iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059264

UUCD1 version

UUC-MeG-00048

Ensembl Protein ID

ENSMGAP00000000465.2

UniProt Accession

G1MQT5; G1MQT5_MELGA

Protein Name

Uncharacterized protein

Gene Name

NEDD4L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000000935.2	ENSMGAT00000001105.2	ENSMGAP00000000465.2
ENSMGAG00000000935.2	ENSMGAT00000020855.1	ENSMGAP00000018497.1
ENSMGAG00000000935.2	ENSMGAT00000019698.1	ENSMGAP00000019539.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-67	228.0	550	822

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen.....dketlqpnpdsglknpehlklFeflGrllgkalqdg 85
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++     d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g
   Q: 550  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATflkkrDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVYHG 638
           57899**************************************9998888888************************************ PP
   S: 86   rlldlplsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeY 173
           +lld    k++  +ll+ +l+l   +e +d+e+ +s    + +           l f  s+  +   +++ L  + ++    ne+  +Y
   Q: 639  KLLDDLTIKPCT-MLLSYQLNLaLQTEVIDSEVQDSFAHSRVH------L----LPFLLSK--VTFEDNYTLQINPNSGLC-NEDHLSY 713
           ***976666665.555666788789999999999998877744......2....3444334..445566667777666655.59999** PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
             lv+++r+ +++++q++af eGf+e++p+ ++++ ++++l+ll+cG  ++dv+d++++t yk+gy +++p+iqwFw+++  +++e+r 
   Q: 714  FTLVIQWRFVNRVQKQMNAFLEGFTELLPILIINI-QQSQLSLLMCGLGDVDVNDWRQHTVYKNGYCPNHPVIQWFWKAVLLMDAEKRI 801
           ******************************99987.8899************************************************* PP
   S: 263  afLqFvTgssrlPlgGfaelk 283
           ++LqFvTg+sr+P++Gfael 
   Q: 802  RLLQFVTGTSRVPMNGFAELY 822
           ******************995 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

TRDDFLGQVD VPLSHLPTEE QHFSERPSIL SVFGIQVKMR PFKIRVYLYY KAASIPGPGQ 60
TSREATSRAE ILKHEWDVTD SNDSASQRQE VLPPPPLPPG WEEKVDNLGR TYYVNHNNRT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTAGAGACG ACTTCCTGGG CCAGGTGGAT GTGCCTCTTA GCCACCTTCC GGTAAGAAAT 60
GCTTTGGTCT GTGTACTTTT TTTGTCATCC CCAGCAGTTA AAAACTCATG ACAATTTACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003893	Anas platyrhynchos	77.07	0.00e+00	1121.00
IUUC-Bta-012679	Bos taurus	73.29	0.00e+00	1051.00
IUUC-Dre-027770	Danio rerio	62.53	0.00e+00	861.00
IUUC-Ete-033145	Echinops telfairi	67.90	0.00e+00	837.00
IUUC-Eca-033445	Equus caballus	73.83	0.00e+00	1063.00
IUUC-Eeu-035247	Erinaceus europaeus	70.38	0.00e+00	979.00
IUUC-Fca-035489	Felis catus	71.11	0.00e+00	1003.00
IUUC-Meu-056712	Macropus eugenii	65.12	3.00e-141	495.00
IUUC-Mlu-067565	Myotis lucifugus	71.89	0.00e+00	1040.00
IUUC-Ont-072044	Oreochromis niloticus	61.87	0.00e+00	898.00
IUUC-Oan-073032	Ornithorhynchus anatinus	72.76	0.00e+00	1014.00
IUUC-Oga-088460	Otolemur garnettii	70.02	0.00e+00	1023.00
IUUC-Pca-100714	Procavia capensis	71.08	0.00e+00	766.00
IUUC-Sha-107482	Sarcophilus harrisii	74.02	0.00e+00	1075.00
IUUC-Tsy-119492	Tarsius syrichta	72.12	0.00e+00	1044.00
IUUC-Tbe-127441	Tupaia belangeri	69.85	6.00e-145	508.00
IUUC-Ttr-128235	Tursiops truncatus	65.04	0.00e+00	896.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence