iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108073

UUCD1 version

UUC-ScP-00257

Ensembl Protein ID

SPAC18B11.07c.1:pep

UniProt Accession

P23566; UBC2_SCHPO

Genbank Protein ID

CAA37340.1; CAA90592.1

Protein Name

Ubiquitin-conjugating enzyme E2 2; E2 ubiquitin-conjugating enzyme 2; RAD6 homolog; Ubiquitin carrier protein 2; Ubiquitin-protein ligase 2

Genbank Nucleotide ID

X53252; CU329670

Gene Name

rhp6; ubc2; SPAC18B11.07c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC18B11.07c	SPAC18B11.07c.1	SPAC18B11.07c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	17456468

Classification

Family	E-value	Score	Start	End
E2/UBC	1.00e-52	175.7	8	142

Active Site

Position(s)	Description	Evidence
88	Glycyl thioester intermediate	N/A

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeee 90
           Rl++++k++++dpp+g+sa+pv++ +++ w+++i+Gp+dtp+e+g+Fkl ++f+e+YP kPP vkf++++fhPnvy+nG++Cl+il+  +
   Q: 8    RLMRDFKRMQQDPPAGVSASPVSD-NVMLWNAVIIGPADTPFEDGTFKLVLSFDEQYPNKPPLVKFVSTMFHPNVYANGELCLDILQ--N 94
           9***********************.9************************************************************9..* PP
   S: 91   kWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           +Wsp+++v+ +l+siqsll++pn++sp+n+eaa+l+++n++ey ++vr
   Q: 95   RWSPTYDVAAILTSIQSLLNDPNNASPANAEAAQLHRENKKEYVRRVR 142
           *********************************************998 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Component of the histone H2B ubiquitin ligase complex (HULC) which plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation (By similarity). Required for obr1 ubiquitination, which regulates mating-type silencing. With cut8, regulates the nuclear accumulation of the proteasome.

Protein Sequence
(Fasta)

MSTTARRRLM RDFKRMQQDP PAGVSASPVS DNVMLWNAVI IGPADTPFED GTFKLVLSFD 60
EQYPNKPPLV KFVSTMFHPN VYANGELCLD ILQNRWSPTY DVAAILTSIQ SLLNDPNNAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTGCCCTT CTCCAACAAC GCAAATCGGA TATCCTAACT CGGTGTAATT CCAAGGCGAT 60
ATCGATATTT GTGCAACTTT TTTTTAAAGT TATCACAAAT AGAAGAGAGG TTGCTATAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0749--Sporulation
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0033503--C:HULC complex
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0071455--P:cellular response to hyperoxia
GO:0031497--P:chromatin assembly
GO:0006325--P:chromatin organization
GO:0006281--P:DNA repair
GO:0071894--P:histone H2B conserved C-terminal lysine ubiquitination
GO:0061186--P:negative regulation of chromatin silencing at silent mating-type cassette
GO:0031939--P:negative regulation of chromatin silencing at telomere
GO:1901487--P:negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolic process in response to increased oxygen levels
GO:0010620--P:negative regulation of transcription by transcription factor catabolism
GO:1990920--P:proteasome localization to nuclear periphery
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1901044--P:protein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
GO:0051569--P:regulation of histone H3-K4 methylation
GO:0030435--P:sporulation resulting in formation of a cellular spore
GO:0006351--P:transcription, DNA-templated

KEGG

spo:SPAC18B11.07c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001001	Aegilops tauschii	69.13	8.00e-63	230.00
IUUC-Aml-002120	Ailuropoda melanoleuca	71.81	2.00e-65	238.00
IUUC-Atr-002623	Amborella trichopoda	71.52	2.00e-64	236.00
IUUC-Apl-004063	Anas platyrhynchos	64.38	6.00e-55	204.00
IUUC-Aca-005001	Anolis carolinensis	71.14	3.00e-65	238.00
IUUC-Aly-005584	Arabidopsis lyrata	70.86	8.00e-64	233.00
IUUC-Ath-007149	Arabidopsis thaliana	70.86	8.00e-64	233.00
IUUC-Ago-007745	Ashbya gossypii	77.33	4.00e-70	254.00
IUUC-Acl-008139	Aspergillus clavatus	82.00	4.00e-75	271.00
IUUC-Afl-008551	Aspergillus flavus	82.67	1.00e-75	272.00
IUUC-Afu-008980	Aspergillus fumigatus	82.67	1.00e-75	272.00
IUUC-Ang-009554	Aspergillus niger	82.67	1.00e-75	272.00
IUUC-Aor-010242	Aspergillus oryzae	82.67	1.00e-75	272.00
IUUC-Ate-010390	Aspergillus terreus	82.67	1.00e-75	272.00
IUUC-Ame-010743	Astyanax mexicanus	72.48	2.00e-66	242.00
IUUC-Bgr-012039	Blumeria graminis	80.00	2.00e-66	242.00
IUUC-Bta-012840	Bos taurus	71.81	2.00e-65	238.00
IUUC-Bci-013919	Botrytis cinerea	82.67	6.00e-76	273.00
IUUC-Bdi-014308	Brachypodium distachyon	70.86	2.00e-63	232.00
IUUC-Bol-016245	Brassica oleracea	70.86	7.00e-64	233.00
IUUC-Bra-016809	Brassica rapa	71.81	7.00e-64	234.00
IUUC-Cel-018244	Caenorhabditis elegans	70.47	2.00e-65	239.00
IUUC-Cja-018783	Callithrix jacchus	72.48	5.00e-66	240.00
IUUC-Cfa-020646	Canis familiaris	72.48	8.00e-66	241.00
IUUC-Cpo-021323	Cavia porcellus	71.81	8.00e-66	240.00
IUUC-Cre-022822	Chlamydomonas reinhardtii	68.99	3.00e-52	195.00
IUUC-Csa-023588	Chlorocebus sabaeus	72.48	5.00e-66	240.00
IUUC-Cho-024773	Choloepus hoffmanni	56.38	1.00e-45	172.00
IUUC-Cin-025537	Ciona intestinalis	69.80	1.00e-53	199.00
IUUC-Csv-025846	Ciona savignyi	71.14	5.00e-58	214.00
IUUC-Cgl-026381	Colletotrichum gloeosporioides	82.67	4.00e-75	271.00
IUUC-Cne-026864	Cryptococcus neoformans	73.83	1.00e-66	243.00
IUUC-Cme-027284	Cyanidioschyzon merolae	64.00	4.00e-51	192.00
IUUC-Dre-027775	Danio rerio	73.15	7.00e-67	243.00
IUUC-Dno-029661	Dasypus novemcinctus	71.81	2.00e-65	238.00
IUUC-Dor-030452	Dipodomys ordii	69.40	5.00e-57	210.00
IUUC-Dse-031487	Dothistroma septosporum	81.33	1.00e-74	269.00
IUUC-Dme-031863	Drosophila melanogaster	71.81	2.00e-65	238.00
IUUC-Ete-032595	Echinops telfairi	70.47	3.00e-64	234.00
IUUC-Eca-033377	Equus caballus	71.81	2.00e-65	238.00
IUUC-Eeu-035191	Erinaceus europaeus	56.95	2.00e-45	172.00
IUUC-Fca-036581	Felis catus	72.48	5.00e-66	240.00
IUUC-Fal-037474	Ficedula albicollis	72.41	2.00e-50	188.00
IUUC-Fox-037808	Fusarium oxysporum	82.67	5.00e-75	270.00
IUUC-Fso-038232	Fusarium solani	82.67	5.00e-75	270.00
IUUC-Gmo-038517	Gadus morhua	72.48	5.00e-66	240.00
IUUC-Ggr-039875	Gaeumannomyces graminis	82.12	9.00e-75	270.00
IUUC-Gga-040588	Gallus gallus	72.48	5.00e-66	240.00
IUUC-Gac-042471	Gasterosteus aculeatus	72.48	5.00e-66	240.00
IUUC-Gma-043865	Glycine max	71.52	1.00e-64	236.00
IUUC-Ggo-044896	Gorilla gorilla	72.48	5.00e-66	240.00
IUUC-Hsa-046383	Homo sapiens	72.48	5.00e-66	240.00
IUUC-Hvu-047054	Hordeum vulgare	69.13	8.00e-63	230.00
IUUC-Itr-048507	Ictidomys tridecemlineatus	72.48	5.00e-66	240.00
IUUC-Kpa-049225	Komagataella pastoris	77.18	3.00e-70	254.00
IUUC-Lch-050283	Latimeria chalumnae	72.48	3.00e-66	241.00
IUUC-Lpe-050826	Leersia perrieri	71.52	3.00e-64	234.00
IUUC-Loc-051962	Lepisosteus oculatus	73.15	7.00e-67	243.00
IUUC-Laf-053680	Loxodonta africana	72.48	5.00e-66	240.00
IUUC-Mcc-055546	Macaca mulatta	72.48	1.00e-65	240.00
IUUC-Meu-056231	Macropus eugenii	72.48	5.00e-66	240.00
IUUC-Mor-057087	Magnaporthe oryzae	80.88	2.00e-66	241.00
IUUC-Mpo-057498	Magnaporthe poae	82.12	6.00e-75	271.00
IUUC-Mtr-058305	Medicago truncatula	71.52	3.00e-64	234.00
IUUC-Mla-058876	Melampsora laricipopulina	75.17	2.00e-63	232.00
IUUC-Mga-059863	Meleagris gallopavo	68.61	1.00e-57	213.00
IUUC-Mvi-060330	Microbotryum violaceum	80.54	2.00e-63	232.00
IUUC-Mmr-060630	Microcebus murinus	71.81	2.00e-65	238.00
IUUC-Mdo-062292	Monodelphis domestica	72.48	5.00e-66	240.00
IUUC-Mmu-063680	Mus musculus	72.48	5.00e-66	240.00
IUUC-Mac-064774	Musa acuminata	71.52	6.00e-64	234.00
IUUC-Mpu-065803	Mustela putorius furo	71.81	2.00e-65	238.00
IUUC-Mlu-067147	Myotis lucifugus	71.81	2.00e-65	238.00
IUUC-Nfi-068580	Neosartorya fischeri	82.67	1.00e-75	272.00
IUUC-Ncr-068913	Neurospora crassa	82.67	2.00e-74	269.00
IUUC-Nle-069121	Nomascus leucogenys	72.48	5.00e-66	240.00
IUUC-Opr-070935	Ochotona princeps	71.81	2.00e-65	238.00
IUUC-Ont-071335	Oreochromis niloticus	72.48	3.00e-66	241.00
IUUC-Oan-072706	Ornithorhynchus anatinus	66.67	2.00e-58	215.00
IUUC-Ocu-074550	Oryctolagus cuniculus	72.48	1.00e-65	240.00
IUUC-Oba-075896	Oryza barthii	71.52	3.00e-64	234.00
IUUC-Obr-076713	Oryza brachyantha	71.52	5.00e-64	234.00
IUUC-Ogl-077117	Oryza glaberrima	71.52	3.00e-64	234.00
IUUC-Ogu-078939	Oryza glumaepatula	71.52	3.00e-64	234.00
IUUC-Oin-079769	Oryza indica	71.52	3.00e-64	234.00
IUUC-Olo-081018	Oryza longistaminata	61.31	4.00e-55	205.00
IUUC-Ome-081285	Oryza meridionalis	71.52	5.00e-64	234.00
IUUC-Oni-082537	Oryza nivara	71.52	3.00e-64	234.00
IUUC-Opu-083310	Oryza punctata	71.52	5.00e-64	234.00
IUUC-Oru-084754	Oryza rufipogon	71.52	3.00e-64	234.00
IUUC-Osa-086290	Oryza sativa	71.52	3.00e-64	234.00
IUUC-Ola-087160	Oryzias latipes	72.48	3.00e-66	241.00
IUUC-Olu-087830	Ostreococcus lucimarinus	67.11	3.00e-54	201.00
IUUC-Oga-088659	Otolemur garnettii	72.48	5.00e-66	240.00
IUUC-Oar-090141	Ovis aries	71.81	2.00e-65	238.00
IUUC-Ptr-091305	Pan troglodytes	72.48	5.00e-66	240.00
IUUC-Pan-092740	Papio anubis	72.48	1.00e-65	240.00
IUUC-Psi-094094	Pelodiscus sinensis	72.48	5.00e-66	240.00
IUUC-Pma-094376	Petromyzon marinus	73.83	3.00e-66	241.00
IUUC-Pno-094935	Phaeosphaeria nodorum	81.33	8.00e-75	270.00
IUUC-Ppa-095689	Physcomitrella patens	73.23	6.00e-55	204.00
IUUC-Pfo-096784	Poecilia formosa	72.48	4.00e-66	241.00
IUUC-Pab-097972	Pongo abelii	72.48	5.00e-66	240.00
IUUC-Pop-099517	Populus trichocarpa	71.52	3.00e-64	234.00
IUUC-Pca-100906	Procavia capensis	67.11	5.00e-59	217.00
IUUC-Ppe-101949	Prunus persica	71.52	4.00e-64	235.00
IUUC-Pva-102380	Pteropus vampyrus	71.81	8.00e-64	233.00
IUUC-Pgr-103611	Puccinia graminis	75.84	7.00e-64	233.00
IUUC-Ptt-103971	Puccinia triticina	81.03	1.00e-49	186.00
IUUC-Pte-104378	Pyrenophora teres	81.33	3.00e-74	268.00
IUUC-Pyt-104757	Pyrenophora triticirepentis	81.33	3.00e-74	268.00
IUUC-Rno-105772	Rattus norvegicus	71.81	1.00e-65	239.00
IUUC-Sce-106283	Saccharomyces cerevisiae	77.33	3.00e-70	254.00
IUUC-Sha-107650	Sarcophilus harrisii	71.14	5.00e-64	234.00
IUUC-Sja-107790	Schizosaccharomyces japonicus	98.68	5.00e-78	280.00
IUUC-Ssl-108432	Sclerotinia sclerotiorum	82.67	6.00e-76	273.00
IUUC-Smo-109036	Selaginella moellendorffii	69.54	3.00e-63	231.00
IUUC-Sit-110731	Setaria italica	71.52	5.00e-64	234.00
IUUC-Sly-111506	Solanum lycopersicum	71.52	2.00e-64	235.00
IUUC-Stu-112080	Solanum tuberosum	71.52	2.00e-64	235.00
IUUC-Sar-113429	Sorex araneus	71.81	2.00e-65	238.00
IUUC-Sbi-114289	Sorghum bicolor	71.52	5.00e-64	234.00
IUUC-Sre-115106	Sporisorium reilianum	79.19	1.00e-64	236.00
IUUC-Ssc-116265	Sus scrofa	72.48	5.00e-66	240.00
IUUC-Tgu-117383	Taeniopygia guttata	72.48	5.00e-66	240.00
IUUC-Tru-118576	Takifugu rubripes	72.48	5.00e-66	241.00
IUUC-Tsy-119000	Tarsius syrichta	71.81	2.00e-65	238.00
IUUC-Tni-119745	Tetraodon nigroviridis	72.48	5.00e-66	241.00
IUUC-Tca-121827	Theobroma cacao	70.86	4.00e-64	234.00
IUUC-Tre-122002	Trichoderma reesei	82.00	1.00e-74	269.00
IUUC-Tvi-122331	Trichoderma virens	82.00	1.00e-74	269.00
IUUC-Tae-124461	Triticum aestivum	71.14	8.00e-64	234.00
IUUC-Tur-126866	Triticum urartu	69.54	7.00e-63	230.00
IUUC-Tme-127148	Tuber melanosporum	82.78	7.00e-76	273.00
IUUC-Tbe-127921	Tupaia belangeri	69.80	4.00e-61	224.00
IUUC-Ttr-129121	Tursiops truncatus	71.81	2.00e-65	238.00
IUUC-Uma-129561	Ustilago maydis	79.19	8.00e-65	237.00
IUUC-Vda-129711	Verticillium dahliae	82.67	4.00e-75	271.00
IUUC-Vpa-130570	Vicugna pacos	64.18	5.00e-51	191.00
IUUC-Vvi-131108	Vitis vinifera	72.48	1.00e-64	236.00
IUUC-Xtr-131824	Xenopus tropicalis	72.48	4.00e-66	241.00
IUUC-Xma-133667	Xiphophorus maculatus	72.48	3.00e-66	241.00
IUUC-Yli-134660	Yarrowia lipolytica	80.54	3.00e-73	264.00
IUUC-Zma-135584	Zea mays	70.20	1.00e-63	233.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence