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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Spo-108068
Ensembl Protein ID SPAC589.07c.1:pep
UniProt Accession Q9HDZ7; ATG18_SCHPO
Genbank Protein ID CAC19764.1
Protein Name Autophagy-related protein 18
Genbank Nucleotide ID CU329670
Gene Name atg1801; atg18; atg18a; SPAC589.07c
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPAC589.07c SPAC589.07c.1 SPAC589.07c.1:pep
Annotation
mRNA Expression
GEO
Protein-protein Interaction
Mentha
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.00e-10 39.6 187 218
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgt.ikvWDl 30
           H+ds  claf sd t+l+++sd+g  i+v+ +
   Q: 187  HKDSLACLAFnSDgTMLATASDNGRiIRVFAI 218
           9**********999***********8888765 PP
   
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the preautophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity). Required for the recruitment of the atg5-atg12/atg16 complex to the preautophagosomal structure.
 The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the preautophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity). Required for the recruitment of the atg5-atg12/atg16 complex to the preautophagosomal structure.
Protein Sequence
(Fasta)
MHFFVRKYRG KAALLSIGTF DGYKIYNCDP FGKCFHKIQG ATSIVEMLFS TSLVALVEKD 60
DGNNRKLKLI NTKKSTTICE LTFPTPLLAV KLNRKRLLAV LEEQIYVYDI SNMLLLHTIE 120
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Protein Fasta Sequence


>IUUC-Spo-108068|E3,WD_repeat|Schizosaccharomyces pombe
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGCATTTCT TTGTTCGGAA GTACCGCGGC AAAGCAGCGT ATGTAAGTGT ATAGCCGCGG 60
GTCATTCCAC TTGTCTCAAG CCAGTCATTA GAACAATATA CGTATCGGCC AATTGTGCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Spo-108068|E3,WD_repeat|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0967--Endosome
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0926--Vacuole
KW-0853--WD repeat
Interpro

IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0010008--C:endosome membrane
GO:0000329--C:fungal-type vacuole membrane
GO:0005794--C:Golgi apparatus
GO:0000407--C:pre-autophagosomal structure
GO:0034045--C:pre-autophagosomal structure membrane
GO:0043234--C:protein complex
GO:0035091--F:phosphatidylinositol binding
GO:0006914--P:autophagy
GO:0016236--P:macroautophagy
GO:0006623--P:protein targeting to vacuole
KEGG spo:SPAC589.07c
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001842 Ailuropoda melanoleuca 37.40 8.00e-54 202.00
IUUC-Apl-003390 Anas platyrhynchos 37.50 9.00e-56 208.00
IUUC-Aca-004975 Anolis carolinensis 37.95 2.00e-55 207.00
IUUC-Aly-006332 Arabidopsis lyrata 34.99 1.00e-45 175.00
IUUC-Ago-007948 Ashbya gossypii 40.26 3.00e-60 224.00
IUUC-Acl-008148 Aspergillus clavatus 40.39 1.00e-73 268.00
IUUC-Afl-008562 Aspergillus flavus 41.87 9.00e-75 271.00
IUUC-Afu-008936 Aspergillus fumigatus 40.80 5.00e-73 266.00
IUUC-Ani-009254 Aspergillus nidulans 41.87 9.00e-79 285.00
IUUC-Ang-009798 Aspergillus niger 41.18 2.00e-74 270.00
IUUC-Aor-010066 Aspergillus oryzae 41.87 9.00e-75 271.00
IUUC-Ate-010266 Aspergillus terreus 42.61 1.00e-80 291.00
IUUC-Ame-010727 Astyanax mexicanus 38.61 2.00e-55 207.00
IUUC-Bta-012655 Bos taurus 37.50 1.00e-55 208.00
IUUC-Bci-013627 Botrytis cinerea 38.82 3.00e-73 266.00
IUUC-Cel-018503 Caenorhabditis elegans 32.13 2.00e-45 174.00
IUUC-Cja-018829 Callithrix jacchus 37.06 9.00e-51 192.00
IUUC-Cfa-020858 Canis familiaris 36.67 2.00e-53 201.00
IUUC-Cpo-022235 Cavia porcellus 37.50 6.00e-53 199.00
IUUC-Cre-022613 Chlamydomonas reinhardtii 32.92 2.00e-40 158.00
IUUC-Csa-023963 Chlorocebus sabaeus 37.22 2.00e-52 197.00
IUUC-Cho-024328 Choloepus hoffmanni 38.04 1.00e-52 198.00
IUUC-Cin-025343 Ciona intestinalis 38.46 1.00e-47 182.00
IUUC-Csv-025920 Ciona savignyi 36.11 1.00e-52 197.00
IUUC-Cgl-026425 Colletotrichum gloeosporioides 50.33 2.00e-36 144.00
IUUC-Cne-026947 Cryptococcus neoformans 44.85 5.00e-78 282.00
IUUC-Dre-027490 Danio rerio 38.06 2.00e-54 204.00
IUUC-Dno-030057 Dasypus novemcinctus 37.40 2.00e-54 204.00
IUUC-Dor-030472 Dipodomys ordii 39.14 4.00e-51 193.00
IUUC-Dse-031215 Dothistroma septosporum 44.27 2.00e-61 227.00
IUUC-Ete-032362 Echinops telfairi 37.38 2.00e-48 184.00
IUUC-Eca-034362 Equus caballus 37.67 2.00e-55 207.00
IUUC-Eeu-034479 Erinaceus europaeus 31.58 1.00e-22 97.80
IUUC-Fca-036230 Felis catus 37.33 4.00e-55 206.00
IUUC-Fal-036782 Ficedula albicollis 37.50 2.00e-55 207.00
IUUC-Fox-037797 Fusarium oxysporum 51.39 1.00e-66 245.00
IUUC-Fso-038174 Fusarium solani 51.39 3.00e-66 243.00
IUUC-Gmo-039706 Gadus morhua 34.92 2.00e-48 184.00
IUUC-Ggr-040113 Gaeumannomyces graminis 53.78 6.00e-71 259.00
IUUC-Gga-040690 Gallus gallus 36.46 6.00e-56 209.00
IUUC-Gac-041360 Gasterosteus aculeatus 37.78 3.00e-54 204.00
IUUC-Gma-043876 Glycine max 33.86 2.00e-47 181.00
IUUC-Hsa-046782 Homo sapiens 37.50 7.00e-53 199.00
IUUC-Itr-048693 Ictidomys tridecemlineatus 37.40 6.00e-53 199.00
IUUC-Kpa-049378 Komagataella pastoris 46.18 3.00e-63 233.00
IUUC-Lch-050413 Latimeria chalumnae 38.84 7.00e-54 202.00
IUUC-Lma-052948 Leptosphaeria maculans 40.79 4.00e-78 283.00
IUUC-Laf-054007 Loxodonta africana 37.22 1.00e-54 205.00
IUUC-Mor-057125 Magnaporthe oryzae 52.99 7.00e-69 252.00
IUUC-Mga-059795 Meleagris gallopavo 37.50 1.00e-55 208.00
IUUC-Mvi-060219 Microbotryum violaceum 42.16 1.00e-75 274.00
IUUC-Mmr-061096 Microcebus murinus 37.78 4.00e-56 210.00
IUUC-Mdo-062881 Monodelphis domestica 36.94 5.00e-55 206.00
IUUC-Mmu-063787 Mus musculus 37.78 2.00e-56 211.00
IUUC-Mpu-066019 Mustela putorius furo 36.94 2.00e-50 191.00
IUUC-Mlu-068016 Myotis lucifugus 37.50 5.00e-55 206.00
IUUC-Nfi-068424 Neosartorya fischeri 41.23 3.00e-74 270.00
IUUC-Ncr-068833 Neurospora crassa 39.85 2.00e-73 267.00
IUUC-Opr-070933 Ochotona princeps 36.50 1.00e-37 148.00
IUUC-Ont-072495 Oreochromis niloticus 38.61 2.00e-55 207.00
IUUC-Oan-073084 Ornithorhynchus anatinus 38.96 3.00e-54 203.00
IUUC-Ocu-074689 Oryctolagus cuniculus 37.50 7.00e-53 199.00
IUUC-Oba-075601 Oryza barthii 30.35 9.00e-37 145.00
IUUC-Ogu-078089 Oryza glumaepatula 30.08 1.00e-36 145.00
IUUC-Oin-079071 Oryza indica 30.08 3.00e-36 143.00
IUUC-Oni-083063 Oryza nivara 30.08 1.00e-36 144.00
IUUC-Oru-084845 Oryza rufipogon 30.08 1.00e-35 142.00
IUUC-Osa-086113 Oryza sativa 30.08 1.00e-36 144.00
IUUC-Oga-088894 Otolemur garnettii 37.50 7.00e-53 199.00
IUUC-Oar-089850 Ovis aries 37.22 2.00e-55 207.00
IUUC-Ptr-090456 Pan troglodytes 37.50 6.00e-53 199.00
IUUC-Pan-092111 Papio anubis 37.50 7.00e-53 199.00
IUUC-Psi-094095 Pelodiscus sinensis 37.50 6.00e-56 209.00
IUUC-Pno-095015 Phaeosphaeria nodorum 40.24 5.00e-71 259.00
IUUC-Pfo-096987 Poecilia formosa 37.50 7.00e-55 206.00
IUUC-Pab-097754 Pongo abelii 37.50 7.00e-53 199.00
IUUC-Pva-103047 Pteropus vampyrus 36.94 3.00e-55 207.00
IUUC-Pte-104139 Pyrenophora teres 39.60 7.00e-71 259.00
IUUC-Pyt-104488 Pyrenophora triticirepentis 39.36 1.00e-70 258.00
IUUC-Rno-105990 Rattus norvegicus 37.78 1.00e-56 211.00
IUUC-Sce-106327 Saccharomyces cerevisiae 42.16 7.00e-62 229.00
IUUC-Sha-106581 Sarcophilus harrisii 37.67 2.00e-55 207.00
IUUC-Sja-107913 Schizosaccharomyces japonicus 60.55 3.00e-117 412.00
IUUC-Ssl-108418 Sclerotinia sclerotiorum 39.56 3.00e-80 290.00
IUUC-Sar-113276 Sorex araneus 36.21 1.00e-22 97.80
IUUC-Sre-115219 Sporisorium reilianum 49.25 1.00e-65 241.00
IUUC-Ssc-116360 Sus scrofa 37.22 3.00e-55 207.00
IUUC-Tgu-116951 Taeniopygia guttata 37.50 1.00e-55 208.00
IUUC-Tru-117889 Takifugu rubripes 37.23 2.00e-54 204.00
IUUC-Tre-121895 Trichoderma reesei 51.57 8.00e-73 265.00
IUUC-Tvi-122311 Trichoderma virens 51.97 3.00e-73 266.00
IUUC-Uma-129438 Ustilago maydis 51.37 2.00e-59 221.00
IUUC-Vda-129782 Verticillium dahliae 54.14 3.00e-48 183.00
IUUC-Xma-133370 Xiphophorus maculatus 37.50 7.00e-55 206.00
IUUC-Yli-134337 Yarrowia lipolytica 45.58 2.00e-79 287.00
Created Date 25-Jun-2017

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