iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ang-009738

Ensembl Protein ID

CAK39787

UniProt Accession

A2QQ28; RSP5_ASPNC

Genbank Protein ID

CAK39787.1

Protein Name

Probable E3 ubiquitin-protein ligase hulA; HECT ubiquitin ligase A; HECT-type E3 ubiquitin transferase hulA

Genbank Nucleotide ID

AM270158

Gene Name

hulA; An08g01060

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
An08g01060	CAK39787	CAK39787

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-123	411.9	489	820

Active Site

Position(s)	Description	Evidence
789	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
           +sdlkkrl+++f gE+gld+gG++ref++lls+e++np ++lf+ys+ d++tlq+np+sg+ npehl++F+f+Gr++g+a++++r+ld ++  +fyk++l+
   Q: 489  ASDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGV-NPEHLNYFKFIGRVVGLAIFHRRFLDSFFIGAFYKMMLR 588
           689*********************************************************9.89************************************* PP
   S: 103  kklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnevipl 203
           kk+sl+d+e vd++l+++l + +en   die + ++ltfsv++e++ge+++ +LkpgG++ipVtneNk eYv+lv+e+++ ++++eq++af +Gfne+ip 
   Q: 589  KKVSLQDMEGVDEDLHRNLAWTLEN---DIEGI-IELTFSVDDEKFGERTTIDLKPGGRDIPVTNENKGEYVELVTEWKIVKRVEEQFNAFMSGFNELIPA 685
           ***********************99...9***9.******************************************************************* PP
   S: 204  ellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPs 300
           +l+++F+e+elelli G ++idv+d+kk+t y+g y+e++++iq+Fw++++ +++e+++++LqF+Tg+sr+P++Gf++l+    pr+f+i+k++++  lP+
   Q: 686  DLVNVFDERELELLIGGIADIDVDDWKKHTDYRG-YQEQDEVIQNFWKIVRTWDAEQKSRLLQFTTGTSRIPVNGFKDLQgsdgPRRFTIEKSGDPIALPK 785
           ********************************76.****************************************************************** PP
   S: 301  snTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           s+TCfn+L+LP+Y++ ++l++kL +A+eet gF++
   Q: 786  SHTCFNRLDLPPYKTHDVLEHKLSIAVEETLGFGQ 820
           *********************************86 PP

Organism

Aspergillus niger

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Probably involved in the regulatory network controlling carbon source utilization.

Protein Sequence
(Fasta)

MGSNLPAQPN LRVTIIAADG LYKRDVFRFP DPFAVATVGG EQTHTTSVIK KTLNPYWNEM 60
FDLRVNEDSI LAIQIFDQKK FKKKDQGFLG VINVRIGDVI DLQMGGDEML TRDLKKSNDN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGTTCCA ACCTGCCAGC GTATGTGCAT ACCTCGGATT CTCCCCTTGC GTGATGTCTT 60
GAACATCAGA GTCGTTTCTG TGTGCGTGCG TGGTGCTACT GGCAGGATGC TAACCATCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043328--P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0016567--P:protein ubiquitination

KEGG

ang:ANI_1_154074

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	48.49	6.00e-157	546.00
IUUC-Apl-003893	Anas platyrhynchos	47.99	2.00e-154	538.00
IUUC-Aca-005338	Anolis carolinensis	46.82	6.00e-153	533.00
IUUC-Ago-007742	Ashbya gossypii	65.82	0.00e+00	1006.00
IUUC-Acl-008273	Aspergillus clavatus	91.40	0.00e+00	1424.00
IUUC-Afl-008713	Aspergillus flavus	93.25	0.00e+00	1432.00
IUUC-Afu-009103	Aspergillus fumigatus	88.77	0.00e+00	1390.00
IUUC-Ani-009259	Aspergillus nidulans	90.63	0.00e+00	1441.00
IUUC-Aor-010053	Aspergillus oryzae	97.66	4.00e-177	611.00
IUUC-Ate-010529	Aspergillus terreus	92.81	0.00e+00	1464.00
IUUC-Ame-010810	Astyanax mexicanus	53.91	5.00e-146	509.00
IUUC-Bgr-012148	Blumeria graminis	72.26	0.00e+00	1104.00
IUUC-Bta-012679	Bos taurus	48.49	3.00e-157	546.00
IUUC-Bci-013785	Botrytis cinerea	73.35	0.00e+00	1177.00
IUUC-Cel-018299	Caenorhabditis elegans	45.58	4.00e-149	520.00
IUUC-Cja-018732	Callithrix jacchus	48.49	2.00e-157	547.00
IUUC-Cfa-021226	Canis familiaris	48.49	6.00e-157	546.00
IUUC-Cpo-021671	Cavia porcellus	48.49	4.00e-157	546.00
IUUC-Csa-023344	Chlorocebus sabaeus	46.92	5.00e-153	533.00
IUUC-Cho-024695	Choloepus hoffmanni	47.49	6.00e-155	539.00
IUUC-Cin-025212	Ciona intestinalis	48.87	8.00e-141	492.00
IUUC-Csv-026256	Ciona savignyi	48.57	2.00e-139	487.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	72.82	0.00e+00	1118.00
IUUC-Cne-026849	Cryptococcus neoformans	61.93	0.00e+00	988.00
IUUC-Dre-027770	Danio rerio	53.91	2.00e-146	511.00
IUUC-Dno-029466	Dasypus novemcinctus	48.49	4.00e-157	546.00
IUUC-Dor-030138	Dipodomys ordii	47.83	3.00e-152	530.00
IUUC-Dse-031241	Dothistroma septosporum	75.61	0.00e+00	1203.00
IUUC-Dme-032041	Drosophila melanogaster	45.53	7.00e-143	499.00
IUUC-Ete-033145	Echinops telfairi	45.65	2.00e-144	504.00
IUUC-Eca-033445	Equus caballus	48.49	1.00e-156	545.00
IUUC-Eeu-035247	Erinaceus europaeus	48.33	3.00e-156	544.00
IUUC-Fca-036384	Felis catus	47.98	1.00e-155	543.00
IUUC-Fal-037547	Ficedula albicollis	46.28	5.00e-150	523.00
IUUC-Fox-037774	Fusarium oxysporum	72.38	0.00e+00	1121.00
IUUC-Fso-038393	Fusarium solani	71.88	0.00e+00	1102.00
IUUC-Gmo-039679	Gadus morhua	46.80	5.00e-148	516.00
IUUC-Ggr-040107	Gaeumannomyces graminis	71.51	0.00e+00	1147.00
IUUC-Gga-040703	Gallus gallus	49.00	9.00e-155	539.00
IUUC-Gac-042020	Gasterosteus aculeatus	52.67	8.00e-146	509.00
IUUC-Ggo-045332	Gorilla gorilla	48.49	9.00e-157	545.00
IUUC-Hsa-045968	Homo sapiens	48.49	6.00e-157	546.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	47.32	3.00e-154	537.00
IUUC-Kpa-049273	Komagataella pastoris	66.01	0.00e+00	1035.00
IUUC-Lch-050443	Latimeria chalumnae	48.33	2.00e-155	541.00
IUUC-Loc-052662	Lepisosteus oculatus	52.67	6.00e-142	496.00
IUUC-Lma-052980	Leptosphaeria maculans	72.08	0.00e+00	693.00
IUUC-Laf-053850	Loxodonta africana	48.49	8.00e-157	546.00
IUUC-Mcc-055821	Macaca mulatta	48.49	5.00e-157	546.00
IUUC-Meu-055953	Macropus eugenii	39.77	4.00e-117	414.00
IUUC-Mor-057097	Magnaporthe oryzae	73.31	0.00e+00	1162.00
IUUC-Mpo-057442	Magnaporthe poae	68.97	0.00e+00	1020.00
IUUC-Mla-058996	Melampsora laricipopulina	78.38	0.00e+00	813.00
IUUC-Mga-059661	Meleagris gallopavo	47.49	2.00e-154	538.00
IUUC-Mvi-060395	Microbotryum violaceum	79.00	0.00e+00	820.00
IUUC-Mmr-061061	Microcebus murinus	47.30	4.00e-157	547.00
IUUC-Mdo-062173	Monodelphis domestica	46.84	2.00e-152	531.00
IUUC-Mmu-064136	Mus musculus	48.49	7.00e-157	546.00
IUUC-Mpu-066765	Mustela putorius furo	48.49	1.00e-156	545.00
IUUC-Mlu-067565	Myotis lucifugus	48.49	2.00e-156	545.00
IUUC-Nfi-068427	Neosartorya fischeri	91.35	0.00e+00	1418.00
IUUC-Ncr-068918	Neurospora crassa	71.91	0.00e+00	1104.00
IUUC-Nle-069070	Nomascus leucogenys	47.41	3.00e-151	527.00
IUUC-Opr-071044	Ochotona princeps	48.33	3.00e-156	544.00
IUUC-Ont-071664	Oreochromis niloticus	46.98	7.00e-144	503.00
IUUC-Oan-073019	Ornithorhynchus anatinus	45.78	1.00e-147	515.00
IUUC-Ocu-074160	Oryctolagus cuniculus	48.41	2.00e-156	544.00
IUUC-Ola-087467	Oryzias latipes	52.26	3.00e-145	507.00
IUUC-Oga-088460	Otolemur garnettii	48.49	9.00e-157	545.00
IUUC-Oar-090198	Ovis aries	48.83	7.00e-157	546.00
IUUC-Ptr-090939	Pan troglodytes	48.49	6.00e-157	546.00
IUUC-Pan-092284	Papio anubis	48.49	6.00e-157	546.00
IUUC-Psi-093645	Pelodiscus sinensis	47.99	5.00e-156	543.00
IUUC-Pma-094364	Petromyzon marinus	52.66	4.00e-143	499.00
IUUC-Pno-095118	Phaeosphaeria nodorum	74.47	0.00e+00	1186.00
IUUC-Pfo-097145	Poecilia formosa	52.06	2.00e-143	501.00
IUUC-Pab-098088	Pongo abelii	48.49	4.00e-157	546.00
IUUC-Pca-100596	Procavia capensis	48.66	6.00e-136	476.00
IUUC-Pva-102354	Pteropus vampyrus	48.49	2.00e-156	545.00
IUUC-Pgr-103620	Puccinia graminis	78.17	0.00e+00	802.00
IUUC-Ptt-103806	Puccinia triticina	78.78	0.00e+00	691.00
IUUC-Pte-104016	Pyrenophora teres	75.00	0.00e+00	1192.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	75.00	0.00e+00	1192.00
IUUC-Rno-105318	Rattus norvegicus	48.49	5.00e-157	546.00
IUUC-Sce-106289	Saccharomyces cerevisiae	74.05	0.00e+00	915.00
IUUC-Sha-107482	Sarcophilus harrisii	52.76	3.00e-146	511.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	65.52	0.00e+00	1037.00
IUUC-Spo-108171	Schizosaccharomyces pombe	65.81	0.00e+00	1040.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	73.82	0.00e+00	1168.00
IUUC-Stu-112894	Solanum tuberosum	34.62	8.00e-56	210.00
IUUC-Sar-113761	Sorex araneus	47.32	3.00e-153	533.00
IUUC-Sre-114929	Sporisorium reilianum	71.72	0.00e+00	872.00
IUUC-Ssc-115368	Sus scrofa	43.53	4.00e-146	510.00
IUUC-Tgu-117130	Taeniopygia guttata	47.99	2.00e-154	538.00
IUUC-Tru-118610	Takifugu rubripes	54.32	4.00e-153	533.00
IUUC-Tsy-119492	Tarsius syrichta	48.66	1.00e-155	541.00
IUUC-Tni-119993	Tetraodon nigroviridis	46.23	1.00e-146	512.00
IUUC-Tre-122203	Trichoderma reesei	72.47	0.00e+00	1103.00
IUUC-Tvi-122595	Trichoderma virens	72.26	0.00e+00	1122.00
IUUC-Tme-126897	Tuber melanosporum	70.57	0.00e+00	1088.00
IUUC-Tbe-127793	Tupaia belangeri	47.42	4.00e-131	460.00
IUUC-Ttr-128235	Tursiops truncatus	53.29	3.00e-147	514.00
IUUC-Uma-129332	Ustilago maydis	71.72	0.00e+00	837.00
IUUC-Vda-129753	Verticillium dahliae	69.46	0.00e+00	1061.00
IUUC-Vpa-130503	Vicugna pacos	51.24	1.00e-137	482.00
IUUC-Xtr-132859	Xenopus tropicalis	49.00	8.00e-157	546.00
IUUC-Xma-133797	Xiphophorus maculatus	53.29	1.00e-148	518.00
IUUC-Yli-134668	Yarrowia lipolytica	73.79	0.00e+00	934.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence