iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033378

Ensembl Protein ID

ENSECAP00000006001.1

UniProt Accession

F6WFB5; F6WFB5_HORSE

Protein Name

Uncharacterized protein

Gene Name

NCK1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000007966.1	ENSECAT00000008070.1	ENSECAP00000006001.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.80e-37	126.2	145	202

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +++vq+ly+++++nd+eL+++kGdv++viek e+d +W+k+ ++ +g  Gl+P+n+v+ 
   Q: 145  LHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKC-RKINGTVGLVPKNYVTI 202
           689**************************************.59*************85 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MGFVPSNYVE RKNSARKASI VKNLKDTLGI GKVKRKPSVP DSASPADDSF VDPGERLYDL 60
NMPAYVKFNY MAEREDELSL IKGTKVIVME KCSDGWWRGS YNGQVGWFPS NYVTEEGDSP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGTGCTGAA GCTGCTGAAA GATGGCAGAA GAAGTGGTGC TAGTAGCCAA ATTCGATTAT 60
GTGGCCCAAC AAGAACAAGA GCTGGACATT AAGAAGAATG AGAAATTGTG GCTTCTGGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005783--C:endoplasmic reticulum
GO:0000164--C:protein phosphatase type 1 complex
GO:0005840--C:ribosome
GO:0012506--C:vesicle membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0007015--P:actin filament organization
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0060548--P:negative regulation of cell death
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0070262--P:peptidyl-serine dephosphorylation
GO:0030838--P:positive regulation of actin filament polymerization
GO:1903676--P:positive regulation of cap-dependent translational initiation
GO:1903679--P:positive regulation of cap-independent translational initiation
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0010976--P:positive regulation of neuron projection development
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress
GO:0030334--P:regulation of cell migration
GO:0051707--P:response to other organism
GO:0006930--P:substrate-dependent cell migration, cell extension
GO:0042110--P:T cell activation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002115	Ailuropoda melanoleuca	99.39	0.00e+00	643.00
IUUC-Bta-013039	Bos taurus	99.09	0.00e+00	641.00
IUUC-Cja-019546	Callithrix jacchus	97.87	0.00e+00	631.00
IUUC-Cfa-020462	Canis familiaris	99.09	0.00e+00	641.00
IUUC-Cpo-022009	Cavia porcellus	97.57	0.00e+00	634.00
IUUC-Csa-023875	Chlorocebus sabaeus	98.78	0.00e+00	640.00
IUUC-Cho-024368	Choloepus hoffmanni	98.18	5.00e-180	623.00
IUUC-Dno-029593	Dasypus novemcinctus	98.87	2.00e-145	508.00
IUUC-Dor-030730	Dipodomys ordii	97.74	2.00e-157	548.00
IUUC-Ete-032906	Echinops telfairi	97.26	0.00e+00	627.00
IUUC-Eeu-034743	Erinaceus europaeus	86.63	5.00e-166	577.00
IUUC-Fca-035745	Felis catus	99.09	0.00e+00	680.00
IUUC-Ggo-045487	Gorilla gorilla	98.78	0.00e+00	640.00
IUUC-Hsa-045902	Homo sapiens	98.78	0.00e+00	640.00
IUUC-Itr-047923	Ictidomys tridecemlineatus	98.48	0.00e+00	639.00
IUUC-Lch-050165	Latimeria chalumnae	81.76	2.00e-154	538.00
IUUC-Laf-053845	Loxodonta africana	98.78	0.00e+00	640.00
IUUC-Meu-056139	Macropus eugenii	90.88	2.00e-164	571.00
IUUC-Mmr-061108	Microcebus murinus	85.41	7.00e-145	506.00
IUUC-Mdo-062258	Monodelphis domestica	94.22	7.00e-178	616.00
IUUC-Mmu-063970	Mus musculus	98.18	0.00e+00	679.00
IUUC-Mpu-066093	Mustela putorius furo	99.09	0.00e+00	640.00
IUUC-Mlu-067193	Myotis lucifugus	99.09	0.00e+00	640.00
IUUC-Nle-069611	Nomascus leucogenys	98.78	0.00e+00	640.00
IUUC-Opr-070984	Ochotona princeps	97.01	6.00e-178	615.00
IUUC-Oan-072976	Ornithorhynchus anatinus	89.25	5.00e-166	576.00
IUUC-Ocu-073905	Oryctolagus cuniculus	98.78	0.00e+00	640.00
IUUC-Oga-088588	Otolemur garnettii	99.39	0.00e+00	642.00
IUUC-Oar-089973	Ovis aries	99.09	0.00e+00	640.00
IUUC-Ptr-090968	Pan troglodytes	98.78	0.00e+00	640.00
IUUC-Pan-092840	Papio anubis	98.87	7.00e-146	509.00
IUUC-Pab-097807	Pongo abelii	98.48	0.00e+00	639.00
IUUC-Pca-100522	Procavia capensis	99.25	2.00e-146	511.00
IUUC-Pva-103083	Pteropus vampyrus	99.39	0.00e+00	641.00
IUUC-Rno-104839	Rattus norvegicus	96.35	0.00e+00	655.00
IUUC-Sha-107294	Sarcophilus harrisii	93.62	4.00e-176	610.00
IUUC-Sar-113675	Sorex araneus	96.96	2.00e-180	624.00
IUUC-Ssc-116442	Sus scrofa	97.26	0.00e+00	672.00
IUUC-Tsy-119184	Tarsius syrichta	93.05	1.00e-169	588.00
IUUC-Ttr-129155	Tursiops truncatus	97.87	0.00e+00	636.00
IUUC-Vpa-130344	Vicugna pacos	98.78	0.00e+00	640.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence