iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-054377

Ensembl Protein ID

ENSLAFP00000008377.4

UniProt Accession

G3T4S5; G3T4S5_LOXAF

Protein Name

Histone-lysine N-methyltransferase

Gene Name

KMT2D

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000009989.4	ENSLAFT00000010001.4	ENSLAFP00000008377.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	5.10e-16	59.0	924	975

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCr 52
            C++C++++ +e+ l++C++C++w+H++C +l  eee+++  +  + C +C+
   Q: 924  TCPICHAPYVEEDLLIQCRHCERWMHAGCESLFTEEEVEQAADegFDCVSCQ 975
           6********************************888888877778******7 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MEELPAHSWK CKACRVCRAC GAGSAELNPN SEWFENYSLC HRCHKAQGGQ PIGPVAEQRP 60
SICSRFSPPE PGDTPTVEPD ALYVACQGQP KGGHVTSMQS KEPGPLQCEA KPLGRTGAQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGAAC TGCCAGCTCA CTCTTGGAAG TGTAAGGTGA GTATCCCTTG ATTCTGCCTT 60
CTCCCTAATT TTGCCTCCTA CAACAGCCCC AGAGTTCTCT GCTGTGACAA GTCCTTTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0008270--F:zinc ion binding
GO:0008284--P:positive regulation of cell proliferation
GO:0033148--P:positive regulation of intracellular estrogen receptor signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043627--P:response to estrogen

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001806	Ailuropoda melanoleuca	92.91	0.00e+00	3672.00
IUUC-Aca-005364	Anolis carolinensis	52.88	0.00e+00	1208.00
IUUC-Ame-010612	Astyanax mexicanus	81.00	0.00e+00	1010.00
IUUC-Bta-013011	Bos taurus	91.01	0.00e+00	3602.00
IUUC-Cel-018354	Caenorhabditis elegans	37.05	2.00e-63	239.00
IUUC-Cja-019841	Callithrix jacchus	91.12	0.00e+00	3670.00
IUUC-Cfa-021131	Canis familiaris	92.57	0.00e+00	3721.00
IUUC-Cpo-021957	Cavia porcellus	89.10	0.00e+00	3739.00
IUUC-Csa-023722	Chlorocebus sabaeus	92.02	0.00e+00	3632.00
IUUC-Dno-029932	Dasypus novemcinctus	90.79	0.00e+00	1659.00
IUUC-Dor-030192	Dipodomys ordii	85.75	0.00e+00	1707.00
IUUC-Ete-032572	Echinops telfairi	88.53	0.00e+00	2069.00
IUUC-Eca-034166	Equus caballus	92.79	0.00e+00	755.00
IUUC-Eeu-034848	Erinaceus europaeus	92.15	0.00e+00	1344.00
IUUC-Fca-035424	Felis catus	92.47	0.00e+00	3702.00
IUUC-Fal-037179	Ficedula albicollis	66.48	0.00e+00	1182.00
IUUC-Gmo-038719	Gadus morhua	82.41	0.00e+00	912.00
IUUC-Gga-040815	Gallus gallus	57.24	0.00e+00	1499.00
IUUC-Gac-042436	Gasterosteus aculeatus	79.68	0.00e+00	994.00
IUUC-Ggo-044711	Gorilla gorilla	92.10	0.00e+00	3621.00
IUUC-Hsa-046567	Homo sapiens	92.10	0.00e+00	3585.00
IUUC-Itr-048510	Ictidomys tridecemlineatus	90.98	0.00e+00	3672.00
IUUC-Loc-051979	Lepisosteus oculatus	82.81	0.00e+00	1060.00
IUUC-Mcc-055577	Macaca mulatta	90.91	0.00e+00	3576.00
IUUC-Meu-055992	Macropus eugenii	78.96	0.00e+00	1329.00
IUUC-Mmr-061772	Microcebus murinus	88.30	0.00e+00	3599.00
IUUC-Mdo-062876	Monodelphis domestica	77.69	0.00e+00	1150.00
IUUC-Mmu-063903	Mus musculus	87.37	0.00e+00	3435.00
IUUC-Mpu-066700	Mustela putorius furo	92.17	0.00e+00	3653.00
IUUC-Mlu-068180	Myotis lucifugus	91.47	0.00e+00	3737.00
IUUC-Nle-069362	Nomascus leucogenys	92.09	0.00e+00	3615.00
IUUC-Opr-070304	Ochotona princeps	87.53	0.00e+00	3421.00
IUUC-Ont-071881	Oreochromis niloticus	64.54	0.00e+00	1392.00
IUUC-Ocu-074053	Oryctolagus cuniculus	89.33	0.00e+00	3562.00
IUUC-Ola-086384	Oryzias latipes	59.62	0.00e+00	1316.00
IUUC-Oga-088450	Otolemur garnettii	90.55	0.00e+00	3795.00
IUUC-Oar-089975	Ovis aries	95.34	0.00e+00	2026.00
IUUC-Ptr-091073	Pan troglodytes	92.67	0.00e+00	3615.00
IUUC-Pan-092871	Papio anubis	90.83	0.00e+00	3628.00
IUUC-Pfo-097525	Poecilia formosa	63.71	0.00e+00	1320.00
IUUC-Pab-097679	Pongo abelii	92.32	0.00e+00	3685.00
IUUC-Pca-100499	Procavia capensis	90.36	0.00e+00	2337.00
IUUC-Pva-102898	Pteropus vampyrus	92.52	0.00e+00	3571.00
IUUC-Rno-105660	Rattus norvegicus	87.51	0.00e+00	3545.00
IUUC-Sha-107431	Sarcophilus harrisii	79.11	0.00e+00	3073.00
IUUC-Ssc-115678	Sus scrofa	91.33	0.00e+00	3529.00
IUUC-Tru-117922	Takifugu rubripes	80.21	0.00e+00	1009.00
IUUC-Tsy-118905	Tarsius syrichta	85.44	0.00e+00	1605.00
IUUC-Tbe-127625	Tupaia belangeri	83.07	5.00e-155	544.00
IUUC-Ttr-129162	Tursiops truncatus	90.42	0.00e+00	2096.00
IUUC-Xtr-132455	Xenopus tropicalis	64.25	0.00e+00	1313.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence