iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013397

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 SUMO-protein ligase NSE2; Non-structural maintenance of chromosomes element 2 homolog

Genbank Nucleotide ID

BC109850

Gene Name

NSMCE2; MMS21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000009394.5	ENSBTAT00000012363.5	ENSBTAP00000012363.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	7.60e-10	38.9	95	173

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlp.sGitydrssIekwlasggk.....tcPvtrqpl...teedlvPnltlrrliqawceens 73
             f+CpI+   M+ Pv  + +G+ty+ ++I + ++s++k      cP+ + +    + +dl+   +lrr i+++ ++++
   Q: 95   TNFICPITQLEMKKPVKNKvCGHTYEEEAIVRMIESKHKrkkkaCCPKIGCSHvdmRMSDLIQDEALRRAIESHKKRRR 173
           57********************************9999999999899866554444999*************9988765 PP

Organism

Bos taurus

Functional Description
(View)

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair. Required for sister chromatid cohesion during prometaphase and mitotic progression (By similarity).

Protein Sequence
(Fasta)

MDRELNHYLK AVQSTINHVK EERSEKIPDL KLLVEKKFLA LQNKNSDADF QNNEKFVQFK 60
QQLKELKKQY GLQSDREADI TEGVDEDMIV TQSQTNFICP ITQLEMKKPV KNKVCGHTYE 120

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Nucleotide Sequence
(Fasta)

TCAGCTGAAG TGAGTAGTGA ATACAGTATG GATAAGGCAA TGGTTGAATT TGCAATGATG 60
GATCGGGAAC TAAACCATTA TTTAAAGGCT GTGCAATCTA CAATAAACCA TGTAAGTTTA 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0436--Ligase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0779--Telomere
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR026846--Nse2(Mms21)
IPR003613--Ubox_domain
IPR004181--Znf_MIZ
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51044--ZF_SP_RING

Pfam

PF11789--zf-Nse

SMART

SM00504--Ubox

Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0016605--C:PML body
GO:0030915--C:Smc5-Smc6 complex
GO:0016874--F:ligase activity
GO:0019789--F:SUMO transferase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0090398--P:cellular senescence
GO:0000724--P:double-strand break repair via homologous recombination
GO:0007067--P:mitotic nuclear division
GO:0034184--P:positive regulation of maintenance of mitotic sister chromatid cohesion
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
GO:0000722--P:telomere maintenance via recombination

KEGG

bta:519974

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001627	Ailuropoda melanoleuca	88.07	3.00e-79	288.00
IUUC-Atr-002438	Amborella trichopoda	33.33	5.00e-06	44.70
IUUC-Apl-004091	Anas platyrhynchos	62.38	1.00e-29	121.00
IUUC-Aca-004433	Anolis carolinensis	54.34	4.00e-52	197.00
IUUC-Ago-007852	Ashbya gossypii	28.38	1.00e-06	46.60
IUUC-Acl-008011	Aspergillus clavatus	32.56	6.00e-03	35.80
IUUC-Afl-008461	Aspergillus flavus	46.67	7.00e-03	35.40
IUUC-Afu-008893	Aspergillus fumigatus	32.56	1.00e-03	37.70
IUUC-Ani-009414	Aspergillus nidulans	31.82	6.00e-04	38.90
IUUC-Ang-009587	Aspergillus niger	40.00	2.00e-03	37.40
IUUC-Ate-010326	Aspergillus terreus	34.88	8.00e-03	36.20
IUUC-Ame-010902	Astyanax mexicanus	39.43	2.00e-32	132.00
IUUC-Bgr-012088	Blumeria graminis	22.99	2.00e-06	47.00
IUUC-Bci-013738	Botrytis cinerea	26.44	2.00e-05	43.90
IUUC-Cja-019246	Callithrix jacchus	92.61	1.00e-82	298.00
IUUC-Cpo-021670	Cavia porcellus	90.17	5.00e-72	263.00
IUUC-Csa-023982	Chlorocebus sabaeus	87.43	2.00e-77	281.00
IUUC-Cin-025127	Ciona intestinalis	30.30	2.00e-14	72.00
IUUC-Cgl-026430	Colletotrichum gloeosporioides	30.26	3.00e-07	49.30
IUUC-Cne-026806	Cryptococcus neoformans	36.59	3.00e-08	52.40
IUUC-Cme-027175	Cyanidioschyzon merolae	29.09	1.00e-04	40.80
IUUC-Dre-028325	Danio rerio	38.95	3.00e-30	124.00
IUUC-Dno-029735	Dasypus novemcinctus	91.86	3.00e-93	334.00
IUUC-Dor-030454	Dipodomys ordii	68.60	6.00e-49	187.00
IUUC-Dse-031273	Dothistroma septosporum	25.00	2.00e-04	40.40
IUUC-Dme-031971	Drosophila melanogaster	26.23	2.00e-08	52.80
IUUC-Ete-032838	Echinops telfairi	64.49	2.00e-45	174.00
IUUC-Eca-034371	Equus caballus	88.07	6.00e-89	320.00
IUUC-Eeu-035258	Erinaceus europaeus	90.58	2.00e-58	218.00
IUUC-Fca-035576	Felis catus	90.12	7.00e-78	283.00
IUUC-Fal-037038	Ficedula albicollis	57.89	3.00e-57	214.00
IUUC-Fox-037843	Fusarium oxysporum	32.86	5.00e-06	45.40
IUUC-Fso-038272	Fusarium solani	35.00	1.00e-05	44.30
IUUC-Ggr-040059	Gaeumannomyces graminis	28.57	2.00e-06	47.00
IUUC-Gga-040737	Gallus gallus	44.75	2.00e-45	176.00
IUUC-Gac-042591	Gasterosteus aculeatus	42.44	8.00e-31	126.00
IUUC-Gma-043177	Glycine max	29.90	2.00e-07	49.70
IUUC-Ggo-045206	Gorilla gorilla	86.05	1.00e-74	272.00
IUUC-Hsa-046704	Homo sapiens	86.63	2.00e-75	275.00
IUUC-Itr-048972	Ictidomys tridecemlineatus	92.74	1.00e-46	177.00
IUUC-Kpa-049181	Komagataella pastoris	25.21	1.00e-09	56.60
IUUC-Loc-052687	Lepisosteus oculatus	40.91	1.00e-30	126.00
IUUC-Lma-053255	Leptosphaeria maculans	30.43	8.00e-06	45.40
IUUC-Laf-054270	Loxodonta africana	85.47	3.00e-76	278.00
IUUC-Mcc-054757	Macaca mulatta	87.43	6.00e-77	279.00
IUUC-Mor-057028	Magnaporthe oryzae	32.47	5.00e-07	48.90
IUUC-Mpo-057462	Magnaporthe poae	27.38	2.00e-06	47.40
IUUC-Mtr-058011	Medicago truncatula	26.14	5.00e-10	57.80
IUUC-Mga-059215	Meleagris gallopavo	64.29	4.00e-31	125.00
IUUC-Mvi-060511	Microbotryum violaceum	35.00	3.00e-08	52.80
IUUC-Mmr-061584	Microcebus murinus	89.71	4.00e-69	254.00
IUUC-Mdo-061863	Monodelphis domestica	62.79	2.00e-60	225.00
IUUC-Mmu-064413	Mus musculus	88.64	5.00e-82	296.00
IUUC-Mpu-066092	Mustela putorius furo	71.00	2.00e-76	278.00
IUUC-Mlu-068198	Myotis lucifugus	91.28	2.00e-92	331.00
IUUC-Nle-070109	Nomascus leucogenys	88.95	1.00e-78	285.00
IUUC-Opr-070540	Ochotona princeps	52.57	4.00e-38	151.00
IUUC-Ont-071575	Oreochromis niloticus	43.18	6.00e-33	134.00
IUUC-Oan-072777	Ornithorhynchus anatinus	73.86	3.00e-23	99.40
IUUC-Ocu-074730	Oryctolagus cuniculus	93.18	2.00e-83	301.00
IUUC-Obr-076506	Oryza brachyantha	36.78	4.00e-07	47.80
IUUC-Oga-087925	Otolemur garnettii	93.75	3.00e-75	274.00
IUUC-Oar-090138	Ovis aries	78.05	7.00e-75	273.00
IUUC-Ptr-091582	Pan troglodytes	86.63	2.00e-75	275.00
IUUC-Pan-092890	Papio anubis	87.43	3.00e-77	281.00
IUUC-Psi-093714	Pelodiscus sinensis	59.77	6.00e-59	220.00
IUUC-Pma-094198	Petromyzon marinus	32.85	2.00e-20	91.30
IUUC-Pno-094931	Phaeosphaeria nodorum	32.47	3.00e-05	43.10
IUUC-Pab-098005	Pongo abelii	86.63	9.00e-76	276.00
IUUC-Pop-099559	Populus trichocarpa	26.39	1.00e-06	46.60
IUUC-Pca-100368	Procavia capensis	83.44	1.00e-49	189.00
IUUC-Ppe-101873	Prunus persica	28.26	5.00e-08	51.20
IUUC-Pva-102951	Pteropus vampyrus	91.43	7.00e-90	323.00
IUUC-Pte-104390	Pyrenophora teres	36.84	1.00e-06	47.40
IUUC-Pyt-104633	Pyrenophora triticirepentis	36.84	2.00e-06	47.00
IUUC-Rno-105346	Rattus norvegicus	88.07	4.00e-81	294.00
IUUC-Sha-107586	Sarcophilus harrisii	70.08	4.00e-41	160.00
IUUC-Sja-107983	Schizosaccharomyces japonicus	34.41	3.00e-10	58.50
IUUC-Spo-108327	Schizosaccharomyces pombe	24.71	7.00e-06	43.90
IUUC-Ssl-108555	Sclerotinia sclerotiorum	32.05	3.00e-06	46.60
IUUC-Sly-111667	Solanum lycopersicum	28.99	4.00e-05	42.00
IUUC-Stu-112211	Solanum tuberosum	31.88	6.00e-06	44.30
IUUC-Sar-113609	Sorex araneus	88.57	4.00e-69	253.00
IUUC-Sre-115187	Sporisorium reilianum	34.07	2.00e-07	49.70
IUUC-Tgu-116472	Taeniopygia guttata	55.56	8.00e-53	199.00
IUUC-Tru-117771	Takifugu rubripes	35.84	9.00e-30	123.00
IUUC-Tni-119821	Tetraodon nigroviridis	37.43	7.00e-30	124.00
IUUC-Tca-121272	Theobroma cacao	26.29	4.00e-07	48.50
IUUC-Tre-122049	Trichoderma reesei	25.56	2.00e-08	53.10
IUUC-Tvi-122642	Trichoderma virens	30.23	5.00e-08	52.00
IUUC-Tme-126988	Tuber melanosporum	31.18	3.00e-07	49.30
IUUC-Tbe-127676	Tupaia belangeri	92.75	4.00e-61	226.00
IUUC-Ttr-128602	Tursiops truncatus	92.61	2.00e-85	308.00
IUUC-Uma-129520	Ustilago maydis	31.17	3.00e-06	45.80
IUUC-Vpa-130510	Vicugna pacos	92.09	2.00e-83	301.00
IUUC-Vvi-131486	Vitis vinifera	29.45	2.00e-07	49.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence