iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050341

Ensembl Protein ID

ENSLACP00000004124.1

UniProt Accession

H3A3A3; H3A3A3_LATCH

Genbank Protein ID

ENSLACP00000004124

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01248347

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000003666.1	ENSLACT00000004160.1	ENSLACP00000004124.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-87	294.3	308	627

Active Site

Position(s)	Description	Evidence
597	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegld.lgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           s+l+k+l vefvgE+  +  gGv +ef+  +++++ +p++g+f y+e++k +++p  +s     e  ++F ++G+l+g+a+++  l+ l
   Q: 308  SELRKELTVEFVGENTSGkVGGVRKEFFLHVFEKMLHPEYGMFAYNEESKLMWFPTHTSV----ETKNYF-LFGILCGLAIYNYCLVHL 391
           7899**********98772599************************************98....677888.55**************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           p++ +++k+llgkk  led+ e+dp + ksl++++++ e d+e+  l+++fsvs     + ++++L+p+Gen+pVtn+N++++v+ +v+
   Q: 392  PFPLALFKKLLGKKPLLEDFIELDPVFGKSLQYLLSY-EYDVEKY-LNMSFSVSW----QNQQKDLVPDGENEPVTNANRKRFVDTLVN 474
           ***********************************99.7899998.*****9776....789999************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           y ++e+++  +++fr+Gf++v+++e+l+ Ft++el  ++ G++++d++ l+++t y+ggy++++p+i++Fw+v++++  +++k+fL F+
   Q: 475  YVFNESVEMLFNEFRRGFYKVCDQEILEFFTPQELMAVMVGNTDYDWQRLQQNTLYDGGYSPSHPTIIMFWNVFHDLPLNKKKDFLLFA 563
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tgs+r+P+ G+++++  +fv +k +sd   P++ TC+ +++LP+Y++ e lke+Ll+A +   gF+
   Q: 564  TGSDRIPPLGMDAVR-IIFVPSK-GSDFYMPEAYTCYDMIQLPTYTTVERLKERLLMALSRHCGFG 627
           **************9.5555555.*************************************99997 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MPFGPCLSHF LGIPSWLLIF VVLCFYFCRC DWSSDAGLEE PLSEGSTTSL DVDLQLVRKI 60
FEQLTRNHWI TVKIVSCLRE KLIPSLSTIC SHKEALAIYL ILPEFLVMLD AQTSLPLVLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTGTACATT GTTTGTTAAC TAGGGAGTTG TGGGGAGGGG TGGGTTGCGC CCCATGGAGG 60
TTATGGGTTT TTGTTTGACC CACATATGGA TTCCCCTTTG TGTGTGGAGG TTGTGGGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Dor-030862	Dipodomys ordii	37.86	3.00e-91	329.00
IUUC-Eeu-035282	Erinaceus europaeus	40.62	3.00e-59	223.00
IUUC-Ocu-074640	Oryctolagus cuniculus	41.78	3.00e-110	392.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence