iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062805

UUCD1 version

UUC-MoD-00933

Ensembl Protein ID

ENSMODP00000032216.2

UniProt Accession

F7FYB4; F7FYB4_MONDO

Protein Name

Uncharacterized protein

Gene Name

SMURF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000003804.3	ENSMODT00000033793.2	ENSMODP00000032216.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.50e-130	433.2	414	746

Active Site

Position(s)	Description	Evidence
715	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 414  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 501
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e vdp+l++sl +i+en   di+   ld tf+v+++ +ge+ ++eLkp+G++i+Vt++Nk+eYv+l+v+
   Q: 502  GFTLPFYKQLLGKSINLDDMELVDPDLHNSLVWILEN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSISVTEDNKKEYVRLYVN 586
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll+ F+e+elel+icG  +idv+d+k +t+ k+ +t+ds+ ++wFw+++e f++e r+++LqFv
   Q: 587  WRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRARLLQFV 674
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ das+++lP+++TCfn++++P+Y+s+e+l+ekLl+Aieet gF +
   Q: 675  TGSSRVPLQGFKALQgaagPRLFTIHQiDASTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAV 746
           **********************************************************************76 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MSNPGGRRNG PVKLRLTVLC AKNLVKKDFF RLPDPFAKVV VDGSGQCHST DTVKNTLDPK 60
WNQHYDLYIG KSDSVTISVW NHKKIHKKQG AGFLGCVRLL SNAINRLKDT GYQRLDLCKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTAACC CCGGGGGCCG GAGGAACGGG CCAGTCAAGC TGCGCCTGAC AGGTGAGGGG 60
AGGGCCTCGG GTTGGCGGGG TGCCCCGGGG CTTGTAGGGC TGGGCCGAAG GGGCCGCGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:1901165--P:positive regulation of trophoblast cell migration
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

KEGG

mdo:100029596

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	97.01	0.00e+00	1463.00
IUUC-Apl-003513	Anas platyrhynchos	96.85	0.00e+00	1463.00
IUUC-Aca-005358	Anolis carolinensis	96.42	0.00e+00	1486.00
IUUC-Ame-011320	Astyanax mexicanus	86.95	0.00e+00	1376.00
IUUC-Bta-013399	Bos taurus	97.40	0.00e+00	1464.00
IUUC-Cja-019355	Callithrix jacchus	96.37	0.00e+00	1462.00
IUUC-Cpo-022200	Cavia porcellus	97.41	0.00e+00	1465.00
IUUC-Cho-024804	Choloepus hoffmanni	98.06	0.00e+00	636.00
IUUC-Cin-025126	Ciona intestinalis	65.75	0.00e+00	971.00
IUUC-Csv-026339	Ciona savignyi	65.13	0.00e+00	1008.00
IUUC-Dre-027650	Danio rerio	90.07	0.00e+00	1420.00
IUUC-Dno-029534	Dasypus novemcinctus	97.19	0.00e+00	1492.00
IUUC-Ete-032715	Echinops telfairi	91.64	0.00e+00	1370.00
IUUC-Eca-033580	Equus caballus	97.41	0.00e+00	1464.00
IUUC-Eeu-034945	Erinaceus europaeus	95.41	0.00e+00	1357.00
IUUC-Fal-037275	Ficedula albicollis	95.55	0.00e+00	1447.00
IUUC-Gga-041060	Gallus gallus	93.09	0.00e+00	1413.00
IUUC-Gac-041295	Gasterosteus aculeatus	90.86	0.00e+00	1386.00
IUUC-Hsa-046726	Homo sapiens	97.46	0.00e+00	1493.00
IUUC-Lch-050026	Latimeria chalumnae	94.30	0.00e+00	1451.00
IUUC-Loc-051760	Lepisosteus oculatus	88.13	0.00e+00	1367.00
IUUC-Laf-053753	Loxodonta africana	97.27	0.00e+00	1462.00
IUUC-Mcc-054815	Macaca mulatta	97.46	0.00e+00	1493.00
IUUC-Meu-056436	Macropus eugenii	77.60	0.00e+00	1129.00
IUUC-Mpo-057442	Magnaporthe poae	38.10	3.00e-145	509.00
IUUC-Mmr-060806	Microcebus murinus	97.14	0.00e+00	1462.00
IUUC-Mmu-064034	Mus musculus	97.73	0.00e+00	1498.00
IUUC-Mpu-066762	Mustela putorius furo	97.01	0.00e+00	1462.00
IUUC-Mlu-066981	Myotis lucifugus	97.27	0.00e+00	1460.00
IUUC-Nle-069804	Nomascus leucogenys	97.45	0.00e+00	1488.00
IUUC-Opr-070591	Ochotona princeps	91.51	0.00e+00	1368.00
IUUC-Ont-072243	Oreochromis niloticus	88.66	0.00e+00	1405.00
IUUC-Oan-072699	Ornithorhynchus anatinus	94.03	0.00e+00	1481.00
IUUC-Ocu-074913	Oryctolagus cuniculus	97.46	0.00e+00	1496.00
IUUC-Ola-086597	Oryzias latipes	84.71	0.00e+00	1271.00
IUUC-Oga-089116	Otolemur garnettii	93.85	0.00e+00	1400.00
IUUC-Oar-089366	Ovis aries	97.13	0.00e+00	1465.00
IUUC-Ptr-091382	Pan troglodytes	97.46	0.00e+00	1493.00
IUUC-Psi-093298	Pelodiscus sinensis	96.46	0.00e+00	1444.00
IUUC-Pma-094354	Petromyzon marinus	73.08	0.00e+00	1119.00
IUUC-Pfo-096071	Poecilia formosa	88.98	0.00e+00	1406.00
IUUC-Pab-098682	Pongo abelii	97.46	0.00e+00	1493.00
IUUC-Pca-100516	Procavia capensis	88.66	0.00e+00	627.00
IUUC-Pva-102754	Pteropus vampyrus	95.48	0.00e+00	1427.00
IUUC-Rno-105600	Rattus norvegicus	97.01	0.00e+00	1262.00
IUUC-Sha-107144	Sarcophilus harrisii	99.12	0.00e+00	1377.00
IUUC-Spo-108171	Schizosaccharomyces pombe	40.29	5.00e-164	571.00
IUUC-Sar-113122	Sorex araneus	86.03	0.00e+00	1245.00
IUUC-Tgu-117112	Taeniopygia guttata	95.75	0.00e+00	1476.00
IUUC-Tru-118497	Takifugu rubripes	89.12	0.00e+00	1368.00
IUUC-Tni-120781	Tetraodon nigroviridis	89.46	0.00e+00	1178.00
IUUC-Tme-126897	Tuber melanosporum	39.47	1.00e-153	536.00
IUUC-Tbe-127371	Tupaia belangeri	86.52	0.00e+00	1192.00
IUUC-Ttr-129305	Tursiops truncatus	90.52	0.00e+00	1262.00
IUUC-Vpa-130591	Vicugna pacos	86.44	0.00e+00	1269.00
IUUC-Xtr-132979	Xenopus tropicalis	75.86	0.00e+00	1095.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence