iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046881

Ensembl Protein ID

ENSP00000411397.2

UniProt Accession

P27448; O60219; Q86TT8; Q8TB41; Q8WX83; Q96RG1; Q9UMY9; Q9UN34; MARK3_HUMAN

Genbank Protein ID

AAC15093.1; AAD48007.1; AAK82367.1; AAL69982.1; AAA59991.1; CAD61882.1; AAH24773.1; AAD51631.1

Protein Name

MAP/microtubule affinity-regulating kinase 3; C-TAK1; Cdc25C-associated protein kinase 1; ELKL motif kinase 2; Protein kinase STK10; Ser/Thr protein kinase PAR-1; Serine/threonine-protein kinase p78

Genbank Nucleotide ID

U64205; AF159295; AF387637; AF465413; M80359; BX161395; AL133367; AF170723

Gene Name

MARK3; CTAK1; EMK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000075413.17	ENST00000440884.7	ENSP00000402104.3
ENSG00000075413.17	ENST00000416682.6	ENSP00000408092.2
ENSG00000075413.17	ENST00000429436.6	ENSP00000411397.2
ENSG00000075413.17	ENST00000303622.13	ENSP00000303698.9
ENSG00000075413.17	ENST00000216288.11	ENSP00000216288.7
ENSG00000075413.17	ENST00000553942.5	ENSP00000450772.1
ENSG00000075413.17	ENST00000560417.5	ENSP00000454169.1
ENSG00000075413.17	ENST00000335102.9	ENSP00000335347.5
ENSG00000075413.17	ENST00000561225.1	ENSP00000452829.1
ENSG00000075413.17	ENST00000554627.5	ENSP00000450460.1
ENSG00000075413.17	ENST00000561314.5	ENSP00000452893.1
ENSG00000075413.17	ENST00000556744.1	ENSP00000451623.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	17726107

Organism

Homo sapiens

Functional Description
(View)

Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.

Protein Sequence
(Fasta)

MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTSRSGARCR NSIASCADEQ PHIGNYRLLK 60
TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAAGCCGAG GGGCGGCCAT CTTGGCTCCG TGAGGCTCTG AGGTGCCGGG GTGCGGCGGC 60
GGCAGCGGCG GCCAGCAGGG CGGAGGCTGA GGCAGCAAGC TCGCTAGAGA GGGAGAAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0418--Kinase
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR028375--KA1/Ssp2_C
IPR001772--KA1_dom
IPR011009--Kinase-like_dom
IPR033624--MARK/par1
IPR033628--MARK3
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA

PROSITE

PS50032--KA1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA

Pfam

PF02149--KA1
PF00069--Pkinase
PF00627--UBA

SMART

SM00220--S_TKc
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0030010--P:establishment of cell polarity
GO:0000165--P:MAPK cascade
GO:0000226--P:microtubule cytoskeleton organization

KEGG

hsa:4140

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004735	Anolis carolinensis	83.35	0.00e+00	1306.00
IUUC-Cfa-020081	Canis familiaris	98.33	0.00e+00	1365.00
IUUC-Cpo-022503	Cavia porcellus	97.35	0.00e+00	1449.00
IUUC-Dre-028387	Danio rerio	85.62	0.00e+00	1255.00
IUUC-Dno-029052	Dasypus novemcinctus	98.14	0.00e+00	1441.00
IUUC-Eca-033300	Equus caballus	98.78	0.00e+00	1440.00
IUUC-Fca-036517	Felis catus	97.83	0.00e+00	1394.00
IUUC-Fal-037115	Ficedula albicollis	88.03	0.00e+00	1194.00
IUUC-Gga-040502	Gallus gallus	87.62	0.00e+00	1367.00
IUUC-Lch-049922	Latimeria chalumnae	92.18	0.00e+00	1346.00
IUUC-Loc-052896	Lepisosteus oculatus	90.74	0.00e+00	1329.00
IUUC-Laf-054590	Loxodonta africana	97.15	0.00e+00	1382.00
IUUC-Mcc-054721	Macaca mulatta	99.73	0.00e+00	1489.00
IUUC-Mmr-060647	Microcebus murinus	97.74	0.00e+00	1434.00
IUUC-Mdo-062445	Monodelphis domestica	83.33	0.00e+00	1311.00
IUUC-Mpu-066504	Mustela putorius furo	98.51	0.00e+00	1402.00
IUUC-Opr-070418	Ochotona princeps	81.93	0.00e+00	1125.00
IUUC-Ont-072503	Oreochromis niloticus	74.66	0.00e+00	1159.00
IUUC-Oan-072929	Ornithorhynchus anatinus	96.09	0.00e+00	1384.00
IUUC-Ocu-073853	Oryctolagus cuniculus	97.88	0.00e+00	1466.00
IUUC-Oar-090325	Ovis aries	95.99	0.00e+00	1420.00
IUUC-Pan-092891	Papio anubis	93.29	0.00e+00	1465.00
IUUC-Psi-092994	Pelodiscus sinensis	96.28	0.00e+00	1404.00
IUUC-Pca-100880	Procavia capensis	90.92	0.00e+00	991.00
IUUC-Ptt-103944	Puccinia triticina	44.73	3.00e-67	251.00
IUUC-Sha-107115	Sarcophilus harrisii	96.15	0.00e+00	1442.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence