iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
CPLM	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-68	231.8	215	521

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +GlkN+g+tCYmNS+LQ+L+++++lr+++    + +      +++++++  +lq++f el ++++k v +++l+k++++e   +++++q
   Q: 215  VGLKNQGATCYMNSLLQTLFFTNQLRKAVYM-MPTEG-----DDSSKSVPLALQRVFYEL-QHSDKPVGTKKLTKSFGWET--LDSFMQ 294
           6******************************.44433.....466889************.88889************887..67**** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +D+qE++++lld++e+++                          k +  + +i +lF+g++ s i+c+e d +s r+e+ +d++l+++g
   Q: 295  HDVQELCRVLLDNVENKM--------------------------KGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKG 357
           ******************..........................789****************************************** PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
           k+     ++ +++ ++++ e+l+g+nky   +  ++qeaek +k+ +lP+vL+l+L+Rf ++ ++++++kin+++efp++L l++f+++
   Q: 358  KK-----NIFESFVDYVAVEQLDGDNKYDAGEH-GLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQK 440
           **.....9*********************9996.7****************************************************** PP
   S: 268  peekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg............staYvlfYkr 337
           ++ k+  + +Y L+av+vHsG  ++GHYv+y +   +gkW++fdD+ V+ +++ee  e +             ++aY+l+Y r
   Q: 441  TDPKD--PANYILHAVLVHSGDNHGGHYVVYLNPkGDGKWCKFDDDVVSRCTKEEAIEHNYgghdddlsvrhcTNAYMLVYIR 521
           88777..*************************9834566************86666664446*******************87 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MNHQQQQQQQ QKAGEQQLSE PEDMEMEAGD TDDPPRITQN PVINGNVALS DGHSNAEEDM 60
EDDTSWRSEA TFQFTVERFS RLSESVLSPP CFVRNLPWKI MVMPRFYPDR PHQKSVGFFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGCCCGGGC CTCCGGCCGC AGGCGAGGCC CAGGCCGCGG CCGACATGAA CCACCAACAG 60
CAGCAGCAGC AGCAGCAGAA AGCGGGCGAG CAGCAGCTGA GCGAGCCCGA GGACATGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR002083--MATH/TRAF_dom
IPR001394--Peptidase_C19_UCH
IPR008974--TRAF-like
IPR024729--USP7_ICP0-binding_dom
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50144--MATH
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00917--MATH
PF00443--UCH
PF14533--USP7_C2
PF12436--USP7_ICP0_bdg

SMART

SM00061--MATH

Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0010216--P:maintenance of DNA methylation
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0050821--P:protein stabilization
GO:0006283--P:transcription-coupled nucleotide-excision repair
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000761	Aegilops tauschii	33.30	5.00e-143	502.00
IUUC-Aml-002408	Ailuropoda melanoleuca	98.98	0.00e+00	2210.00
IUUC-Atr-003067	Amborella trichopoda	36.95	7.00e-124	438.00
IUUC-Apl-003558	Anas platyrhynchos	96.38	0.00e+00	2192.00
IUUC-Aca-004518	Anolis carolinensis	90.78	0.00e+00	2056.00
IUUC-Aly-006427	Arabidopsis lyrata	35.89	2.00e-157	550.00
IUUC-Ath-006591	Arabidopsis thaliana	35.68	2.00e-157	550.00
IUUC-Ago-007849	Ashbya gossypii	32.79	3.00e-139	489.00
IUUC-Acl-008327	Aspergillus clavatus	34.11	1.00e-170	593.00
IUUC-Afl-008491	Aspergillus flavus	34.66	4.00e-164	572.00
IUUC-Afu-008804	Aspergillus fumigatus	35.13	4.00e-162	565.00
IUUC-Ang-009776	Aspergillus niger	34.88	1.00e-161	564.00
IUUC-Aor-009998	Aspergillus oryzae	33.92	6.00e-156	545.00
IUUC-Ate-010428	Aspergillus terreus	34.69	1.00e-164	573.00
IUUC-Ame-010903	Astyanax mexicanus	93.27	0.00e+00	2154.00
IUUC-Bgr-012132	Blumeria graminis	31.71	1.00e-143	504.00
IUUC-Bta-013192	Bos taurus	98.89	0.00e+00	2211.00
IUUC-Bci-013924	Botrytis cinerea	34.04	3.00e-150	526.00
IUUC-Bdi-015069	Brachypodium distachyon	36.64	2.00e-154	540.00
IUUC-Bol-015224	Brassica oleracea	36.86	1.00e-157	551.00
IUUC-Bra-017448	Brassica rapa	36.64	4.00e-157	548.00
IUUC-Cel-018219	Caenorhabditis elegans	33.78	7.00e-155	541.00
IUUC-Cja-019006	Callithrix jacchus	97.87	0.00e+00	2179.00
IUUC-Cfa-020361	Canis familiaris	98.08	0.00e+00	2211.00
IUUC-Cpo-022320	Cavia porcellus	99.44	0.00e+00	2219.00
IUUC-Cre-022708	Chlamydomonas reinhardtii	43.84	1.00e-91	330.00
IUUC-Csa-024050	Chlorocebus sabaeus	99.18	0.00e+00	2246.00
IUUC-Cho-024434	Choloepus hoffmanni	90.17	0.00e+00	1434.00
IUUC-Cin-025689	Ciona intestinalis	54.26	0.00e+00	1214.00
IUUC-Csv-025963	Ciona savignyi	52.41	0.00e+00	1166.00
IUUC-Cgl-026650	Colletotrichum gloeosporioides	33.48	5.00e-151	528.00
IUUC-Cne-026968	Cryptococcus neoformans	36.39	0.00e+00	627.00
IUUC-Cme-027103	Cyanidioschyzon merolae	35.69	4.00e-115	410.00
IUUC-Dre-028510	Danio rerio	93.24	0.00e+00	2146.00
IUUC-Dno-029696	Dasypus novemcinctus	98.98	0.00e+00	2204.00
IUUC-Dor-030611	Dipodomys ordii	84.35	0.00e+00	964.00
IUUC-Dse-031433	Dothistroma septosporum	34.09	3.00e-147	516.00
IUUC-Dme-031583	Drosophila melanogaster	48.58	0.00e+00	1044.00
IUUC-Ete-033191	Echinops telfairi	96.75	0.00e+00	2157.00
IUUC-Eca-034122	Equus caballus	98.61	0.00e+00	2205.00
IUUC-Eeu-035292	Erinaceus europaeus	84.30	0.00e+00	679.00
IUUC-Fca-036377	Felis catus	98.89	0.00e+00	2207.00
IUUC-Fal-036964	Ficedula albicollis	96.49	0.00e+00	2150.00
IUUC-Fox-037695	Fusarium oxysporum	33.39	1.00e-158	553.00
IUUC-Fso-038084	Fusarium solani	33.54	1.00e-158	554.00
IUUC-Gmo-038644	Gadus morhua	92.95	0.00e+00	2145.00
IUUC-Ggr-040029	Gaeumannomyces graminis	33.67	1.00e-156	548.00
IUUC-Gga-040944	Gallus gallus	96.52	0.00e+00	2191.00
IUUC-Gac-041740	Gasterosteus aculeatus	93.29	0.00e+00	2164.00
IUUC-Gma-043300	Glycine max	36.73	2.00e-168	587.00
IUUC-Ggo-044947	Gorilla gorilla	99.07	0.00e+00	2215.00
IUUC-Hsa-046278	Homo sapiens	99.18	0.00e+00	2245.00
IUUC-Hvu-047749	Hordeum vulgare	37.01	8.00e-142	498.00
IUUC-Itr-047904	Ictidomys tridecemlineatus	99.25	0.00e+00	1904.00
IUUC-Kpa-049121	Komagataella pastoris	30.87	3.00e-127	449.00
IUUC-Lch-049847	Latimeria chalumnae	95.86	0.00e+00	2188.00
IUUC-Lpe-051505	Leersia perrieri	35.67	1.00e-143	504.00
IUUC-Loc-052234	Lepisosteus oculatus	93.59	0.00e+00	1445.00
IUUC-Lma-053169	Leptosphaeria maculans	36.77	4.00e-168	585.00
IUUC-Laf-053566	Loxodonta africana	98.89	0.00e+00	2210.00
IUUC-Mcc-055549	Macaca mulatta	98.61	0.00e+00	2210.00
IUUC-Meu-056887	Macropus eugenii	88.11	0.00e+00	1278.00
IUUC-Mor-057149	Magnaporthe oryzae	34.42	1.00e-157	550.00
IUUC-Mpo-057536	Magnaporthe poae	33.51	3.00e-157	549.00
IUUC-Mtr-058583	Medicago truncatula	37.56	2.00e-164	573.00
IUUC-Mla-058899	Melampsora laricipopulina	37.05	5.00e-171	595.00
IUUC-Mga-060148	Meleagris gallopavo	96.56	0.00e+00	2199.00
IUUC-Mvi-060207	Microbotryum violaceum	37.52	0.00e+00	633.00
IUUC-Mmr-060946	Microcebus murinus	98.90	0.00e+00	2233.00
IUUC-Mdo-062079	Monodelphis domestica	90.02	0.00e+00	1969.00
IUUC-Mmu-063678	Mus musculus	99.35	0.00e+00	2219.00
IUUC-Mac-065416	Musa acuminata	36.83	3.00e-157	549.00
IUUC-Mpu-066744	Mustela putorius furo	98.77	0.00e+00	2160.00
IUUC-Mlu-067949	Myotis lucifugus	97.25	0.00e+00	2186.00
IUUC-Nfi-068342	Neosartorya fischeri	35.47	5.00e-162	565.00
IUUC-Ncr-068818	Neurospora crassa	34.51	2.00e-162	566.00
IUUC-Nle-070064	Nomascus leucogenys	99.37	0.00e+00	2250.00
IUUC-Opr-071001	Ochotona princeps	97.70	0.00e+00	1828.00
IUUC-Ont-072095	Oreochromis niloticus	92.90	0.00e+00	2149.00
IUUC-Oan-073483	Ornithorhynchus anatinus	97.25	0.00e+00	2132.00
IUUC-Ocu-073967	Oryctolagus cuniculus	98.66	0.00e+00	2130.00
IUUC-Oba-075811	Oryza barthii	34.23	2.00e-141	496.00
IUUC-Obr-076514	Oryza brachyantha	36.68	3.00e-156	546.00
IUUC-Ogl-077038	Oryza glaberrima	35.79	2.00e-150	527.00
IUUC-Ogu-078265	Oryza glumaepatula	34.19	2.00e-136	480.00
IUUC-Oin-079513	Oryza indica	35.05	2.00e-142	500.00
IUUC-Olo-081067	Oryza longistaminata	34.18	1.00e-139	490.00
IUUC-Ome-081879	Oryza meridionalis	36.11	3.00e-152	533.00
IUUC-Oni-082409	Oryza nivara	33.55	1.00e-140	494.00
IUUC-Opu-083199	Oryza punctata	35.73	1.00e-147	517.00
IUUC-Oru-085109	Oryza rufipogon	35.50	4.00e-147	515.00
IUUC-Osa-085418	Oryza sativa	36.97	6.00e-131	462.00
IUUC-Ola-086640	Oryzias latipes	92.93	0.00e+00	2145.00
IUUC-Olu-087874	Ostreococcus lucimarinus	32.93	9.00e-144	504.00
IUUC-Oga-089059	Otolemur garnettii	91.90	0.00e+00	2013.00
IUUC-Oar-089710	Ovis aries	99.16	0.00e+00	2210.00
IUUC-Ptr-091334	Pan troglodytes	99.07	0.00e+00	2215.00
IUUC-Pan-091717	Papio anubis	99.43	0.00e+00	2147.00
IUUC-Psi-093933	Pelodiscus sinensis	96.08	0.00e+00	2218.00
IUUC-Pma-094648	Petromyzon marinus	82.97	0.00e+00	1720.00
IUUC-Pno-095020	Phaeosphaeria nodorum	35.26	1.00e-150	527.00
IUUC-Ppa-096020	Physcomitrella patens	34.71	1.00e-161	564.00
IUUC-Pfo-096181	Poecilia formosa	92.61	0.00e+00	2138.00
IUUC-Pab-098231	Pongo abelii	96.48	0.00e+00	2144.00
IUUC-Pop-099680	Populus trichocarpa	37.45	2.00e-160	560.00
IUUC-Pca-100543	Procavia capensis	81.35	0.00e+00	1009.00
IUUC-Ppe-101523	Prunus persica	36.23	9.00e-155	541.00
IUUC-Pva-102472	Pteropus vampyrus	96.79	0.00e+00	2159.00
IUUC-Pgr-103463	Puccinia graminis	35.91	1.00e-170	593.00
IUUC-Ptt-103716	Puccinia triticina	37.75	4.00e-167	582.00
IUUC-Pte-104360	Pyrenophora teres	36.23	2.00e-151	530.00
IUUC-Pyt-104581	Pyrenophora triticirepentis	35.85	1.00e-149	524.00
IUUC-Sce-106230	Saccharomyces cerevisiae	30.02	2.00e-123	437.00
IUUC-Sha-107439	Sarcophilus harrisii	97.58	0.00e+00	2182.00
IUUC-Sja-107690	Schizosaccharomyces japonicus	33.09	2.00e-138	487.00
IUUC-Spo-108019	Schizosaccharomyces pombe	34.63	4.00e-144	506.00
IUUC-Smo-109308	Selaginella moellendorffii	36.14	4.00e-153	535.00
IUUC-Sit-110367	Setaria italica	36.35	5.00e-158	551.00
IUUC-Sly-111337	Solanum lycopersicum	37.87	2.00e-164	573.00
IUUC-Stu-112387	Solanum tuberosum	36.84	6.00e-166	578.00
IUUC-Sar-113685	Sorex araneus	98.14	0.00e+00	2185.00
IUUC-Sbi-114037	Sorghum bicolor	36.79	5.00e-159	555.00
IUUC-Sre-115156	Sporisorium reilianum	36.91	0.00e+00	630.00
IUUC-Ssc-116297	Sus scrofa	98.91	0.00e+00	2242.00
IUUC-Tgu-116767	Taeniopygia guttata	96.20	0.00e+00	2221.00
IUUC-Tru-118208	Takifugu rubripes	93.04	0.00e+00	2121.00
IUUC-Tsy-119277	Tarsius syrichta	89.03	0.00e+00	710.00
IUUC-Tni-119890	Tetraodon nigroviridis	93.22	0.00e+00	2126.00
IUUC-Tca-121696	Theobroma cacao	36.75	9.00e-156	544.00
IUUC-Tre-122169	Trichoderma reesei	33.51	1.00e-153	537.00
IUUC-Tvi-122600	Trichoderma virens	34.24	2.00e-161	563.00
IUUC-Tae-125264	Triticum aestivum	36.11	4.00e-156	546.00
IUUC-Tur-126287	Triticum urartu	35.22	2.00e-149	523.00
IUUC-Tme-127045	Tuber melanosporum	35.16	7.00e-167	581.00
IUUC-Tbe-127696	Tupaia belangeri	88.27	4.00e-160	558.00
IUUC-Ttr-129161	Tursiops truncatus	99.07	0.00e+00	2205.00
IUUC-Uma-129535	Ustilago maydis	36.75	0.00e+00	640.00
IUUC-Vda-129708	Verticillium dahliae	33.09	3.00e-159	556.00
IUUC-Vvi-131048	Vitis vinifera	35.97	9.00e-159	554.00
IUUC-Xtr-132073	Xenopus tropicalis	91.47	0.00e+00	2073.00
IUUC-Xma-133949	Xiphophorus maculatus	92.50	0.00e+00	2128.00
IUUC-Yli-134527	Yarrowia lipolytica	32.63	4.00e-138	486.00
IUUC-Zma-135550	Zea mays	35.07	1.00e-147	517.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence