iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.40e-85	286.2	1	626

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 12   mNSvLQcLsnipelrellle..........kkkeklneenp.........kepkgellkslqklfeelwkskkkavsprellkalkkea 81
           mN++LQcLsn++ ++e+l            +         p         ++ +ge++++l++l+++lw+ + +    r+++++++k a
   Q: 1    MNATLQCLSNTELFAEYLALgqyragrpepE---------PepeqpagrgPHGQGEVTEQLAHLVRALWTLEYTPQHSRDFKSIVSKNA 80
           9*****************9954444443331.........133333333356666********************************** PP
   S: 82   eefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
            +++g++q+DaqEfl +lld+++e+l++ + k+  +   +  se++++ e       ++++++lFq q++s+++c++c+++s++++pfl
   Q: 81   LQYRGNSQHDAQEFLLWLLDRVHEDLNH-AVKQSGQPPLKPPSETDMMPEGPSFPVCSTFVQELFQAQYRSSLTCPHCQKQSNTFDPFL 168
           **************************66.33333344444445666677777888889******************************* PP
   S: 171  dlslpvpgkeetkke.......................................................................... 185
            +slp+p  +++ ++                                                                          
   Q: 169  CISLPIPLPHTR-PLyvtvvyqgkcshcmrigvavplsgtvarlreavsmetkiptdqivltemyydgfhrsfsdtddletvhesdcif 256
           *******87755.34689*********************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 257  afetpeifrpegilsqrgihlnnnlnhlkfgldhhrlssstptaakqgrvdlpsrvasdkivllvcnractgqqgkrfglpfvlhlekt 345
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 346  vawdllqkeilekmkyflrptvsvqvcpfslrvvsvvgityllpqeeqplchptveralkscgpggtahvklvvewdketkdflfvnte 434
           ***************************************************************************************** PP
   S: 186  .......................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekink 251
                                  +l++c++ +tkee+l  ++++ c++ck++q+ + +l+l++lP+vLi+hLkRf  ++e+++r k+++
   Q: 435  deyipdaesvrlqkeqhhqpqtcTLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRF--RQEGDRRMKLQN 521
           ***************************************************************************..99********** PP
   S: 252  kvefple.Ldlspfctspeekqke...................kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevke 319
            v+fpl+ Ld++p+++++++++ +                   +++Y+L+av++H+G++++GHY+ay+kn+ ++ W++fdDs V++++e
   Q: 522  MVKFPLTgLDMTPHVVKRSQSSWSlpshwspwrrpyglgrdpeDYIYDLYAVCNHHGTMQGGHYTAYCKNSVDGlWYCFDDSDVQQLSE 610
           ****************977666559999999999999999999***************************87777************** PP
   S: 320  eevleetgstaYvlfYkrr 338
           +ev++   +taY+lfY+rr
   Q: 611  DEVCT---QTAYILFYQRR 626
           *****...*********96 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MNATLQCLSN TELFAEYLAL GQYRAGRPEP EPEPEQPAGR GPHGQGEVTE QLAHLVRALW 60
TLEYTPQHSR DFKSIVSKNA LQYRGNSQHD AQEFLLWLLD RVHEDLNHAV KQSGQPPLKP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGGTGCCCG GCGTGGCGGG GCTCCGCAAC CACGGCAACA CGTGCTTCAT GAACGCCACG 60
CTGCAATGCC TCAGTAACAC CGAGCTCTTC GCCGAATACC TGGCACTCGG CCAGTACCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001207	Ailuropoda melanoleuca	89.31	0.00e+00	1861.00
IUUC-Apl-003186	Anas platyrhynchos	75.81	0.00e+00	1456.00
IUUC-Aca-004949	Anolis carolinensis	69.72	0.00e+00	1384.00
IUUC-Ame-010968	Astyanax mexicanus	69.31	0.00e+00	1051.00
IUUC-Bta-013271	Bos taurus	89.65	0.00e+00	1805.00
IUUC-Cja-019663	Callithrix jacchus	90.30	0.00e+00	1691.00
IUUC-Cfa-021258	Canis familiaris	89.33	0.00e+00	1866.00
IUUC-Csa-024188	Chlorocebus sabaeus	94.69	0.00e+00	1560.00
IUUC-Cho-024813	Choloepus hoffmanni	83.87	0.00e+00	1516.00
IUUC-Csv-026086	Ciona savignyi	39.54	2.00e-135	476.00
IUUC-Dre-027372	Danio rerio	71.11	0.00e+00	1019.00
IUUC-Dno-029964	Dasypus novemcinctus	85.25	0.00e+00	1736.00
IUUC-Dor-030448	Dipodomys ordii	79.58	0.00e+00	1133.00
IUUC-Dme-032088	Drosophila melanogaster	41.83	1.00e-57	218.00
IUUC-Ete-032975	Echinops telfairi	73.91	0.00e+00	1411.00
IUUC-Eca-034030	Equus caballus	89.81	0.00e+00	1835.00
IUUC-Eeu-034629	Erinaceus europaeus	71.26	0.00e+00	1142.00
IUUC-Fca-035788	Felis catus	93.89	0.00e+00	1558.00
IUUC-Fal-036874	Ficedula albicollis	75.02	0.00e+00	1393.00
IUUC-Gmo-039479	Gadus morhua	68.31	0.00e+00	1115.00
IUUC-Gga-041092	Gallus gallus	74.20	0.00e+00	1511.00
IUUC-Gac-041609	Gasterosteus aculeatus	73.76	0.00e+00	1089.00
IUUC-Ggo-044782	Gorilla gorilla	86.00	0.00e+00	707.00
IUUC-Hsa-046805	Homo sapiens	91.28	0.00e+00	1858.00
IUUC-Itr-048158	Ictidomys tridecemlineatus	91.07	0.00e+00	1722.00
IUUC-Lch-050332	Latimeria chalumnae	65.90	0.00e+00	1273.00
IUUC-Loc-051953	Lepisosteus oculatus	72.28	0.00e+00	1149.00
IUUC-Mcc-055398	Macaca mulatta	90.72	0.00e+00	1859.00
IUUC-Meu-056822	Macropus eugenii	77.25	0.00e+00	1450.00
IUUC-Mga-060115	Meleagris gallopavo	73.82	0.00e+00	1430.00
IUUC-Mmr-061150	Microcebus murinus	90.99	0.00e+00	1830.00
IUUC-Mdo-062700	Monodelphis domestica	82.65	0.00e+00	1753.00
IUUC-Mmu-063512	Mus musculus	97.69	0.00e+00	1921.00
IUUC-Mpu-066059	Mustela putorius furo	85.08	0.00e+00	1640.00
IUUC-Mlu-067870	Myotis lucifugus	84.36	0.00e+00	1647.00
IUUC-Nle-069898	Nomascus leucogenys	91.04	0.00e+00	1820.00
IUUC-Opr-070338	Ochotona princeps	80.08	0.00e+00	831.00
IUUC-Ont-072469	Oreochromis niloticus	68.32	0.00e+00	1078.00
IUUC-Oan-073175	Ornithorhynchus anatinus	77.78	0.00e+00	1516.00
IUUC-Ola-087303	Oryzias latipes	73.02	0.00e+00	1046.00
IUUC-Oga-089021	Otolemur garnettii	94.38	0.00e+00	1561.00
IUUC-Oar-090016	Ovis aries	89.24	0.00e+00	1761.00
IUUC-Ptr-090864	Pan troglodytes	91.53	0.00e+00	1861.00
IUUC-Pan-092370	Papio anubis	90.80	0.00e+00	1804.00
IUUC-Psi-093881	Pelodiscus sinensis	73.82	0.00e+00	1445.00
IUUC-Pfo-097427	Poecilia formosa	72.85	0.00e+00	1081.00
IUUC-Pab-098104	Pongo abelii	87.42	0.00e+00	1772.00
IUUC-Pca-100640	Procavia capensis	76.56	0.00e+00	643.00
IUUC-Pva-102287	Pteropus vampyrus	79.51	0.00e+00	1475.00
IUUC-Sha-107041	Sarcophilus harrisii	83.65	0.00e+00	1641.00
IUUC-Ssc-116412	Sus scrofa	77.49	0.00e+00	729.00
IUUC-Tgu-116889	Taeniopygia guttata	75.28	0.00e+00	1458.00
IUUC-Tru-118340	Takifugu rubripes	73.13	0.00e+00	1073.00
IUUC-Tsy-118887	Tarsius syrichta	83.22	0.00e+00	1592.00
IUUC-Tni-120463	Tetraodon nigroviridis	72.99	0.00e+00	1074.00
IUUC-Tbe-127491	Tupaia belangeri	91.36	1.00e-130	461.00
IUUC-Ttr-128210	Tursiops truncatus	84.36	0.00e+00	1705.00
IUUC-Vpa-130222	Vicugna pacos	82.77	0.00e+00	789.00
IUUC-Xtr-132509	Xenopus tropicalis	64.25	0.00e+00	1310.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence