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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063853
UUCD1 version UUC-MuM-01168
Ensembl Protein ID ENSMUSP00000022458.4
UniProt Accession Q99PU7; Q3TCR6; Q6ZQE6; BAP1_MOUSE
Genbank Protein ID BAB32976.1; BAC97918.1; BAE41889.1; AAH50901.1
Protein Name Ubiquitin carboxyl-terminal hydrolase BAP1; BRCA1-associated protein 1; Ubiquitin C-terminal hydrolase X4
Genbank Nucleotide ID AB047820; AK129108; AK170576; BC050901
Gene Name Bap1; Kiaa0272
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000021901.10 ENSMUST00000022458.10 ENSMUSP00000022458.4
ENSMUSG00000021901.10 ENSMUST00000188453.1 ENSMUSP00000139824.1
ENSMUSG00000021901.10 ENSMUST00000187156.1 ENSMUSP00000139903.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/UCH 1.60e-169 564.9 3 728
Active Site
Position(s) Description Evidence
91 Nucleophile ECO:0000305}
169 Proton donor ECO:0000250}
Domain Profile

   DUB/UCH
   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqv 94
           k+wleLesdPglftllvedfgvk++ qvee+y+L++++    q+pv+g+++lFk++e+r+s+rk++++++d++v+d+di++++ffa+q+
   Q: 3    KGWLELESDPGLFTLLVEDFGVKGV-QVEEIYDLQSKC----QGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQL 86
           89***********************.************....*********************************************** PP
   S: 95   igNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           i+NsCat+Allsvllnc+++  dlG+tlsr+k++tk++spe+k++a+gn+++l+++hns+ar+e+r++pe+q+++++++t+eafhfvsy
   Q: 87   IPNSCATHALLSVLLNCSNV--DLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSY 173
           ******************99..******************************************************************* PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid......... 259
           v+i+grl+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr++++ rl+vlk++         
   Q: 174  VPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRIKYETRLHVLKVNrqtvlealq 260
           *************************************..************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 261  qlirvtqpeliqthksqesqlpeeskpassksplgleagrtpvasectqtdgaeevagscpqttthsppskcklvvkppgsslngvppn 349
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 350  papivqrlpafldnhnyakspmqeeedlaagvgrsrvpvrapqqysededdyedededvqntnpairykrkgtgkpgslsnssdgqlsv 438
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 439  lqpntinvlteklqesqkdlsvplsiktssgagspavavpthsqpsptpsnestdtaseigsafnsplrspirsanptrpsspvtshis 527
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 528  kvlfgeddsllrvdcirynravrdlgpvistgllhlaedgvlsplalteggkgsspstrssqgsqgssgleekevvevtesrdkpglnr 616
           ***************************************************************************************** PP
   S: 260  ............keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgvne 336
                       keLl+Llk++e+e++++ea+l++e+ekrkkfkidd+rRt+nydefic+fi++la+eg+l++lve++is++r++gv++
   Q: 617  sseplsgekyspKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSI 705
           ***************************************************************************************** PP
   S: 337  grlakqrkqgrekkirplkrkrk 359
           grl+kqrk++r+k++rp+k+kr+
   Q: 706  GRLHKQRKPDRRKRSRPYKAKRQ 728
           *********************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor (By similarity).
 Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor (By similarity).
Protein Sequence
(Fasta)
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR 60
KVSTLVDDTS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCSNVDLGP TLSRMKDFTK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063853|DUB,UCH|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCGTCGTGT GATGATGACG TTGTACGTCC GGCGCGGGCG AGTGACGCGG CGCGGCCCGT 60
TGTCTGTGCG GGGCTGAGAA GCCCTAAGGG CGGTGGGCGC TCCCGGTTGG GGGCGGCGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063853|DUB,UCH|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR001578--Peptidase_C12_UCH
Pfam

PF01088--Peptidase_C12
PRINTS

PR00707--UBCTHYDRLASE
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035517--C:PR-DUB complex
GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0061519--P:macrophage homeostasis
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0008285--P:negative regulation of cell proliferation
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0051726--P:regulation of cell cycle
GO:0001558--P:regulation of cell growth
GO:1900015--P:regulation of cytokine production involved in inflammatory response
GO:0050727--P:regulation of inflammatory response
GO:0010035--P:response to inorganic substance
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:104416
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001263 Ailuropoda melanoleuca 91.85 0.00e+00 1186.00
IUUC-Apl-003405 Anas platyrhynchos 68.11 1.00e-177 615.00
IUUC-Aca-004836 Anolis carolinensis 79.67 0.00e+00 1143.00
IUUC-Ame-011946 Astyanax mexicanus 64.11 0.00e+00 892.00
IUUC-Bta-013131 Bos taurus 89.21 0.00e+00 1044.00
IUUC-Cja-019599 Callithrix jacchus 94.51 0.00e+00 1280.00
IUUC-Cfa-021003 Canis familiaris 93.69 0.00e+00 1176.00
IUUC-Cpo-022143 Cavia porcellus 92.87 0.00e+00 1248.00
IUUC-Csa-023477 Chlorocebus sabaeus 93.83 0.00e+00 1244.00
IUUC-Cho-024734 Choloepus hoffmanni 80.66 0.00e+00 713.00
IUUC-Csv-025842 Ciona savignyi 56.67 1.00e-93 336.00
IUUC-Dre-027793 Danio rerio 65.55 0.00e+00 724.00
IUUC-Dno-029253 Dasypus novemcinctus 92.66 0.00e+00 1237.00
IUUC-Dor-030891 Dipodomys ordii 87.79 0.00e+00 1167.00
IUUC-Dme-031796 Drosophila melanogaster 61.19 2.00e-92 332.00
IUUC-Ete-032646 Echinops telfairi 84.37 6.00e-166 577.00
IUUC-Eca-033805 Equus caballus 93.00 0.00e+00 1230.00
IUUC-Eeu-035216 Erinaceus europaeus 91.16 5.00e-137 481.00
IUUC-Fca-035611 Felis catus 93.18 0.00e+00 1140.00
IUUC-Fal-037186 Ficedula albicollis 78.65 0.00e+00 981.00
IUUC-Gmo-038824 Gadus morhua 68.54 1.00e-179 623.00
IUUC-Gga-040875 Gallus gallus 81.23 0.00e+00 1114.00
IUUC-Gac-042226 Gasterosteus aculeatus 67.97 0.00e+00 929.00
IUUC-Ggo-045122 Gorilla gorilla 92.73 0.00e+00 1274.00
IUUC-Hsa-045882 Homo sapiens 93.42 0.00e+00 1274.00
IUUC-Itr-048185 Ictidomys tridecemlineatus 95.06 0.00e+00 1260.00
IUUC-Lch-049960 Latimeria chalumnae 71.51 0.00e+00 988.00
IUUC-Loc-052408 Lepisosteus oculatus 75.75 0.00e+00 656.00
IUUC-Laf-054187 Loxodonta africana 93.00 0.00e+00 1217.00
IUUC-Mcc-055273 Macaca mulatta 92.87 0.00e+00 1242.00
IUUC-Meu-056267 Macropus eugenii 81.89 0.00e+00 1152.00
IUUC-Mga-059958 Meleagris gallopavo 86.94 2.00e-155 541.00
IUUC-Mmr-061280 Microcebus murinus 93.29 0.00e+00 1225.00
IUUC-Mdo-062625 Monodelphis domestica 88.20 0.00e+00 1248.00
IUUC-Mlu-067771 Myotis lucifugus 92.87 0.00e+00 1224.00
IUUC-Opr-070741 Ochotona princeps 91.63 0.00e+00 1250.00
IUUC-Ont-072172 Oreochromis niloticus 67.15 0.00e+00 939.00
IUUC-Oan-073167 Ornithorhynchus anatinus 78.74 0.00e+00 1126.00
IUUC-Ocu-074176 Oryctolagus cuniculus 92.71 0.00e+00 1199.00
IUUC-Ola-087203 Oryzias latipes 85.23 4.00e-135 474.00
IUUC-Oga-089153 Otolemur garnettii 92.80 0.00e+00 1242.00
IUUC-Oar-090008 Ovis aries 91.76 0.00e+00 1218.00
IUUC-Ptr-091234 Pan troglodytes 93.69 0.00e+00 1279.00
IUUC-Pan-092005 Papio anubis 93.83 0.00e+00 1271.00
IUUC-Psi-093995 Pelodiscus sinensis 83.42 0.00e+00 655.00
IUUC-Pma-094110 Petromyzon marinus 88.19 5.00e-65 242.00
IUUC-Pfo-097418 Poecilia formosa 63.21 0.00e+00 916.00
IUUC-Pab-098267 Pongo abelii 93.00 0.00e+00 1253.00
IUUC-Pca-101084 Procavia capensis 91.53 0.00e+00 1179.00
IUUC-Pva-102292 Pteropus vampyrus 93.01 0.00e+00 893.00
IUUC-Rno-105251 Rattus norvegicus 95.41 0.00e+00 1286.00
IUUC-Sha-107100 Sarcophilus harrisii 86.94 0.00e+00 1246.00
IUUC-Sar-113559 Sorex araneus 84.59 0.00e+00 1047.00
IUUC-Ssc-115688 Sus scrofa 93.00 0.00e+00 1244.00
IUUC-Tgu-117424 Taeniopygia guttata 80.22 0.00e+00 1098.00
IUUC-Tru-118585 Takifugu rubripes 67.07 0.00e+00 926.00
IUUC-Tsy-119299 Tarsius syrichta 82.30 0.00e+00 927.00
IUUC-Tni-120808 Tetraodon nigroviridis 67.60 0.00e+00 922.00
IUUC-Tbe-127705 Tupaia belangeri 94.62 2.00e-180 624.00
IUUC-Ttr-128225 Tursiops truncatus 92.04 0.00e+00 1209.00
IUUC-Vpa-130193 Vicugna pacos 92.42 6.00e-125 441.00
IUUC-Xtr-132449 Xenopus tropicalis 70.38 0.00e+00 937.00
Created Date 25-Jun-2017

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