iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098543

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01088129

Gene Name

USP37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000013175.2	ENSPPYT00000015319.2	ENSPPYP00000014722.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.10e-64	215.8	339	866

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
           + + qDa+Efl+++ldql+e+++k  nk++++e  + +++++d    + ++ +++++ ++++++++++i+c++c+++  ++e+f+dls+
   Q: 339  QQQLQDAHEFLSQCLDQLKEDMEK-LNKTWKTEPVSGEENSPDT---SATRVYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSI 423
           55669*****************55.8999999988887788777...799*************************************** PP
   S: 175  pvpgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           ++p++++  ++ s+qd+L+ f+++eele    y+cekc +k+ a  ++k+++lP+vLilhLkR+sf+ + + ++ki ++v +p+ L+ls
   Q: 424  DLPRRKKPLPPrSIQDSLDLFFRAEELE----YSCEKCGGKC-ALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLS 507
           ***999886545***************9....*********9.89999***************************************** PP
   S: 263  pfcts.................................................................................... 267
           ++ct+                                                                                    
   Q: 508  SHCTEntkppftlgwsahmaisrplkasqmvnscitspstpskkftfksksslalcldsdsedelkrsvalsqrlcemlgneqqqedle 596
           *****99*****************99999999999999999999999999999999999999999999999999999999998888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 597  kdsklcpiepdkselensgfdrmseeellaavleiskrdaspslshedddkptsspdtgfaeddiqempenpdtmetekpktiteldpa 685
           88888888888888888888888888888888888888888888877777777777777777777777777777777777777777766 PP
   S: 268  .................peekqke................................................................. 274
                            p     e                                                                 
   Q: 686  sfteitkdcdenkenktP-----Egsqgevdwlqqydmerereeqelqqalaqslqeqeaweqkedddlkratelslqefnnsfvdalg 769
           666666666655555550.....055555555555555555555566666666666666777777777777777777778888888888 PP
   S: 275  ................................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgst 329
                                           +++Y+Li+vv+H G ++ssGHY+++v++ k++ W++++D +V++++e+ v+++++++
   Q: 770  sdedsgnedvfdmeyteaeaeelkrnaetgnlPHSYRLISVVSHIGsTSSSGHYISDVYDIKKQaWFTYNDLEVSKIQEAAVQSDRDRS 858
           88888888888888888888888899999999****************************99999************************ PP
   S: 330  aYvlfYkr 337
           +Y++fY++
   Q: 859  GYIFFYMH 866
           ******98 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MSPLKIHGPI RIRSMQTGIT KWKEGSFEIV EKENKVSLVV HYNTGGIPRI FQLSHNIKNV 60
VLRPSGAKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD EVHQNRLPAA MKPSQGSGSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAATTACTAG TAAGTTATAG CTTATCTTAT TTTTCTTCCT TAGAACCTGC CAGGTGAAGG 60
TATATTTTTG CTTTTTAATT TATCTGGAAG CAATTTATTT TTAAAGAAAA TATGTCTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0006275--P:regulation of DNA replication
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	93.66	0.00e+00	947.00
IUUC-Apl-004033	Anas platyrhynchos	78.93	0.00e+00	788.00
IUUC-Aca-005370	Anolis carolinensis	72.56	0.00e+00	758.00
IUUC-Ame-011884	Astyanax mexicanus	61.54	2.00e-173	602.00
IUUC-Bta-012725	Bos taurus	93.83	0.00e+00	919.00
IUUC-Cja-019939	Callithrix jacchus	96.20	0.00e+00	913.00
IUUC-Cfa-020835	Canis familiaris	94.20	0.00e+00	955.00
IUUC-Cpo-022067	Cavia porcellus	92.29	0.00e+00	746.00
IUUC-Csa-023085	Chlorocebus sabaeus	97.46	0.00e+00	952.00
IUUC-Cho-024390	Choloepus hoffmanni	86.35	1.00e-157	550.00
IUUC-Dre-028255	Danio rerio	60.50	8.00e-154	537.00
IUUC-Dno-028986	Dasypus novemcinctus	92.93	0.00e+00	907.00
IUUC-Dor-031062	Dipodomys ordii	81.87	1.00e-173	603.00
IUUC-Ete-032359	Echinops telfairi	73.40	3.00e-152	532.00
IUUC-Eca-033964	Equus caballus	92.56	0.00e+00	935.00
IUUC-Eeu-034492	Erinaceus europaeus	85.12	0.00e+00	809.00
IUUC-Fca-036359	Felis catus	93.12	0.00e+00	938.00
IUUC-Fal-037640	Ficedula albicollis	79.29	0.00e+00	803.00
IUUC-Gmo-039600	Gadus morhua	56.75	3.00e-156	545.00
IUUC-Gga-040126	Gallus gallus	79.29	0.00e+00	798.00
IUUC-Gac-041557	Gasterosteus aculeatus	58.39	3.00e-161	562.00
IUUC-Ggo-045571	Gorilla gorilla	95.10	0.00e+00	934.00
IUUC-Hsa-046043	Homo sapiens	98.01	0.00e+00	961.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	94.01	0.00e+00	917.00
IUUC-Lch-050357	Latimeria chalumnae	69.22	2.00e-172	599.00
IUUC-Loc-052849	Lepisosteus oculatus	63.62	2.00e-173	602.00
IUUC-Laf-054570	Loxodonta africana	90.40	0.00e+00	867.00
IUUC-Mcc-054989	Macaca mulatta	98.71	0.00e+00	834.00
IUUC-Meu-056273	Macropus eugenii	64.79	2.00e-115	410.00
IUUC-Mga-059814	Meleagris gallopavo	76.07	0.00e+00	800.00
IUUC-Mmr-061726	Microcebus murinus	94.37	0.00e+00	910.00
IUUC-Mdo-062974	Monodelphis domestica	85.13	0.00e+00	852.00
IUUC-Mmu-064069	Mus musculus	89.66	0.00e+00	869.00
IUUC-Mpu-066008	Mustela putorius furo	92.75	0.00e+00	904.00
IUUC-Nle-069259	Nomascus leucogenys	97.82	0.00e+00	958.00
IUUC-Opr-070882	Ochotona princeps	58.33	2.00e-75	277.00
IUUC-Ont-072441	Oreochromis niloticus	57.89	7.00e-157	548.00
IUUC-Ocu-074879	Oryctolagus cuniculus	93.83	0.00e+00	913.00
IUUC-Ola-087007	Oryzias latipes	58.26	3.00e-157	549.00
IUUC-Oga-088385	Otolemur garnettii	93.47	0.00e+00	909.00
IUUC-Oar-090305	Ovis aries	93.28	0.00e+00	946.00
IUUC-Ptr-091299	Pan troglodytes	97.82	0.00e+00	958.00
IUUC-Pan-091996	Papio anubis	99.05	0.00e+00	923.00
IUUC-Psi-093176	Pelodiscus sinensis	79.14	0.00e+00	790.00
IUUC-Pma-094331	Petromyzon marinus	52.03	2.00e-128	453.00
IUUC-Pfo-096503	Poecilia formosa	60.11	1.00e-157	550.00
IUUC-Pca-101099	Procavia capensis	87.86	0.00e+00	869.00
IUUC-Pva-103163	Pteropus vampyrus	85.48	0.00e+00	825.00
IUUC-Rno-105766	Rattus norvegicus	91.65	0.00e+00	889.00
IUUC-Sha-106610	Sarcophilus harrisii	77.62	0.00e+00	756.00
IUUC-Sar-113256	Sorex araneus	88.79	6.00e-111	395.00
IUUC-Ssc-116353	Sus scrofa	94.01	0.00e+00	911.00
IUUC-Tgu-116971	Taeniopygia guttata	78.93	0.00e+00	796.00
IUUC-Tru-117932	Takifugu rubripes	49.18	5.00e-124	438.00
IUUC-Tsy-119185	Tarsius syrichta	84.57	1.00e-147	516.00
IUUC-Tbe-127281	Tupaia belangeri	73.25	7.00e-143	501.00
IUUC-Ttr-128177	Tursiops truncatus	93.28	0.00e+00	943.00
IUUC-Vpa-130031	Vicugna pacos	93.65	0.00e+00	947.00
IUUC-Xtr-132949	Xenopus tropicalis	70.33	0.00e+00	687.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence