iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098653

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01324714

Gene Name

UBA7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000013860.1	ENSPPYT00000016123.1	ENSPPYP00000015508.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.20e-217	723.0	415	890

Active Site

Position(s)	Description	Evidence
599	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G+  qekl+++++llvGag++GcEllK ++l+G+     g +tvvDmd++e snl+rq Lfr +dvg++KAevaa+a++ l
   Q: 415  YDGQIAVFGAGFQEKLSRQHYLLVGAGAIGCELLKVFALVGLgagnsGGLTVVDMDHIERSNLSRQLLFRSQDVGRPKAEVAAAAARGL 503
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dpp 167
           npd +v + ++++++++e+i+   Ff+++d+V++ald+++ar +v+ +c+++ +pl+e+gt G++G  +v+++++te+y+++     ++
   Q: 504  NPDLQVIPLTYPLDPTTEHIYgenFFSRVDGVAAALDSFQARHYVAARCTHYLKPLLEAGTSGTWGSCSVFMPHVTEAYRAPVsaaASE 592
           ***********************************************************************************9999** PP
   S: 168  qktiPfctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakt 248
           +  +P+ct++ +p++aeht++wa        +  ++++++++++++ l+++d+ ++++ +++v   l+  +++n+++++++a+ +++ +
   Q: 593  DAPYPICTVRYFPSTAEHTLQWArhefeglfRRSAETINHHQQAHTSLADMDEPQTLTLLKPVLGVLRV-RPQNWQDCVAWALGHWKLC 680
           ****************************9998899****************************888777.6****************** PP
   S: 249  tinsikqllksfecdivtkskspfwv................................................sfcsnaealqvpekv 289
           ++++ikqll++f++++v ++++pfw+                                                ++ ++ + +q+ +  
   Q: 681  FHYGIKQLLRHFPPNKVLEDGTPFWSgpkqcpqplefdtnqdthllyvlaaanlyaqmhglpgsqdwtalrellKLLPQPDPQQMAPIF 769
           ***************************************************************************************** PP
   S: 290  ekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiat 371
           +++ e  +asa+     ++ l +ale ++  + +kp  l+fekddds  ++d+v aaa+lr++++gi+p +++ + k+i+g+iipaiat
   Q: 770  ASNLELASASAEfgpeqQKELNKALEVWSVGPPLKP--LMFEKDDDSnfHMDFVSAAASLRCQNYGIPP-VNRAQSKRIVGQIIPAIAT 855
           ***********9***********************9..*******************************.******************* PP
   S: 372  tnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           t+a+v+Gl+ +E++Kvv g  + +++++ +l++ae
   Q: 856  TTAAVAGLLGLELYKVVGGprPRSAFRHSYLHLAE 890
           *******************7777789988888765 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MDALDASKLL DEELYSRQLY VLGSPAMQRI QGARVLVSGL QGLGAEVAKN LVLMGVGSLT 60
LHDPHPTCWS DLAAQFLLSE QHLERSRAEA SQEFLAQLNR AVQVIVHTGD ITEDLLLDFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATGCCC TGGATGCTTC GAAGCTGCTG GATGAGGAGC TGTATTCAAG ACAGCTGTGA 60
GGCCCGAGGT GGGGGGTGAA GAGTGGGATG GTCTTCAGAC CTTGATCTAT AACTGCTTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	74.33	0.00e+00	1377.00
IUUC-Bta-012665	Bos taurus	72.47	0.00e+00	1258.00
IUUC-Cja-019047	Callithrix jacchus	84.29	0.00e+00	1589.00
IUUC-Cfa-021225	Canis familiaris	75.89	0.00e+00	1439.00
IUUC-Cpo-022336	Cavia porcellus	67.19	0.00e+00	1241.00
IUUC-Csa-023462	Chlorocebus sabaeus	95.93	0.00e+00	1606.00
IUUC-Cho-024436	Choloepus hoffmanni	75.95	7.00e-98	351.00
IUUC-Dno-029347	Dasypus novemcinctus	74.41	0.00e+00	1362.00
IUUC-Dor-030997	Dipodomys ordii	70.36	0.00e+00	1267.00
IUUC-Ete-033124	Echinops telfairi	74.26	0.00e+00	958.00
IUUC-Eca-033929	Equus caballus	76.68	0.00e+00	1473.00
IUUC-Eeu-034717	Erinaceus europaeus	63.92	0.00e+00	882.00
IUUC-Fca-036564	Felis catus	76.73	0.00e+00	1414.00
IUUC-Ggo-044480	Gorilla gorilla	91.32	0.00e+00	1655.00
IUUC-Hsa-046498	Homo sapiens	91.30	0.00e+00	1633.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	73.49	0.00e+00	1348.00
IUUC-Laf-054119	Loxodonta africana	73.81	0.00e+00	1404.00
IUUC-Mcc-055597	Macaca mulatta	87.67	0.00e+00	1573.00
IUUC-Meu-056534	Macropus eugenii	54.24	0.00e+00	843.00
IUUC-Mdo-063058	Monodelphis domestica	54.20	0.00e+00	965.00
IUUC-Mmu-063578	Mus musculus	68.76	0.00e+00	1308.00
IUUC-Mpu-066255	Mustela putorius furo	75.25	0.00e+00	1423.00
IUUC-Mlu-067814	Myotis lucifugus	71.35	0.00e+00	1251.00
IUUC-Nle-069193	Nomascus leucogenys	90.41	0.00e+00	1644.00
IUUC-Opr-070715	Ochotona princeps	72.83	0.00e+00	1243.00
IUUC-Oan-073306	Ornithorhynchus anatinus	54.38	0.00e+00	747.00
IUUC-Ocu-074162	Oryctolagus cuniculus	73.35	0.00e+00	1344.00
IUUC-Oga-088895	Otolemur garnettii	76.07	0.00e+00	1387.00
IUUC-Oar-089579	Ovis aries	76.46	0.00e+00	1250.00
IUUC-Ptr-090581	Pan troglodytes	91.14	0.00e+00	1593.00
IUUC-Pan-092458	Papio anubis	96.15	0.00e+00	1605.00
IUUC-Pca-100578	Procavia capensis	75.89	0.00e+00	769.00
IUUC-Pva-102914	Pteropus vampyrus	79.90	0.00e+00	1129.00
IUUC-Rno-106066	Rattus norvegicus	68.23	0.00e+00	1297.00
IUUC-Sha-107368	Sarcophilus harrisii	56.02	0.00e+00	1018.00
IUUC-Ssc-115743	Sus scrofa	76.09	0.00e+00	1410.00
IUUC-Tbe-127587	Tupaia belangeri	73.92	0.00e+00	1248.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence