iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bra-017336

Ensembl Protein ID

Bra014421.1-P

UniProt Accession

M4DD53; M4DD53_BRARP

Protein Name

E3 ubiquitin-protein ligase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bra014421	Bra014421.1	Bra014421.1-P

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	36.29	1.00e-39	161.00	IUUC-Mmu-064129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Brassica rapa

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MDLDSMDCTS TIDVTDDDEE IHQDRHSYAS VSKHHSNNST NANAASGLLP TTTSVHELLE 60
CPVCTNSMYP PIHQCQNGHT LCSTCKNRVH NRCPTCRQEL GDIRCLALEK VAESLELPCK 120

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Nucleotide Sequence
(Fasta)

ATGGATTTGG ATAGCATGGA CTGCACTTCA ACCATCGATG TCACCGACGA CGACGAAGAG 60
ATCCATCAAG ATCGCCATTC CTACGCATCG GTTTCAAAGC ATCATAGTAA TAACAGCACC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	69.38	1.00e-125	442.00
IUUC-Aml-001186	Ailuropoda melanoleuca	33.68	1.00e-41	163.00
IUUC-Atr-003118	Amborella trichopoda	79.78	9.00e-134	469.00
IUUC-Ath-007092	Arabidopsis thaliana	92.41	7.00e-172	595.00
IUUC-Ame-011196	Astyanax mexicanus	34.38	1.00e-42	166.00
IUUC-Cfa-020642	Canis familiaris	35.96	8.00e-42	163.00
IUUC-Cho-024933	Choloepus hoffmanni	34.82	7.00e-38	150.00
IUUC-Cin-025674	Ciona intestinalis	35.37	1.00e-40	159.00
IUUC-Csv-026233	Ciona savignyi	35.34	7.00e-41	160.00
IUUC-Dre-028041	Danio rerio	34.38	1.00e-42	166.00
IUUC-Ete-032423	Echinops telfairi	35.46	4.00e-41	161.00
IUUC-Eeu-035314	Erinaceus europaeus	36.76	4.00e-41	161.00
IUUC-Fca-035362	Felis catus	33.68	1.00e-41	163.00
IUUC-Gmo-039091	Gadus morhua	35.63	6.00e-37	147.00
IUUC-Gma-042926	Glycine max	80.22	2.00e-134	471.00
IUUC-Hvu-047574	Hordeum vulgare	69.06	5.00e-126	443.00
IUUC-Lpe-050879	Leersia perrieri	79.13	1.00e-124	438.00
IUUC-Loc-052191	Lepisosteus oculatus	34.38	2.00e-42	166.00
IUUC-Meu-055922	Macropus eugenii	34.41	7.00e-37	147.00
IUUC-Mdo-061971	Monodelphis domestica	35.22	3.00e-38	152.00
IUUC-Mmu-064129	Mus musculus	35.96	9.00e-42	163.00
IUUC-Ocu-074876	Oryctolagus cuniculus	34.72	2.00e-41	162.00
IUUC-Ome-081318	Oryza meridionalis	79.92	1.00e-124	438.00
IUUC-Opu-084065	Oryza punctata	79.53	2.00e-124	437.00
IUUC-Oga-088114	Otolemur garnettii	37.07	4.00e-44	171.00
IUUC-Ptr-090692	Pan troglodytes	34.72	2.00e-41	162.00
IUUC-Psi-093687	Pelodiscus sinensis	33.68	7.00e-42	163.00
IUUC-Pma-094387	Petromyzon marinus	35.06	1.00e-42	166.00
IUUC-Ppa-095212	Physcomitrella patens	85.27	5.00e-137	479.00
IUUC-Pca-100328	Procavia capensis	34.68	2.00e-35	142.00
IUUC-Rno-104866	Rattus norvegicus	35.96	9.00e-42	163.00
IUUC-Smo-109412	Selaginella moellendorffii	85.60	2.00e-137	481.00
IUUC-Sly-111259	Solanum lycopersicum	79.06	4.00e-148	516.00
IUUC-Ssc-116441	Sus scrofa	34.82	7.00e-38	150.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence