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Tag Content
iUUCD ID IUUC-Fox-037996
Ensembl Protein ID FOXG_08655P0
UniProt Accession A0A0D2XXD9; A0A0D2XXD9_FUSO4
Genbank Protein ID KNB07522.1
Protein Name Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog
Genbank Nucleotide ID DS231705
Gene Name PAC1; LIS1; FOXG_08655
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FOXG_08655 FOXG_08655T0 FOXG_08655P0
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.70e-44 147.6 357 390
UBD/Beta-Prp 7.30e-62 208.9 113 407
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrt 32
    gH ++v++l f ++ ++l+s sdD+ti++WDl++
   Q: 357 GHDNWVRGLVFhPSgKFLLSVSDDKTIRCWDLSQ 390
    8***********666****************976 PP
   


   UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdls.tgkcvhtlkghedsvlsl 100
    ++h ++i+cv+f+p s +a+g +d+tik+wd++ g l r+++gh+++v ++++ + +l+++s+D tik+wd+s ++ ++tl gh++sv ++
   Q: 113 QSHRTPINCVAFHPIFSSIASGDEDATIKIWDWEFGELERTVKGHTKAVLDLDYGGPKGhtLLASCSSDLTIKLWDPSnEYQNIRTLPGHDHSVSAV 209
    56888*************************************************7655557**************98857899************** PP
   S: 101 sfsp........sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl..tgghtdsvysls 187
    +f p sg+ l+s+s+d t+r+wd+ tg+c++ t +gh ++++ v+ + dg++l s ++DrtvrlWd++ + +l g h++ v++ +
   Q: 210 RFIPsgapgaplSGNLLASASRDVTVRIWDVTTGYCVK-TIRGHVDWIRDVAPSLDGKYLLSTGNDRTVRLWDISVPNPEAKLvmIG-HEHFVECCT 304
    ***99999999999************************.***********************************9999999998676.********* PP
   S: 188 fdsng.....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl.rsgdllktlql 262
    f + +++++g++d+t+klwd +g+c++tl gh+++v+ + f+p +++l+s+s+D++ir+Wdl + g+++kt+++
   Q: 305 FAPPAayshlatlagvkkappasstaEFMATGGRDKTIKLWDG-RGTCIKTLVGHDNWVRGLVFHPSGKFLLSVSDDKTIRCWDLsQEGKCVKTVEG 400
    88877888888888888888999998****************8.899************************************973679******** PP
   S: 263 hnssvis 269
    ++++i
   Q: 401 AHEHFIT 407
    9977664 PP
   

Organism Fusarium oxysporum
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Protein Sequence
(Fasta)
MSRTLTSRQA EELHKSIIAY LAANNLQESA NAMRTELSLG EDAFDTATAK KYETLLEKKW 60
TSVVRLQKKI MDLEAQNNAL QTELNSATPT SLSNRRGDPS SWLPSGPPRH VLQSHRTPIN 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Fox-037996|E3,WD_repeat;UBD,Beta-Prp|Fusarium oxysporum
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGCCGGA CGTTGACGAG CCGGCAGGCC GAGGAGCTGT TCGTACAGGG GAGCTTCTGG 60
AGCTTTGATT TGCCCATCTG ACACTGCTGC AGGCATAAAT CCATCATCGC CTACCTCGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Fox-037996|E3,WD_repeat;UBD,Beta-Prp|Fusarium oxysporum
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 46.21 5.00e-102 362.00
IUUC-Apl-004024 Anas platyrhynchos 46.41 2.00e-105 373.00
IUUC-Aca-004564 Anolis carolinensis 46.17 2.00e-103 367.00
IUUC-Ago-007862 Ashbya gossypii 28.76 1.00e-37 148.00
IUUC-Acl-008360 Aspergillus clavatus 67.52 0.00e+00 635.00
IUUC-Afl-008502 Aspergillus flavus 62.72 1.00e-167 580.00
IUUC-Afu-008848 Aspergillus fumigatus 68.51 0.00e+00 666.00
IUUC-Ani-009173 Aspergillus nidulans 59.40 5.00e-161 558.00
IUUC-Ang-009873 Aspergillus niger 57.70 1.00e-157 547.00
IUUC-Aor-009973 Aspergillus oryzae 60.56 1.00e-162 563.00
IUUC-Ate-010523 Aspergillus terreus 59.78 1.00e-163 567.00
IUUC-Ame-011154 Astyanax mexicanus 45.43 7.00e-104 368.00
IUUC-Bgr-011972 Blumeria graminis 66.81 0.00e+00 655.00
IUUC-Bta-013106 Bos taurus 46.41 2.00e-105 373.00
IUUC-Bci-013615 Botrytis cinerea 68.88 0.00e+00 654.00
IUUC-Cel-018459 Caenorhabditis elegans 44.01 1.00e-94 337.00
IUUC-Cja-018755 Callithrix jacchus 45.45 2.00e-102 363.00
IUUC-Cfa-020749 Canis familiaris 46.41 2.00e-105 373.00
IUUC-Cpo-022371 Cavia porcellus 46.41 2.00e-105 373.00
IUUC-Csa-023524 Chlorocebus sabaeus 46.88 2.00e-88 317.00
IUUC-Cho-024764 Choloepus hoffmanni 44.09 2.00e-85 307.00
IUUC-Cin-025753 Ciona intestinalis 45.80 7.00e-99 352.00
IUUC-Csv-025817 Ciona savignyi 45.08 2.00e-99 353.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 71.65 0.00e+00 669.00
IUUC-Cne-027087 Cryptococcus neoformans 51.21 9.00e-112 395.00
IUUC-Dre-028314 Danio rerio 45.95 7.00e-103 365.00
IUUC-Dno-029050 Dasypus novemcinctus 46.41 2.00e-105 373.00
IUUC-Dor-030222 Dipodomys ordii 43.17 8.00e-95 338.00
IUUC-Dse-031164 Dothistroma septosporum 66.31 0.00e+00 647.00
IUUC-Dme-031745 Drosophila melanogaster 46.34 5.00e-93 332.00
IUUC-Ete-032508 Echinops telfairi 47.33 1.00e-70 258.00
IUUC-Eca-034288 Equus caballus 45.72 5.00e-101 359.00
IUUC-Eeu-034984 Erinaceus europaeus 42.93 1.00e-93 335.00
IUUC-Fca-036498 Felis catus 46.41 2.00e-105 373.00
IUUC-Fal-036920 Ficedula albicollis 46.41 2.00e-105 373.00
IUUC-Fso-038160 Fusarium solani 86.58 0.00e+00 829.00
IUUC-Gmo-038983 Gadus morhua 45.93 2.00e-103 367.00
IUUC-Ggr-040051 Gaeumannomyces graminis 68.32 0.00e+00 660.00
IUUC-Gga-040623 Gallus gallus 46.41 2.00e-105 373.00
IUUC-Gac-041613 Gasterosteus aculeatus 45.43 1.00e-103 368.00
IUUC-Ggo-045410 Gorilla gorilla 42.08 1.00e-85 308.00
IUUC-Hsa-046358 Homo sapiens 46.41 3.00e-105 373.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 46.41 2.00e-105 373.00
IUUC-Kpa-049351 Komagataella pastoris 30.36 4.00e-48 183.00
IUUC-Lch-049936 Latimeria chalumnae 45.57 2.00e-103 367.00
IUUC-Loc-052476 Lepisosteus oculatus 45.95 7.00e-102 362.00
IUUC-Lma-053170 Leptosphaeria maculans 68.60 0.00e+00 630.00
IUUC-Laf-053713 Loxodonta africana 46.36 4.00e-103 366.00
IUUC-Mcc-054628 Macaca mulatta 46.41 3.00e-105 373.00
IUUC-Meu-055927 Macropus eugenii 40.93 3.00e-53 199.00
IUUC-Mor-056962 Magnaporthe oryzae 70.28 0.00e+00 686.00
IUUC-Mpo-057583 Magnaporthe poae 68.68 0.00e+00 640.00
IUUC-Mla-058819 Melampsora laricipopulina 47.87 1.00e-115 407.00
IUUC-Mga-059945 Meleagris gallopavo 46.41 3.00e-105 373.00
IUUC-Mvi-060403 Microbotryum violaceum 48.50 1.00e-120 424.00
IUUC-Mmr-061289 Microcebus murinus 45.80 4.00e-102 363.00
IUUC-Mdo-061912 Monodelphis domestica 46.41 8.00e-105 371.00
IUUC-Mmu-063253 Mus musculus 46.41 2.00e-105 373.00
IUUC-Mpu-066638 Mustela putorius furo 46.41 2.00e-105 373.00
IUUC-Mlu-067267 Myotis lucifugus 45.22 2.00e-102 363.00
IUUC-Nfi-068571 Neosartorya fischeri 63.97 2.00e-176 610.00
IUUC-Ncr-068895 Neurospora crassa 71.00 0.00e+00 671.00
IUUC-Nle-069087 Nomascus leucogenys 44.51 5.00e-84 302.00
IUUC-Opr-070579 Ochotona princeps 46.41 2.00e-105 373.00
IUUC-Ont-072432 Oreochromis niloticus 45.93 3.00e-105 373.00
IUUC-Oan-073072 Ornithorhynchus anatinus 46.41 2.00e-105 373.00
IUUC-Ocu-074180 Oryctolagus cuniculus 46.41 2.00e-105 373.00
IUUC-Ola-086815 Oryzias latipes 45.11 8.00e-104 368.00
IUUC-Oga-088219 Otolemur garnettii 45.45 2.00e-102 364.00
IUUC-Oar-090394 Ovis aries 46.41 2.00e-105 373.00
IUUC-Ptr-091517 Pan troglodytes 46.41 2.00e-105 373.00
IUUC-Pan-092421 Papio anubis 46.41 3.00e-105 373.00
IUUC-Psi-093370 Pelodiscus sinensis 46.41 1.00e-104 371.00
IUUC-Pma-094319 Petromyzon marinus 46.31 9.00e-88 315.00
IUUC-Pno-094815 Phaeosphaeria nodorum 68.59 0.00e+00 645.00
IUUC-Pfo-097089 Poecilia formosa 45.91 8.00e-105 371.00
IUUC-Pab-098421 Pongo abelii 46.41 2.00e-105 373.00
IUUC-Pca-100120 Procavia capensis 37.71 5.00e-59 219.00
IUUC-Pva-102960 Pteropus vampyrus 46.17 3.00e-104 369.00
IUUC-Pgr-103538 Puccinia graminis 48.83 1.00e-119 421.00
IUUC-Ptt-103990 Puccinia triticina 41.76 3.00e-42 165.00
IUUC-Pte-104261 Pyrenophora teres 69.33 0.00e+00 642.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 69.55 0.00e+00 643.00
IUUC-Rno-105123 Rattus norvegicus 46.41 2.00e-105 373.00
IUUC-Sce-106208 Saccharomyces cerevisiae 27.27 3.00e-39 154.00
IUUC-Sha-107010 Sarcophilus harrisii 46.41 1.00e-104 371.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 37.35 4.00e-70 256.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 70.74 0.00e+00 635.00
IUUC-Sar-113309 Sorex araneus 45.72 2.00e-100 357.00
IUUC-Sre-115003 Sporisorium reilianum 48.58 2.00e-122 430.00
IUUC-Ssc-116148 Sus scrofa 46.41 2.00e-105 373.00
IUUC-Tgu-117299 Taeniopygia guttata 46.41 3.00e-105 373.00
IUUC-Tru-118179 Takifugu rubripes 45.32 6.00e-104 369.00
IUUC-Tsy-119493 Tarsius syrichta 45.69 3.00e-103 366.00
IUUC-Tni-120355 Tetraodon nigroviridis 45.43 1.00e-102 364.00
IUUC-Tre-121977 Trichoderma reesei 67.44 0.00e+00 642.00
IUUC-Tvi-122661 Trichoderma virens 68.03 0.00e+00 627.00
IUUC-Tme-127031 Tuber melanosporum 65.21 2.00e-175 606.00
IUUC-Tbe-127492 Tupaia belangeri 41.64 2.00e-51 194.00
IUUC-Ttr-128929 Tursiops truncatus 46.41 5.00e-105 372.00
IUUC-Uma-129347 Ustilago maydis 48.38 3.00e-122 429.00
IUUC-Vda-129837 Verticillium dahliae 68.10 0.00e+00 635.00
IUUC-Vpa-130532 Vicugna pacos 40.93 1.00e-84 304.00
IUUC-Xtr-131985 Xenopus tropicalis 46.17 3.00e-105 373.00
IUUC-Xma-133314 Xiphophorus maculatus 45.78 3.00e-104 370.00
IUUC-Yli-134403 Yarrowia lipolytica 39.54 1.00e-94 337.00
Created Date 25-Jun-2017

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