iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053916

UUCD1 version

UUC-LoA-01062

Ensembl Protein ID

ENSLAFP00000027182.1

UniProt Accession

G3UH74; G3UH74_LOXAF

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Gene Name

UCHL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000002494.2	ENSLAFT00000025588.1	ENSLAFP00000027182.1
ENSLAFG00000002494.2	ENSLAFT00000002494.2	ENSLAFP00000002083.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.50e-64	218.9	4	228

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqv 94
           +++ ++e +P+++++++ ++gv +++++ ++ +L++e+lg+++ p ++llllF+++ ++e++rk+q++    e ++++i  +++f+kq+
   Q: 4    MQLKPMEINPEMLNKVLARLGVAGQWRFVDVLGLEEETLGSVPAPACALLLLFPLTAQHENFRKKQIE----ELKGQEISPKVYFMKQT 88
           57889*************************************************************99....99*************** PP
   S: 95   igNsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvs 182
           igNsC+t +l+++++n++dkl ++ G+ l++++++t+++spe++a++++++++++++h+++a++++++  + +       +k +fhf++
   Q: 89   IGNSCGTVGLIHAVANNQDKLeFENGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRPVKVD-------DKVNFHFIL 170
           *****************************************************************99866544.......5789***** PP
   S: 183  yvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivad 244
           + n++g+lyeldg++pfP+++g + e+  l+d++kv+r+f+er    e++e+rf+++a++++
   Q: 171  FNNVDGHLYELDGRMPFPVNHGTSAEDSLLQDAAKVCREFTER----EQGEVRFSAVALCKA 228
           *******************************************....***********9986 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

FSKMQLKPME INPEMLNKVL ARLGVAGQWR FVDVLGLEEE TLGSVPAPAC ALLLLFPLTA 60
QHENFRKKQI EELKGQEISP KVYFMKQTIG NSCGTVGLIH AVANNQDKLE FENGSVLKQF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCTCGAAGA TGCAGCTCAA ACCGATGGAG ATTAACCCCG AGGTGAGCGC CAGGTGCACA 60
GATGCCCAGG GAGTGCAGGC GCAGGTGCAG CCTTGGCTAG GCAGCCGTAT CCTGGACTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR030297--UCHL1

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0044306--C:neuron projection terminus
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0016874--F:ligase activity
GO:0008242--F:omega peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007628--P:adult walking behavior
GO:0007412--P:axon target recognition
GO:0019896--P:axonal transport of mitochondrion
GO:0008283--P:cell proliferation
GO:0042755--P:eating behavior
GO:0048747--P:muscle fiber development
GO:0043407--P:negative regulation of MAP kinase activity
GO:0050905--P:neuromuscular process
GO:0016579--P:protein deubiquitination
GO:0002931--P:response to ischemia
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001376	Ailuropoda melanoleuca	78.68	1.00e-110	392.00
IUUC-Apl-003693	Anas platyrhynchos	68.58	3.00e-89	320.00
IUUC-Aca-004716	Anolis carolinensis	73.33	2.00e-99	354.00
IUUC-Ame-011806	Astyanax mexicanus	67.56	9.00e-86	309.00
IUUC-Bta-013521	Bos taurus	80.31	6.00e-113	399.00
IUUC-Cja-018752	Callithrix jacchus	94.69	9.00e-116	409.00
IUUC-Cfa-020442	Canis familiaris	94.69	1.00e-115	408.00
IUUC-Cpo-021723	Cavia porcellus	95.24	3.00e-93	333.00
IUUC-Csa-023626	Chlorocebus sabaeus	94.22	1.00e-115	408.00
IUUC-Cho-024548	Choloepus hoffmanni	84.26	1.00e-40	159.00
IUUC-Dre-027854	Danio rerio	66.37	8.00e-86	309.00
IUUC-Dno-029325	Dasypus novemcinctus	95.56	4.00e-117	413.00
IUUC-Dor-030114	Dipodomys ordii	92.89	9.00e-125	438.00
IUUC-Ete-033092	Echinops telfairi	76.44	2.00e-95	341.00
IUUC-Eca-033854	Equus caballus	94.44	5.00e-78	282.00
IUUC-Eeu-034493	Erinaceus europaeus	91.11	1.00e-111	395.00
IUUC-Fal-036693	Ficedula albicollis	72.04	3.00e-90	324.00
IUUC-Gmo-038848	Gadus morhua	62.15	1.00e-76	278.00
IUUC-Gga-041078	Gallus gallus	72.89	5.00e-99	353.00
IUUC-Gac-042064	Gasterosteus aculeatus	61.71	2.00e-78	284.00
IUUC-Ggo-044827	Gorilla gorilla	94.22	5.00e-116	409.00
IUUC-Hsa-045820	Homo sapiens	94.22	5.00e-116	409.00
IUUC-Itr-048496	Ictidomys tridecemlineatus	95.11	1.00e-116	411.00
IUUC-Lch-050121	Latimeria chalumnae	71.81	1.00e-96	345.00
IUUC-Loc-052342	Lepisosteus oculatus	69.43	1.00e-91	328.00
IUUC-Mcc-054838	Macaca mulatta	94.22	1.00e-115	408.00
IUUC-Meu-056478	Macropus eugenii	85.78	1.00e-117	414.00
IUUC-Mga-059878	Meleagris gallopavo	71.56	5.00e-93	333.00
IUUC-Mdo-062544	Monodelphis domestica	85.27	1.00e-106	378.00
IUUC-Mmu-063300	Mus musculus	94.22	5.00e-126	442.00
IUUC-Mpu-066128	Mustela putorius furo	93.10	9.00e-102	362.00
IUUC-Mlu-067778	Myotis lucifugus	94.67	7.00e-126	442.00
IUUC-Nle-069686	Nomascus leucogenys	94.22	8.00e-116	409.00
IUUC-Opr-070535	Ochotona princeps	77.33	3.00e-97	347.00
IUUC-Ont-071510	Oreochromis niloticus	62.50	1.00e-80	292.00
IUUC-Ocu-074590	Oryctolagus cuniculus	94.67	3.00e-116	410.00
IUUC-Oga-089013	Otolemur garnettii	79.92	3.00e-111	394.00
IUUC-Oar-089861	Ovis aries	80.31	5.00e-113	400.00
IUUC-Ptr-091536	Pan troglodytes	92.44	1.00e-113	402.00
IUUC-Pan-092909	Papio anubis	94.22	1.00e-115	408.00
IUUC-Psi-093818	Pelodiscus sinensis	76.44	2.00e-101	361.00
IUUC-Pfo-097335	Poecilia formosa	59.11	1.00e-78	285.00
IUUC-Pab-098048	Pongo abelii	94.22	5.00e-116	409.00
IUUC-Pca-100818	Procavia capensis	72.73	2.00e-67	248.00
IUUC-Pva-102954	Pteropus vampyrus	93.33	3.00e-111	394.00
IUUC-Pyt-104587	Pyrenophora triticirepentis	37.50	1.00e-31	129.00
IUUC-Rno-105966	Rattus norvegicus	94.22	5.00e-126	442.00
IUUC-Sha-107111	Sarcophilus harrisii	84.43	2.00e-84	303.00
IUUC-Sar-113190	Sorex araneus	71.55	5.00e-36	142.00
IUUC-Ssc-115908	Sus scrofa	77.09	5.00e-98	349.00
IUUC-Tgu-117465	Taeniopygia guttata	68.72	1.00e-85	308.00
IUUC-Tru-118565	Takifugu rubripes	60.19	9.00e-71	259.00
IUUC-Tsy-119561	Tarsius syrichta	75.56	3.00e-94	337.00
IUUC-Tbe-128048	Tupaia belangeri	92.81	6.00e-91	325.00
IUUC-Ttr-128494	Tursiops truncatus	92.89	9.00e-113	399.00
IUUC-Vda-129850	Verticillium dahliae	34.20	2.00e-29	122.00
IUUC-Xtr-132286	Xenopus tropicalis	67.86	5.00e-89	320.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence