iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001592

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01052601

Gene Name

CUL4A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000010104.1	ENSAMET00000011188.1	ENSAMEP00000010727.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	6.60e-216	718.8	28	624

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 1    klreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqv.kkkveesedeq.lLktynreWekfreqlkvlrki 86
           kl+eavk+i++++s+++++eely+av+nlc++kv+  lY++l++v+e+++ +q+ ++   +s d+  +Lk++n++W+++++q+ ++r+i
   Q: 28   KLHEAVKAIQSSTSIRYNLEELYQAVENLCSHKVSPTLYRQLRQVCEDHVqAQIlQQVCTDSLDSVlFLKKINTCWQDHCRQMIMIRSI 116
           5899**********************************************9888355568999999*********************** PP
   S: 87   fayldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfl 173
           f++ldrtyv +++++ ++++++l+l+r++i++d  ++++ ++ +l lie+eR+geavdr+ll+++ ++l++L     ++yk+sFE kfl
   Q: 117  FLFLDRTYVLQNSMLPSIWDMGLELFRNHIISDkmVQSKSIDGILLLIERERNGEAVDRSLLRSLLSMLSDL-----QVYKDSFELKFL 200
           ********************************************************************9998.....9*********** PP
   S: 174  eatqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll.aelvallrdkktedlsrmykL 261
           e+t+ +y+ae ++++qe+ev eYl++v +rl+ee +r+ +yl++st+++L+++vek+l+ +hl+++l ++l++ll++++  dl++my+L
   Q: 201  EETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILhKGLEHLLDENRVPDLTQMYQL 289
           ****************************************************************9988********************* PP
   S: 262  lsrvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaaksp. 349
           +srv+ g + ll++++ +ik+ g+++++++ek+kd   +V++ll++k++++++++ +F+ ++kF++ ++++fetf+nk+     +++p 
   Q: 290  FSRVKGGQQVLLQHWSDYIKTFGTTIVINPEKDKD---MVQDLLDFKDRVDHVIEVCFQRNEKFVNLMKESFETFINKR-----PNKPa 370
           ***********************************...*****************************************.....66666 PP
   S: 350  EllAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMf 438
           El+A+++D++Lr+++k++t+eele++ldkv+++f++i++kdvFe++Ykk+LakRLl+gksas +aE+s+++kLk+ecga+ftskLe+Mf
   Q: 371  ELIAKHVDSKLRAGNKEATDEELERILDKVMIIFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMF 459
           ***************************************************************************************** PP
   S: 439  qdlkvSedlnrqFkeekenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelk 527
           +d+++S+d++ qFk+ ++n+++  s++l+v++L++g+Wpt++ +e v+L++e+ k++e f++fYl kh  RkLqWq+tlg+a lkae+k
   Q: 460  KDMELSKDIMVQFKQYMQNQSDPGSIDLTVNILTMGYWPTYTPME-VHLTPEMVKLQEVFKTFYLRKHRDRKLQWQTTLGHAVLKAEFK 547
           *****************************************9999.******************************************* PP
   S: 528  kgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
           +gk+e+qVs fQ++vLL+fn+ + +s+ee+k+at+++++eLrrtlqsL+++k++vl k+p++ke+e++d+f++N ef
   Q: 548  EGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLVKSPKGKEVEDGDTFTFNGEF 624
           **************************************************************************999 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

GCSSSLMLSG FTDRPKLPDN YTQDTWQKLH EAVKAIQSST SIRYNLEELY QAVENLCSHK 60
VSPTLYRQLR QVCEDHVQAQ ILQQVCTDSL DSVLFLKKIN TCWQDHCRQM IMIRSIFLFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGATGCTCGT CCTCACTGAT GCTCTCTGGA TTCACAGACA GACCTAAACT GCCTGACAAC 60
TACACTCAGG ACACCTGGCA GAAGCTCCAC GAGGCCGTGA AAGCCATACA GAGCAGCACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0030097--P:hemopoiesis
GO:0001701--P:in utero embryonic development
GO:0030853--P:negative regulation of granulocyte differentiation
GO:0008284--P:positive regulation of cell proliferation
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:2000001--P:regulation of DNA damage checkpoint
GO:2000819--P:regulation of nucleotide-excision repair
GO:0051246--P:regulation of protein metabolic process
GO:0035019--P:somatic stem cell population maintenance

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003269	Anas platyrhynchos	91.84	0.00e+00	1323.00
IUUC-Bta-012355	Bos taurus	94.72	0.00e+00	1384.00
IUUC-Cja-019861	Callithrix jacchus	92.75	0.00e+00	1355.00
IUUC-Cfa-021009	Canis familiaris	97.07	0.00e+00	1406.00
IUUC-Cpo-021867	Cavia porcellus	93.59	0.00e+00	1363.00
IUUC-Csa-024139	Chlorocebus sabaeus	93.44	0.00e+00	1360.00
IUUC-Cho-024899	Choloepus hoffmanni	96.23	0.00e+00	1010.00
IUUC-Cme-027355	Cyanidioschyzon merolae	31.73	2.00e-109	389.00
IUUC-Dno-028879	Dasypus novemcinctus	87.86	0.00e+00	1279.00
IUUC-Dor-030698	Dipodomys ordii	92.65	0.00e+00	1343.00
IUUC-Ete-033101	Echinops telfairi	89.47	0.00e+00	1269.00
IUUC-Eca-033696	Equus caballus	95.16	0.00e+00	1384.00
IUUC-Fca-036333	Felis catus	97.33	0.00e+00	1407.00
IUUC-Fal-036995	Ficedula albicollis	91.23	0.00e+00	1330.00
IUUC-Gga-040358	Gallus gallus	90.55	0.00e+00	1344.00
IUUC-Hsa-045679	Homo sapiens	93.44	0.00e+00	1362.00
IUUC-Itr-048182	Ictidomys tridecemlineatus	92.74	0.00e+00	1269.00
IUUC-Laf-054100	Loxodonta africana	95.15	0.00e+00	1371.00
IUUC-Mcc-055168	Macaca mulatta	94.23	0.00e+00	1251.00
IUUC-Meu-056492	Macropus eugenii	82.91	5.00e-162	564.00
IUUC-Mga-059866	Meleagris gallopavo	92.42	0.00e+00	1342.00
IUUC-Mmr-061551	Microcebus murinus	92.90	0.00e+00	1355.00
IUUC-Mdo-062215	Monodelphis domestica	93.87	0.00e+00	1380.00
IUUC-Mmu-063402	Mus musculus	93.48	0.00e+00	1365.00
IUUC-Mpu-066383	Mustela putorius furo	97.90	0.00e+00	1419.00
IUUC-Mlu-067450	Myotis lucifugus	91.12	0.00e+00	1316.00
IUUC-Nle-069606	Nomascus leucogenys	93.31	0.00e+00	1362.00
IUUC-Opr-070671	Ochotona princeps	84.11	8.00e-115	407.00
IUUC-Oan-073299	Ornithorhynchus anatinus	89.40	0.00e+00	1311.00
IUUC-Ocu-074731	Oryctolagus cuniculus	93.76	0.00e+00	1372.00
IUUC-Oar-089346	Ovis aries	93.87	0.00e+00	1375.00
IUUC-Ptr-091177	Pan troglodytes	93.44	0.00e+00	1362.00
IUUC-Pan-092191	Papio anubis	93.60	0.00e+00	1369.00
IUUC-Pab-097622	Pongo abelii	93.17	0.00e+00	1359.00
IUUC-Pca-100391	Procavia capensis	84.79	0.00e+00	1001.00
IUUC-Rno-105829	Rattus norvegicus	93.22	0.00e+00	1365.00
IUUC-Sha-106762	Sarcophilus harrisii	93.33	0.00e+00	1320.00
IUUC-Ssc-116133	Sus scrofa	93.73	0.00e+00	1351.00
IUUC-Tgu-116961	Taeniopygia guttata	91.38	0.00e+00	1339.00
IUUC-Tre-121907	Trichoderma reesei	40.03	3.00e-126	446.00
IUUC-Tvi-122568	Trichoderma virens	39.60	1.00e-128	453.00
IUUC-Ttr-128326	Tursiops truncatus	88.66	0.00e+00	1177.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence