00e-172	595.00
IUUC-Mmu-063575	Mus musculus	93.81	8.00e-178	615.00
IUUC-Mac-065322	Musa acuminata	51.04	1.00e-90	326.00
IUUC-Mlu-067755	Myotis lucifugus	95.87	0.00e+00	630.00
IUUC-Nfi-068327	Neosartorya fischeri	31.90	3.00e-49	189.00
IUUC-Ncr-068845	Neurospora crassa	33.23	7.00e-33	135.00
IUUC-Nle-069406	Nomascus leucogenys	94.40	4.00e-177	613.00
IUUC-Opr-070416	Ochotona princeps	75.22	2.00e-133	468.00
IUUC-Ont-071936	Oreochromis niloticus	75.07	3.00e-143	501.00
IUUC-Oan-073452	Ornithorhynchus anatinus	92.12	9.00e-75	271.00
IUUC-Ocu-074791	Oryctolagus cuniculus	94.69	3.00e-180	623.00
IUUC-Oba-075636	Oryza barthii	49.55	6.00e-88	317.00
IUUC-Obr-076742	Oryza brachyantha	48.60	1.00e-76	279.00
IUUC-Ogl-077766	Oryza glaberrima	49.55	6.00e-88	317.00
IUUC-Ogu-079039	Oryza glumaepatula	49.55	3.00e-88	318.00
IUUC-Oin-079315	Oryza indica	49.32	2.00e-77	282.00
IUUC-Olo-080669	Oryza longistaminata	44.01	5.00e-80	291.00
IUUC-Ome-081490	Oryza meridionalis	49.55	4.00e-88	317.00
IUUC-Oni-082572	Oryza nivara	49.55	6.00e-88	317.00
IUUC-Opu-083732	Oryza punctata	49.70	4.00e-88	318.00
IUUC-Oru-084763	Oryza rufipogon	49.55	6.00e-88	317.00
IUUC-Osa-085372	Oryza sativa	49.55	6.00e-88	317.00
IUUC-Ola-087379	Oryzias latipes	72.65	2.00e-138	485.00
IUUC-Olu-087801	Ostreococcus lucimarinus	36.31	6.00e-45	174.00
IUUC-Oga-089076	Otolemur garnettii	96.46	0.00e+00	635.00
IUUC-Oar-090022	Ovis aries	94.40	3.00e-178	617.00
IUUC-Ptr-090809	Pan troglodytes	96.76	0.00e+00	634.00
IUUC-Pan-091685	Papio anubis	96.76	0.00e+00	640.00
IUUC-Psi-093046	Pelodiscus sinensis	87.83	2.00e-167	581.00
IUUC-Pma-094181	Petromyzon marinus	64.09	1.00e-131	462.00
IUUC-Pno-094882	Phaeosphaeria nodorum	35.27	9.00e-56	211.00
IUUC-Ppa-095172	Physcomitrella patens	47.97	3.00e-85	308.00
IUUC-Pfo-096396	Poecilia formosa	71.81	1.00e-139	489.00
IUUC-Pab-098427	Pongo abelii	96.17	0.00e+00	625.00
IUUC-Pop-100016	Populus trichocarpa	51.76	1.00e-90	326.00
IUUC-Pca-101048	Procavia capensis	95.28	1.00e-179	621.00
IUUC-Ppe-102050	Prunus persica	48.57	6.00e-88	317.00
IUUC-Pva-103117	Pteropus vampyrus	96.17	0.00e+00	629.00
IUUC-Pgr-103307	Puccinia graminis	34.02	2.00e-56	213.00
IUUC-Ptt-103938	Puccinia triticina	38.75	1.00e-48	187.00
IUUC-Pte-104315	Pyrenophora teres	34.05	9.00e-57	214.00
IUUC-Pyt-104825	Pyrenophora triticirepentis	33.57	3.00e-56	212.00
IUUC-Rno-105523	Rattus norvegicus	93.51	6.00e-178	616.00
IUUC-Sce-106297	Saccharomyces cerevisiae	42.27	6.00e-65	240.00
IUUC-Sha-106981	Sarcophilus harrisii	93.13	3.00e-143	501.00
IUUC-Sja-107715	Schizosaccharomyces japonicus	39.77	9.00e-56	211.00
IUUC-Spo-108214	Schizosaccharomyces pombe	41.39	6.00e-57	215.00
IUUC-Smo-109034	Selaginella moellendorffii	45.60	4.00e-82	298.00
IUUC-Sit-110663	Setaria italica	51.34	7.00e-90	323.00
IUUC-Sly-110898	Solanum lycopersicum	47.97	1.00e-83	303.00
IUUC-Stu-112647	Solanum tuberosum	51.50	5.00e-71	260.00
IUUC-Sbi-114288	Sorghum bicolor	48.96	1.00e-85	309.00
IUUC-Sre-115065	Sporisorium reilianum	43.80	1.00e-77	283.00
IUUC-Ssc-115960	Sus scrofa	89.91	6.00e-179	619.00
IUUC-Tru-118382	Takifugu rubripes	71.51	6.00e-147	513.00
IUUC-Tsy-119585	Tarsius syrichta	88.20	1.00e-161	561.00
IUUC-Tni-120133	Tetraodon nigroviridis	74.24	9.00e-143	499.00
IUUC-Tca-121167	Theobroma cacao	49.56	2.00e-82	299.00
IUUC-Tre-122119	Trichoderma reesei	30.28	5.00e-42	165.00
IUUC-Tvi-122407	Trichoderma virens	29.66	6.00e-41	161.00
IUUC-Tae-125748	Triticum aestivum	48.96	4.00e-82	298.00
IUUC-Tur-126682	Triticum urartu	50.00	1.00e-68	252.00
IUUC-Tme-127095	Tuber melanosporum	35.51	2.00e-60	226.00
IUUC-Tbe-128004	Tupaia belangeri	96.76	0.00e+00	633.00
IUUC-Ttr-129284	Tursiops truncatus	91.52	1.00e-171	595.00
IUUC-Uma-129527	Ustilago maydis	44.50	1.00e-77	283.00
IUUC-Vda-129854	Verticillium dahliae	32.39	1.00e-39	157.00
IUUC-Vpa-130681	Vicugna pacos	96.55	2.00e-49	189.00
IUUC-Vvi-131004	Vitis vinifera	54.05	2.00e-88	318.00
IUUC-Xtr-131928	Xenopus tropicalis	81.01	1.00e-154	538.00
IUUC-Xma-134290	Xiphophorus maculatus	71.22	3.00e-136	478.00
IUUC-Yli-134364	Yarrowia lipolytica	43.97	4.00e-67	248.00
IUUC-Zma-135658	Zea mays	49.85	2.00e-86	311.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence