iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132398

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAMC01013927

Gene Name

brca1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000024564.2	ENSXETT00000021462.3	ENSXETP00000021462.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.30e-06	29.0	24	66

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle +k+ p+ + C H+f++ C  ++  l+++++ +  CPlC+
   Q: 24   CPICLELMKE-PVATKCDHIFCKFCMLQL--LSKKKKENVPCPLCK 66
           ********99.999***********9666..4556888889****7 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

LSCSRMDIEG IRNVISVMQK NLECPICLEL MKEPVATKCD HIFCKFCMLQ LLSKKKKENV 60
PCPLCKTEVT RRSLQESHRF KLLVEGLLKI IKAFELDSGC KFFPSQENTV SGFESTIKDV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTTGGCGT GTTGGAAGGA AGTTCGGTTT CCTCAGCGAA TGAATTGTGT TTCAGGGAAA 60
GGTATATTTT TGAAAACTTT AGACGTGTTT TAATGGGGTT AGCGTATTGT ATGTTTTAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00533--BRCT
PF12820--BRCT_assoc
PF00097--zf-C3HC4

PRINTS

PR00493--BRSTCANCERI

SMART

SM00292--BRCT
SM00184--RING

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005886--C:plasma membrane
GO:0003677--F:DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043009--P:chordate embryonic development
GO:0000724--P:double-strand break repair via homologous recombination
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0071158--P:positive regulation of cell cycle arrest
GO:0035066--P:positive regulation of histone acetylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042127--P:regulation of cell proliferation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002388	Ailuropoda melanoleuca	51.11	4.00e-63	237.00
IUUC-Apl-003252	Anas platyrhynchos	62.15	2.00e-78	288.00
IUUC-Aca-004526	Anolis carolinensis	50.00	1.00e-61	231.00
IUUC-Ame-011720	Astyanax mexicanus	56.16	4.00e-62	233.00
IUUC-Bgr-011969	Blumeria graminis	37.50	1.00e-08	53.90
IUUC-Bta-013433	Bos taurus	36.92	5.00e-79	290.00
IUUC-Cel-018208	Caenorhabditis elegans	33.33	5.00e-12	65.90
IUUC-Cja-019149	Callithrix jacchus	53.66	5.00e-61	230.00
IUUC-Cfa-020322	Canis familiaris	37.69	5.00e-76	280.00
IUUC-Cpo-021583	Cavia porcellus	34.85	4.00e-63	237.00
IUUC-Csa-024227	Chlorocebus sabaeus	34.23	5.00e-40	159.00
IUUC-Cho-024530	Choloepus hoffmanni	56.86	8.00e-49	189.00
IUUC-Cin-025364	Ciona intestinalis	39.47	1.00e-12	66.60
IUUC-Dno-029247	Dasypus novemcinctus	33.33	5.00e-30	127.00
IUUC-Dme-032032	Drosophila melanogaster	51.06	2.00e-09	53.90
IUUC-Ete-032472	Echinops telfairi	45.67	2.00e-45	179.00
IUUC-Eca-033446	Equus caballus	34.51	2.00e-69	258.00
IUUC-Eeu-034858	Erinaceus europaeus	41.45	5.00e-36	147.00
IUUC-Fca-035991	Felis catus	54.81	2.00e-63	238.00
IUUC-Fal-036803	Ficedula albicollis	59.07	2.00e-74	275.00
IUUC-Gmo-038782	Gadus morhua	47.42	4.00e-48	187.00
IUUC-Gga-040969	Gallus gallus	60.48	1.00e-74	275.00
IUUC-Gac-042296	Gasterosteus aculeatus	48.39	2.00e-55	211.00
IUUC-Ggo-044740	Gorilla gorilla	47.87	4.00e-54	207.00
IUUC-Hsa-046086	Homo sapiens	52.88	1.00e-57	219.00
IUUC-Itr-048512	Ictidomys tridecemlineatus	38.11	1.00e-30	129.00
IUUC-Lch-049789	Latimeria chalumnae	59.19	2.00e-79	291.00
IUUC-Loc-051952	Lepisosteus oculatus	51.79	1.00e-64	242.00
IUUC-Laf-053648	Loxodonta africana	54.34	6.00e-64	240.00
IUUC-Mcc-055210	Macaca mulatta	52.40	1.00e-61	232.00
IUUC-Meu-056342	Macropus eugenii	42.94	1.00e-30	129.00
IUUC-Mga-060163	Meleagris gallopavo	58.72	1.00e-74	275.00
IUUC-Mmr-061402	Microcebus murinus	36.89	3.00e-07	50.10
IUUC-Mdo-062209	Monodelphis domestica	39.13	2.00e-79	291.00
IUUC-Mmu-064003	Mus musculus	46.89	1.00e-50	195.00
IUUC-Mpu-065825	Mustela putorius furo	34.73	4.00e-38	153.00
IUUC-Mlu-068176	Myotis lucifugus	34.63	1.00e-65	245.00
IUUC-Nle-069178	Nomascus leucogenys	52.88	2.00e-57	218.00
IUUC-Opr-070574	Ochotona princeps	43.81	2.00e-44	175.00
IUUC-Ont-072380	Oreochromis niloticus	49.07	3.00e-59	224.00
IUUC-Oan-073243	Ornithorhynchus anatinus	55.14	3.00e-27	114.00
IUUC-Ocu-074424	Oryctolagus cuniculus	48.79	4.00e-63	237.00
IUUC-Ola-086863	Oryzias latipes	49.07	2.00e-56	214.00
IUUC-Oar-089938	Ovis aries	54.98	2.00e-64	241.00
IUUC-Ptr-090960	Pan troglodytes	52.88	1.00e-57	219.00
IUUC-Pan-092609	Papio anubis	58.54	4.00e-24	107.00
IUUC-Pfo-096328	Poecilia formosa	47.20	7.00e-58	219.00
IUUC-Pab-097982	Pongo abelii	52.40	4.00e-57	217.00
IUUC-Pca-100698	Procavia capensis	54.09	4.00e-62	234.00
IUUC-Pva-102631	Pteropus vampyrus	38.13	2.00e-74	274.00
IUUC-Rno-105879	Rattus norvegicus	33.33	7.00e-61	229.00
IUUC-Sha-106701	Sarcophilus harrisii	36.73	4.00e-40	160.00
IUUC-Sit-110609	Setaria italica	27.15	2.00e-16	81.30
IUUC-Sar-113047	Sorex araneus	53.23	2.00e-30	129.00
IUUC-Sbi-114470	Sorghum bicolor	28.05	3.00e-18	87.40
IUUC-Ssc-115846	Sus scrofa	37.03	2.00e-75	278.00
IUUC-Tgu-116785	Taeniopygia guttata	55.14	1.00e-68	256.00
IUUC-Tru-117895	Takifugu rubripes	44.13	1.00e-57	218.00
IUUC-Tsy-118885	Tarsius syrichta	46.39	2.00e-29	125.00
IUUC-Tni-119654	Tetraodon nigroviridis	40.00	8.00e-47	182.00
IUUC-Tbe-127421	Tupaia belangeri	44.85	1.00e-35	145.00
IUUC-Ttr-128685	Tursiops truncatus	54.33	3.00e-58	221.00
IUUC-Vpa-130216	Vicugna pacos	38.48	4.00e-70	260.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence