iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/ULP	84.23	0.00e+00	810.00	IUUC-Hsa-046929

Active Site

Position(s)	Description	Evidence
294	N/A	{ECO:0000250\|UniProtKB:Q99K23}
418		{ECO:0000250\|UniProtKB:Q99K23}
420		{ECO:0000250\|UniProtKB:Q99K23}

Organism

Rattus norvegicus

Functional Description
(View)

Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation.

Protein Sequence
(Fasta)

MDILFRIRGG FDLAFQLAPP KEMFIKNALR QVLNDLTTKL SSDALVFRIC NSSVYLWPNS 60
DANTGELTDS SACKSVVDLI QFDQEEDTKR KFMKKKDKKL TDMQQIVNID LMLEISTPLG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCACTTCCG GGACGACCCT GGCTTGCACG AAGTAGGTGT TCTTGCCTTC GCCAGTGGTT 60
CCTGGTAAGT GATTCTGATT GCCAGTGACC TTCCTGTACT TACCTCTAGG ACTTCGGCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR012462--Peptidase_C78_UfSP1/2

Pfam

PF07910--Peptidase_C78

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0016790--F:thiolester hydrolase activity
GO:0071567--F:UFM1 hydrolase activity
GO:0006508--P:proteolysis
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway

KEGG

rno:361151

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000578	Aegilops tauschii	40.00	7.00e-71	261.00
IUUC-Aml-001757	Ailuropoda melanoleuca	84.60	0.00e+00	804.00
IUUC-Atr-002641	Amborella trichopoda	44.54	2.00e-72	266.00
IUUC-Apl-003911	Anas platyrhynchos	68.82	0.00e+00	637.00
IUUC-Aca-005294	Anolis carolinensis	71.71	0.00e+00	697.00
IUUC-Aly-006185	Arabidopsis lyrata	45.25	1.00e-70	261.00
IUUC-Ath-006919	Arabidopsis thaliana	55.25	3.00e-69	256.00
IUUC-Ame-011931	Astyanax mexicanus	55.19	2.00e-147	515.00
IUUC-Bta-012389	Bos taurus	85.10	0.00e+00	814.00
IUUC-Bdi-014306	Brachypodium distachyon	42.86	2.00e-68	253.00
IUUC-Bol-016591	Brassica oleracea	42.33	2.00e-71	263.00
IUUC-Bra-017122	Brassica rapa	40.21	1.00e-62	234.00
IUUC-Cel-018132	Caenorhabditis elegans	49.82	1.00e-81	296.00
IUUC-Cja-019735	Callithrix jacchus	82.83	0.00e+00	801.00
IUUC-Cfa-020814	Canis familiaris	83.73	0.00e+00	798.00
IUUC-Cpo-021576	Cavia porcellus	83.59	0.00e+00	792.00
IUUC-Cre-022668	Chlamydomonas reinhardtii	58.59	2.00e-66	244.00
IUUC-Csa-023368	Chlorocebus sabaeus	84.02	0.00e+00	810.00
IUUC-Cho-024731	Choloepus hoffmanni	76.99	0.00e+00	691.00
IUUC-Cin-025359	Ciona intestinalis	50.00	3.00e-105	375.00
IUUC-Csv-025886	Ciona savignyi	68.78	5.00e-88	316.00
IUUC-Dre-027673	Danio rerio	56.93	2.00e-161	562.00
IUUC-Dno-030101	Dasypus novemcinctus	82.21	0.00e+00	778.00
IUUC-Dor-030612	Dipodomys ordii	81.17	0.00e+00	750.00
IUUC-Dme-032198	Drosophila melanogaster	45.08	3.00e-79	289.00
IUUC-Ete-032738	Echinops telfairi	72.35	0.00e+00	649.00
IUUC-Eca-034093	Equus caballus	84.67	0.00e+00	810.00
IUUC-Eeu-034624	Erinaceus europaeus	80.95	0.00e+00	781.00
IUUC-Fca-035542	Felis catus	82.94	0.00e+00	791.00
IUUC-Fal-036770	Ficedula albicollis	74.03	0.00e+00	699.00
IUUC-Gmo-039601	Gadus morhua	54.11	3.00e-149	521.00
IUUC-Gga-040670	Gallus gallus	72.51	0.00e+00	684.00
IUUC-Gac-042013	Gasterosteus aculeatus	54.35	9.00e-155	540.00
IUUC-Gma-043320	Glycine max	45.45	1.00e-78	287.00
IUUC-Ggo-045051	Gorilla gorilla	84.23	0.00e+00	808.00
IUUC-Hsa-046929	Homo sapiens	84.23	0.00e+00	808.00
IUUC-Itr-047967	Ictidomys tridecemlineatus	84.23	0.00e+00	800.00
IUUC-Lch-049884	Latimeria chalumnae	63.12	0.00e+00	630.00
IUUC-Lpe-051425	Leersia perrieri	54.46	2.00e-71	263.00
IUUC-Loc-052568	Lepisosteus oculatus	60.09	1.00e-160	559.00
IUUC-Laf-053435	Loxodonta africana	82.07	0.00e+00	785.00
IUUC-Mcc-055106	Macaca mulatta	84.45	0.00e+00	815.00
IUUC-Mtr-057740	Medicago truncatula	44.69	2.00e-78	286.00
IUUC-Mga-060094	Meleagris gallopavo	72.29	0.00e+00	669.00
IUUC-Mmr-061634	Microcebus murinus	81.21	0.00e+00	764.00
IUUC-Mdo-062862	Monodelphis domestica	75.16	0.00e+00	728.00
IUUC-Mmu-063729	Mus musculus	94.58	0.00e+00	887.00
IUUC-Mac-065086	Musa acuminata	43.44	3.00e-74	273.00
IUUC-Mpu-066461	Mustela putorius furo	84.16	0.00e+00	802.00
IUUC-Mlu-067443	Myotis lucifugus	82.37	0.00e+00	785.00
IUUC-Nle-069354	Nomascus leucogenys	84.23	0.00e+00	808.00
IUUC-Opr-070818	Ochotona princeps	89.21	1.00e-133	469.00
IUUC-Ont-072430	Oreochromis niloticus	56.74	1.00e-160	559.00
IUUC-Oan-072972	Ornithorhynchus anatinus	82.05	1.00e-96	345.00
IUUC-Ocu-074052	Oryctolagus cuniculus	83.15	0.00e+00	798.00
IUUC-Oba-075331	Oryza barthii	58.73	2.00e-67	249.00
IUUC-Obr-076810	Oryza brachyantha	53.52	6.00e-71	261.00
IUUC-Ogl-077185	Oryza glaberrima	58.73	2.00e-67	250.00
IUUC-Ogu-078014	Oryza glumaepatula	58.73	2.00e-67	250.00
IUUC-Oin-080170	Oryza indica	58.73	2.00e-67	250.00
IUUC-Olo-080561	Oryza longistaminata	58.73	2.00e-67	249.00
IUUC-Ome-081878	Oryza meridionalis	58.73	2.00e-67	250.00
IUUC-Oni-083106	Oryza nivara	58.73	3.00e-67	249.00
IUUC-Opu-083384	Oryza punctata	40.84	4.00e-71	262.00
IUUC-Oru-085240	Oryza rufipogon	58.73	2.00e-67	249.00
IUUC-Osa-086230	Oryza sativa	58.73	1.00e-67	250.00
IUUC-Ola-087525	Oryzias latipes	62.76	2.00e-136	478.00
IUUC-Oga-088657	Otolemur garnettii	84.23	0.00e+00	805.00
IUUC-Oar-089494	Ovis aries	85.31	0.00e+00	823.00
IUUC-Ptr-091189	Pan troglodytes	84.23	0.00e+00	808.00
IUUC-Pan-092071	Papio anubis	84.45	0.00e+00	814.00
IUUC-Psi-092991	Pelodiscus sinensis	72.57	0.00e+00	717.00
IUUC-Pma-094182	Petromyzon marinus	72.86	1.00e-62	231.00
IUUC-Ppa-095743	Physcomitrella patens	55.45	2.00e-71	263.00
IUUC-Pfo-096271	Poecilia formosa	55.99	3.00e-154	538.00
IUUC-Pab-097928	Pongo abelii	81.08	0.00e+00	769.00
IUUC-Pop-098826	Populus trichocarpa	42.66	1.00e-74	274.00
IUUC-Pca-100279	Procavia capensis	77.32	0.00e+00	756.00
IUUC-Ppe-101401	Prunus persica	47.04	9.00e-70	258.00
IUUC-Pva-102713	Pteropus vampyrus	82.72	0.00e+00	784.00
IUUC-Sha-106956	Sarcophilus harrisii	74.73	0.00e+00	731.00
IUUC-Smo-109070	Selaginella moellendorffii	43.18	8.00e-79	288.00
IUUC-Sit-109821	Setaria italica	44.64	2.00e-74	273.00
IUUC-Sly-110903	Solanum lycopersicum	45.68	1.00e-74	274.00
IUUC-Stu-111930	Solanum tuberosum	45.62	4.00e-74	272.00
IUUC-Sar-113264	Sorex araneus	84.16	0.00e+00	803.00
IUUC-Sbi-114732	Sorghum bicolor	36.66	7.00e-54	205.00
IUUC-Ssc-115435	Sus scrofa	80.17	0.00e+00	758.00
IUUC-Tgu-116761	Taeniopygia guttata	80.91	7.00e-124	436.00
IUUC-Tru-118435	Takifugu rubripes	53.70	4.00e-147	514.00
IUUC-Tsy-119445	Tarsius syrichta	79.27	0.00e+00	732.00
IUUC-Tni-119948	Tetraodon nigroviridis	70.67	5.00e-99	353.00
IUUC-Tca-121332	Theobroma cacao	45.14	3.00e-73	269.00
IUUC-Tae-123925	Triticum aestivum	42.57	3.00e-72	266.00
IUUC-Tur-126833	Triticum urartu	41.05	2.00e-68	253.00
IUUC-Tbe-127826	Tupaia belangeri	76.89	0.00e+00	709.00
IUUC-Ttr-129116	Tursiops truncatus	89.06	2.00e-143	501.00
IUUC-Vpa-130588	Vicugna pacos	83.37	0.00e+00	776.00
IUUC-Vvi-130898	Vitis vinifera	45.62	1.00e-75	277.00
IUUC-Xtr-132571	Xenopus tropicalis	62.04	3.00e-175	608.00
IUUC-Xma-133755	Xiphophorus maculatus	54.47	2.00e-152	531.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence