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Tag Content
iUUCD ID IUUC-Afu-008848
Ensembl Protein ID CADAFUAP00002073
UniProt Accession Q4WLM7; LIS1_ASPFU
Genbank Protein ID EAL89137.1
Protein Name Nuclear distribution protein nudF; Lissencephaly-1 homolog
Genbank Nucleotide ID AAHF01000006
Gene Name AFUA_6G12970; nudF; lis1; pac1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
CADAFUAG00002073 CADAFUAT00002073 CADAFUAP00002073
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.40e-49 162.8 200 247
UBD/Beta-Prp 8.60e-66 221.1 113 466
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..........sdtllvsGsdDgtikvWDlrtgvllks 38
    gH sv++++f s++llvs+s+D+t+++WD++tg ++k+
   Q: 200 GHDHSVSSVRFipsgaagspmSGNLLVSASRDKTLRIWDVTTGYCVKT 247
    8*****************976669*******************99875 PP
   


   UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdls.tgkcvhtlkghedsv 97
    h +++tcv+f+p s la+gs+d tik+wd++ g l r+++gh+++v +v++ + +l+++s+D tik+wd+s ++k ++tl gh++sv
   Q: 113 GHRNPVTCVAFHPVFSSLASGSDDTTIKIWDWELGELERTVKGHTKAVLDVDYGGPRGgtLLASCSSDLTIKLWDPSdNYKNIRTLPGHDHSV 205
    47789************************************************7544446**************88779************** PP
   S: 98 lslsfsp........sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtds 182
    s++f p sg+ lvs+s+d+t+r+wd+ tg+c++ tlsgh ++v+ v+ + dg+ l ++++Dr+ rlWdl++++ t+ g h++
   Q: 206 SSVRFIPsgaagspmSGNLLVSASRDKTLRIWDVTTGYCVK-TLSGHVDWVRAVAPSIDGRFLLAAGDDRIPRLWDLSSAETKSTFLG-HEHV 296
    *****999999999999************************.******************9999999********************9.**** PP
   S: 183 vyslsfdsng.....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsg 254
    ++++++ + +++++gs+d+t++lwd +g+ ++tl gh+++v+ ++f+p +++l+s+++D++ir+Wdl++
   Q: 297 IECVAIAPAAsyphlavlsglkkpppasssaEFFATGSRDKTIRLWDS-RGNLIKTLVGHDNWVRALAFHPGGKHLLSVADDKTIRCWDLTQE 388
    *****55555555566666666666667777****************8.7889************************************9765 PP
   S: 255 .dllktlqlhn........................ssvisvav.....lsfgdnvl...............vlgsedskvniwk 293
    +++++++ + ++ ++ a+ + ++gs d+kv+i++
   Q: 389 cKCVRVISDAHghfvtclrwapplikdggangeaeTNGTPAATsttngV------RpdpnvatkisircviATGSVDQKVRIFA 466
    499*****99977777777777777777777777744444444333331......13333334444444448888888888885 PP
   

Organism Aspergillus fumigatus
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Protein Sequence
(Fasta)
MSQLLTARQA EELHKSIIAY LASVNLTESS AALRAELGDS VSIDDATLKK YEGLLEKKWT 60
SVVRLQKKIM DLESRCAALQ SELDSATPTS LLRKNQDPTS WLPRSPARHI LEGHRNPVTC 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Afu-008848|E3,WD_repeat;UBD,Beta-Prp|Aspergillus fumigatus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGCCAGC TACTCACGGC GCGGCAGGCA GAGGAGCTGT ACGTCATTGC TCCTGGTTAC 60
AATAACTGAA AAGAGACTGA GGAGGAGAGG GTGTGACGCT GACATCGCTT AAAACGTTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Afu-008848|E3,WD_repeat;UBD,Beta-Prp|Aspergillus fumigatus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

KEGG afm:AFUA_6G12970
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 47.12 6.00e-104 369.00
IUUC-Apl-004024 Anas platyrhynchos 47.19 3.00e-107 380.00
IUUC-Aca-004564 Anolis carolinensis 46.70 9.00e-105 371.00
IUUC-Ago-007862 Ashbya gossypii 31.24 9.00e-42 162.00
IUUC-Acl-008360 Aspergillus clavatus 92.29 0.00e+00 823.00
IUUC-Afl-008502 Aspergillus flavus 61.89 6.00e-160 555.00
IUUC-Ani-009173 Aspergillus nidulans 59.10 1.00e-160 557.00
IUUC-Ang-009873 Aspergillus niger 57.42 2.00e-157 546.00
IUUC-Aor-009973 Aspergillus oryzae 59.15 5.00e-154 535.00
IUUC-Ate-010523 Aspergillus terreus 58.71 8.00e-164 568.00
IUUC-Ame-010969 Astyanax mexicanus 46.94 1.00e-106 377.00
IUUC-Bgr-011972 Blumeria graminis 68.52 0.00e+00 664.00
IUUC-Bta-013106 Bos taurus 47.19 4.00e-107 379.00
IUUC-Bci-013615 Botrytis cinerea 74.36 0.00e+00 692.00
IUUC-Cel-018459 Caenorhabditis elegans 42.43 3.00e-94 337.00
IUUC-Cja-018755 Callithrix jacchus 46.72 1.00e-104 370.00
IUUC-Cfa-020749 Canis familiaris 47.19 4.00e-107 379.00
IUUC-Cpo-022371 Cavia porcellus 47.19 4.00e-107 379.00
IUUC-Csa-023524 Chlorocebus sabaeus 47.81 3.00e-90 323.00
IUUC-Cho-024764 Choloepus hoffmanni 44.97 5.00e-89 319.00
IUUC-Cin-025753 Ciona intestinalis 44.69 6.00e-97 345.00
IUUC-Csv-025817 Ciona savignyi 44.34 7.00e-100 355.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 72.82 0.00e+00 675.00
IUUC-Cne-027087 Cryptococcus neoformans 51.44 5.00e-112 395.00
IUUC-Dre-028314 Danio rerio 46.70 1.00e-106 378.00
IUUC-Dno-029050 Dasypus novemcinctus 47.19 5.00e-107 379.00
IUUC-Dor-030222 Dipodomys ordii 43.67 2.00e-97 347.00
IUUC-Dse-031164 Dothistroma septosporum 68.15 0.00e+00 643.00
IUUC-Dme-031745 Drosophila melanogaster 44.79 6.00e-96 342.00
IUUC-Ete-032508 Echinops telfairi 47.79 1.00e-70 258.00
IUUC-Eca-034288 Equus caballus 46.62 9.00e-103 365.00
IUUC-Eeu-034984 Erinaceus europaeus 43.42 2.00e-96 343.00
IUUC-Fca-036498 Felis catus 47.19 4.00e-107 379.00
IUUC-Fal-036920 Ficedula albicollis 47.19 3.00e-107 380.00
IUUC-Fox-037996 Fusarium oxysporum 68.51 0.00e+00 666.00
IUUC-Fso-038160 Fusarium solani 66.31 0.00e+00 634.00
IUUC-Gmo-038983 Gadus morhua 45.75 1.00e-106 378.00
IUUC-Ggr-040051 Gaeumannomyces graminis 65.75 1.00e-179 620.00
IUUC-Gga-040623 Gallus gallus 47.19 3.00e-107 380.00
IUUC-Gac-041613 Gasterosteus aculeatus 46.08 4.00e-107 379.00
IUUC-Ggo-045410 Gorilla gorilla 43.70 9.00e-87 311.00
IUUC-Hsa-046358 Homo sapiens 47.19 3.00e-107 380.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 47.19 4.00e-107 379.00
IUUC-Kpa-049351 Komagataella pastoris 31.32 4.00e-47 180.00
IUUC-Lch-049936 Latimeria chalumnae 45.52 4.00e-107 379.00
IUUC-Loc-052476 Lepisosteus oculatus 47.12 2.00e-103 367.00
IUUC-Lma-053170 Leptosphaeria maculans 75.16 0.00e+00 684.00
IUUC-Laf-053713 Loxodonta africana 46.34 4.00e-105 372.00
IUUC-Mcc-054628 Macaca mulatta 47.19 6.00e-107 379.00
IUUC-Meu-055927 Macropus eugenii 38.95 4.00e-51 192.00
IUUC-Mor-056962 Magnaporthe oryzae 67.38 0.00e+00 653.00
IUUC-Mpo-057583 Magnaporthe poae 66.38 2.00e-174 603.00
IUUC-Mla-058819 Melampsora laricipopulina 45.88 3.00e-114 403.00
IUUC-Mga-059945 Meleagris gallopavo 46.94 7.00e-107 378.00
IUUC-Mvi-060403 Microbotryum violaceum 50.11 4.00e-128 449.00
IUUC-Mmr-061289 Microcebus murinus 46.68 4.00e-104 369.00
IUUC-Mdo-061912 Monodelphis domestica 46.78 3.00e-106 376.00
IUUC-Mmu-063253 Mus musculus 47.19 4.00e-107 379.00
IUUC-Mpu-066638 Mustela putorius furo 47.19 4.00e-107 379.00
IUUC-Mlu-067267 Myotis lucifugus 46.32 2.00e-104 370.00
IUUC-Nfi-068571 Neosartorya fischeri 92.29 0.00e+00 843.00
IUUC-Ncr-068895 Neurospora crassa 70.21 0.00e+00 648.00
IUUC-Nle-069087 Nomascus leucogenys 45.51 1.00e-88 317.00
IUUC-Opr-070579 Ochotona princeps 47.19 5.00e-107 379.00
IUUC-Ont-072432 Oreochromis niloticus 46.48 7.00e-107 379.00
IUUC-Oan-073072 Ornithorhynchus anatinus 47.19 4.00e-107 379.00
IUUC-Ocu-074180 Oryctolagus cuniculus 47.19 5.00e-107 379.00
IUUC-Ola-086815 Oryzias latipes 47.43 5.00e-107 379.00
IUUC-Oga-088219 Otolemur garnettii 46.34 4.00e-105 373.00
IUUC-Oar-090394 Ovis aries 47.19 4.00e-107 379.00
IUUC-Ptr-091517 Pan troglodytes 47.19 4.00e-107 379.00
IUUC-Pan-092421 Papio anubis 47.19 6.00e-107 379.00
IUUC-Psi-093370 Pelodiscus sinensis 47.19 7.00e-107 378.00
IUUC-Pma-094319 Petromyzon marinus 46.57 3.00e-88 316.00
IUUC-Pno-094815 Phaeosphaeria nodorum 73.88 0.00e+00 698.00
IUUC-Pfo-097089 Poecilia formosa 46.95 1.00e-108 384.00
IUUC-Pab-098421 Pongo abelii 47.19 4.00e-107 379.00
IUUC-Pca-100120 Procavia capensis 37.71 6.00e-62 229.00
IUUC-Pva-102960 Pteropus vampyrus 46.94 8.00e-106 375.00
IUUC-Pgr-103538 Puccinia graminis 50.00 2.00e-122 430.00
IUUC-Ptt-103990 Puccinia triticina 42.37 6.00e-44 170.00
IUUC-Pte-104261 Pyrenophora teres 74.36 0.00e+00 693.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 74.36 0.00e+00 694.00
IUUC-Rno-105123 Rattus norvegicus 47.19 4.00e-107 379.00
IUUC-Sce-106208 Saccharomyces cerevisiae 26.90 5.00e-36 143.00
IUUC-Sha-107010 Sarcophilus harrisii 46.78 4.00e-106 376.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 36.62 2.00e-70 257.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 76.43 0.00e+00 666.00
IUUC-Sar-113309 Sorex araneus 46.37 3.00e-101 359.00
IUUC-Sre-115003 Sporisorium reilianum 50.44 2.00e-126 444.00
IUUC-Ssc-116148 Sus scrofa 47.19 4.00e-107 379.00
IUUC-Tgu-117299 Taeniopygia guttata 47.19 4.00e-107 379.00
IUUC-Tru-117721 Takifugu rubripes 46.96 8.00e-107 378.00
IUUC-Tsy-119493 Tarsius syrichta 46.94 2.00e-105 374.00
IUUC-Tni-120355 Tetraodon nigroviridis 45.84 8.00e-106 375.00
IUUC-Tre-121977 Trichoderma reesei 64.11 2.00e-170 590.00
IUUC-Tvi-122661 Trichoderma virens 65.19 4.00e-169 585.00
IUUC-Tme-127031 Tuber melanosporum 67.38 0.00e+00 632.00
IUUC-Tbe-127492 Tupaia belangeri 40.07 6.00e-48 182.00
IUUC-Ttr-128929 Tursiops truncatus 47.19 7.00e-107 379.00
IUUC-Uma-129347 Ustilago maydis 51.28 3.00e-125 440.00
IUUC-Vda-129837 Verticillium dahliae 72.49 0.00e+00 654.00
IUUC-Vpa-130532 Vicugna pacos 40.45 4.00e-86 309.00
IUUC-Xtr-131985 Xenopus tropicalis 47.19 2.00e-107 380.00
IUUC-Xma-133314 Xiphophorus maculatus 46.95 1.00e-108 384.00
IUUC-Yli-134403 Yarrowia lipolytica 42.13 7.00e-101 358.00
Created Date 25-Jun-2017

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