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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046967
UUCD1 version UUC-HoS-00254
Ensembl Protein ID ENSP00000252015.2
UniProt Accession Q8TEL6; E1P5Q0; E1P5Q1; Q96H82; Q9BVB8; Q9H429; Q9UFS6; TP4AP_HUMAN
Genbank Protein ID BAB84932.1; BAJ20695.1; CAC14946.1; EAW76233.1; EAW76235.1; EAW76229.1; EAW76234.1; AAH01323.1; AAH08836.2; AAH13144.1; CAB55953.1
Protein Name Short transient receptor potential channel 4-associated protein; Protein TAP1; TNF-receptor ubiquitous scaffolding/signaling protein
Genbank Nucleotide ID AK074106; AB590540; AL132825; CH471077; CH471077; CH471077; CH471077; BC001323; BC008836; BC013144; AL117480
Gene Name TRPC4AP; C20orf188; TRRP4AP
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000100991.11 ENST00000451813.6 ENSP00000400614.1
ENSG00000100991.11 ENST00000252015.2 ENSP00000252015.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/Other E3 adaptor/Cullin RING/Other 20551172
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.
 Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.
Protein Sequence
(Fasta)
MAAAPVAAGS GAGRGRRSAA TVAAWGGWGG RPRPGNILLQ LRQGQLTGRG LVRAVQFTET 60
FLTERDKQSK WSGIPQLLLK LHTTSHLHSD FVECQNILKE ISPLLSMEAM AFVTEERKLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046967|E3,Cullin RING/Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTGGGGGCG CTGCGGCGAC CCCTCCGCCG CCCCGTAGAA ATCTCCGCGG CCCCGAGGCC 60
GCTTGCTTCC TGTTTGTCCG ACGAGGAGAC ATGGCGGCGG CGCCGGTAGC GGCTGGGTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046967|E3,Cullin RING/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR022162--DUF3689
Pfam

PF12463--DUF3689
Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0005886--C:plasma membrane
GO:0005262--F:calcium channel activity
GO:0019902--F:phosphatase binding
GO:0070588--P:calcium ion transmembrane transport
GO:0048820--P:hair follicle maturation
GO:0016567--P:protein ubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:26133
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002271 Ailuropoda melanoleuca 97.12 0.00e+00 1458.00
IUUC-Apl-003296 Anas platyrhynchos 85.37 0.00e+00 1249.00
IUUC-Aca-004428 Anolis carolinensis 82.41 0.00e+00 1276.00
IUUC-Bta-013309 Bos taurus 99.06 0.00e+00 1456.00
IUUC-Cja-019857 Callithrix jacchus 99.60 0.00e+00 1469.00
IUUC-Cfa-020458 Canis familiaris 99.19 0.00e+00 1463.00
IUUC-Cpo-021530 Cavia porcellus 98.66 0.00e+00 1450.00
IUUC-Csa-024042 Chlorocebus sabaeus 99.60 0.00e+00 1468.00
IUUC-Dno-029698 Dasypus novemcinctus 91.86 0.00e+00 1352.00
IUUC-Dor-030424 Dipodomys ordii 88.89 4.00e-93 336.00
IUUC-Ete-032935 Echinops telfairi 78.48 0.00e+00 1107.00
IUUC-Eca-033775 Equus caballus 99.60 0.00e+00 1466.00
IUUC-Eeu-034570 Erinaceus europaeus 93.55 0.00e+00 1367.00
IUUC-Fca-035469 Felis catus 99.33 0.00e+00 1461.00
IUUC-Itr-049049 Ictidomys tridecemlineatus 99.78 0.00e+00 889.00
IUUC-Lch-049503 Latimeria chalumnae 79.62 0.00e+00 1197.00
IUUC-Laf-054113 Loxodonta africana 99.19 0.00e+00 1471.00
IUUC-Mcc-054997 Macaca mulatta 99.73 0.00e+00 1470.00
IUUC-Mga-059837 Meleagris gallopavo 81.79 0.00e+00 1248.00
IUUC-Mmr-061617 Microcebus murinus 98.92 0.00e+00 1461.00
IUUC-Mmu-064323 Mus musculus 98.12 0.00e+00 1442.00
IUUC-Mpu-066520 Mustela putorius furo 99.33 0.00e+00 1465.00
IUUC-Mlu-067982 Myotis lucifugus 98.79 0.00e+00 1453.00
IUUC-Nfi-068409 Neosartorya fischeri 34.04 1.90e-02 32.30
IUUC-Nle-069547 Nomascus leucogenys 95.70 0.00e+00 1392.00
IUUC-Opr-070688 Ochotona princeps 90.52 0.00e+00 1369.00
IUUC-Ocu-074062 Oryctolagus cuniculus 98.56 0.00e+00 1485.00
IUUC-Oga-088592 Otolemur garnettii 98.92 0.00e+00 1458.00
IUUC-Oar-090121 Ovis aries 98.13 0.00e+00 1445.00
IUUC-Ptr-090791 Pan troglodytes 99.87 0.00e+00 1442.00
IUUC-Pan-092043 Papio anubis 100.00 0.00e+00 1365.00
IUUC-Pab-097973 Pongo abelii 99.87 0.00e+00 1442.00
IUUC-Pca-100766 Procavia capensis 91.94 0.00e+00 1377.00
IUUC-Pva-102516 Pteropus vampyrus 97.78 0.00e+00 1231.00
IUUC-Rno-105758 Rattus norvegicus 98.12 0.00e+00 1444.00
IUUC-Sha-107329 Sarcophilus harrisii 84.36 0.00e+00 1303.00
IUUC-Sar-112997 Sorex araneus 87.30 2.00e-157 549.00
IUUC-Ssc-115491 Sus scrofa 99.33 0.00e+00 1462.00
IUUC-Tgu-116860 Taeniopygia guttata 84.38 0.00e+00 1324.00
IUUC-Tru-117727 Takifugu rubripes 73.79 0.00e+00 1143.00
IUUC-Tbe-127852 Tupaia belangeri 83.15 3.00e-117 416.00
IUUC-Ttr-129195 Tursiops truncatus 99.19 0.00e+00 1456.00
Created Date 25-Jun-2017

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