iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	2.00e-06	28.2	8	81
E3 activity/RING/RING	1.20e-09	38.9	13	54

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 3    peeflCpIslelMrdPvvlpsGitydrssI.ekwlasggk.tcPvtrqpl.teedlvPnltlrrliqawceens 73
            ee+ C+I le++++Pv++p+G+ + rs++ e w+ +g    cP +r+      +l  n++l +++++++++++
   Q: 8    AEELSCSICLEPFKEPVTTPCGHNFCRSCLnETWVVQGPPyRCPQCRTVYqVRPQLHKNTVLCAVVEQFLQAEQ 81
           5899*************************956799999989*******99555677999999999999999876 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCle+fk+ p+++pCgH f+++Cl + w     ++ +  rCP Cr
   Q: 13   CSICLEPFKE-PVTTPCGHNFCRSCLnETW----VVQGPPYRCPQCR 54
           ********99.*******************....99999*******8 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAELFPLAEE LSCSICLEPF KEPVTTPCGH NFCRSCLNET WVVQGPPYRC PQCRTVYQVR 60
PQLHKNTVLC AVVEQFLQAE QARTPVDDWI PPTRSAASSS DTQVSCDHCL KEVAVKTCLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACCGCGCGG TGGTGTGTGC AGCTGTCCGT GCGCGTCCCG TCGGGTGCCC CCAGGAGAGC 60
GATGGCCGAG CTGTTTCCTC TGGCCGAGGA GCTGTCGTGC TCCATCTGCC TGGAGCCCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0003723--F:RNA binding
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0006513--P:protein monoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043627--P:response to estrogen
GO:0033280--P:response to vitamin D

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002424	Ailuropoda melanoleuca	67.74	0.00e+00	880.00
IUUC-Apl-004101	Anas platyrhynchos	48.67	3.00e-168	585.00
IUUC-Aca-005025	Anolis carolinensis	47.52	1.00e-168	586.00
IUUC-Bta-012735	Bos taurus	69.18	0.00e+00	906.00
IUUC-Cja-019996	Callithrix jacchus	60.64	2.00e-162	565.00
IUUC-Cfa-020466	Canis familiaris	68.06	0.00e+00	894.00
IUUC-Cpo-021737	Cavia porcellus	67.18	0.00e+00	882.00
IUUC-Csa-023217	Chlorocebus sabaeus	71.65	0.00e+00	922.00
IUUC-Cho-024346	Choloepus hoffmanni	46.98	8.00e-65	240.00
IUUC-Dno-030082	Dasypus novemcinctus	67.71	0.00e+00	892.00
IUUC-Dor-030335	Dipodomys ordii	52.76	1.00e-130	460.00
IUUC-Ete-032923	Echinops telfairi	62.77	0.00e+00	751.00
IUUC-Eca-033411	Equus caballus	67.99	0.00e+00	904.00
IUUC-Eeu-034656	Erinaceus europaeus	69.35	9.00e-154	536.00
IUUC-Fca-035371	Felis catus	67.74	0.00e+00	882.00
IUUC-Fal-037008	Ficedula albicollis	45.34	8.00e-153	533.00
IUUC-Gmo-038668	Gadus morhua	33.81	5.00e-100	358.00
IUUC-Gga-040608	Gallus gallus	46.65	2.00e-164	572.00
IUUC-Gac-041409	Gasterosteus aculeatus	35.15	8.00e-112	397.00
IUUC-Ggo-044518	Gorilla gorilla	70.52	0.00e+00	899.00
IUUC-Hsa-045828	Homo sapiens	71.03	0.00e+00	913.00
IUUC-Itr-049070	Ictidomys tridecemlineatus	69.03	1.00e-140	493.00
IUUC-Lch-050478	Latimeria chalumnae	38.17	5.00e-128	451.00
IUUC-Loc-052864	Lepisosteus oculatus	37.21	8.00e-114	404.00
IUUC-Laf-054325	Loxodonta africana	72.01	4.00e-163	566.00
IUUC-Mcc-054920	Macaca mulatta	71.96	0.00e+00	924.00
IUUC-Meu-056367	Macropus eugenii	71.76	5.00e-72	265.00
IUUC-Mga-059975	Meleagris gallopavo	47.59	6.00e-161	560.00
IUUC-Mmr-060748	Microcebus murinus	70.35	0.00e+00	906.00
IUUC-Mdo-062904	Monodelphis domestica	57.03	0.00e+00	687.00
IUUC-Mmu-063891	Mus musculus	82.72	0.00e+00	1088.00
IUUC-Mpu-066473	Mustela putorius furo	70.54	0.00e+00	932.00
IUUC-Mlu-068185	Myotis lucifugus	67.64	0.00e+00	878.00
IUUC-Nle-070177	Nomascus leucogenys	70.42	0.00e+00	910.00
IUUC-Opr-070558	Ochotona princeps	57.39	3.00e-146	511.00
IUUC-Ont-072074	Oreochromis niloticus	34.44	9.00e-56	211.00
IUUC-Ocu-074461	Oryctolagus cuniculus	56.97	0.00e+00	673.00
IUUC-Ogu-078203	Oryza glumaepatula	45.59	5.00e-10	58.90
IUUC-Oga-088937	Otolemur garnettii	65.39	0.00e+00	859.00
IUUC-Oar-089781	Ovis aries	66.30	2.00e-170	591.00
IUUC-Ptr-090771	Pan troglodytes	71.03	0.00e+00	904.00
IUUC-Pan-092830	Papio anubis	71.96	0.00e+00	922.00
IUUC-Psi-093664	Pelodiscus sinensis	50.42	2.00e-94	339.00
IUUC-Pma-094147	Petromyzon marinus	29.28	2.00e-68	253.00
IUUC-Pfo-096528	Poecilia formosa	35.81	4.00e-112	398.00
IUUC-Pab-097588	Pongo abelii	70.42	0.00e+00	902.00
IUUC-Pca-100890	Procavia capensis	69.57	2.00e-152	533.00
IUUC-Pva-102314	Pteropus vampyrus	70.77	0.00e+00	879.00
IUUC-Sce-106362	Saccharomyces cerevisiae	44.29	2.00e-09	57.40
IUUC-Sha-106807	Sarcophilus harrisii	55.42	0.00e+00	672.00
IUUC-Sar-113283	Sorex araneus	59.82	7.00e-115	407.00
IUUC-Ssc-115878	Sus scrofa	80.00	8.00e-107	379.00
IUUC-Tgu-117026	Taeniopygia guttata	46.53	5.00e-134	471.00
IUUC-Tru-117794	Takifugu rubripes	33.24	2.00e-52	200.00
IUUC-Tbe-127580	Tupaia belangeri	68.59	4.00e-145	507.00
IUUC-Ttr-128648	Tursiops truncatus	62.53	2.00e-165	575.00
IUUC-Vpa-130254	Vicugna pacos	84.97	1.00e-91	330.00
IUUC-Xtr-132892	Xenopus tropicalis	40.52	1.00e-65	243.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence