iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	17098253; 17614368
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	10675567; 11827521; 12972570; 18199683

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	5.50e-10	40.7	582	619
ULD/UDP/UBQ/UBQ_PIM	6.40e-23	82.2	33	106

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGF.dreealqaLraannnleaAveyLl 39
           ++++leql +MGF +re++lqaL a++++++aA+e+Ll
   Q: 582  FQQQLEQLNAMGFlNREANLQALIATGGDINAAIERLL 619
           799**********************************9 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           +k+tvkt+k+ke e+ v e+++v+++Ke+i+k+++ + +q+ LI+aGkiLkD++tL ++gi+dg +vhlv+k ++
   Q: 33   IKVTVKTPKEKE-EFAVPENSSVQQFKEAISKRFKSQTDQLVLIFAGKILKDQDTLIQHGIHDGLTVHLVIKSQN 106
           69**********.***********************************************************986 PP

Organism

Homo sapiens

Functional Description
(View)

Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683).

Protein Sequence
(Fasta)

MAENGESSGP PRPSRGPAAA QGSAAAPAEP KIIKVTVKTP KEKEEFAVPE NSSVQQFKEA 60
ISKRFKSQTD QLVLIFAGKI LKDQDTLIQH GIHDGLTVHL VIKSQNRPQG QSTQPSNAAG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAGGAGGC CCAGAGACCG GAGCGCGGAG ACCTCAGCCA GCGGCCTACG CCCAGGCCTT 60
TCTCCACCGG AGGACCAGGG AACCGCAGTC TTCATCACAG AGGTACCGTG CTCCGCGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0036--Amyotrophic lateral sclerosis
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0225--Disease mutation
KW-0472--Membrane
KW-0523--Neurodegeneration
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR016024--ARM-type_fold
IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR015496--Ubiquilin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

Gene Ontology

GO:0005776--C:autophagosome
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0006914--P:autophagy
GO:1900186--P:negative regulation of clathrin-dependent endocytosis
GO:1904021--P:negative regulation of G-protein coupled receptor internalization
GO:1903071--P:positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:2000785--P:regulation of autophagosome assembly
GO:0016241--P:regulation of macroautophagy
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

hsa:29978

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013571	Bos taurus	97.07	0.00e+00	741.00
IUUC-Cfa-020799	Canis familiaris	97.52	0.00e+00	636.00
IUUC-Cpo-022093	Cavia porcellus	97.00	2.00e-174	605.00
IUUC-Cre-022634	Chlamydomonas reinhardtii	48.15	3.00e-11	62.80
IUUC-Csa-023627	Chlorocebus sabaeus	99.48	0.00e+00	758.00
IUUC-Cho-024552	Choloepus hoffmanni	92.81	5.00e-174	603.00
IUUC-Csv-026009	Ciona savignyi	45.34	4.00e-101	362.00
IUUC-Cne-026833	Cryptococcus neoformans	27.47	2.00e-13	70.10
IUUC-Dno-029647	Dasypus novemcinctus	94.26	0.00e+00	629.00
IUUC-Ete-033071	Echinops telfairi	88.01	0.00e+00	734.00
IUUC-Eeu-034727	Erinaceus europaeus	94.15	0.00e+00	713.00
IUUC-Fca-035803	Felis catus	97.97	1.00e-179	623.00
IUUC-Fso-038204	Fusarium solani	40.85	2.00e-07	50.80
IUUC-Hvu-047094	Hordeum vulgare	50.98	3.00e-09	53.50
IUUC-Itr-048556	Ictidomys tridecemlineatus	92.15	1.00e-173	603.00
IUUC-Mmr-061605	Microcebus murinus	97.74	7.00e-172	597.00
IUUC-Mpu-066474	Mustela putorius furo	97.52	9.00e-180	623.00
IUUC-Mlu-067252	Myotis lucifugus	87.19	1.00e-163	570.00
IUUC-Nle-069038	Nomascus leucogenys	99.66	0.00e+00	758.00
IUUC-Oga-088005	Otolemur garnettii	98.87	1.00e-178	620.00
IUUC-Oar-089878	Ovis aries	97.07	0.00e+00	753.00
IUUC-Ptr-090781	Pan troglodytes	100.00	2.00e-179	622.00
IUUC-Pan-091716	Papio anubis	92.76	0.00e+00	694.00
IUUC-Pab-097891	Pongo abelii	99.77	4.00e-179	621.00
IUUC-Pca-100227	Procavia capensis	96.62	1.00e-95	343.00
IUUC-Pgr-103261	Puccinia graminis	54.76	2.00e-07	50.10
IUUC-Sce-106332	Saccharomyces cerevisiae	44.16	9.00e-11	61.20
IUUC-Spo-108223	Schizosaccharomyces pombe	27.48	2.00e-10	59.70
IUUC-Sre-115081	Sporisorium reilianum	26.52	4.00e-11	62.80
IUUC-Tsy-119008	Tarsius syrichta	96.06	3.00e-172	598.00
IUUC-Uma-129639	Ustilago maydis	27.16	8.00e-11	61.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence