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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064114
UUCD1 version UUC-MuM-01130
Ensembl Protein ID ENSMUSP00000035328.7
UniProt Accession Q8C7R4; UBA6_MOUSE
Genbank Protein ID BAC33836.1; AAH63048.1
Protein Name Ubiquitin-like modifier-activating enzyme 6; Ubiquitin-activating enzyme E1-like protein 2
Genbank Nucleotide ID AK049603; BC063048
Gene Name Uba6; Ube1l2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000035898.13 ENSMUST00000039373.13 ENSMUSP00000035328.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDPINAHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E1 1.90e-216 720.2 443 930
Active Site
Position(s) Description Evidence
625 Glycyl thioester intermediate N/A
Domain Profile

   E1
   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv......gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealke 83
           YD  ++++G + ++kl++ +++lvG+g++GcE+lKn++l+Gv      g++tv+D d +e+snlnrqFLfr+++++k+K+ +aaea  +
   Q: 443  YDAIRACIGNTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVgtgrekGMVTVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAAEATLK 531
           9**************************************************************************************** PP
   S: 84   lnpdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqk 169
           +np+ +++ah +++++ +e+i+   F++k d++++aldn+earr+v+++cl++ +pl++sgt+G++G++++i+++lte+y++++dpp++
   Q: 532  INPQLKIDAHLNKVCPATESIYsdeFYTKQDIIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEIIVPQLTESYNSHRDPPEE 620
           ***************************************************************************************** PP
   S: 170  tiPfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafa 246
           +iPfctlk++p+a+ehti+wa            +lfnk+++ ++++e+vl+k+++ +++eg+++v  +l s++++ +++++e+a+ +f+
   Q: 621  EIPFCTLKSFPAAIEHTIQWArdkfessfshkpSLFNKFWQAYPSAEDVLQKIQNGQSLEGCFQV-IKLLSRRPRIWSQCVELARLKFE 708
           *****************************************************************.999******************** PP
   S: 247  kttinsikqllksfecdivtkskspfwv.........................................................sfcs 278
           k++++++ qll++f+ + + k++s fw+                                                         +f++
   Q: 709  KYFNHKALQLLHCFPLETRLKDGSLFWQspkrppspikfdlneplhlsflqsaaklyatvycipfsekdlsvnslmdilsevkieEFKP 797
           ***************************************************************************************** PP
   S: 279  naealqvpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlike 360
            ++ +q++e++ k+ +v  +s++     ++l+ +  ++ ++k+++++++lsfekddd   ++d++taa+nlra++++iep +d++++k+
   Q: 798  SNKVVQTDETARKPDHVPVSSEDernavFQLEEALSSNKATKSDLQMTVLSFEKDDDRngHIDFITAASNLRAKMYSIEP-ADRFKTKR 885
           ****************998888899*988888888899999***************************************.******** PP
   S: 361  iagniipaiattnavvgGlaaqEviKvvsg.kfeplknfflfdae 404
           iag+iipaiat +a+v+Gl+a+E+iKv+ g +f+++kn+fl++a+
   Q: 886  IAGKIIPAIATSTAAVSGLVALEMIKVAGGyPFDAYKNCFLNLAI 930
           *****************************************9886 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34 (By similarity). Essential for embryonic development. Required for UBD/FAT10 conjugation.
 Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34 (By similarity). Essential for embryonic development. Required for UBD/FAT10 conjugation.
Protein Sequence
(Fasta)
MERSEPLAVL SCEEASCSSW GACGASKNLP TMTTESLEID DGLYSRQRYV LGDTAMQKMA 60
KSCVFLSGMG GLGVEIAKNL VLAGIKALTI HDTKKCQAWD LGTNFFLCED DVVNERNRAE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064114|E1,E1_ThiF|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACCCTCGCG GCCCCGCCCC CTCGCCTGCC TCCCCGCCTC GCTGCAGTCA GTCTGTCGGA 60
AGGCGATGGA GCGGTCCGAG CCGTTGGCTG TGCTTTCCTG TGAAGAGGCG TCCTGCTCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064114|E1,E1_ThiF|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR000011--UBQ/SUMO-activ_enz_E1-like
Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys
PRINTS

PR01849--UBIQUITINACT
SMART

SM00985--UBA_e1_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0019780--F:FAT10 activating enzyme activity
GO:0004839--F:ubiquitin activating enzyme activity
GO:0021764--P:amygdala development
GO:0060996--P:dendritic spine development
GO:0021766--P:hippocampus development
GO:0007612--P:learning
GO:0007626--P:locomotory behavior
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:231380
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001608 Ailuropoda melanoleuca 90.11 0.00e+00 1994.00
IUUC-Apl-004158 Anas platyrhynchos 79.13 0.00e+00 1721.00
IUUC-Aca-005349 Anolis carolinensis 80.02 0.00e+00 1752.00
IUUC-Bta-012696 Bos taurus 88.51 0.00e+00 1960.00
IUUC-Cja-019563 Callithrix jacchus 89.35 0.00e+00 1951.00
IUUC-Cfa-020951 Canis familiaris 90.02 0.00e+00 1997.00
IUUC-Cpo-022307 Cavia porcellus 87.19 0.00e+00 1905.00
IUUC-Csa-023647 Chlorocebus sabaeus 89.45 0.00e+00 1955.00
IUUC-Cho-024682 Choloepus hoffmanni 73.08 0.00e+00 888.00
IUUC-Dre-028022 Danio rerio 68.11 0.00e+00 1489.00
IUUC-Dno-029796 Dasypus novemcinctus 88.10 0.00e+00 1885.00
IUUC-Dor-030981 Dipodomys ordii 75.20 0.00e+00 1503.00
IUUC-Ete-032514 Echinops telfairi 76.50 0.00e+00 1124.00
IUUC-Eca-033697 Equus caballus 89.17 0.00e+00 1936.00
IUUC-Eeu-035323 Erinaceus europaeus 80.36 0.00e+00 1300.00
IUUC-Fca-035858 Felis catus 90.93 0.00e+00 1963.00
IUUC-Fal-036848 Ficedula albicollis 79.73 0.00e+00 1721.00
IUUC-Gmo-039326 Gadus morhua 66.73 0.00e+00 1387.00
IUUC-Gga-040747 Gallus gallus 79.92 0.00e+00 1714.00
IUUC-Gac-041406 Gasterosteus aculeatus 67.22 0.00e+00 1394.00
IUUC-Ggo-044577 Gorilla gorilla 88.98 0.00e+00 1951.00
IUUC-Hsa-046007 Homo sapiens 89.07 0.00e+00 1945.00
IUUC-Itr-048191 Ictidomys tridecemlineatus 93.07 0.00e+00 1049.00
IUUC-Lch-049992 Latimeria chalumnae 71.82 0.00e+00 1520.00
IUUC-Loc-051899 Lepisosteus oculatus 69.40 0.00e+00 1508.00
IUUC-Laf-054413 Loxodonta africana 89.44 0.00e+00 1821.00
IUUC-Mcc-054656 Macaca mulatta 89.45 0.00e+00 1954.00
IUUC-Meu-056463 Macropus eugenii 71.41 0.00e+00 1407.00
IUUC-Mga-059721 Meleagris gallopavo 79.24 0.00e+00 1611.00
IUUC-Mmr-060908 Microcebus murinus 86.22 0.00e+00 1901.00
IUUC-Mdo-062096 Monodelphis domestica 84.11 0.00e+00 1877.00
IUUC-Mpu-066017 Mustela putorius furo 90.02 0.00e+00 2005.00
IUUC-Mlu-068037 Myotis lucifugus 86.67 0.00e+00 1885.00
IUUC-Nle-069494 Nomascus leucogenys 88.88 0.00e+00 1941.00
IUUC-Opr-070910 Ochotona princeps 64.16 1.00e-164 573.00
IUUC-Ont-071592 Oreochromis niloticus 68.46 0.00e+00 1443.00
IUUC-Oan-073268 Ornithorhynchus anatinus 79.18 0.00e+00 1572.00
IUUC-Ocu-074296 Oryctolagus cuniculus 89.73 0.00e+00 1966.00
IUUC-Ola-086376 Oryzias latipes 69.05 0.00e+00 1406.00
IUUC-Oga-088186 Otolemur garnettii 88.36 0.00e+00 1923.00
IUUC-Oar-089307 Ovis aries 89.08 0.00e+00 1971.00
IUUC-Ptr-090609 Pan troglodytes 89.16 0.00e+00 1945.00
IUUC-Pan-092905 Papio anubis 89.00 0.00e+00 1858.00
IUUC-Psi-093489 Pelodiscus sinensis 80.71 0.00e+00 1731.00
IUUC-Pma-094203 Petromyzon marinus 65.73 2.00e-56 211.00
IUUC-Pfo-096670 Poecilia formosa 69.57 0.00e+00 1472.00
IUUC-Pab-098418 Pongo abelii 89.26 0.00e+00 1946.00
IUUC-Pca-100889 Procavia capensis 73.00 0.00e+00 1537.00
IUUC-Pva-103144 Pteropus vampyrus 77.85 0.00e+00 1678.00
IUUC-Rno-105612 Rattus norvegicus 96.77 0.00e+00 2104.00
IUUC-Sha-107388 Sarcophilus harrisii 85.93 0.00e+00 1856.00
IUUC-Sar-113128 Sorex araneus 86.67 0.00e+00 1878.00
IUUC-Ssc-116117 Sus scrofa 89.55 0.00e+00 1976.00
IUUC-Tgu-116565 Taeniopygia guttata 80.12 0.00e+00 1731.00
IUUC-Tru-118591 Takifugu rubripes 67.64 0.00e+00 1425.00
IUUC-Tsy-119436 Tarsius syrichta 77.85 0.00e+00 1667.00
IUUC-Tni-120880 Tetraodon nigroviridis 67.41 0.00e+00 1420.00
IUUC-Tbe-127714 Tupaia belangeri 78.07 0.00e+00 1384.00
IUUC-Ttr-129159 Tursiops truncatus 78.14 0.00e+00 1664.00
IUUC-Vpa-130716 Vicugna pacos 87.88 0.00e+00 1844.00
IUUC-Xtr-132947 Xenopus tropicalis 69.34 0.00e+00 1506.00
Created Date 25-Jun-2017

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