iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Meu-056809

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase makorin-1; RING-type E3 ubiquitin transferase makorin-1

Genbank Nucleotide ID

AF192786

Gene Name

MKRN1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMEUG00000007399.1	ENSMEUT00000007414.1	ENSMEUP00000006753.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	8.70e-06	25.8	277	331

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf........kdg.plvlpCgHvfhadClqkw.pglknssskefrCPlCr 46
           C iC+e          +    ++ +C+H+++++C+ kw   ++ +s+   +CP Cr
   Q: 277  CGICMEVVyekanpseR-RfGILSNCNHTYCLKCIRKWrSAKQFESKIIKSCPECR 331
           99**9977666555432.1233577*************4444444444558****8 PP

Organism

Macropus eugenii

Functional Description
(View)

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.

Protein Sequence
(Fasta)

MAEAAAPGTT ATTSGAAAAA AVAAASPTLT PTVASQSPAA GGGGGGSGGG WTKQVTCRYF 60
MHGVCKEGNN CRYSHDLSTS QSAMVCRYYQ RGCCAYGDRC RYEHTKPLKR EEVTAANLAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAGG CTGCAGCTCC CGGAACAACA GCCACAACAT CAGGAGCGGC AGCGGCGGCG 60
GCGGTGGCAG CGGCCTCCCC CACCCTCACC CCCACAGTCG CTTCCCAGTC CCCGGCGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0479--Metal-binding
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR029035--DHS-like_NAD/FAD-binding_dom
IPR026290--Makorin-1
IPR031644--MKRN1_C
IPR018957--Znf_C3HC4_RING-type
IPR000571--Znf_CCCH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50103--ZF_C3H1
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF15815--MKRN1_C
PF00097--zf-C3HC4
PF00642--zf-CCCH

SMART

SM00184--RING
SM00356--ZnF_C3H1

Gene Ontology

GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000297	Aegilops tauschii	41.15	6.00e-43	167.00
IUUC-Aml-001937	Ailuropoda melanoleuca	88.60	0.00e+00	637.00
IUUC-Atr-003024	Amborella trichopoda	35.11	9.00e-64	236.00
IUUC-Apl-004110	Anas platyrhynchos	81.92	7.00e-173	599.00
IUUC-Aca-005385	Anolis carolinensis	86.60	0.00e+00	676.00
IUUC-Aly-006128	Arabidopsis lyrata	35.47	1.00e-55	209.00
IUUC-Ath-006918	Arabidopsis thaliana	40.20	2.00e-42	166.00
IUUC-Ame-011246	Astyanax mexicanus	68.08	6.00e-145	506.00
IUUC-Bta-012318	Bos taurus	86.32	0.00e+00	659.00
IUUC-Bdi-015008	Brachypodium distachyon	35.84	9.00e-58	216.00
IUUC-Bol-015688	Brassica oleracea	38.62	4.00e-36	144.00
IUUC-Bra-017861	Brassica rapa	41.21	4.00e-43	167.00
IUUC-Cel-018642	Caenorhabditis elegans	36.57	1.00e-56	213.00
IUUC-Cja-019550	Callithrix jacchus	88.36	1.00e-175	608.00
IUUC-Cfa-020166	Canis familiaris	87.62	0.00e+00	655.00
IUUC-Cpo-021887	Cavia porcellus	84.43	0.00e+00	674.00
IUUC-Cre-022707	Chlamydomonas reinhardtii	37.93	2.00e-35	142.00
IUUC-Csa-023930	Chlorocebus sabaeus	88.52	0.00e+00	693.00
IUUC-Cho-024307	Choloepus hoffmanni	89.02	0.00e+00	677.00
IUUC-Cin-025619	Ciona intestinalis	47.63	3.00e-105	374.00
IUUC-Csv-026322	Ciona savignyi	46.98	7.00e-96	343.00
IUUC-Dre-027762	Danio rerio	70.05	5.00e-153	533.00
IUUC-Dno-029666	Dasypus novemcinctus	86.98	0.00e+00	671.00
IUUC-Dor-030133	Dipodomys ordii	93.33	2.00e-101	362.00
IUUC-Dme-031705	Drosophila melanogaster	36.93	2.00e-62	232.00
IUUC-Ete-032356	Echinops telfairi	71.64	3.00e-103	367.00
IUUC-Eca-033340	Equus caballus	88.60	0.00e+00	676.00
IUUC-Eeu-035167	Erinaceus europaeus	85.15	4.00e-160	556.00
IUUC-Fca-035536	Felis catus	87.65	0.00e+00	668.00
IUUC-Fal-036881	Ficedula albicollis	85.05	0.00e+00	656.00
IUUC-Gmo-039495	Gadus morhua	76.79	5.00e-104	370.00
IUUC-Ggr-039835	Gaeumannomyces graminis	40.68	1.00e-09	58.20
IUUC-Gga-041148	Gallus gallus	84.45	7.00e-178	616.00
IUUC-Gac-041790	Gasterosteus aculeatus	65.61	1.00e-149	522.00
IUUC-Ggo-045245	Gorilla gorilla	86.37	0.00e+00	721.00
IUUC-Hsa-046589	Homo sapiens	88.79	0.00e+00	703.00
IUUC-Hvu-047044	Hordeum vulgare	37.46	7.00e-51	193.00
IUUC-Itr-048468	Ictidomys tridecemlineatus	82.56	8.00e-109	386.00
IUUC-Lch-049777	Latimeria chalumnae	72.04	3.00e-152	531.00
IUUC-Loc-052281	Lepisosteus oculatus	72.79	1.00e-177	615.00
IUUC-Laf-054551	Loxodonta africana	84.58	0.00e+00	638.00
IUUC-Mcc-055160	Macaca mulatta	88.08	0.00e+00	665.00
IUUC-Mla-059005	Melampsora laricipopulina	27.54	5.00e-21	95.50
IUUC-Mga-059767	Meleagris gallopavo	85.30	7.00e-177	612.00
IUUC-Mmr-061574	Microcebus murinus	87.11	0.00e+00	661.00
IUUC-Mdo-061974	Monodelphis domestica	98.26	0.00e+00	770.00
IUUC-Mmu-063887	Mus musculus	87.15	0.00e+00	680.00
IUUC-Mac-064993	Musa acuminata	33.52	5.00e-60	224.00
IUUC-Mpu-066756	Mustela putorius furo	87.08	1.00e-179	622.00
IUUC-Mlu-067691	Myotis lucifugus	85.11	0.00e+00	650.00
IUUC-Nle-069845	Nomascus leucogenys	88.32	0.00e+00	701.00
IUUC-Opr-070262	Ochotona princeps	83.06	0.00e+00	640.00
IUUC-Ont-071561	Oreochromis niloticus	66.36	8.00e-167	579.00
IUUC-Oan-073517	Ornithorhynchus anatinus	45.20	9.00e-53	199.00
IUUC-Ocu-074869	Oryctolagus cuniculus	78.81	3.00e-158	550.00
IUUC-Ola-086506	Oryzias latipes	64.97	6.00e-156	543.00
IUUC-Olu-087870	Ostreococcus lucimarinus	44.07	7.00e-29	119.00
IUUC-Oga-088871	Otolemur garnettii	88.08	0.00e+00	707.00
IUUC-Oar-090436	Ovis aries	85.25	0.00e+00	627.00
IUUC-Ptr-091519	Pan troglodytes	88.55	0.00e+00	702.00
IUUC-Pan-092582	Papio anubis	87.96	0.00e+00	689.00
IUUC-Psi-093168	Pelodiscus sinensis	91.65	0.00e+00	706.00
IUUC-Pfo-096075	Poecilia formosa	66.82	4.00e-166	577.00
IUUC-Pab-098764	Pongo abelii	87.80	0.00e+00	688.00
IUUC-Pop-099909	Populus trichocarpa	34.71	4.00e-62	231.00
IUUC-Pca-100903	Procavia capensis	80.95	0.00e+00	662.00
IUUC-Ppe-101248	Prunus persica	43.85	4.00e-44	171.00
IUUC-Pva-103124	Pteropus vampyrus	77.34	5.00e-154	537.00
IUUC-Rno-104976	Rattus norvegicus	87.15	0.00e+00	682.00
IUUC-Sha-107572	Sarcophilus harrisii	98.69	0.00e+00	714.00
IUUC-Smo-109483	Selaginella moellendorffii	41.38	4.00e-48	184.00
IUUC-Sit-110077	Setaria italica	34.09	3.00e-57	215.00
IUUC-Sar-113068	Sorex araneus	84.05	0.00e+00	632.00
IUUC-Sbi-114884	Sorghum bicolor	33.62	9.00e-59	220.00
IUUC-Ssc-115272	Sus scrofa	87.85	0.00e+00	667.00
IUUC-Tgu-116537	Taeniopygia guttata	85.37	0.00e+00	662.00
IUUC-Tru-118205	Takifugu rubripes	63.76	3.00e-156	544.00
IUUC-Tsy-118929	Tarsius syrichta	93.33	4.00e-145	507.00
IUUC-Tni-120744	Tetraodon nigroviridis	62.96	5.00e-143	500.00
IUUC-Tca-121675	Theobroma cacao	34.40	4.00e-56	211.00
IUUC-Tur-126806	Triticum urartu	36.13	4.00e-49	188.00
IUUC-Tme-127048	Tuber melanosporum	26.36	9.00e-19	87.40
IUUC-Tbe-128131	Tupaia belangeri	82.17	1.00e-137	481.00
IUUC-Ttr-129099	Tursiops truncatus	88.08	0.00e+00	679.00
IUUC-Vpa-130663	Vicugna pacos	83.29	6.00e-148	516.00
IUUC-Xtr-132036	Xenopus tropicalis	60.16	3.00e-106	377.00
IUUC-Xma-134162	Xiphophorus maculatus	66.36	5.00e-165	573.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence