iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-29	100.9	755	791
UBD/Beta-Prp	2.60e-59	201.2	659	917

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtcla.fsdtllvsGsdDgtikvWDlrtgvll 36
           gHt+ + +l  +s+++++sGs D+t++ WDlr   ++
   Q: 755  GHTGHILALYtWSGWMIASGSQDKTVRFWDLRVPSCV 791
           89999***966977*****************988887 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkfspdksllatgsrdgtikvwdvttgkl.....lrslsgheaevtavkfspdgk....ilvtgse.Drtikvwdlstg 84
           ++hhk+ i+cv++sp ++llatgs d+ +kv  +  +++       ++s h+++++++ f +  +    il++++  D +i+  d + g
   Q: 659  NKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCnatgpDLEFSMHDGTIRDLAFMEGPEsggaILISAGAgDCNIYTTDCQRG 747
           68*****************************99999999889888899************987667778777765516788888***** PP
   S: 85   kcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee...tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk 170
           + +h+l+gh+  +l+l     g  ++sGs+d+t+r wdl+  +c++    t+ g+ ++v +v+v+p+g+ll++G  D+ ++l+d++ g+
   Q: 748  QGLHALSGHTGHILALYTWS-GWMIASGSQDKTVRFWDLRVPSCVRVvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGR 835
           **************997777.9***********************99999*************************************** PP
   S: 171  llrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlq....tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +++     h ++v+s+ f++   +l++gs+d ++k+ dlq    ++  ++ + +h+d v + r + +d  ++s s+D+++ +W
   Q: 836  MVQSYHP-HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQgdltKQLPLMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 917
           *****98.********************************99977778*********************************** PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MTAEETVNVK EVEIIKLILD FLNSKKLHIS MLALEKESGV INGLFSDDML FLRQLILDGQ 60
WDEVLQFIQP LECMEKFDKK RFRYIILKQK FLEALCVNNA MSAEDEPQHL EFTMQEAVQC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCGGTCGG AGGCGGGATA GGGGCGGACG CGAGAAGGAC CGGCTGACGA GCTGATGGAT 60
TGACGTGCGG GCTGCTGAGC CCAGACCGCC GCCCTCGCGC TCGCGCCTTA GCCTGGAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR006595--CTLH_C
IPR006594--LisH
IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50897--CTLH
PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00668--CTLH
SM00667--LisH
SM00320--WD40

KEGG

rno:310785

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001519	Ailuropoda melanoleuca	95.04	0.00e+00	1616.00
IUUC-Apl-003954	Anas platyrhynchos	90.26	0.00e+00	1538.00
IUUC-Aca-004766	Anolis carolinensis	87.65	0.00e+00	1472.00
IUUC-Ame-010725	Astyanax mexicanus	68.82	4.00e-176	611.00
IUUC-Bta-013072	Bos taurus	93.71	0.00e+00	1575.00
IUUC-Cel-018667	Caenorhabditis elegans	48.33	4.00e-94	339.00
IUUC-Cja-018835	Callithrix jacchus	94.50	0.00e+00	1600.00
IUUC-Cfa-020380	Canis familiaris	92.27	0.00e+00	972.00
IUUC-Cpo-021883	Cavia porcellus	94.79	0.00e+00	1568.00
IUUC-Csa-023467	Chlorocebus sabaeus	95.22	0.00e+00	1612.00
IUUC-Cho-024342	Choloepus hoffmanni	85.22	0.00e+00	1431.00
IUUC-Cin-025112	Ciona intestinalis	44.20	2.00e-74	271.00
IUUC-Dre-027530	Danio rerio	76.90	0.00e+00	1257.00
IUUC-Dno-029290	Dasypus novemcinctus	95.12	0.00e+00	1603.00
IUUC-Dor-030258	Dipodomys ordii	82.00	0.00e+00	1352.00
IUUC-Dme-032040	Drosophila melanogaster	53.33	6.00e-104	370.00
IUUC-Ete-032248	Echinops telfairi	87.92	0.00e+00	771.00
IUUC-Eca-033623	Equus caballus	95.44	0.00e+00	1610.00
IUUC-Fca-036425	Felis catus	93.74	0.00e+00	1419.00
IUUC-Fal-036661	Ficedula albicollis	89.38	0.00e+00	1511.00
IUUC-Gmo-039527	Gadus morhua	74.49	0.00e+00	1224.00
IUUC-Gga-041177	Gallus gallus	89.15	0.00e+00	1498.00
IUUC-Gac-042049	Gasterosteus aculeatus	73.89	0.00e+00	1232.00
IUUC-Ggo-044833	Gorilla gorilla	94.61	0.00e+00	1611.00
IUUC-Hsa-046084	Homo sapiens	94.72	0.00e+00	1612.00
IUUC-Lch-050313	Latimeria chalumnae	79.72	0.00e+00	1387.00
IUUC-Loc-051790	Lepisosteus oculatus	80.49	0.00e+00	1397.00
IUUC-Laf-053521	Loxodonta africana	94.25	0.00e+00	1583.00
IUUC-Mcc-055053	Macaca mulatta	95.22	0.00e+00	1612.00
IUUC-Meu-056734	Macropus eugenii	93.32	0.00e+00	687.00
IUUC-Mga-059381	Meleagris gallopavo	89.27	0.00e+00	1508.00
IUUC-Mmr-060859	Microcebus murinus	94.83	0.00e+00	1605.00
IUUC-Mdo-062501	Monodelphis domestica	91.20	0.00e+00	1449.00
IUUC-Mmu-063126	Mus musculus	98.05	0.00e+00	1650.00
IUUC-Mpu-066718	Mustela putorius furo	95.25	0.00e+00	1270.00
IUUC-Mlu-067246	Myotis lucifugus	94.79	0.00e+00	1597.00
IUUC-Nle-069807	Nomascus leucogenys	94.72	0.00e+00	1612.00
IUUC-Opr-070862	Ochotona princeps	66.36	3.00e-87	316.00
IUUC-Ont-072519	Oreochromis niloticus	76.21	0.00e+00	1252.00
IUUC-Oan-072740	Ornithorhynchus anatinus	87.81	0.00e+00	776.00
IUUC-Ocu-074898	Oryctolagus cuniculus	95.77	0.00e+00	1587.00
IUUC-Ola-086396	Oryzias latipes	76.21	0.00e+00	1285.00
IUUC-Oga-088563	Otolemur garnettii	94.07	0.00e+00	1600.00
IUUC-Oar-089926	Ovis aries	95.01	0.00e+00	1603.00
IUUC-Ptr-090706	Pan troglodytes	94.61	0.00e+00	1608.00
IUUC-Pan-091740	Papio anubis	95.33	0.00e+00	1613.00
IUUC-Psi-093938	Pelodiscus sinensis	89.12	0.00e+00	1524.00
IUUC-Pfo-096531	Poecilia formosa	76.67	0.00e+00	1255.00
IUUC-Pab-098312	Pongo abelii	95.11	0.00e+00	1613.00
IUUC-Pca-101100	Procavia capensis	88.69	0.00e+00	721.00
IUUC-Pva-102734	Pteropus vampyrus	90.61	0.00e+00	713.00
IUUC-Sha-106999	Sarcophilus harrisii	89.18	0.00e+00	1493.00
IUUC-Sar-112988	Sorex araneus	83.29	0.00e+00	1164.00
IUUC-Ssc-115384	Sus scrofa	95.23	0.00e+00	1580.00
IUUC-Tgu-116808	Taeniopygia guttata	89.07	0.00e+00	1506.00
IUUC-Tru-118233	Takifugu rubripes	76.15	0.00e+00	1224.00
IUUC-Tsy-119509	Tarsius syrichta	98.67	0.00e+00	677.00
IUUC-Tni-120473	Tetraodon nigroviridis	74.30	0.00e+00	1244.00
IUUC-Tbe-127447	Tupaia belangeri	90.43	1.00e-145	509.00
IUUC-Ttr-128459	Tursiops truncatus	92.84	0.00e+00	1481.00
IUUC-Vpa-130258	Vicugna pacos	89.42	0.00e+00	982.00
IUUC-Xtr-132609	Xenopus tropicalis	79.46	0.00e+00	1322.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence