iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.30e-16	58.6	196	231
UBD/Beta-Prp	1.90e-44	153.1	17	263

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 4    dsvtclaf.sdtllvsGsdDgtikvWDlrtgvllks 38
           + v+++af sd++++s    g++++WD  tg+l+ks
   Q: 196  CIVWGVAFlSDGTVISVDSVGKVQLWDSATGTLVKS 231
           56899999*99888999999**********999875 PP

UBD/Beta-Prp

   S: 11   svitcvkfspdksllatgsrdgtikvwdvttgkllrsl.sghea.evtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           s i+cv++ ++++ la++ +dgt+++++++   + +++  ghe+ ++ a+++   +  l +++  + i  +dl++  + +tl +    +
   Q: 17   SGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFfPGHESrGTEALCWAGGQ-RLFSAGLNGEILEYDLQALNIKYTLDAFGGPI 104
           5689******************************9999988865279999999998.77777777777779****************** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqclee.tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl...tgghtds 182
           +s++ spsg+ l++G +d  ++++++  ++   +  ++ +++ + ++++hp g  +++GslD  + ++d+k+g+++r++   +  ++  
   Q: 105  WSMTASPSGSQLLVGCEDGSVKLFEVTPEKIQFArNFDRQKSRILSLCWHPAGTHVAAGSLDY-ISVFDVKSGSIIRKMvldR--QHLG 190
           *************************98776554449999999********************7.9**************9752..4444 PP
   S: 183  vysls.......fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           v++         f s+g  ++s++  g+v+lwd  tg+ v++    ++ v+s+++ ++++ +v+g+++g+++ +
   Q: 191  VTKSRcivwgvaFLSDG-TVISVDSVGKVQLWDSATGTLVKSHLVANADVQSIAVADQEDSFVVGTAEGTVFHF 263
           44444455666788887.9****************************************************987 PP

Organism

Mus musculus

Functional Description
(View)

May be a transcriptional regulator. Acts as a positive regulator of HIVEP1. Ribosome biogenesis factor involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b.

Protein Sequence
(Fasta)

MGEFKVHRVR FFNYVPSGIR CVAYNNQSNR LAVSRTDGTV EIYNLSANYF QEKFFPGHES 60
RGTEALCWAG GQRLFSAGLN GEILEYDLQA LNIKYTLDAF GGPIWSMTAS PSGSQLLVGC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTCGAGTGC GCAAGCGCGC ACGTGGGGCC GGGGCGGAGA GAAGCGAGGT CCGGGGTTGG 60
CGAGTTCCCG GCGGTAGGTG AGTTCGGGGA GAACTCCGGG GGCAGCTAAA ACCCACTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0158--Chromosome
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0698--rRNA processing
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005694--C:chromosome
GO:0001650--C:fibrillar center
GO:0005730--C:nucleolus
GO:0034455--C:t-UTP complex
GO:0003723--F:RNA binding
GO:0030490--P:maturation of SSU-rRNA
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:21771

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001161	Aegilops tauschii	25.97	2.00e-47	184.00
IUUC-Aml-001310	Ailuropoda melanoleuca	90.52	0.00e+00	1325.00
IUUC-Atr-003076	Amborella trichopoda	23.49	1.00e-36	148.00
IUUC-Apl-003367	Anas platyrhynchos	56.57	7.00e-55	206.00
IUUC-Aca-004429	Anolis carolinensis	59.03	1.00e-139	489.00
IUUC-Aly-006271	Arabidopsis lyrata	23.58	6.00e-41	162.00
IUUC-Ath-007331	Arabidopsis thaliana	24.93	8.00e-40	159.00
IUUC-Ago-007843	Ashbya gossypii	25.33	1.00e-40	161.00
IUUC-Acl-008229	Aspergillus clavatus	25.69	6.00e-40	159.00
IUUC-Afl-008438	Aspergillus flavus	26.22	3.00e-40	160.00
IUUC-Afu-008910	Aspergillus fumigatus	24.76	6.00e-36	146.00
IUUC-Ani-009321	Aspergillus nidulans	28.96	7.00e-39	155.00
IUUC-Ang-009592	Aspergillus niger	26.40	1.00e-41	165.00
IUUC-Aor-010220	Aspergillus oryzae	25.75	5.00e-40	159.00
IUUC-Ate-010317	Aspergillus terreus	26.18	3.00e-39	157.00
IUUC-Ame-010957	Astyanax mexicanus	53.34	0.00e+00	771.00
IUUC-Bgr-012057	Blumeria graminis	27.13	9.00e-40	159.00
IUUC-Bta-012473	Bos taurus	87.34	0.00e+00	1277.00
IUUC-Bdi-014203	Brachypodium distachyon	23.50	2.00e-40	161.00
IUUC-Bol-016163	Brassica oleracea	25.00	4.00e-48	186.00
IUUC-Bra-017482	Brassica rapa	24.70	2.00e-47	184.00
IUUC-Cja-019942	Callithrix jacchus	88.34	0.00e+00	1296.00
IUUC-Cfa-020549	Canis familiaris	90.04	0.00e+00	924.00
IUUC-Cpo-022088	Cavia porcellus	90.38	0.00e+00	1300.00
IUUC-Csa-023773	Chlorocebus sabaeus	89.80	0.00e+00	1310.00
IUUC-Cho-024302	Choloepus hoffmanni	86.64	0.00e+00	1038.00
IUUC-Cin-025384	Ciona intestinalis	33.91	7.00e-115	408.00
IUUC-Dre-027460	Danio rerio	52.98	0.00e+00	763.00
IUUC-Dno-029594	Dasypus novemcinctus	88.47	0.00e+00	1254.00
IUUC-Dor-030564	Dipodomys ordii	86.14	0.00e+00	794.00
IUUC-Dse-031179	Dothistroma septosporum	25.38	9.00e-35	142.00
IUUC-Dme-031603	Drosophila melanogaster	25.00	2.00e-57	217.00
IUUC-Ete-032655	Echinops telfairi	81.92	0.00e+00	1179.00
IUUC-Eca-033838	Equus caballus	90.38	0.00e+00	1320.00
IUUC-Eeu-034548	Erinaceus europaeus	86.01	0.00e+00	1247.00
IUUC-Fca-035715	Felis catus	90.09	0.00e+00	1318.00
IUUC-Fal-037394	Ficedula albicollis	56.45	0.00e+00	748.00
IUUC-Gmo-039235	Gadus morhua	47.67	0.00e+00	682.00
IUUC-Ggr-040043	Gaeumannomyces graminis	27.14	7.00e-33	135.00
IUUC-Gga-041172	Gallus gallus	60.03	0.00e+00	865.00
IUUC-Gac-042466	Gasterosteus aculeatus	53.56	0.00e+00	768.00
IUUC-Gma-044222	Glycine max	25.33	2.00e-42	167.00
IUUC-Ggo-045416	Gorilla gorilla	86.65	0.00e+00	1251.00
IUUC-Hsa-046115	Homo sapiens	89.64	0.00e+00	1274.00
IUUC-Hvu-047229	Hordeum vulgare	24.81	2.00e-44	174.00
IUUC-Itr-048015	Ictidomys tridecemlineatus	90.38	0.00e+00	1320.00
IUUC-Kpa-049370	Komagataella pastoris	20.91	1.00e-31	131.00
IUUC-Lch-050153	Latimeria chalumnae	58.23	0.00e+00	834.00
IUUC-Lpe-051220	Leersia perrieri	24.61	1.00e-45	178.00
IUUC-Loc-052617	Lepisosteus oculatus	53.75	0.00e+00	797.00
IUUC-Laf-053613	Loxodonta africana	87.32	0.00e+00	1272.00
IUUC-Mcc-055707	Macaca mulatta	89.52	0.00e+00	1273.00
IUUC-Meu-056800	Macropus eugenii	65.55	0.00e+00	785.00
IUUC-Mor-057245	Magnaporthe oryzae	27.59	5.00e-31	129.00
IUUC-Mpo-057446	Magnaporthe poae	27.56	4.00e-32	133.00
IUUC-Mtr-058748	Medicago truncatula	23.45	2.00e-42	167.00
IUUC-Mga-060018	Meleagris gallopavo	59.70	0.00e+00	834.00
IUUC-Mmr-061115	Microcebus murinus	89.65	0.00e+00	1289.00
IUUC-Mdo-062235	Monodelphis domestica	75.07	0.00e+00	1118.00
IUUC-Mac-065380	Musa acuminata	24.64	2.00e-53	204.00
IUUC-Mpu-065805	Mustela putorius furo	89.94	0.00e+00	1322.00
IUUC-Mlu-066951	Myotis lucifugus	88.34	0.00e+00	1285.00
IUUC-Nfi-068295	Neosartorya fischeri	24.64	2.00e-37	151.00
IUUC-Ncr-068880	Neurospora crassa	25.61	1.00e-38	155.00
IUUC-Nle-069657	Nomascus leucogenys	90.09	0.00e+00	1321.00
IUUC-Opr-070250	Ochotona princeps	87.32	0.00e+00	1263.00
IUUC-Ont-072642	Oreochromis niloticus	52.11	0.00e+00	736.00
IUUC-Ocu-074741	Oryctolagus cuniculus	88.92	0.00e+00	1299.00
IUUC-Oba-074974	Oryza barthii	23.87	1.00e-45	178.00
IUUC-Obr-076586	Oryza brachyantha	25.69	2.00e-42	167.00
IUUC-Ogl-077782	Oryza glaberrima	24.27	2.00e-48	187.00
IUUC-Ogu-078333	Oryza glumaepatula	24.55	1.00e-43	172.00
IUUC-Oin-079852	Oryza indica	25.03	2.00e-49	190.00
IUUC-Olo-080370	Oryza longistaminata	26.84	7.00e-40	158.00
IUUC-Ome-081442	Oryza meridionalis	24.16	2.00e-48	187.00
IUUC-Oni-082341	Oryza nivara	24.55	8.00e-44	172.00
IUUC-Opu-083824	Oryza punctata	24.15	2.00e-47	184.00
IUUC-Oru-084827	Oryza rufipogon	24.11	2.00e-47	184.00
IUUC-Osa-085742	Oryza sativa	24.48	5.00e-50	192.00
IUUC-Ola-086466	Oryzias latipes	53.39	0.00e+00	746.00
IUUC-Olu-087761	Ostreococcus lucimarinus	24.64	2.00e-51	197.00
IUUC-Oga-088721	Otolemur garnettii	82.50	0.00e+00	1162.00
IUUC-Oar-089532	Ovis aries	88.34	0.00e+00	1290.00
IUUC-Ptr-091604	Pan troglodytes	89.80	0.00e+00	1313.00
IUUC-Pan-092060	Papio anubis	91.49	0.00e+00	756.00
IUUC-Psi-093070	Pelodiscus sinensis	59.48	0.00e+00	842.00
IUUC-Pma-094201	Petromyzon marinus	49.79	2.00e-140	492.00
IUUC-Ppa-095599	Physcomitrella patens	28.61	5.00e-32	133.00
IUUC-Pfo-097207	Poecilia formosa	51.09	0.00e+00	720.00
IUUC-Pab-097746	Pongo abelii	89.80	0.00e+00	1311.00
IUUC-Pop-099669	Populus trichocarpa	24.79	1.00e-54	207.00
IUUC-Pca-100562	Procavia capensis	78.45	0.00e+00	901.00
IUUC-Ppe-101747	Prunus persica	23.59	1.00e-49	191.00
IUUC-Pva-103054	Pteropus vampyrus	88.92	0.00e+00	1304.00
IUUC-Pte-104064	Pyrenophora teres	24.83	8.00e-29	122.00
IUUC-Pyt-104595	Pyrenophora triticirepentis	25.86	3.00e-31	130.00
IUUC-Rno-105155	Rattus norvegicus	97.23	0.00e+00	1399.00
IUUC-Sce-106369	Saccharomyces cerevisiae	24.50	3.00e-45	176.00
IUUC-Sha-107149	Sarcophilus harrisii	74.64	0.00e+00	1115.00
IUUC-Sja-107777	Schizosaccharomyces japonicus	28.44	1.00e-66	247.00
IUUC-Spo-108372	Schizosaccharomyces pombe	28.21	6.00e-70	258.00
IUUC-Ssl-108650	Sclerotinia sclerotiorum	28.10	3.00e-44	173.00
IUUC-Smo-108851	Selaginella moellendorffii	23.53	4.00e-51	196.00
IUUC-Sit-110454	Setaria italica	25.42	1.00e-43	172.00
IUUC-Sly-111875	Solanum lycopersicum	25.15	1.00e-51	198.00
IUUC-Stu-112275	Solanum tuberosum	23.82	2.00e-45	177.00
IUUC-Sar-113254	Sorex araneus	76.82	0.00e+00	685.00
IUUC-Sbi-114624	Sorghum bicolor	25.35	2.00e-43	170.00
IUUC-Sre-114985	Sporisorium reilianum	21.68	1.00e-17	85.50
IUUC-Tgu-117407	Taeniopygia guttata	58.37	2.00e-143	501.00
IUUC-Tru-118733	Takifugu rubripes	48.18	0.00e+00	687.00
IUUC-Tsy-119213	Tarsius syrichta	78.67	0.00e+00	1010.00
IUUC-Tni-120894	Tetraodon nigroviridis	48.50	6.00e-98	350.00
IUUC-Tca-121606	Theobroma cacao	24.02	2.00e-44	174.00
IUUC-Tre-121958	Trichoderma reesei	25.05	2.00e-37	151.00
IUUC-Tvi-122290	Trichoderma virens	26.29	2.00e-38	154.00
IUUC-Tae-125441	Triticum aestivum	25.77	2.00e-46	181.00
IUUC-Tme-126995	Tuber melanosporum	25.89	2.00e-33	137.00
IUUC-Tbe-127605	Tupaia belangeri	72.00	8.00e-67	248.00
IUUC-Ttr-128720	Tursiops truncatus	87.76	0.00e+00	1280.00
IUUC-Uma-129564	Ustilago maydis	21.31	3.00e-17	84.70
IUUC-Vpa-130412	Vicugna pacos	89.02	6.00e-134	471.00
IUUC-Vvi-131256	Vitis vinifera	23.80	1.00e-49	191.00
IUUC-Xtr-131828	Xenopus tropicalis	55.51	0.00e+00	800.00
IUUC-Xma-133394	Xiphophorus maculatus	52.17	0.00e+00	732.00
IUUC-Yli-134565	Yarrowia lipolytica	29.12	4.00e-36	146.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence