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Tag Content
UUCD2 ID IUUC-Pab-098267
UUCD1 version UUC-PoA-01038
Ensembl Protein ID ENSPPYP00000015452.2
UniProt Accession H2PAJ9; H2PAJ9_PONAB
Genbank Protein ID ENSPPYP00000015452
Protein Name Ubiquitin carboxyl-terminal hydrolase
Genbank Nucleotide ID ABGA01132807
Gene Name BAP1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPPYG00000013809.2 ENSPPYT00000016065.2 ENSPPYP00000015452.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/UCH 1.80e-169 563.7 3 729
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/UCH
   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqv 94
           k+wleLesdPglftllvedfgvk++ qvee+y+L++++    q+pv+g+++lFk++e+r+s+rk++++++d++v+d+di++++ffa+q+
   Q: 3    KGWLELESDPGLFTLLVEDFGVKGV-QVEEIYDLQSKC----QGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQL 86
           89***********************.************....*********************************************** PP
   S: 95   igNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           i+NsCat+Allsvllnc+++  dlG+tlsr+k++tk++spe+k++a+gn+++l+++hns+ar+e+r++pe+q+++++++t+eafhfvsy
   Q: 87   IPNSCATHALLSVLLNCSNV--DLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSY 173
           ******************99..******************************************************************* PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid......... 259
           v+i+grl+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr+++++rl+vlk++         
   Q: 174  VPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRIKYEARLHVLKVNrqtvlealq 260
           *************************************..************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 261  qlirvtqpeliqthksqesqlpeesksasnksplvleanrapaasegthtdgaeeaagscaqapshsppnkpklvvkppgsslngvppn 349
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 350  ptpivqrlpafldnhnyakspmqeeedlaagvgrsrvpvrppqqysddeddyeddeeddvqntnsalrykgkgtgkpgalsgsadgqls 438
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 439  vlqpntinvlaeklkesqkdlsiplsiktssgagspavavpthsqpsptpsnestdtaseigsafnsplrspirsanptrpsspvtshi 527
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 528  skvlfgeddsllrvdcirynravrdlgpvistgllhlaedgvlsplalteggkgsspsvrpiqgsqgssspvekevveatdsrektgmv 616
           ***************************************************************************************** PP
   S: 260  .............keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgvn 335
                        keLl+Llk++e+e++++ea+l++e ekrkkfkidd+rRt+nydefic+fi++la+eg+l++lve++is++r++gv+
   Q: 617  rpgeplsgekyspKELLALLKCVEAEIANYEACLKEEIEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVS 705
           ***************************************************************************************** PP
   S: 336  egrlakqrkqgrekkirplkrkrk 359
           +grl+kqrk++r+k++rp+k+kr+
   Q: 706  IGRLHKQRKPDRRKRSRPYKAKRQ 729
           **********************97 PP
   
Organism Pongo abelii
Protein Sequence
(Fasta)
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR 60
KVSTLVDDTS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCSNVDLGP TLSRMKDFTK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Pab-098267|DUB,UCH|Pongo abelii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
NNNCGCACCA CCCGGGCCTA GTACTTCCCC GGTCCCGCCC CTTCCCCTCG CCCGTCCCGC 60
CCCTCCTCCC GAGCCTGAGC GCTCAGCATC GCCCGGACCC CCTCTTCCCT TCGCCCGCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Pab-098267|DUB,UCH|Pongo abelii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR001578--Peptidase_C12_UCH
Pfam

PF01088--Peptidase_C12
PRINTS

PR00707--UBCTHYDRLASE
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0035517--C:PR-DUB complex
GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0061519--P:macrophage homeostasis
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0071108--P:protein K48-linked deubiquitination
GO:0051726--P:regulation of cell cycle
GO:0001558--P:regulation of cell growth
GO:1900015--P:regulation of cytokine production involved in inflammatory response
GO:0010035--P:response to inorganic substance
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG pon:100462322
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001263 Ailuropoda melanoleuca 93.61 0.00e+00 1210.00
IUUC-Apl-003405 Anas platyrhynchos 69.42 0.00e+00 635.00
IUUC-Aca-004836 Anolis carolinensis 79.40 0.00e+00 1137.00
IUUC-Ame-011946 Astyanax mexicanus 63.32 0.00e+00 889.00
IUUC-Bta-013131 Bos taurus 91.25 0.00e+00 1080.00
IUUC-Cja-019599 Callithrix jacchus 97.67 0.00e+00 1365.00
IUUC-Cfa-021003 Canis familiaris 96.02 0.00e+00 1220.00
IUUC-Cpo-022143 Cavia porcellus 95.61 0.00e+00 1314.00
IUUC-Csa-023477 Chlorocebus sabaeus 98.49 0.00e+00 1345.00
IUUC-Cho-024734 Choloepus hoffmanni 83.20 0.00e+00 782.00
IUUC-Csv-025842 Ciona savignyi 58.95 7.00e-94 337.00
IUUC-Dre-027793 Danio rerio 65.40 0.00e+00 907.00
IUUC-Dno-029253 Dasypus novemcinctus 95.15 0.00e+00 1310.00
IUUC-Dor-030891 Dipodomys ordii 88.75 0.00e+00 1220.00
IUUC-Dme-031796 Drosophila melanogaster 61.19 1.00e-92 333.00
IUUC-Ete-032646 Echinops telfairi 85.44 9.00e-174 603.00
IUUC-Eca-033805 Equus caballus 94.92 0.00e+00 1266.00
IUUC-Eeu-035216 Erinaceus europaeus 93.54 2.00e-152 532.00
IUUC-Fca-035611 Felis catus 95.54 0.00e+00 1164.00
IUUC-Fal-037186 Ficedula albicollis 80.18 0.00e+00 993.00
IUUC-Gmo-038824 Gadus morhua 69.79 0.00e+00 632.00
IUUC-Gga-040875 Gallus gallus 81.78 0.00e+00 1123.00
IUUC-Gac-042226 Gasterosteus aculeatus 68.11 0.00e+00 936.00
IUUC-Ggo-045122 Gorilla gorilla 99.18 0.00e+00 1390.00
IUUC-Hsa-045882 Homo sapiens 99.31 0.00e+00 1390.00
IUUC-Itr-048185 Ictidomys tridecemlineatus 97.26 0.00e+00 1333.00
IUUC-Lch-049960 Latimeria chalumnae 72.42 0.00e+00 1008.00
IUUC-Loc-052408 Lepisosteus oculatus 75.11 0.00e+00 657.00
IUUC-Laf-054187 Loxodonta africana 96.16 0.00e+00 1273.00
IUUC-Mcc-055273 Macaca mulatta 97.53 0.00e+00 1342.00
IUUC-Meu-056267 Macropus eugenii 82.44 0.00e+00 1171.00
IUUC-Mga-059958 Meleagris gallopavo 87.91 3.00e-154 537.00
IUUC-Mmr-061280 Microcebus murinus 96.71 0.00e+00 1304.00
IUUC-Mdo-062625 Monodelphis domestica 89.16 0.00e+00 1280.00
IUUC-Mmu-063853 Mus musculus 93.00 0.00e+00 1277.00
IUUC-Mlu-067771 Myotis lucifugus 94.38 0.00e+00 1243.00
IUUC-Opr-070741 Ochotona princeps 93.55 0.00e+00 1291.00
IUUC-Ont-072172 Oreochromis niloticus 66.84 0.00e+00 946.00
IUUC-Oan-073167 Ornithorhynchus anatinus 80.52 0.00e+00 1150.00
IUUC-Ocu-074176 Oryctolagus cuniculus 95.32 0.00e+00 1243.00
IUUC-Ola-087203 Oryzias latipes 85.23 3.00e-135 474.00
IUUC-Oga-089153 Otolemur garnettii 96.12 0.00e+00 1314.00
IUUC-Oar-090008 Ovis aries 92.04 0.00e+00 1241.00
IUUC-Ptr-091234 Pan troglodytes 99.59 0.00e+00 1396.00
IUUC-Pan-092005 Papio anubis 98.49 0.00e+00 1370.00
IUUC-Psi-093995 Pelodiscus sinensis 83.68 0.00e+00 657.00
IUUC-Pma-094110 Petromyzon marinus 48.67 3.00e-119 422.00
IUUC-Pfo-097418 Poecilia formosa 65.66 0.00e+00 935.00
IUUC-Pca-101084 Procavia capensis 94.16 0.00e+00 1220.00
IUUC-Pva-102292 Pteropus vampyrus 95.73 0.00e+00 905.00
IUUC-Rno-105251 Rattus norvegicus 91.64 0.00e+00 1253.00
IUUC-Sha-107100 Sarcophilus harrisii 87.92 0.00e+00 1273.00
IUUC-Sar-113559 Sorex araneus 87.06 0.00e+00 1076.00
IUUC-Ssc-115688 Sus scrofa 94.79 0.00e+00 1300.00
IUUC-Tgu-117424 Taeniopygia guttata 80.58 0.00e+00 1119.00
IUUC-Tru-118585 Takifugu rubripes 66.49 0.00e+00 934.00
IUUC-Tsy-119299 Tarsius syrichta 84.87 0.00e+00 997.00
IUUC-Tni-120808 Tetraodon nigroviridis 66.93 0.00e+00 928.00
IUUC-Tbe-127705 Tupaia belangeri 95.97 0.00e+00 641.00
IUUC-Ttr-128225 Tursiops truncatus 94.79 0.00e+00 1249.00
IUUC-Vpa-130193 Vicugna pacos 93.86 8.00e-131 460.00
IUUC-Xtr-132449 Xenopus tropicalis 71.41 0.00e+00 948.00
Created Date 25-Jun-2017

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