iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088300

Ensembl Protein ID

ENSOGAP00000006634.2

UniProt Accession

H0WW90; H0WW90_OTOGA

Genbank Protein ID

ENSOGAP00000006634

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03179294

Gene Name

SHARPIN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000007415.2	ENSOGAT00000007419.2	ENSOGAP00000006634.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	1.00e-12	47.3	345	372
ULD/UDP/UBQ/UBQ_Other	2.00e-11	43.6	234	295

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 3    aqWaCsaCTflNePeavkCemCsrpRgc 30
           ++WaC++CTf+N P++++CemCs++R+c
   Q: 345  PGWACPSCTFINTPSRPGCEMCSTQRPC 372
           79*************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 11   s.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadygl.kdgstihll 70
           s + tl+v p++t+a L+e++++++g+pp+ qr+i+ G++L  + ++La+yg+ +dg++++l+
   Q: 234  SaHVTLQVYPHCTIAALQEQVFSEFGFPPAVQRWII-GQCLcVPERSLASYGVwQDGDHAFLY 295
           44778889****************************.**************654889988887 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

PPAGGAATVS VPGSTAVLLA VNAAVRPLGA GPEVEAQLRR LQLSADLEHP GRFRLELLGT 60
GPGTVSLEWP LESVSYTIRG PNQHELQPPP GGPGTFSLHF LNPQEAQRWA ALVRSATVEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCCCGCCG GCGGGGCGGC GACTGTGTCA GTCCCGGGCT CCACCGCAGT GCTCCTGGCT 60
GTGAACGCCG CGGTGAGGCC GCTGGGTGCC GGGCCAGAGG TCGAAGCGCA GCTACGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF16764--Sharpin_PH

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0071797--C:LUBAC complex
GO:0008270--F:zinc ion binding
GO:0030262--P:apoptotic nuclear changes
GO:0031424--P:keratinization
GO:0007005--P:mitochondrion organization
GO:0050728--P:negative regulation of inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0097039--P:protein linear polyubiquitination
GO:2000348--P:regulation of CD40 signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001223	Ailuropoda melanoleuca	76.32	1.00e-121	429.00
IUUC-Apl-004151	Anas platyrhynchos	59.68	3.00e-18	82.40
IUUC-Acl-008308	Aspergillus clavatus	39.53	5.60e-02	32.00
IUUC-Ang-009713	Aspergillus niger	35.00	3.00e-03	36.20
IUUC-Bta-012948	Bos taurus	76.30	8.00e-132	463.00
IUUC-Cja-019031	Callithrix jacchus	81.62	3.00e-131	461.00
IUUC-Cfa-020863	Canis familiaris	71.39	1.00e-107	382.00
IUUC-Cpo-022499	Cavia porcellus	73.85	4.00e-126	444.00
IUUC-Csa-023641	Chlorocebus sabaeus	80.33	1.00e-129	456.00
IUUC-Cne-026853	Cryptococcus neoformans	32.81	5.00e-03	36.20
IUUC-Dre-027612	Danio rerio	36.34	2.00e-46	179.00
IUUC-Dno-029459	Dasypus novemcinctus	55.39	1.00e-53	203.00
IUUC-Dor-030914	Dipodomys ordii	62.11	9.00e-82	296.00
IUUC-Ete-032940	Echinops telfairi	67.30	7.00e-96	343.00
IUUC-Eca-033537	Equus caballus	75.78	2.00e-125	442.00
IUUC-Eeu-035176	Erinaceus europaeus	59.82	8.00e-53	200.00
IUUC-Fca-035971	Felis catus	73.28	2.00e-117	415.00
IUUC-Gmo-039219	Gadus morhua	37.37	4.00e-50	192.00
IUUC-Gac-041562	Gasterosteus aculeatus	55.56	2.00e-33	136.00
IUUC-Ggo-044678	Gorilla gorilla	79.95	6.00e-131	460.00
IUUC-Hsa-046578	Homo sapiens	82.17	2.00e-137	481.00
IUUC-Itr-047913	Ictidomys tridecemlineatus	73.70	2.00e-131	461.00
IUUC-Mcc-055686	Macaca mulatta	73.44	1.00e-130	459.00
IUUC-Meu-055912	Macropus eugenii	51.41	2.00e-56	212.00
IUUC-Mmr-060584	Microcebus murinus	83.70	6.00e-149	520.00
IUUC-Mdo-062191	Monodelphis domestica	53.69	2.00e-78	285.00
IUUC-Mmu-063740	Mus musculus	70.72	2.00e-111	395.00
IUUC-Mpu-066878	Mustela putorius furo	69.81	5.00e-106	377.00
IUUC-Mlu-067878	Myotis lucifugus	76.55	4.00e-129	454.00
IUUC-Nle-069748	Nomascus leucogenys	80.83	3.00e-128	451.00
IUUC-Ont-072270	Oreochromis niloticus	40.22	7.00e-55	207.00
IUUC-Obr-076087	Oryza brachyantha	44.19	2.00e-04	39.30
IUUC-Oar-089549	Ovis aries	76.82	2.00e-134	471.00
IUUC-Ptr-090961	Pan troglodytes	82.94	6.00e-125	440.00
IUUC-Pan-092687	Papio anubis	80.82	3.00e-133	468.00
IUUC-Pno-095076	Phaeosphaeria nodorum	34.09	4.00e-03	34.70
IUUC-Pab-097872	Pongo abelii	81.21	3.00e-126	444.00
IUUC-Pca-100363	Procavia capensis	68.60	7.00e-65	241.00
IUUC-Pva-102595	Pteropus vampyrus	75.76	8.00e-109	387.00
IUUC-Rno-105856	Rattus norvegicus	71.95	6.00e-111	394.00
IUUC-Sha-106838	Sarcophilus harrisii	52.82	3.00e-68	252.00
IUUC-Sly-111366	Solanum lycopersicum	38.46	6.00e-05	41.20
IUUC-Sar-113611	Sorex araneus	70.51	1.00e-24	106.00
IUUC-Ssc-116263	Sus scrofa	73.91	3.00e-132	464.00
IUUC-Tru-118089	Takifugu rubripes	41.87	1.00e-58	220.00
IUUC-Tni-120004	Tetraodon nigroviridis	42.67	2.00e-52	199.00
IUUC-Tvi-122402	Trichoderma virens	30.77	6.00e-04	38.50
IUUC-Tbe-127471	Tupaia belangeri	69.76	2.00e-104	372.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence