iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ola-087203

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

BAAF04095135

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000002293.1	ENSORLT00000002841.1	ENSORLP00000002840.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.60e-130	435.1	4	318

Active Site

Position(s)	Description	Evidence
88	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
166	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 4    qvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffak 92
            +k+wleLesdPglftllvedfgvk++ qvee+y+L+ ++ +    pv+g+++lFk++e+r+s+          +v+de+i++ +ffa+
   Q: 4    MNKGWLELESDPGLFTLLVEDFGVKGV-QVEEIYDLQIKTTENG-IPVYGFIFLFKWIEERRSRS---------SVIDEEIVNDMFFAH 81
           459************************.**********996665.8******************9.........99************* PP
   S: 93   qvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfv 181
           q+i+NsCat+Allsvllnc+ +  +lG+tlsr+k +tk++spe+k++a+gn+++l+ +hns+ar+e+r++pe+q++ ++++t+eafhfv
   Q: 82   QLIPNSCATHALLSVLLNCSGV--ELGSTLSRIKAFTKGFSPESKGYAIGNAPELARAHNSHARPEPRHLPEKQNGISAVRTMEAFHFV 168
           ********************99..9**************************************************************** PP
   S: 182  syvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid....... 259
           syv+i++rl+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr++++ +l+vlk +       
   Q: 169  SYVPIKDRLFELDGLKAYPIDHGPWGEEEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRMKYESKLEVLKKNrqtileg 255
           ***************************************..************************************************ PP
   S: 260  ......keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlareg 316
                  eLl+Llk++e+ ++++e  l++e+ekrkk+kidd+rRt+nydefic+fi++la+e 
   Q: 256  lqkdksSELLALLKCVEADIANYEVYLKEEVEKRKKYKIDDQRRTHNYDEFICTFISMLAQEV 318
           ************************************************************985 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

KNNMNKGWLE LESDPGLFTL LVEDFGVKGV QVEEIYDLQI KTTENGIPVY GFIFLFKWIE 60
ERRSRSSVID EEIVNDMFFA HQLIPNSCAT HALLSVLLNC SGVELGSTLS RIKAFTKGFS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGGTAACC GGCGACCGAC TCGATCTATT GTGTTTATGT TGAATTTTCT GTTGAGGATT 60
TTTAAATACC AAAGAAATAG AAGCGGCATT CAGATAAACA TTGCTCTCGC GCTGTCGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005622--C:intracellular
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001263	Ailuropoda melanoleuca	85.23	2.00e-129	456.00
IUUC-Aca-004836	Anolis carolinensis	84.65	4.00e-127	448.00
IUUC-Ame-011946	Astyanax mexicanus	88.64	6.00e-141	494.00
IUUC-Bta-013131	Bos taurus	78.41	2.00e-114	406.00
IUUC-Cja-019599	Callithrix jacchus	85.23	5.00e-130	457.00
IUUC-Cfa-021003	Canis familiaris	85.23	1.00e-129	456.00
IUUC-Cpo-022143	Cavia porcellus	85.23	9.00e-130	457.00
IUUC-Csa-023477	Chlorocebus sabaeus	85.23	7.00e-130	457.00
IUUC-Cho-024734	Choloepus hoffmanni	88.00	7.00e-37	148.00
IUUC-Csv-025842	Ciona savignyi	51.37	4.00e-90	324.00
IUUC-Dre-027793	Danio rerio	85.09	3.00e-141	495.00
IUUC-Dno-029253	Dasypus novemcinctus	83.66	4.00e-123	435.00
IUUC-Dor-030891	Dipodomys ordii	74.33	2.00e-111	396.00
IUUC-Dme-031796	Drosophila melanogaster	54.11	9.00e-100	357.00
IUUC-Ete-032646	Echinops telfairi	85.00	8.00e-109	387.00
IUUC-Eca-033805	Equus caballus	85.23	1.00e-129	457.00
IUUC-Eeu-035216	Erinaceus europaeus	87.27	9.00e-55	207.00
IUUC-Fca-035611	Felis catus	84.58	5.00e-122	431.00
IUUC-Fal-037186	Ficedula albicollis	90.11	3.00e-100	359.00
IUUC-Gmo-038824	Gadus morhua	90.15	3.00e-142	498.00
IUUC-Gga-040875	Gallus gallus	85.61	5.00e-135	474.00
IUUC-Gac-042226	Gasterosteus aculeatus	91.29	3.00e-145	508.00
IUUC-Ggo-045122	Gorilla gorilla	85.23	5.00e-130	458.00
IUUC-Hsa-045882	Homo sapiens	85.23	5.00e-130	458.00
IUUC-Itr-048185	Ictidomys tridecemlineatus	85.23	8.00e-130	457.00
IUUC-Lch-049960	Latimeria chalumnae	75.47	1.00e-114	407.00
IUUC-Loc-052408	Lepisosteus oculatus	83.04	2.00e-137	482.00
IUUC-Laf-054187	Loxodonta africana	85.61	8.00e-135	474.00
IUUC-Mcc-055273	Macaca mulatta	81.82	2.00e-121	430.00
IUUC-Meu-056267	Macropus eugenii	81.82	5.00e-127	448.00
IUUC-Mga-059958	Meleagris gallopavo	84.98	3.00e-127	447.00
IUUC-Mmr-061280	Microcebus murinus	85.23	1.00e-129	456.00
IUUC-Mdo-062625	Monodelphis domestica	86.74	2.00e-136	479.00
IUUC-Mmu-063853	Mus musculus	85.23	6.00e-130	457.00
IUUC-Mlu-067771	Myotis lucifugus	80.99	4.00e-129	455.00
IUUC-Opr-070741	Ochotona princeps	84.85	2.00e-129	456.00
IUUC-Ont-072172	Oreochromis niloticus	91.67	2.00e-145	509.00
IUUC-Oan-073167	Ornithorhynchus anatinus	86.74	1.00e-136	480.00
IUUC-Ocu-074176	Oryctolagus cuniculus	85.23	1.00e-128	454.00
IUUC-Oga-089153	Otolemur garnettii	83.66	5.00e-123	435.00
IUUC-Oar-090008	Ovis aries	85.23	6.00e-130	457.00
IUUC-Ptr-091234	Pan troglodytes	85.23	4.00e-130	458.00
IUUC-Pan-092005	Papio anubis	85.23	7.00e-130	457.00
IUUC-Psi-093995	Pelodiscus sinensis	80.07	5.00e-127	448.00
IUUC-Pma-094110	Petromyzon marinus	87.93	4.00e-59	222.00
IUUC-Pfo-097418	Poecilia formosa	91.63	1.00e-143	503.00
IUUC-Pab-098267	Pongo abelii	85.23	4.00e-130	458.00
IUUC-Pca-101084	Procavia capensis	85.61	8.00e-135	474.00
IUUC-Pva-102292	Pteropus vampyrus	85.23	1.00e-129	457.00
IUUC-Rno-105251	Rattus norvegicus	81.23	4.00e-127	448.00
IUUC-Sha-107100	Sarcophilus harrisii	85.10	3.00e-128	452.00
IUUC-Sar-113559	Sorex araneus	85.91	8.00e-109	387.00
IUUC-Ssc-115688	Sus scrofa	85.61	6.00e-130	457.00
IUUC-Tgu-117424	Taeniopygia guttata	84.92	4.00e-127	448.00
IUUC-Tru-118585	Takifugu rubripes	92.05	7.00e-145	507.00
IUUC-Tsy-119299	Tarsius syrichta	69.32	1.00e-96	347.00
IUUC-Tni-120808	Tetraodon nigroviridis	91.67	3.00e-144	505.00
IUUC-Tbe-127705	Tupaia belangeri	83.33	5.00e-121	427.00
IUUC-Ttr-128225	Tursiops truncatus	85.23	8.00e-130	457.00
IUUC-Vpa-130193	Vicugna pacos	65.40	3.00e-81	295.00
IUUC-Xtr-132449	Xenopus tropicalis	85.32	1.00e-127	449.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence