iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gga-041139

Ensembl Protein ID

ENSGALP00000012993.2

UniProt Accession

A3R0S3; A3R0S3_CHICK

Genbank Protein ID

ABM91436.1

Protein Name

Growth factor receptor-bound protein 2

Genbank Nucleotide ID

AADN04000355

Gene Name

GRB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000008016.4	ENSGALT00000013008.4	ENSGALP00000012993.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.40e-36	124.6	157	214

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +  +vq+l+d+++q+++eL +++Gd+++v+  ++ d +W+kg    +g+ G+fP n+v+ ++
   Q: 157  QPTYVQALFDFDPQEEGELGFRRGDFIQVL--DNSDPNWWKG--ACHGQTGMFPRNYVTPVN 214
           5689**************************..9*********..8**************997 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW 60
FFGKIPRAKA EEMLGKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGACGGGGT TGGAGCTCAG GTGGCAACTG AGGCGGCGCT GGAGGGACGA GCAGGCGACG 60
AGAAGCCTCG GGCGGGGCGG CGGCCCCCAG CGTTGCGCGG TGAGTCCGGG GCGGGGGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0675--Receptor
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0008180--C:COP9 signalosome
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0070436--C:Grb2-EGFR complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0012506--C:vesicle membrane
GO:0003723--F:RNA binding
GO:0048646--P:anatomical structure formation involved in morphogenesis
GO:0030154--P:cell differentiation
GO:0071479--P:cellular response to ionizing radiation
GO:0008286--P:insulin receptor signaling pathway
GO:0030838--P:positive regulation of actin filament polymerization
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0009967--P:positive regulation of signal transduction
GO:0031623--P:receptor internalization
GO:0043408--P:regulation of MAPK cascade
GO:0042770--P:signal transduction in response to DNA damage

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001345	Ailuropoda melanoleuca	96.88	4.00e-112	396.00
IUUC-Apl-003322	Anas platyrhynchos	100.00	6.00e-114	402.00
IUUC-Aca-005193	Anolis carolinensis	99.54	3.00e-129	453.00
IUUC-Ago-007965	Ashbya gossypii	50.00	5.00e-13	67.80
IUUC-Ame-010929	Astyanax mexicanus	92.63	9.00e-122	428.00
IUUC-Bta-012932	Bos taurus	97.70	3.00e-127	447.00
IUUC-Cel-018665	Caenorhabditis elegans	58.06	7.00e-72	263.00
IUUC-Cja-019225	Callithrix jacchus	97.70	3.00e-127	447.00
IUUC-Cfa-020887	Canis familiaris	97.70	3.00e-127	447.00
IUUC-Cpo-022488	Cavia porcellus	97.70	3.00e-127	447.00
IUUC-Csa-023326	Chlorocebus sabaeus	97.70	3.00e-127	447.00
IUUC-Cho-024953	Choloepus hoffmanni	79.72	9.00e-96	342.00
IUUC-Cin-025144	Ciona intestinalis	63.21	6.00e-74	269.00
IUUC-Csv-026210	Ciona savignyi	60.66	1.00e-71	262.00
IUUC-Dre-028403	Danio rerio	95.39	1.00e-124	438.00
IUUC-Dno-029187	Dasypus novemcinctus	96.31	4.00e-126	443.00
IUUC-Dor-030763	Dipodomys ordii	97.70	3.00e-127	447.00
IUUC-Dme-031741	Drosophila melanogaster	65.09	3.00e-78	283.00
IUUC-Ete-032354	Echinops telfairi	68.52	9.00e-81	292.00
IUUC-Eca-033222	Equus caballus	97.70	3.00e-127	447.00
IUUC-Eeu-034513	Erinaceus europaeus	71.43	6.00e-86	309.00
IUUC-Fca-036294	Felis catus	97.70	3.00e-127	447.00
IUUC-Fal-037130	Ficedula albicollis	99.08	8.00e-128	448.00
IUUC-Gmo-039546	Gadus morhua	94.93	6.00e-124	435.00
IUUC-Gac-041968	Gasterosteus aculeatus	95.85	5.00e-125	439.00
IUUC-Ggo-044562	Gorilla gorilla	97.70	3.00e-127	447.00
IUUC-Hsa-046730	Homo sapiens	97.70	3.00e-127	447.00
IUUC-Itr-049025	Ictidomys tridecemlineatus	97.70	3.00e-127	447.00
IUUC-Lch-050230	Latimeria chalumnae	96.27	4.00e-74	271.00
IUUC-Loc-052723	Lepisosteus oculatus	96.31	9.00e-126	441.00
IUUC-Laf-053774	Loxodonta africana	96.31	3.00e-126	443.00
IUUC-Mcc-054603	Macaca mulatta	97.70	3.00e-127	447.00
IUUC-Meu-056173	Macropus eugenii	82.03	3.00e-101	360.00
IUUC-Mga-059950	Meleagris gallopavo	100.00	2.00e-129	453.00
IUUC-Mmr-060878	Microcebus murinus	97.70	3.00e-127	447.00
IUUC-Mdo-062454	Monodelphis domestica	99.08	2.00e-128	450.00
IUUC-Mmu-063913	Mus musculus	97.24	5.00e-127	446.00
IUUC-Mpu-066125	Mustela putorius furo	97.70	3.00e-127	447.00
IUUC-Mlu-068007	Myotis lucifugus	97.70	3.00e-127	447.00
IUUC-Nle-069101	Nomascus leucogenys	97.70	3.00e-127	447.00
IUUC-Opr-071075	Ochotona princeps	97.70	3.00e-127	447.00
IUUC-Ont-072253	Oreochromis niloticus	92.63	3.00e-121	426.00
IUUC-Ocu-074583	Oryctolagus cuniculus	97.70	3.00e-127	447.00
IUUC-Ola-086586	Oryzias latipes	95.51	4.00e-86	310.00
IUUC-Oga-089047	Otolemur garnettii	97.70	3.00e-127	447.00
IUUC-Oar-089904	Ovis aries	90.83	8.00e-117	412.00
IUUC-Ptr-090678	Pan troglodytes	97.70	3.00e-127	447.00
IUUC-Pan-092090	Papio anubis	97.70	3.00e-127	447.00
IUUC-Psi-093765	Pelodiscus sinensis	99.54	8.00e-129	452.00
IUUC-Pma-094650	Petromyzon marinus	84.79	4.00e-111	393.00
IUUC-Pfo-096131	Poecilia formosa	95.39	7.00e-125	439.00
IUUC-Pab-098709	Pongo abelii	97.70	3.00e-127	447.00
IUUC-Pca-100581	Procavia capensis	96.34	3.00e-111	393.00
IUUC-Pva-103066	Pteropus vampyrus	97.70	3.00e-127	447.00
IUUC-Rno-105224	Rattus norvegicus	97.70	3.00e-127	447.00
IUUC-Sce-106302	Saccharomyces cerevisiae	53.70	7.00e-16	77.00
IUUC-Sha-107247	Sarcophilus harrisii	99.48	2.00e-113	400.00
IUUC-Sar-113277	Sorex araneus	82.03	2.00e-101	361.00
IUUC-Ssc-115478	Sus scrofa	97.70	3.00e-127	447.00
IUUC-Tgu-117479	Taeniopygia guttata	98.62	2.00e-127	447.00
IUUC-Tru-118451	Takifugu rubripes	86.03	8.00e-108	382.00
IUUC-Tsy-119029	Tarsius syrichta	93.12	3.00e-83	299.00
IUUC-Tbe-128097	Tupaia belangeri	97.24	3.00e-126	443.00
IUUC-Ttr-128871	Tursiops truncatus	99.36	9.00e-90	321.00
IUUC-Vpa-130754	Vicugna pacos	97.70	3.00e-127	447.00
IUUC-Xtr-132275	Xenopus tropicalis	92.14	6.00e-124	436.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence