iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-063058

UUCD1 version

UUC-MoD-01059

Ensembl Protein ID

ENSMODP00000015519.3

UniProt Accession

F6PN80; F6PN80_MONDO

Protein Name

Uncharacterized protein

Gene Name

UBA7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000012394.3	ENSMODT00000015805.3	ENSMODP00000015519.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	3.90e-182	606.1	414	866

Active Site

Position(s)	Description	Evidence
596	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G++ q+kl++++++lvGag++GcEllK+++++G+     g itv+Dmdtve+snl+rqFLfr +d  k KA++aa a+k++
   Q: 414  YDGQIAVFGADFQKKLGEQNYFLVGAGAIGCELLKTFAMVGLgagpgGGITVTDMDTVELSNLSRQFLFRSQDLNKHKAKAAALAVKDM 502
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd.dppqk 169
           np  +v+ah++++ +++e+++   Ff+ +d+V++ald +ear +v ++c++  +p++esgt G+ G++ ++++ lt  ys ++ d  ++
   Q: 503  NPALRVTAHTNELGPDTEHVYgedFFSSLDGVACALDTFEARQYVSERCIHSLKPMLESGTQGIQGEAAIFVPFLTQPYSMPPeDAIET 591
           ***********************************************************************************89999* PP
   S: 170  tiPfctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafaktti 250
            +P+ctl+ +p+++eht++wa        +l +++++ + +e + l++++  + ++ ++  + +     ++ + +++++a ++++ +++
   Q: 592  AYPICTLRYFPSTIEHTLQWAlnefeglfRLPAETINRYLQEPDFLKRMEGPQALNCLRTASTSFLH-PPQCWRDCVAWAQSHWQHCFH 679
           *****************************77777777777888889999999999988888666555.79******************* PP
   S: 251  nsikqllksfecdivtkskspfwv................................................sfcsnaealqvpekvek 291
            si+ ll+  ++d+v ++++pfw+                                                +  +  +++   ++ ++
   Q: 680  DSISHLLQVYPPDKVDEEGVPFWSgarrcpqpldfdlssdahldyilaaanlyakthrlagsqdrdglrgmlQASPALASVFAGDRQLE 768
           **********************************************9999999988887777777777765544444444444466666 PP
   S: 292  deevvkasaplylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgG 378
           +  +  ++a l++ll aler+  ++ +    + fekd+d   ++d+v aa+nlra+++gi+  +d+++ k+iag+iipaia+t+avv+G
   Q: 769  EASAERDPAHLQALLSALERWPGTSLE---PQLFEKDEDGhfHMDFVVAASNLRAKNYGIPL-ADRRKSKKIAGRIIPAIASTTAVVAG 853
           666667777799999999999766666...579999999999********************.************************** PP
   S: 379  laaqEviKvvsgk 391
           l  +E++K+v g+
   Q: 854  LMGLELYKAVMGH 866
           *********9884 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MKAIETSLEI NEQLYSRQLY VLGTEAMRRL RRSSMLVSGM KGLGVEIAKN LVLAGVGRLT 60
LHDPSPTCWM DLASQFFLAE EDIGQNRAKA SLPHLAQLNS SVCLDAHDGP LAEIELQAFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGGCCA TTGAGACCTC TTTGGAGATC AATGAACAAC TGTACTCCAG ACAGCTGTAA 60
GTCCCGGAGG ATGGGGAGCA GGGCTAGGAG CCACCTTTTC AGCCTCCTCT TCAGAAGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

KEGG

mdo:100028084

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	55.77	0.00e+00	1015.00
IUUC-Bta-012665	Bos taurus	54.64	0.00e+00	955.00
IUUC-Cja-019047	Callithrix jacchus	55.37	0.00e+00	990.00
IUUC-Cfa-021225	Canis familiaris	57.64	0.00e+00	1040.00
IUUC-Cpo-022336	Cavia porcellus	53.78	0.00e+00	978.00
IUUC-Csa-023462	Chlorocebus sabaeus	56.75	0.00e+00	984.00
IUUC-Dno-029347	Dasypus novemcinctus	57.64	0.00e+00	1063.00
IUUC-Dor-030997	Dipodomys ordii	54.32	0.00e+00	968.00
IUUC-Ete-033124	Echinops telfairi	56.72	0.00e+00	738.00
IUUC-Eca-033929	Equus caballus	56.55	0.00e+00	1082.00
IUUC-Eeu-034717	Erinaceus europaeus	56.57	0.00e+00	756.00
IUUC-Fca-036564	Felis catus	57.78	0.00e+00	1047.00
IUUC-Ggo-044480	Gorilla gorilla	56.25	0.00e+00	972.00
IUUC-Hsa-046498	Homo sapiens	56.65	0.00e+00	974.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	56.06	0.00e+00	991.00
IUUC-Laf-054119	Loxodonta africana	56.51	0.00e+00	1068.00
IUUC-Mcc-055597	Macaca mulatta	55.06	0.00e+00	928.00
IUUC-Meu-056534	Macropus eugenii	61.59	0.00e+00	1149.00
IUUC-Mmu-063578	Mus musculus	53.69	0.00e+00	1016.00
IUUC-Mpu-066255	Mustela putorius furo	57.13	0.00e+00	1038.00
IUUC-Mlu-067814	Myotis lucifugus	54.64	0.00e+00	908.00
IUUC-Nle-069193	Nomascus leucogenys	55.67	0.00e+00	965.00
IUUC-Opr-070715	Ochotona princeps	51.83	0.00e+00	927.00
IUUC-Oan-073306	Ornithorhynchus anatinus	54.60	0.00e+00	790.00
IUUC-Ocu-074162	Oryctolagus cuniculus	55.92	0.00e+00	997.00
IUUC-Oga-088895	Otolemur garnettii	54.65	0.00e+00	962.00
IUUC-Oar-089579	Ovis aries	55.26	0.00e+00	976.00
IUUC-Ptr-090581	Pan troglodytes	56.53	0.00e+00	947.00
IUUC-Pan-092458	Papio anubis	56.45	0.00e+00	975.00
IUUC-Pma-094214	Petromyzon marinus	53.66	1.00e-43	169.00
IUUC-Pab-098653	Pongo abelii	54.00	0.00e+00	940.00
IUUC-Rno-106066	Rattus norvegicus	54.70	0.00e+00	1040.00
IUUC-Sha-107368	Sarcophilus harrisii	75.00	0.00e+00	1492.00
IUUC-Ssc-115743	Sus scrofa	57.54	0.00e+00	1035.00
IUUC-Tbe-127587	Tupaia belangeri	57.80	0.00e+00	778.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence