iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-023149

Ensembl Protein ID

ENSCSAP00000000950.1

UniProt Accession

A0A0D9QX61; A0A0D9QX61_CHLSB

Genbank Protein ID

ENSCSAP00000000950

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AQIB01137192

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000004620.1	ENSCSAT00000002651.1	ENSCSAP00000000950.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.20e-95	320.3	58	504

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 69   v..gksKAevaaealkelnpdvnveaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviik 154
              +k++Ae+a+e+l+eln+dv+++++ees+++l ++++ Ff++f+vVv+++ ++++ ++++++++n ++pl++++t+Gl+G++r+iik
   Q: 58   FvfKKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPsFFCRFTVVVATQLPESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIK 146
           3569************************************************************************************* PP
   S: 155  gltecyscsd...dppqktiPfctlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks... 228
           ++++++s++d   +++++++Pf++l+e+++         +++++++w+v+++k+l+++++e++++ +++++eke+++d++++++ +   
   Q: 147  EHPVIESHPDnalEDLRLDKPFPELREHFQsydldhmekKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKnen 235
           ****************************99999999998***********************************************9** PP
   S: 229  ...edeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv....................................... 274
              edeenfeeai+++++a+++t+i+s i++++++++c ++tk++++fw+                                       
   Q: 236  gapEDEENFEEAIKNVNTALNTTQIPSsIEDIFNDDRCINITKQTPSFWIlaralkefvakegqgnlpvrgtipdmiadsgkyiklqnv 324
           ***************************************************************************************** PP
   S: 275  ....................................sfcsnaealqvp...........ekvekdeevvkasap.....lylllraler 311
                                                +csn++ l+v            ++++kde+++++++p     lyl+lra++r
   Q: 325  yrekakkdaaavgnhvakllqsigqapesisekelkLLCSNSAFLRVVrcrslaeeyglDTINKDEIISSMDSPdneivLYLMLRAVDR 413
           ************************************99********7777777888888****************************** PP
   S: 312  fekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknf 398
           f+k++gr+pg++++++++d+  + +++t ++    +++g++ +++dd+++e++++++++ +t++a++gG+aaqEviK+++++f+ ++n+
   Q: 414  FHKQHGRYPGVSNYQVEEDIgkLKSCLTGFL----QEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNT 498
           ********************999********....****************************************************** PP
   S: 399  flfdae 404
           +++ ++
   Q: 499  YIYSGM 504
           **9776 PP

Organism

Chlorocebus sabaeus

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MLHTGQQNKS LSLKRKKKGN RVVILMPEIW IVLQYVCLFH KLGDYIVTKF FLIQVKCFVF 60
KKNRAEAAME FLQELNSDVS GSFVEESPEN LLDNDPSFFC RFTVVVATQL PESTLLRLAD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAAAGTTA ACTAATTTTT CTCATCTTGT AAATCTTCAT ATGTTTGGTA GTTTAAAAAC 60
TTAGAAGTAC TGTCTGTGTT TATACGTTGT ATCCTGTATT AAAGCTAAAT CTTGAGTAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	39.45	2.00e-97	349.00
IUUC-Aml-002333	Ailuropoda melanoleuca	95.90	0.00e+00	929.00
IUUC-Atr-002644	Amborella trichopoda	38.17	8.00e-86	310.00
IUUC-Apl-003446	Anas platyrhynchos	80.68	0.00e+00	790.00
IUUC-Aca-004450	Anolis carolinensis	77.07	0.00e+00	774.00
IUUC-Aly-006187	Arabidopsis lyrata	36.85	3.00e-97	348.00
IUUC-Ath-007600	Arabidopsis thaliana	37.50	2.00e-98	352.00
IUUC-Ago-007900	Ashbya gossypii	25.06	2.00e-26	113.00
IUUC-Acl-008333	Aspergillus clavatus	31.23	8.00e-58	218.00
IUUC-Afl-008529	Aspergillus flavus	34.19	2.00e-63	236.00
IUUC-Afu-009071	Aspergillus fumigatus	31.18	5.00e-58	218.00
IUUC-Ani-009443	Aspergillus nidulans	30.54	2.00e-55	209.00
IUUC-Ang-009669	Aspergillus niger	30.49	2.00e-58	220.00
IUUC-Aor-009914	Aspergillus oryzae	33.40	5.00e-60	225.00
IUUC-Ate-010450	Aspergillus terreus	31.61	1.00e-60	227.00
IUUC-Ame-011183	Astyanax mexicanus	69.47	0.00e+00	704.00
IUUC-Bgr-012111	Blumeria graminis	28.87	3.00e-38	152.00
IUUC-Bta-012583	Bos taurus	97.79	0.00e+00	926.00
IUUC-Bci-013892	Botrytis cinerea	29.37	5.00e-46	179.00
IUUC-Bdi-014592	Brachypodium distachyon	40.30	6.00e-100	357.00
IUUC-Bol-016399	Brassica oleracea	37.31	3.00e-96	345.00
IUUC-Bra-017506	Brassica rapa	35.90	2.00e-91	329.00
IUUC-Cel-018456	Caenorhabditis elegans	34.61	6.00e-72	265.00
IUUC-Cja-020007	Callithrix jacchus	98.89	0.00e+00	934.00
IUUC-Cfa-020324	Canis familiaris	97.79	0.00e+00	924.00
IUUC-Cpo-022248	Cavia porcellus	68.12	4.00e-172	597.00
IUUC-Cho-024537	Choloepus hoffmanni	85.40	0.00e+00	792.00
IUUC-Cin-025763	Ciona intestinalis	45.92	1.00e-118	420.00
IUUC-Csv-026113	Ciona savignyi	44.00	8.00e-111	394.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	29.17	2.00e-39	157.00
IUUC-Cne-026884	Cryptococcus neoformans	26.60	1.00e-47	184.00
IUUC-Dre-028140	Danio rerio	69.68	0.00e+00	716.00
IUUC-Dno-030033	Dasypus novemcinctus	97.95	0.00e+00	802.00
IUUC-Dor-030513	Dipodomys ordii	68.69	7.00e-115	407.00
IUUC-Dse-031536	Dothistroma septosporum	31.42	9.00e-60	224.00
IUUC-Dme-031683	Drosophila melanogaster	41.39	1.00e-96	347.00
IUUC-Ete-032420	Echinops telfairi	79.19	0.00e+00	759.00
IUUC-Eca-033992	Equus caballus	98.20	0.00e+00	919.00
IUUC-Eeu-034713	Erinaceus europaeus	79.92	1.00e-117	416.00
IUUC-Fca-036548	Felis catus	96.46	0.00e+00	913.00
IUUC-Fal-037600	Ficedula albicollis	77.92	0.00e+00	761.00
IUUC-Fox-038037	Fusarium oxysporum	29.66	4.00e-51	195.00
IUUC-Fso-038387	Fusarium solani	30.71	8.00e-53	201.00
IUUC-Gmo-038562	Gadus morhua	67.72	0.00e+00	693.00
IUUC-Ggr-040005	Gaeumannomyces graminis	29.85	8.00e-48	184.00
IUUC-Gga-041129	Gallus gallus	81.10	0.00e+00	789.00
IUUC-Gac-042558	Gasterosteus aculeatus	68.29	0.00e+00	692.00
IUUC-Gma-043610	Glycine max	39.12	4.00e-93	335.00
IUUC-Ggo-045611	Gorilla gorilla	99.34	0.00e+00	937.00
IUUC-Hsa-046563	Homo sapiens	99.34	0.00e+00	936.00
IUUC-Hvu-047790	Hordeum vulgare	38.11	6.00e-77	281.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	98.45	0.00e+00	930.00
IUUC-Kpa-049309	Komagataella pastoris	31.91	9.00e-63	234.00
IUUC-Lch-050038	Latimeria chalumnae	72.19	0.00e+00	714.00
IUUC-Lpe-051535	Leersia perrieri	40.38	5.00e-91	328.00
IUUC-Loc-051917	Lepisosteus oculatus	70.54	0.00e+00	709.00
IUUC-Lma-053112	Leptosphaeria maculans	32.51	1.00e-62	234.00
IUUC-Laf-053690	Loxodonta africana	96.68	0.00e+00	921.00
IUUC-Mcc-055117	Macaca mulatta	99.78	0.00e+00	965.00
IUUC-Meu-056761	Macropus eugenii	83.14	0.00e+00	729.00
IUUC-Mor-057230	Magnaporthe oryzae	29.79	2.00e-52	200.00
IUUC-Mpo-057514	Magnaporthe poae	29.38	8.00e-46	177.00
IUUC-Mtr-058551	Medicago truncatula	38.12	9.00e-90	324.00
IUUC-Mla-059183	Melampsora laricipopulina	33.12	2.00e-69	256.00
IUUC-Mga-060144	Meleagris gallopavo	80.89	0.00e+00	785.00
IUUC-Mvi-060221	Microbotryum violaceum	31.89	6.00e-55	208.00
IUUC-Mmr-061325	Microcebus murinus	94.27	0.00e+00	926.00
IUUC-Mdo-062532	Monodelphis domestica	91.59	0.00e+00	872.00
IUUC-Mmu-063956	Mus musculus	97.57	0.00e+00	925.00
IUUC-Mac-064521	Musa acuminata	38.58	5.00e-94	338.00
IUUC-Mpu-066716	Mustela putorius furo	93.62	0.00e+00	857.00
IUUC-Mlu-067459	Myotis lucifugus	96.91	0.00e+00	917.00
IUUC-Nfi-068245	Neosartorya fischeri	31.45	2.00e-58	219.00
IUUC-Ncr-068910	Neurospora crassa	29.90	3.00e-53	202.00
IUUC-Nle-070034	Nomascus leucogenys	99.33	0.00e+00	935.00
IUUC-Opr-070552	Ochotona princeps	86.78	0.00e+00	737.00
IUUC-Ont-071426	Oreochromis niloticus	71.68	0.00e+00	713.00
IUUC-Oan-073389	Ornithorhynchus anatinus	83.82	0.00e+00	778.00
IUUC-Ocu-074911	Oryctolagus cuniculus	96.68	0.00e+00	922.00
IUUC-Oba-075437	Oryza barthii	40.52	5.00e-101	361.00
IUUC-Obr-076684	Oryza brachyantha	40.95	1.00e-96	347.00
IUUC-Ogl-077170	Oryza glaberrima	40.52	5.00e-101	361.00
IUUC-Ogu-078844	Oryza glumaepatula	41.27	4.00e-94	338.00
IUUC-Oin-079105	Oryza indica	40.52	2.00e-100	359.00
IUUC-Olo-080943	Oryza longistaminata	41.31	4.00e-94	338.00
IUUC-Oni-082891	Oryza nivara	40.84	1.00e-99	356.00
IUUC-Opu-083457	Oryza punctata	40.52	2.00e-100	359.00
IUUC-Oru-084960	Oryza rufipogon	41.31	4.00e-94	338.00
IUUC-Osa-085358	Oryza sativa	40.73	3.00e-101	362.00
IUUC-Ola-086420	Oryzias latipes	71.05	2.00e-167	581.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.35	4.00e-47	182.00
IUUC-Oga-088810	Otolemur garnettii	92.83	0.00e+00	915.00
IUUC-Oar-089196	Ovis aries	97.79	0.00e+00	927.00
IUUC-Ptr-090617	Pan troglodytes	99.34	0.00e+00	937.00
IUUC-Pan-092761	Papio anubis	99.34	0.00e+00	937.00
IUUC-Psi-093191	Pelodiscus sinensis	83.86	0.00e+00	838.00
IUUC-Pma-094380	Petromyzon marinus	57.08	2.00e-152	531.00
IUUC-Pno-095084	Phaeosphaeria nodorum	28.60	1.00e-48	188.00
IUUC-Ppa-095875	Physcomitrella patens	37.72	6.00e-92	331.00
IUUC-Pfo-096467	Poecilia formosa	68.57	0.00e+00	697.00
IUUC-Pab-098255	Pongo abelii	95.28	0.00e+00	751.00
IUUC-Pop-099722	Populus trichocarpa	37.74	7.00e-97	347.00
IUUC-Pca-100807	Procavia capensis	69.59	1.00e-80	293.00
IUUC-Ppe-101280	Prunus persica	37.58	8.00e-95	340.00
IUUC-Pva-102333	Pteropus vampyrus	92.92	0.00e+00	868.00
IUUC-Pgr-103401	Puccinia graminis	30.10	5.00e-62	232.00
IUUC-Ptt-103889	Puccinia triticina	26.44	3.00e-41	163.00
IUUC-Pte-104355	Pyrenophora teres	33.96	4.00e-67	249.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	33.96	6.00e-68	251.00
IUUC-Rno-105810	Rattus norvegicus	95.12	0.00e+00	931.00
IUUC-Sce-106397	Saccharomyces cerevisiae	25.15	5.00e-26	112.00
IUUC-Sha-106770	Sarcophilus harrisii	88.94	3.00e-107	381.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	31.58	2.00e-59	223.00
IUUC-Spo-108276	Schizosaccharomyces pombe	32.53	1.00e-58	220.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	28.60	2.00e-48	187.00
IUUC-Smo-109296	Selaginella moellendorffii	40.04	5.00e-96	344.00
IUUC-Sit-110157	Setaria italica	42.03	8.00e-107	380.00
IUUC-Sly-111105	Solanum lycopersicum	37.50	1.00e-93	337.00
IUUC-Stu-112469	Solanum tuberosum	37.90	9.00e-96	343.00
IUUC-Sar-113083	Sorex araneus	69.69	4.00e-179	620.00
IUUC-Sbi-113813	Sorghum bicolor	42.03	1.00e-105	376.00
IUUC-Sre-115058	Sporisorium reilianum	35.27	5.00e-61	229.00
IUUC-Tgu-116772	Taeniopygia guttata	78.31	0.00e+00	751.00
IUUC-Tru-118686	Takifugu rubripes	67.52	0.00e+00	697.00
IUUC-Tsy-119111	Tarsius syrichta	92.39	7.00e-109	387.00
IUUC-Tni-120231	Tetraodon nigroviridis	67.72	0.00e+00	688.00
IUUC-Tca-121491	Theobroma cacao	37.80	2.00e-88	319.00
IUUC-Tre-122103	Trichoderma reesei	32.08	4.00e-56	212.00
IUUC-Tvi-122672	Trichoderma virens	32.22	6.00e-50	191.00
IUUC-Tae-125679	Triticum aestivum	40.09	8.00e-100	357.00
IUUC-Tur-126487	Triticum urartu	39.23	1.00e-97	350.00
IUUC-Tme-127097	Tuber melanosporum	34.85	7.00e-68	251.00
IUUC-Ttr-128465	Tursiops truncatus	89.38	0.00e+00	837.00
IUUC-Uma-129645	Ustilago maydis	31.03	7.00e-67	248.00
IUUC-Vda-129989	Verticillium dahliae	29.05	5.00e-30	125.00
IUUC-Vpa-130529	Vicugna pacos	92.70	0.00e+00	871.00
IUUC-Vvi-131059	Vitis vinifera	38.02	1.00e-92	333.00
IUUC-Xtr-132002	Xenopus tropicalis	74.52	0.00e+00	763.00
IUUC-Xma-133930	Xiphophorus maculatus	69.00	0.00e+00	702.00
IUUC-Yli-134505	Yarrowia lipolytica	32.15	6.00e-59	221.00
IUUC-Zma-135895	Zea mays	41.59	3.00e-105	375.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence