iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dse-031241

Ensembl Protein ID

EME44674

UniProt Accession

N1PQH5; N1PQH5_DOTSN

Genbank Protein ID

EME44674.1

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

KB446539

Gene Name

DOTSEDRAFT_72208

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
DOTSEDRAFT_72208	EME44674	EME44674

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.00e-123	410.8	482	813

Active Site

Position(s)	Description	Evidence
782	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
           ++dlkkrl+++f gE+gld+gG++ref++lls+e++np ++lf+ys+ d++tlq+np+sg+ npehl +F+f+Gr++g+a++++r+ld+++  +fyk++l+
   Q: 482  PNDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGI-NPEHLGYFKFIGRVVGLAIFHRRFLDAFFIGAFYKMILK 581
           689*********************************************************9.89************************************* PP
   S: 103  kklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnevipl 203
           kk++l d+e vd+e++++l++ ken   di++  +  tfsv++e +ge  +++LkpgG++i+VtneNkeeY++l++e+r++++++eq++af +Gf+e+ip 
   Q: 582  KKVNLADMEGVDAEFHRTLTWAKEN---DITDV-IYSTFSVEDERFGEKVTVDLKPGGRDIEVTNENKEEYIELITEWRIQKRVEEQFNAFVAGFHELIPA 678
           ***********************99...9***8.******************************************************************* PP
   S: 204  ellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPs 300
           +l+++F+e+elelli G ++idv+d+kk+t y+g yte++ +iq Fw++++++++e+++++LqF+Tg+sr+P++Gf++l+    pr+f+i+k++++++lP+
   Q: 679  DLVNVFDERELELLIGGIADIDVDDWKKHTDYRG-YTENDAVIQSFWKCIRSWDAEQKSRLLQFATGTSRIPVNGFKDLQgsdgPRRFTIEKSGEEAQLPK 778
           ********************************76.****************************************************************** PP
   S: 301  snTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           s+TCfn+L+LP+Y+s++ l +kL++A+eet gF++
   Q: 779  SHTCFNRLDLPPYKSYDALTQKLTWAVEETVGFGQ 813
           *********************************96 PP

Organism

Dothistroma septosporum

Protein Sequence
(Fasta)

MELPSQPNLR VTIIAADGLY KRDVFRFPDP FAVATISGEQ TRTTGVIKKT LNPYWNESFD 60
MRVTEESILA VQIFDQKKFK KKDQGFLGVV NVRIGSVIDM DAGGDEMITR DLRKSNDNLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TACGCCGGAC GACACGCCCC ACGGACCATC ACTACCACCT CTTGGAAGCG CCTATCTGGG 60
TGCATAGAAC ATCAATACCG GTGGGCGGCG GCATCGAGGC GGCGCTGAGC GCAGAGACCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	46.27	2.00e-155	541.00
IUUC-Apl-003893	Anas platyrhynchos	44.00	5.00e-153	533.00
IUUC-Aca-005338	Anolis carolinensis	47.80	2.00e-156	544.00
IUUC-Ago-007742	Ashbya gossypii	64.37	0.00e+00	1002.00
IUUC-Acl-008273	Aspergillus clavatus	74.18	0.00e+00	1180.00
IUUC-Afl-008713	Aspergillus flavus	75.21	0.00e+00	1178.00
IUUC-Afu-009103	Aspergillus fumigatus	72.43	0.00e+00	1151.00
IUUC-Ani-009259	Aspergillus nidulans	73.45	0.00e+00	1187.00
IUUC-Ang-009738	Aspergillus niger	74.79	0.00e+00	1201.00
IUUC-Aor-010053	Aspergillus oryzae	81.94	1.00e-152	530.00
IUUC-Ate-010529	Aspergillus terreus	75.03	0.00e+00	1191.00
IUUC-Ame-011138	Astyanax mexicanus	50.10	6.00e-141	493.00
IUUC-Bgr-012148	Blumeria graminis	72.84	0.00e+00	1108.00
IUUC-Bta-012679	Bos taurus	47.07	3.00e-155	540.00
IUUC-Bci-013785	Botrytis cinerea	72.81	0.00e+00	1168.00
IUUC-Cel-018299	Caenorhabditis elegans	45.19	8.00e-147	512.00
IUUC-Cja-018732	Callithrix jacchus	47.07	2.00e-155	541.00
IUUC-Cfa-021226	Canis familiaris	44.53	2.00e-155	541.00
IUUC-Cpo-021671	Cavia porcellus	46.27	3.00e-155	541.00
IUUC-Csa-023344	Chlorocebus sabaeus	45.53	2.00e-151	528.00
IUUC-Cho-024695	Choloepus hoffmanni	45.04	6.00e-160	556.00
IUUC-Cin-025157	Ciona intestinalis	45.39	1.00e-149	522.00
IUUC-Csv-026256	Ciona savignyi	45.29	9.00e-148	515.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	72.85	0.00e+00	1135.00
IUUC-Cne-026849	Cryptococcus neoformans	62.67	0.00e+00	1003.00
IUUC-Dre-028809	Danio rerio	44.95	2.00e-151	527.00
IUUC-Dno-029466	Dasypus novemcinctus	47.07	3.00e-155	541.00
IUUC-Dor-030138	Dipodomys ordii	44.07	5.00e-151	526.00
IUUC-Dme-032041	Drosophila melanogaster	46.62	2.00e-144	505.00
IUUC-Ete-033145	Echinops telfairi	41.80	1.00e-141	496.00
IUUC-Eca-033445	Equus caballus	47.07	5.00e-155	540.00
IUUC-Eeu-035247	Erinaceus europaeus	46.27	1.00e-154	538.00
IUUC-Fca-036384	Felis catus	48.07	4.00e-158	550.00
IUUC-Fal-037126	Ficedula albicollis	48.22	1.00e-156	545.00
IUUC-Fox-037774	Fusarium oxysporum	72.55	0.00e+00	1137.00
IUUC-Fso-038393	Fusarium solani	70.84	0.00e+00	1101.00
IUUC-Gmo-039674	Gadus morhua	42.78	1.00e-150	525.00
IUUC-Ggr-040107	Gaeumannomyces graminis	72.84	0.00e+00	1157.00
IUUC-Gga-040703	Gallus gallus	47.32	3.00e-153	534.00
IUUC-Gac-042020	Gasterosteus aculeatus	46.08	2.00e-150	525.00
IUUC-Ggo-045332	Gorilla gorilla	47.07	5.00e-155	540.00
IUUC-Hsa-045968	Homo sapiens	47.07	2.00e-155	541.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	45.09	6.00e-157	546.00
IUUC-Kpa-049273	Komagataella pastoris	67.48	0.00e+00	1060.00
IUUC-Lch-050443	Latimeria chalumnae	46.57	1.00e-153	535.00
IUUC-Loc-052645	Lepisosteus oculatus	47.38	6.00e-153	533.00
IUUC-Lma-052980	Leptosphaeria maculans	74.75	0.00e+00	707.00
IUUC-Laf-053850	Loxodonta africana	44.53	3.00e-155	541.00
IUUC-Mcc-055821	Macaca mulatta	47.07	3.00e-155	540.00
IUUC-Meu-055953	Macropus eugenii	40.27	2.00e-118	418.00
IUUC-Mor-057097	Magnaporthe oryzae	73.53	0.00e+00	1182.00
IUUC-Mpo-057442	Magnaporthe poae	68.77	0.00e+00	1036.00
IUUC-Mla-058996	Melampsora laricipopulina	64.12	0.00e+00	1017.00
IUUC-Mga-059661	Meleagris gallopavo	46.32	3.00e-156	544.00
IUUC-Mvi-060395	Microbotryum violaceum	80.71	0.00e+00	844.00
IUUC-Mmr-061061	Microcebus murinus	47.55	3.00e-160	558.00
IUUC-Mdo-062173	Monodelphis domestica	43.23	9.00e-151	526.00
IUUC-Mmu-064136	Mus musculus	47.24	2.00e-155	541.00
IUUC-Mpu-066765	Mustela putorius furo	47.07	3.00e-155	540.00
IUUC-Mlu-067565	Myotis lucifugus	47.07	1.00e-154	538.00
IUUC-Nfi-068427	Neosartorya fischeri	75.12	0.00e+00	1186.00
IUUC-Ncr-068918	Neurospora crassa	70.71	0.00e+00	1115.00
IUUC-Nle-069244	Nomascus leucogenys	47.88	1.00e-156	545.00
IUUC-Opr-071044	Ochotona princeps	46.27	2.00e-154	538.00
IUUC-Ont-071664	Oreochromis niloticus	45.92	1.00e-143	502.00
IUUC-Oan-073019	Ornithorhynchus anatinus	46.05	3.00e-148	517.00
IUUC-Ocu-074160	Oryctolagus cuniculus	44.46	9.00e-155	539.00
IUUC-Ola-087467	Oryzias latipes	46.47	5.00e-151	526.00
IUUC-Oga-088460	Otolemur garnettii	47.07	3.00e-155	540.00
IUUC-Oar-090198	Ovis aries	46.07	9.00e-156	542.00
IUUC-Ptr-090939	Pan troglodytes	47.07	2.00e-155	541.00
IUUC-Pan-092284	Papio anubis	47.07	3.00e-155	540.00
IUUC-Psi-093645	Pelodiscus sinensis	47.16	1.00e-155	541.00
IUUC-Pma-094364	Petromyzon marinus	52.34	2.00e-142	496.00
IUUC-Pno-095118	Phaeosphaeria nodorum	77.13	0.00e+00	1262.00
IUUC-Pfo-097145	Poecilia formosa	46.43	2.00e-147	514.00
IUUC-Pab-098088	Pongo abelii	47.07	2.00e-155	541.00
IUUC-Pca-100596	Procavia capensis	49.59	1.00e-140	491.00
IUUC-Pva-102354	Pteropus vampyrus	44.53	5.00e-155	540.00
IUUC-Pgr-103620	Puccinia graminis	68.83	0.00e+00	876.00
IUUC-Ptt-103806	Puccinia triticina	80.87	0.00e+00	712.00
IUUC-Pte-104016	Pyrenophora teres	78.67	0.00e+00	1257.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	78.67	0.00e+00	1257.00
IUUC-Rno-105318	Rattus norvegicus	47.24	2.00e-155	541.00
IUUC-Sce-106289	Saccharomyces cerevisiae	65.57	0.00e+00	1017.00
IUUC-Sha-107482	Sarcophilus harrisii	44.53	2.00e-153	534.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	66.54	0.00e+00	1051.00
IUUC-Spo-108171	Schizosaccharomyces pombe	66.87	0.00e+00	1051.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	71.98	0.00e+00	1162.00
IUUC-Sar-113761	Sorex araneus	47.71	7.00e-156	542.00
IUUC-Sre-114929	Sporisorium reilianum	72.42	0.00e+00	896.00
IUUC-Ssc-115368	Sus scrofa	43.65	6.00e-148	516.00
IUUC-Tgu-117130	Taeniopygia guttata	46.90	6.00e-153	533.00
IUUC-Tru-118442	Takifugu rubripes	44.97	7.00e-157	546.00
IUUC-Tsy-119492	Tarsius syrichta	46.10	6.00e-153	533.00
IUUC-Tni-119993	Tetraodon nigroviridis	45.71	5.00e-147	513.00
IUUC-Tre-122203	Trichoderma reesei	72.44	0.00e+00	1114.00
IUUC-Tvi-122595	Trichoderma virens	72.86	0.00e+00	1143.00
IUUC-Tme-126897	Tuber melanosporum	70.76	0.00e+00	1106.00
IUUC-Tbe-127793	Tupaia belangeri	48.35	1.00e-135	475.00
IUUC-Ttr-128275	Tursiops truncatus	46.87	5.00e-152	530.00
IUUC-Uma-129332	Ustilago maydis	72.59	0.00e+00	857.00
IUUC-Vda-129753	Verticillium dahliae	70.55	0.00e+00	1088.00
IUUC-Vpa-130503	Vicugna pacos	49.79	2.00e-137	481.00
IUUC-Xtr-132859	Xenopus tropicalis	44.38	2.00e-154	538.00
IUUC-Xma-133797	Xiphophorus maculatus	48.01	3.00e-153	534.00
IUUC-Yli-134668	Yarrowia lipolytica	75.28	0.00e+00	969.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence