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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046037
UUCD1 version UUC-HoS-00547
Ensembl Protein ID ENSP00000424417.1
UniProt Accession O43660; B3KMK4; Q3KQY5; Q8WUD8; PLRG1_HUMAN
Genbank Protein ID AAD09407.1; BAG51016.1; EAX04941.1; AAH20786.1; AAI06005.1
Protein Name Pleiotropic regulator 1
Genbank Nucleotide ID AF044333; AK002108; CH471056; BC020786; BC106004
Gene Name PLRG1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000171566.11 ENST00000499023.6 ENSP00000424417.1
ENSG00000171566.11 ENST00000506627.5 ENSP00000425914.1
ENSG00000171566.11 ENST00000503251.5 ENSP00000426497.1
ENSG00000171566.11 ENST00000302078.9 ENSP00000303191.5
ENSG00000171566.11 ENST00000506192.5 ENSP00000424616.1
ENSG00000171566.11 ENST00000504341.1 ENSP00000423454.1
ENSG00000171566.11 ENST00000509975.5 ENSP00000425147.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACmiRWalkTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.60e-43 146.4 202 238
UBD/Beta-Prp 1.40e-63 216.6 297 490
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gH ++v+c+a  ++   +v+Gs D tik+WDl +g+l
   Q: 202  GHLGWVRCIAVePGnQWFVTGSADRTIKIWDLASGKL 238
           8***********77799***************99987 PP
   

   UBD/Beta-Prp
   S: 19   spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklv 110
           +p  ++l+t srd+t ++wdv+t+  +++lsgh+++v++v+++  ++ ++tgs D ti++wdl +gk+ +tl++h++sv+++ ++p  ++++
   Q: 297  HPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFA 388
           44445566666666666666666666666666666666666666666666666666666666666666666666666666666666666666 PP
   S: 111  sGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl.......tgghtdsvyslsfdsngkel 195
           sGs d+ i+ w+ + g+ ++  lsgh++++n+++v++ + +lvsG++++t+ lWd +tg   ++        + + ++ +   +fd++  +l
   Q: 389  SGSPDN-IKQWKFPDGSFIQ-NLSGHNAIINTLTVNS-DGVLVSGADNGTMHLWDWRTGYNFQRVhaavqpgSLDSESGIFACAFDQSESRL 477
           666443.5666666666666.6666666666666666.445566666666666666666555555443333322233333344466666666 PP
   S: 196  vsgsldgtvklwd 208
           +++  d+t+k++ 
   Q: 478  LTAEADKTIKVYR 490
           6666666666654 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.
 Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.
Protein Sequence
(Fasta)
MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN EYGPVLHMPT 60
SKENLKEKGP QNATDSYVHK QYPANQGQEV EYFVAGTHPY PPGPGVALTA DTKIQRMPSE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046037|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCAGAGCTTG CATCACATCC GCCGCCTGGG CGCCCAATTC CGGAAGGTGC TGCACAGCTG 60
TGGCGGCGGG TACTGCGTTA GTGATTAGAG TTTCTTCCCT GCCGGAGGTG GGATACACGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046037|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0001650--C:fibrillar center
GO:0031965--C:nuclear membrane
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0071011--C:precatalytic spliceosome
GO:0000974--C:Prp19 complex
GO:0000398--P:mRNA splicing, via spliceosome
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0034504--P:protein localization to nucleus
KEGG hsa:5356
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000084 Aegilops tauschii 47.18 1.00e-129 456.00
IUUC-Aml-001605 Ailuropoda melanoleuca 96.10 0.00e+00 1029.00
IUUC-Atr-002757 Amborella trichopoda 49.29 2.00e-129 456.00
IUUC-Apl-003198 Anas platyrhynchos 89.15 0.00e+00 959.00
IUUC-Aca-004683 Anolis carolinensis 88.37 0.00e+00 944.00
IUUC-Aly-005775 Arabidopsis lyrata 59.94 2.00e-125 442.00
IUUC-Ath-007460 Arabidopsis thaliana 53.07 4.00e-125 441.00
IUUC-Ago-007884 Ashbya gossypii 46.49 7.00e-108 384.00
IUUC-Acl-008153 Aspergillus clavatus 64.02 3.00e-128 452.00
IUUC-Afl-008384 Aspergillus flavus 64.63 3.00e-129 455.00
IUUC-Afu-009045 Aspergillus fumigatus 64.63 4.00e-129 454.00
IUUC-Ani-009229 Aspergillus nidulans 62.32 4.00e-129 454.00
IUUC-Ang-009812 Aspergillus niger 65.30 1.00e-123 435.00
IUUC-Aor-010059 Aspergillus oryzae 64.63 3.00e-129 455.00
IUUC-Ate-010351 Aspergillus terreus 62.79 2.00e-135 475.00
IUUC-Ame-011613 Astyanax mexicanus 58.56 1.00e-153 536.00
IUUC-Bgr-012042 Blumeria graminis 63.41 7.00e-135 473.00
IUUC-Bta-012406 Bos taurus 95.15 0.00e+00 1018.00
IUUC-Bci-013760 Botrytis cinerea 61.73 3.00e-134 471.00
IUUC-Bdi-014776 Brachypodium distachyon 51.05 6.00e-131 461.00
IUUC-Bol-016189 Brassica oleracea 53.17 3.00e-126 445.00
IUUC-Bra-018044 Brassica rapa 53.17 5.00e-126 444.00
IUUC-Cel-018651 Caenorhabditis elegans 53.37 2.00e-156 545.00
IUUC-Cja-019974 Callithrix jacchus 98.83 0.00e+00 1061.00
IUUC-Cfa-021085 Canis familiaris 95.73 0.00e+00 1030.00
IUUC-Cpo-021458 Cavia porcellus 95.92 0.00e+00 1030.00
IUUC-Cre-022880 Chlamydomonas reinhardtii 59.57 1.00e-123 436.00
IUUC-Csa-023883 Chlorocebus sabaeus 99.42 0.00e+00 1068.00
IUUC-Cho-024623 Choloepus hoffmanni 94.12 0.00e+00 994.00
IUUC-Cin-025190 Ciona intestinalis 60.31 0.00e+00 642.00
IUUC-Csv-026367 Ciona savignyi 60.08 0.00e+00 654.00
IUUC-Cgl-026499 Colletotrichum gloeosporioides 56.96 5.00e-140 491.00
IUUC-Cne-027069 Cryptococcus neoformans 63.44 8.00e-127 447.00
IUUC-Cme-027233 Cyanidioschyzon merolae 30.18 7.00e-35 141.00
IUUC-Dre-028260 Danio rerio 77.91 0.00e+00 833.00
IUUC-Dno-029112 Dasypus novemcinctus 96.30 0.00e+00 1041.00
IUUC-Dor-031118 Dipodomys ordii 94.63 0.00e+00 800.00
IUUC-Dse-031493 Dothistroma septosporum 46.48 5.00e-127 447.00
IUUC-Dme-032138 Drosophila melanogaster 76.62 5.00e-160 557.00
IUUC-Ete-032411 Echinops telfairi 83.17 0.00e+00 832.00
IUUC-Eca-033521 Equus caballus 95.15 0.00e+00 1026.00
IUUC-Eeu-035249 Erinaceus europaeus 80.98 0.00e+00 658.00
IUUC-Fca-036358 Felis catus 95.15 0.00e+00 1025.00
IUUC-Fal-036933 Ficedula albicollis 89.53 0.00e+00 958.00
IUUC-Fox-037713 Fusarium oxysporum 59.30 1.00e-138 486.00
IUUC-Fso-038380 Fusarium solani 63.45 2.00e-138 485.00
IUUC-Gmo-039133 Gadus morhua 78.21 0.00e+00 831.00
IUUC-Ggr-039915 Gaeumannomyces graminis 66.36 3.00e-132 465.00
IUUC-Gga-041176 Gallus gallus 88.18 0.00e+00 952.00
IUUC-Gac-042344 Gasterosteus aculeatus 76.36 0.00e+00 825.00
IUUC-Gma-043328 Glycine max 49.60 1.00e-132 466.00
IUUC-Ggo-044478 Gorilla gorilla 99.42 0.00e+00 1067.00
IUUC-Hvu-047349 Hordeum vulgare 50.31 6.00e-133 467.00
IUUC-Itr-048390 Ictidomys tridecemlineatus 96.89 0.00e+00 1043.00
IUUC-Kpa-049343 Komagataella pastoris 58.46 1.00e-118 419.00
IUUC-Lch-049830 Latimeria chalumnae 83.53 0.00e+00 896.00
IUUC-Lpe-051442 Leersia perrieri 48.87 3.00e-129 455.00
IUUC-Loc-051794 Lepisosteus oculatus 81.49 0.00e+00 848.00
IUUC-Lma-053137 Leptosphaeria maculans 44.10 8.00e-127 447.00
IUUC-Laf-053471 Loxodonta africana 95.32 0.00e+00 1020.00
IUUC-Mcc-055627 Macaca mulatta 99.22 0.00e+00 1065.00
IUUC-Meu-056148 Macropus eugenii 81.41 0.00e+00 868.00
IUUC-Mor-056960 Magnaporthe oryzae 66.26 2.00e-137 482.00
IUUC-Mtr-057816 Medicago truncatula 58.86 6.00e-127 447.00
IUUC-Mla-059031 Melampsora laricipopulina 65.41 3.00e-127 448.00
IUUC-Mga-059337 Meleagris gallopavo 88.52 0.00e+00 952.00
IUUC-Mvi-060217 Microbotryum violaceum 64.78 5.00e-130 457.00
IUUC-Mmr-061018 Microcebus murinus 96.89 0.00e+00 1040.00
IUUC-Mdo-062863 Monodelphis domestica 90.12 0.00e+00 942.00
IUUC-Mmu-063988 Mus musculus 96.11 0.00e+00 1030.00
IUUC-Mac-064459 Musa acuminata 48.69 2.00e-122 432.00
IUUC-Mpu-066559 Mustela putorius furo 95.92 0.00e+00 1032.00
IUUC-Mlu-067361 Myotis lucifugus 92.95 0.00e+00 983.00
IUUC-Nfi-068492 Neosartorya fischeri 64.94 3.00e-129 455.00
IUUC-Ncr-068808 Neurospora crassa 65.14 9.00e-137 480.00
IUUC-Nle-069875 Nomascus leucogenys 99.81 0.00e+00 1070.00
IUUC-Opr-070462 Ochotona princeps 98.12 5.00e-158 551.00
IUUC-Ont-071365 Oreochromis niloticus 76.55 0.00e+00 829.00
IUUC-Oan-072708 Ornithorhynchus anatinus 90.27 0.00e+00 970.00
IUUC-Ocu-074594 Oryctolagus cuniculus 96.12 0.00e+00 1033.00
IUUC-Oba-075570 Oryza barthii 59.66 3.00e-127 448.00
IUUC-Obr-076366 Oryza brachyantha 64.83 2.00e-92 331.00
IUUC-Ogl-077153 Oryza glaberrima 59.33 1.00e-126 446.00
IUUC-Ogu-078540 Oryza glumaepatula 59.33 2.00e-127 449.00
IUUC-Oin-079612 Oryza indica 58.52 2.00e-125 442.00
IUUC-Olo-081077 Oryza longistaminata 58.52 2.00e-125 442.00
IUUC-Ome-081236 Oryza meridionalis 58.24 2.00e-125 442.00
IUUC-Oni-082499 Oryza nivara 59.33 2.00e-127 449.00
IUUC-Opu-083499 Oryza punctata 58.52 3.00e-125 442.00
IUUC-Oru-084276 Oryza rufipogon 59.33 2.00e-127 449.00
IUUC-Osa-085849 Oryza sativa 59.33 2.00e-127 449.00
IUUC-Ola-086655 Oryzias latipes 75.44 0.00e+00 815.00
IUUC-Olu-087637 Ostreococcus lucimarinus 58.06 5.00e-120 424.00
IUUC-Oga-087934 Otolemur garnettii 96.71 0.00e+00 1035.00
IUUC-Oar-090185 Ovis aries 94.38 0.00e+00 1009.00
IUUC-Ptr-091198 Pan troglodytes 99.81 0.00e+00 1070.00
IUUC-Pan-092622 Papio anubis 99.42 0.00e+00 1068.00
IUUC-Psi-093320 Pelodiscus sinensis 88.78 0.00e+00 954.00
IUUC-Pma-094638 Petromyzon marinus 76.70 0.00e+00 834.00
IUUC-Pno-094826 Phaeosphaeria nodorum 46.15 4.00e-105 375.00
IUUC-Ppa-095576 Physcomitrella patens 63.99 3.00e-124 438.00
IUUC-Pfo-096894 Poecilia formosa 77.61 0.00e+00 840.00
IUUC-Pab-098020 Pongo abelii 99.61 0.00e+00 1070.00
IUUC-Pop-099180 Populus trichocarpa 48.62 8.00e-127 447.00
IUUC-Pca-100909 Procavia capensis 90.05 0.00e+00 815.00
IUUC-Ppe-101346 Prunus persica 46.85 4.00e-126 444.00
IUUC-Pva-102167 Pteropus vampyrus 77.67 0.00e+00 788.00
IUUC-Pgr-103516 Puccinia graminis 49.90 7.00e-130 457.00
IUUC-Ptt-103738 Puccinia triticina 50.00 1.00e-130 459.00
IUUC-Pte-104352 Pyrenophora teres 57.89 7.00e-131 460.00
IUUC-Pyt-104632 Pyrenophora triticirepentis 58.48 8.00e-132 463.00
IUUC-Rno-105291 Rattus norvegicus 96.30 0.00e+00 1038.00
IUUC-Sce-106204 Saccharomyces cerevisiae 50.15 9.00e-104 370.00
IUUC-Sha-106943 Sarcophilus harrisii 89.75 0.00e+00 933.00
IUUC-Sja-107659 Schizosaccharomyces japonicus 65.08 9.00e-130 456.00
IUUC-Spo-108049 Schizosaccharomyces pombe 62.54 5.00e-135 474.00
IUUC-Smo-109043 Selaginella moellendorffii 60.48 3.00e-125 441.00
IUUC-Sit-110431 Setaria italica 51.16 3.00e-131 462.00
IUUC-Sly-111391 Solanum lycopersicum 48.95 5.00e-120 424.00
IUUC-Stu-112364 Solanum tuberosum 55.26 5.00e-96 344.00
IUUC-Sar-113450 Sorex araneus 98.85 0.00e+00 725.00
IUUC-Sbi-113829 Sorghum bicolor 50.21 9.00e-131 460.00
IUUC-Sre-115153 Sporisorium reilianum 61.16 1.00e-121 429.00
IUUC-Ssc-115798 Sus scrofa 94.96 0.00e+00 1019.00
IUUC-Tgu-117417 Taeniopygia guttata 89.86 0.00e+00 959.00
IUUC-Tru-117615 Takifugu rubripes 75.24 0.00e+00 780.00
IUUC-Tsy-119480 Tarsius syrichta 97.46 0.00e+00 1040.00
IUUC-Tni-119847 Tetraodon nigroviridis 74.95 0.00e+00 809.00
IUUC-Tca-121287 Theobroma cacao 48.16 2.00e-128 452.00
IUUC-Tre-122010 Trichoderma reesei 64.91 1.00e-142 499.00
IUUC-Tvi-122475 Trichoderma virens 61.19 8.00e-142 496.00
IUUC-Tae-124397 Triticum aestivum 50.31 9.00e-135 473.00
IUUC-Tur-126116 Triticum urartu 42.35 4.00e-101 362.00
IUUC-Tme-126992 Tuber melanosporum 65.24 2.00e-136 479.00
IUUC-Tbe-127803 Tupaia belangeri 85.75 0.00e+00 744.00
IUUC-Ttr-128933 Tursiops truncatus 95.53 0.00e+00 1026.00
IUUC-Uma-129447 Ustilago maydis 59.69 1.00e-117 417.00
IUUC-Vda-129780 Verticillium dahliae 54.69 3.00e-138 485.00
IUUC-Vpa-130557 Vicugna pacos 87.83 1.00e-117 416.00
IUUC-Vvi-130918 Vitis vinifera 47.19 3.00e-121 428.00
IUUC-Xtr-132409 Xenopus tropicalis 84.91 0.00e+00 881.00
IUUC-Xma-133420 Xiphophorus maculatus 77.71 0.00e+00 844.00
IUUC-Yli-134362 Yarrowia lipolytica 51.83 2.00e-121 429.00
IUUC-Zma-135804 Zea mays 58.84 2.00e-125 442.00
Created Date 25-Jun-2017

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