iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-091619

Ensembl Protein ID

ENSPTRP00000040385.3

UniProt Accession

H2R099; H2R099_PANTR

Genbank Protein ID

ENSPTRP00000040385

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03075274

Gene Name

OPTN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000002298.6	ENSPTRT00000046629.3	ENSPTRP00000040385.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBAN	4.00e-26	90.7	454	513

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndslkas 60
           +ee+let+++L++Q+e+Y++DF+aERa+RE+++eeke+L+ q+++l+k++++++d++++s
   Q: 454  QEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQS 513
           79********************************************************98 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MSHQPLSCLT EKEDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE NHQLKEAMKL 60
NNQAMKGRFE ELSAWTEKQK EERQFFEIQS KEAKERLMAL SHENEKLKEE LGKLKGKSER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGCGGGCA GGGAGCGGCT GGCTGTCAGC TGAGCTGCGC TGGGCGGGGT CGCGAGGCCG 60
CGCATCAGCC CCAGGCACCC CAGTCCCCGC TGCCCCCTCC GCCGCCGCCG CCGCCCGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005802--C:trans-Golgi network
GO:0070530--F:K63-linked polyubiquitin binding
GO:0050829--P:defense response to Gram-negative bacterium
GO:0090161--P:Golgi ribbon formation
GO:0043001--P:Golgi to plasma membrane protein transport
GO:0016236--P:macroautophagy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0001920--P:negative regulation of receptor recycling
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1904417--P:positive regulation of xenophagy
GO:0000042--P:protein targeting to Golgi
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002037	Ailuropoda melanoleuca	80.60	0.00e+00	782.00
IUUC-Apl-003812	Anas platyrhynchos	56.14	3.00e-150	525.00
IUUC-Aca-004625	Anolis carolinensis	57.54	8.00e-148	516.00
IUUC-Aly-005781	Arabidopsis lyrata	55.00	1.90e-02	33.50
IUUC-Ame-011116	Astyanax mexicanus	37.31	4.00e-70	259.00
IUUC-Bta-013240	Bos taurus	82.90	0.00e+00	896.00
IUUC-Cja-019911	Callithrix jacchus	94.11	0.00e+00	981.00
IUUC-Cfa-020330	Canis familiaris	83.97	0.00e+00	833.00
IUUC-Cpo-021753	Cavia porcellus	80.24	0.00e+00	815.00
IUUC-Csa-023662	Chlorocebus sabaeus	96.36	0.00e+00	993.00
IUUC-Cho-024574	Choloepus hoffmanni	67.17	1.00e-128	452.00
IUUC-Cme-027299	Cyanidioschyzon merolae	35.96	2.00e-03	37.00
IUUC-Dre-027720	Danio rerio	40.64	9.00e-92	330.00
IUUC-Dno-029079	Dasypus novemcinctus	79.31	0.00e+00	771.00
IUUC-Dor-030890	Dipodomys ordii	80.31	0.00e+00	828.00
IUUC-Ete-032568	Echinops telfairi	81.30	0.00e+00	749.00
IUUC-Eca-033528	Equus caballus	83.42	0.00e+00	845.00
IUUC-Eeu-035219	Erinaceus europaeus	74.44	0.00e+00	813.00
IUUC-Fca-035852	Felis catus	83.78	0.00e+00	840.00
IUUC-Fal-036862	Ficedula albicollis	57.62	4.00e-149	521.00
IUUC-Gmo-038735	Gadus morhua	40.04	7.00e-78	284.00
IUUC-Gga-040939	Gallus gallus	58.81	3.00e-151	528.00
IUUC-Gac-041580	Gasterosteus aculeatus	42.49	2.00e-94	339.00
IUUC-Ggo-045034	Gorilla gorilla	88.21	0.00e+00	942.00
IUUC-Hsa-046624	Homo sapiens	99.13	0.00e+00	1059.00
IUUC-Itr-048288	Ictidomys tridecemlineatus	77.66	0.00e+00	811.00
IUUC-Lch-049720	Latimeria chalumnae	49.87	2.00e-81	295.00
IUUC-Loc-052185	Lepisosteus oculatus	45.88	5.00e-105	374.00
IUUC-Laf-054079	Loxodonta africana	81.82	0.00e+00	820.00
IUUC-Mcc-055674	Macaca mulatta	95.67	0.00e+00	966.00
IUUC-Meu-056769	Macropus eugenii	83.33	2.00e-73	270.00
IUUC-Mga-060203	Meleagris gallopavo	59.43	3.00e-144	504.00
IUUC-Mmr-061492	Microcebus murinus	85.52	0.00e+00	840.00
IUUC-Mdo-063051	Monodelphis domestica	74.87	0.00e+00	791.00
IUUC-Mmu-063409	Mus musculus	76.65	0.00e+00	855.00
IUUC-Mpu-065907	Mustela putorius furo	77.95	0.00e+00	821.00
IUUC-Mlu-066957	Myotis lucifugus	82.24	0.00e+00	781.00
IUUC-Ncr-068766	Neurospora crassa	32.69	3.90e-01	29.60
IUUC-Nle-069973	Nomascus leucogenys	96.53	0.00e+00	1022.00
IUUC-Opr-071049	Ochotona princeps	78.24	0.00e+00	740.00
IUUC-Ont-071915	Oreochromis niloticus	42.62	2.00e-91	330.00
IUUC-Oan-072965	Ornithorhynchus anatinus	72.09	0.00e+00	760.00
IUUC-Ocu-074029	Oryctolagus cuniculus	75.32	0.00e+00	689.00
IUUC-Ola-087019	Oryzias latipes	40.28	5.00e-91	328.00
IUUC-Oga-088613	Otolemur garnettii	87.09	0.00e+00	891.00
IUUC-Oar-090386	Ovis aries	82.56	0.00e+00	888.00
IUUC-Pan-092178	Papio anubis	95.34	0.00e+00	969.00
IUUC-Psi-093214	Pelodiscus sinensis	63.56	4.00e-170	590.00
IUUC-Pfo-096901	Poecilia formosa	41.03	2.00e-83	303.00
IUUC-Pab-097560	Pongo abelii	88.21	0.00e+00	900.00
IUUC-Pca-100853	Procavia capensis	75.90	8.00e-128	450.00
IUUC-Pva-102255	Pteropus vampyrus	83.42	0.00e+00	787.00
IUUC-Rno-105812	Rattus norvegicus	78.72	0.00e+00	850.00
IUUC-Sha-107225	Sarcophilus harrisii	78.61	2.00e-156	545.00
IUUC-Sar-113736	Sorex araneus	73.77	1.00e-130	459.00
IUUC-Ssc-115422	Sus scrofa	82.93	0.00e+00	874.00
IUUC-Tgu-116924	Taeniopygia guttata	59.13	2.00e-150	525.00
IUUC-Tru-117695	Takifugu rubripes	37.94	4.00e-88	318.00
IUUC-Tsy-119090	Tarsius syrichta	84.92	3.00e-157	548.00
IUUC-Tni-120645	Tetraodon nigroviridis	41.17	6.00e-93	334.00
IUUC-Tbe-127970	Tupaia belangeri	68.91	0.00e+00	669.00
IUUC-Ttr-129244	Tursiops truncatus	82.90	0.00e+00	824.00
IUUC-Vpa-130313	Vicugna pacos	81.52	0.00e+00	792.00
IUUC-Xtr-132115	Xenopus tropicalis	44.89	1.00e-100	360.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence