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Tag Content
iUUCD ID IUUC-Sha-106711
Ensembl Protein ID ENSSHAP00000019280.1
UniProt Accession G3WV25; G3WV25_SARHA
Genbank Protein ID ENSSHAP00000019280
Protein Name Tyrosine-protein kinase
Genbank Nucleotide ID AEFK01022510
Gene Name ABL1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSHAG00000016375.1 ENSSHAT00000019436.1 ENSSHAP00000019280.1
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.80e-14 53.0 64 121
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
    +++ +lyd+ a+ d++L+++kG++++v+ ++++++W+++ ++++ +G +P+n+++ ++
   Q: 64 PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNHNGEWCEA--QTKNGQGWVPSNYITPVN 121
    68899************************.***********..79999**********997 PP
   

Organism Sarcophilus harrisii
Protein Sequence
(Fasta)
MLEICLKLVG CKSKKGLSSS SSCYLEEALQ RPVTASDFEP QGLSEAARWN SKENLLAGPS 60
ENDPNLFVAL YDFVASGDNT LSITKGEKLR VLGYNHNGEW CEAQTKNGQG WVPSNYITPV 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Sha-106711|UBD,SH3|Sarcophilus harrisii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TAAGAATCCA CCCACTTGAG CTTCTGTGGG CGTTGCTAGC CTGCCTGATG TCATGAAGTC 60
AGACAGCCCC AGCCTGAAGG GGGCCCTTTG TTGGCAGTTT AACCCAGCAC TTCTTTCTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Sha-106711|UBD,SH3|Sarcophilus harrisii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR033221--ABL1
IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0031252--C:cell leading edge
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0030145--F:manganese ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0090135--P:actin filament branching
GO:0050798--P:activated T cell proliferation
GO:1990051--P:activation of protein kinase C activity
GO:0046632--P:alpha-beta T cell differentiation
GO:0002322--P:B cell proliferation involved in immune response
GO:0050853--P:B cell receptor signaling pathway
GO:0001922--P:B-1 B cell homeostasis
GO:0060020--P:Bergmann glial cell differentiation
GO:0072358--P:cardiovascular system development
GO:0070301--P:cellular response to hydrogen peroxide
GO:0071222--P:cellular response to lipopolysaccharide
GO:0021587--P:cerebellum morphogenesis
GO:0048668--P:collateral sprouting
GO:0006975--P:DNA damage induced protein phosphorylation
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0045184--P:establishment of protein localization
GO:0030035--P:microspike assembly
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0022408--P:negative regulation of cell-cell adhesion
GO:2000773--P:negative regulation of cellular senescence
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045930--P:negative regulation of mitotic cell cycle
GO:1900275--P:negative regulation of phospholipase C activity
GO:0071901--P:negative regulation of protein serine/threonine kinase activity
GO:0051444--P:negative regulation of ubiquitin-protein transferase activity
GO:0001843--P:neural tube closure
GO:0060563--P:neuroepithelial cell differentiation
GO:0050885--P:neuromuscular process controlling balance
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0006909--P:phagocytosis
GO:0035791--P:platelet-derived growth factor receptor-beta signaling pathway
GO:1904531--P:positive regulation of actin filament binding
GO:0043065--P:positive regulation of apoptotic process
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1902715--P:positive regulation of interferon-gamma secretion
GO:1900042--P:positive regulation of interleukin-2 secretion
GO:1904528--P:positive regulation of microtubule binding
GO:0045931--P:positive regulation of mitotic cell cycle
GO:1901216--P:positive regulation of neuron death
GO:0033690--P:positive regulation of osteoblast proliferation
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol
GO:2000096--P:positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:0009791--P:post-embryonic development
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0030516--P:regulation of axon extension
GO:1903053--P:regulation of extracellular matrix organization
GO:0031113--P:regulation of microtubule polymerization
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0042770--P:signal transduction in response to DNA damage
GO:0048536--P:spleen development
GO:0034446--P:substrate adhesion-dependent cell spreading
GO:0048538--P:thymus development
GO:0002333--P:transitional one stage B cell differentiation

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001550 Ailuropoda melanoleuca 84.57 0.00e+00 1662.00
IUUC-Atr-002778 Amborella trichopoda 28.83 3.00e-23 103.00
IUUC-Apl-003452 Anas platyrhynchos 83.66 0.00e+00 1680.00
IUUC-Aca-005312 Anolis carolinensis 80.92 0.00e+00 1282.00
IUUC-Ame-011903 Astyanax mexicanus 85.62 0.00e+00 1028.00
IUUC-Bta-012351 Bos taurus 83.78 0.00e+00 1661.00
IUUC-Bol-015857 Brassica oleracea 32.28 5.00e-21 95.90
IUUC-Cja-019491 Callithrix jacchus 85.30 0.00e+00 1721.00
IUUC-Cfa-021256 Canis familiaris 84.21 0.00e+00 1694.00
IUUC-Cpo-022046 Cavia porcellus 85.58 0.00e+00 1404.00
IUUC-Csa-023046 Chlorocebus sabaeus 85.90 0.00e+00 1761.00
IUUC-Dre-028190 Danio rerio 67.00 0.00e+00 1199.00
IUUC-Dno-029853 Dasypus novemcinctus 83.56 0.00e+00 1702.00
IUUC-Dor-030635 Dipodomys ordii 75.77 0.00e+00 1504.00
IUUC-Dme-032098 Drosophila melanogaster 74.27 0.00e+00 784.00
IUUC-Eca-033720 Equus caballus 83.66 0.00e+00 1717.00
IUUC-Eeu-035173 Erinaceus europaeus 82.25 0.00e+00 1316.00
IUUC-Fca-035967 Felis catus 84.75 0.00e+00 1670.00
IUUC-Fal-036723 Ficedula albicollis 83.57 0.00e+00 1699.00
IUUC-Gmo-039550 Gadus morhua 77.42 0.00e+00 1090.00
IUUC-Gga-040481 Gallus gallus 84.57 0.00e+00 1674.00
IUUC-Gac-041643 Gasterosteus aculeatus 74.02 0.00e+00 1103.00
IUUC-Ggo-045299 Gorilla gorilla 85.22 0.00e+00 1748.00
IUUC-Hsa-047033 Homo sapiens 98.68 6.00e-41 157.00
IUUC-Itr-047935 Ictidomys tridecemlineatus 82.13 0.00e+00 1627.00
IUUC-Lch-050530 Latimeria chalumnae 77.53 0.00e+00 1548.00
IUUC-Loc-052430 Lepisosteus oculatus 92.53 0.00e+00 979.00
IUUC-Laf-053609 Loxodonta africana 84.99 0.00e+00 1669.00
IUUC-Mcc-055654 Macaca mulatta 85.84 0.00e+00 1789.00
IUUC-Meu-056488 Macropus eugenii 85.90 0.00e+00 1692.00
IUUC-Mga-059270 Meleagris gallopavo 84.33 0.00e+00 1712.00
IUUC-Mmr-060593 Microcebus murinus 83.82 0.00e+00 1711.00
IUUC-Mdo-062227 Monodelphis domestica 95.75 0.00e+00 1333.00
IUUC-Mmu-064002 Mus musculus 81.21 0.00e+00 1654.00
IUUC-Mac-065247 Musa acuminata 30.07 4.00e-22 99.80
IUUC-Mpu-066197 Mustela putorius furo 84.03 0.00e+00 1675.00
IUUC-Mlu-067255 Myotis lucifugus 85.51 0.00e+00 1697.00
IUUC-Nle-069977 Nomascus leucogenys 75.92 0.00e+00 1514.00
IUUC-Opr-070327 Ochotona princeps 77.33 0.00e+00 1486.00
IUUC-Ont-072307 Oreochromis niloticus 66.10 0.00e+00 1227.00
IUUC-Oan-073100 Ornithorhynchus anatinus 85.59 0.00e+00 1715.00
IUUC-Ocu-074892 Oryctolagus cuniculus 77.08 0.00e+00 1501.00
IUUC-Ome-081788 Oryza meridionalis 28.16 6.00e-26 112.00
IUUC-Ola-087389 Oryzias latipes 69.13 0.00e+00 1051.00
IUUC-Oga-088145 Otolemur garnettii 85.61 0.00e+00 1732.00
IUUC-Oar-090432 Ovis aries 88.99 0.00e+00 1373.00
IUUC-Ptr-090800 Pan troglodytes 85.84 0.00e+00 1755.00
IUUC-Psi-093078 Pelodiscus sinensis 83.57 0.00e+00 1745.00
IUUC-Pma-094420 Petromyzon marinus 77.70 0.00e+00 895.00
IUUC-Pfo-096979 Poecilia formosa 71.48 0.00e+00 1051.00
IUUC-Pca-100874 Procavia capensis 98.81 0.00e+00 669.00
IUUC-Pva-102415 Pteropus vampyrus 84.12 0.00e+00 1676.00
IUUC-Rno-105370 Rattus norvegicus 81.08 0.00e+00 1675.00
IUUC-Ssc-115472 Sus scrofa 84.10 0.00e+00 1663.00
IUUC-Tgu-117037 Taeniopygia guttata 83.71 0.00e+00 1716.00
IUUC-Tru-118324 Takifugu rubripes 60.96 0.00e+00 1096.00
IUUC-Tsy-119216 Tarsius syrichta 94.87 0.00e+00 1056.00
IUUC-Tni-119950 Tetraodon nigroviridis 61.22 0.00e+00 1071.00
IUUC-Ttr-128209 Tursiops truncatus 84.03 0.00e+00 1735.00
IUUC-Xtr-132477 Xenopus tropicalis 75.37 0.00e+00 1085.00
Created Date 25-Jun-2017

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