iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000009371.8	ENSRNOT00000012617.4	ENSRNOP00000012617.2
ENSRNOG00000009371.8	ENSRNOT00000043661.1	ENSRNOP00000042940.1

Annotation

mRNA Expression
GEO
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.40e-14	52.9	63	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++++++W+++  ++++ +G +P+n+++ ++
   Q: 63   PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNHNGEWCEA--QTKNGQGWVPSNYITPVN 120
           68899************************.***********..79999**********997 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MLEICLKLVG CKSKKGLSSS SSCYLEEALQ RPVASDFEPQ GLSEAARWNS KENLLAGPSE 60
NDPNLFVALY DFVASGDNTL SITKGEKLRV LGYNHNGEWC EAQTKNGQGW VPSNYITPVN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTGGAGA TCTGCTTGAA GTTGGTGGGC TGCAAATCCA AGAAGGGGCT CTCTTCGTCC 60
TCCAGCTGCT ACCTAGAAGG TAAATCCCGG CCTGGGCGTG GGGACCAACC AGGAGTGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR033221--ABL1
IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0030426--C:growth cone
GO:0005739--C:mitochondrion
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0001726--C:ruffle
GO:0045202--C:synapse
GO:0005524--F:ATP binding
GO:0070097--F:delta-catenin binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004672--F:protein kinase activity
GO:0019901--F:protein kinase binding
GO:0030041--P:actin filament polymerization
GO:0008306--P:associative learning
GO:0034599--P:cellular response to oxidative stress
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:1903210--P:glomerular visceral epithelial cell apoptotic process
GO:0007611--P:learning or memory
GO:0043065--P:positive regulation of apoptotic process
GO:1900006--P:positive regulation of dendrite development
GO:1903055--P:positive regulation of extracellular matrix organization
GO:0048146--P:positive regulation of fibroblast proliferation
GO:1901300--P:positive regulation of hydrogen peroxide-mediated programmed cell death
GO:0043525--P:positive regulation of neuron apoptotic process
GO:1901216--P:positive regulation of neuron death
GO:0045907--P:positive regulation of vasoconstriction
GO:0046777--P:protein autophosphorylation
GO:0042493--P:response to drug
GO:0034976--P:response to endoplasmic reticulum stress
GO:0071871--P:response to epinephrine

KEGG

rno:100909750

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003452	Anas platyrhynchos	80.05	0.00e+00	1624.00
IUUC-Aca-005312	Anolis carolinensis	80.26	0.00e+00	1291.00
IUUC-Bta-012351	Bos taurus	85.10	0.00e+00	1707.00
IUUC-Csa-023046	Chlorocebus sabaeus	86.95	0.00e+00	1797.00
IUUC-Eca-033720	Equus caballus	86.01	0.00e+00	1741.00
IUUC-Fal-036723	Ficedula albicollis	79.50	0.00e+00	1620.00
IUUC-Gga-040481	Gallus gallus	78.46	0.00e+00	1573.00
IUUC-Hsa-047033	Homo sapiens	100.00	3.00e-42	162.00
IUUC-Mlu-067255	Myotis lucifugus	86.67	0.00e+00	1721.00
IUUC-Opr-070327	Ochotona princeps	79.27	0.00e+00	1524.00
IUUC-Oan-073100	Ornithorhynchus anatinus	80.72	0.00e+00	1654.00
IUUC-Ocu-074892	Oryctolagus cuniculus	80.32	0.00e+00	1580.00
IUUC-Oga-088145	Otolemur garnettii	87.74	0.00e+00	1770.00
IUUC-Oar-090432	Ovis aries	90.59	0.00e+00	1405.00
IUUC-Psi-093078	Pelodiscus sinensis	81.30	0.00e+00	1708.00
IUUC-Pma-094420	Petromyzon marinus	77.98	0.00e+00	900.00
IUUC-Sha-106711	Sarcophilus harrisii	80.99	0.00e+00	1665.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence