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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Spo-108369
UUCD1 version UUC-ScP-00016
Ensembl Protein ID SPAC144.13c.1:pep
UniProt Accession O13286; A7VJ97; SRW1_SCHPO
Genbank Protein ID BAA22152.1; BAF76646.1; CAB59693.1
Protein Name WD repeat-containing protein srw1; Suppressor of rad/wee1
Genbank Nucleotide ID AB005589; AB001285; CU329670
Gene Name srw1; ste9; SPAC144.13c
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPAC144.13c SPAC144.13c.1 SPAC144.13c.1:pep
Annotation
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProt
Protein Expression/Proteomics
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 12724408; 15791259; 18082611
E3 adaptor/Cullin RING/APC_C/CDC20 CDC20 12724408; 15791259; 18082611
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.00e-31 103.1 373 403
E3 adaptor/Cullin RING/APC_C/CDC20 2.90e-145 481.3 238 540
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H  +v++l++ s+ +ll+sG++D+ ++vWD 
   Q: 373  HRQEVCGLEWnSNeNLLASGGNDNALMVWDK 403
           999*******9667****************6 PP
   

   E3 adaptor/Cullin RING/APC_C/CDC20
   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladleekdlvtsvswieegtllavGtkkgeveiyDveekkkvrtl 92
           p++vldap l+ dfylnLldW++ n+lavaL+s+vylws  +++v+ ++++ ++d+vts++w+++gt+lavGt++g+vei+D++++kk+rt+
   Q: 238  PYRVLDAPGLAGDFYLNLLDWGQCNMLAVALASRVYLWSGISSEVTVMHNFYPTDTVTSLRWVQRGTHLAVGTHNGSVEIWDAATCKKTRTM 329
           79****************************************************************************************** PP
   S: 93   tghsarvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfkehkaavka 184
           +gh++rvgaLsWn++vlssG+rd++ilhrdvr++e+ +++l+ah+qevCGl+wn++++lLasGGnDn+++vwd+ +++Pl++f++h aavka
   Q: 330  SGHTERVGALSWNDHVLSSGGRDNHILHRDVRAPEHYFRVLTAHRQEVCGLEWNSNENLLASGGNDNALMVWDKFEEKPLYSFHNHIAAVKA 421
           ******************************************************************************************** PP
   S: 185  iawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgheaRvlslals 276
           i+wsP+q+++LasGGGtaDr+ik+wnt++g++l++idtgsqvc+llwsk+++e++sthGf+en+++lw+yps+s+v +lkgh+ Rvl+la+s
   Q: 422  ITWSPHQRGILASGGGTADRTIKLWNTQRGSMLHNIDTGSQVCNLLWSKQTNEFISTHGFMENEVALWNYPSVSRVGTLKGHTDRVLYLAMS 513
           ******************************************************************************************** PP
   S: 277  pdgeaivtaagDetlrfwklfdkkkak 303
           p+ge+ivt+a+Detlrfwklfd+k+++
   Q: 514  PNGENIVTGAADETLRFWKLFDSKSKH 540
           **********************99875 PP
   
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     Has a role in cell differentiation and cell cycling by negatively regulating cig2 and cdc12-associated cdc2. Down-regulates the level of cdc13, particularly in a nitrogen deprived environment. Regulator of cell cycle G1 phase progression. Prevents onset of mitosis during the pre-Start G1 period. Required for degradation of cdc13 mitotic cyclin B during G1 arrest but not during mitotic exit.
 Has a role in cell differentiation and cell cycling by negatively regulating cig2 and cdc12-associated cdc2. Down-regulates the level of cdc13, particularly in a nitrogen deprived environment. Regulator of cell cycle G1 phase progression. Prevents onset of mitosis during the pre-Start G1 period. Required for degradation of cdc13 mitotic cyclin B during G1 arrest but not during mitotic exit.
Protein Sequence
(Fasta)
MDEFDGFTRP TSSNSSANRN SNNSMNRVEN NNSNSDSANT VDSRGDAHTR MRQGFEKSFP 60
SSPNKKRPRT NEGDRFIPSR DASTELWTGF TKVEGPLTPV KKKQSVADRN FTTLLRSELF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Spo-108369|E3,WD_repeat;E3,CDC20|Schizosaccharomyces pombe
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGACATGTT AGCTTTAGCA TTTACTAACT GTTGCTTCCG AAGTTTGTTT GAAGTTTGAA 60
TTTATTGCTT CTAAATGTCA ATGAGTCCAA ACGTATATGT TATAATGATC ATGTCAATAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Spo-108369|E3,WD_repeat;E3,CDC20|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:1990757--F:ubiquitin ligase activator activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0071851--P:mitotic G1 cell cycle arrest in response to nitrogen starvation
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
KEGG spo:SPAC144.13c
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000670 Aegilops tauschii 53.77 4.00e-98 350.00
IUUC-Atr-002753 Amborella trichopoda 52.80 1.00e-105 374.00
IUUC-Aly-005442 Arabidopsis lyrata 43.97 5.00e-110 389.00
IUUC-Ath-006938 Arabidopsis thaliana 44.01 7.00e-111 392.00
IUUC-Ago-007784 Ashbya gossypii 44.00 2.00e-106 377.00
IUUC-Acl-008269 Aspergillus clavatus 48.91 7.00e-133 465.00
IUUC-Afl-008432 Aspergillus flavus 48.80 2.00e-135 474.00
IUUC-Afu-008829 Aspergillus fumigatus 47.91 5.00e-132 462.00
IUUC-Ani-009471 Aspergillus nidulans 49.01 7.00e-134 468.00
IUUC-Ang-009711 Aspergillus niger 48.38 2.00e-129 454.00
IUUC-Aor-010118 Aspergillus oryzae 48.80 2.00e-135 474.00
IUUC-Ate-010534 Aspergillus terreus 48.52 4.00e-133 466.00
IUUC-Bgr-012013 Blumeria graminis 45.38 4.00e-126 442.00
IUUC-Bci-013807 Botrytis cinerea 48.32 5.00e-120 422.00
IUUC-Bdi-014981 Brachypodium distachyon 57.76 1.00e-108 384.00
IUUC-Bol-016301 Brassica oleracea 52.51 1.00e-109 387.00
IUUC-Bra-017453 Brassica rapa 52.51 1.00e-109 388.00
IUUC-Cho-024920 Choloepus hoffmanni 50.89 9.00e-35 139.00
IUUC-Cgl-026631 Colletotrichum gloeosporioides 47.93 1.00e-132 464.00
IUUC-Cne-026933 Cryptococcus neoformans 51.33 7.00e-113 399.00
IUUC-Cme-027143 Cyanidioschyzon merolae 54.52 1.00e-98 352.00
IUUC-Dno-029629 Dasypus novemcinctus 50.73 8.00e-99 352.00
IUUC-Dse-031502 Dothistroma septosporum 45.73 5.00e-118 416.00
IUUC-Ete-032562 Echinops telfairi 39.56 3.00e-89 320.00
IUUC-Fox-037814 Fusarium oxysporum 58.65 1.00e-114 404.00
IUUC-Fso-038420 Fusarium solani 48.10 5.00e-129 452.00
IUUC-Ggr-039774 Gaeumannomyces graminis 48.12 3.00e-129 453.00
IUUC-Gma-042657 Glycine max 44.72 1.00e-107 381.00
IUUC-Hvu-047486 Hordeum vulgare 56.20 6.00e-96 341.00
IUUC-Kpa-049239 Komagataella pastoris 47.28 1.00e-127 448.00
IUUC-Lpe-051568 Leersia perrieri 52.88 6.00e-96 342.00
IUUC-Meu-056276 Macropus eugenii 51.78 4.00e-102 362.00
IUUC-Mor-057113 Magnaporthe oryzae 46.85 4.00e-128 449.00
IUUC-Mpo-057599 Magnaporthe poae 48.51 1.00e-129 455.00
IUUC-Mtr-057689 Medicago truncatula 45.74 1.00e-109 387.00
IUUC-Mvi-060465 Microbotryum violaceum 45.96 8.00e-123 431.00
IUUC-Mac-064942 Musa acuminata 43.12 3.00e-111 393.00
IUUC-Nfi-068536 Neosartorya fischeri 48.51 7.00e-133 465.00
IUUC-Ncr-068734 Neurospora crassa 46.08 2.00e-125 440.00
IUUC-Oan-073634 Ornithorhynchus anatinus 54.61 2.00e-93 333.00
IUUC-Oba-075417 Oryza barthii 52.88 5.00e-96 342.00
IUUC-Obr-076033 Oryza brachyantha 56.61 8.00e-106 375.00
IUUC-Ogl-077441 Oryza glaberrima 55.59 2.00e-104 370.00
IUUC-Ogu-077996 Oryza glumaepatula 53.41 1.00e-104 371.00
IUUC-Oin-080172 Oryza indica 53.41 1.00e-104 371.00
IUUC-Olo-081068 Oryza longistaminata 53.41 1.00e-104 370.00
IUUC-Ome-081250 Oryza meridionalis 53.41 9.00e-105 371.00
IUUC-Oni-083048 Oryza nivara 53.41 9.00e-105 371.00
IUUC-Opu-083333 Oryza punctata 53.41 9.00e-105 372.00
IUUC-Oru-085001 Oryza rufipogon 53.41 9.00e-105 371.00
IUUC-Osa-085451 Oryza sativa 55.59 2.00e-104 370.00
IUUC-Olu-087647 Ostreococcus lucimarinus 50.00 8.00e-96 342.00
IUUC-Pno-095139 Phaeosphaeria nodorum 54.04 2.00e-104 371.00
IUUC-Ppa-095366 Physcomitrella patens 46.06 3.00e-117 413.00
IUUC-Pop-099953 Populus trichocarpa 54.36 6.00e-103 365.00
IUUC-Ppe-101924 Prunus persica 44.19 1.00e-106 378.00
IUUC-Pte-104097 Pyrenophora teres 43.63 3.00e-120 423.00
IUUC-Pyt-104445 Pyrenophora triticirepentis 40.45 3.00e-106 376.00
IUUC-Sce-106240 Saccharomyces cerevisiae 40.89 1.00e-102 365.00
IUUC-Sja-107785 Schizosaccharomyces japonicus 54.11 1.00e-162 564.00
IUUC-Ssl-108391 Sclerotinia sclerotiorum 48.32 3.00e-124 436.00
IUUC-Smo-108878 Selaginella moellendorffii 45.66 2.00e-117 414.00
IUUC-Sly-111446 Solanum lycopersicum 43.43 5.00e-109 385.00
IUUC-Stu-112491 Solanum tuberosum 43.43 2.00e-108 384.00
IUUC-Sre-115222 Sporisorium reilianum 44.07 2.00e-122 430.00
IUUC-Tre-122249 Trichoderma reesei 48.90 6.00e-130 455.00
IUUC-Tvi-122675 Trichoderma virens 48.30 3.00e-131 459.00
IUUC-Tae-124272 Triticum aestivum 54.30 4.00e-110 389.00
IUUC-Tur-126545 Triticum urartu 51.61 3.00e-93 332.00
IUUC-Tme-127151 Tuber melanosporum 48.83 2.00e-136 476.00
IUUC-Tbe-128056 Tupaia belangeri 50.16 6.00e-87 311.00
IUUC-Vda-130027 Verticillium dahliae 49.21 7.00e-130 455.00
IUUC-Vvi-131749 Vitis vinifera 43.15 2.00e-106 377.00
IUUC-Yli-134584 Yarrowia lipolytica 47.21 1.00e-122 431.00
Created Date 25-Jun-2017

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