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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045938
Ensembl Protein ID ENSP00000451263.2
UniProt Accession P80192; A3KN85; Q0D2G7; Q6EH31; Q9H2N5; M3K9_HUMAN
Genbank Protein ID AAQ23054.1; AAI11408.1; AAI33707.1; AAG44591.1
Protein Name Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1
Genbank Nucleotide ID AY327900; BC111407; BC133706; AF251442
Gene Name MAP3K9; MLK1; PRKE1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000006432.15 ENST00000554752.6 ENSP00000451612.2
ENSG00000006432.15 ENST00000555993.6 ENSP00000451263.2
ENSG00000006432.15 ENST00000381250.8 ENSP00000370649.4
ENSG00000006432.15 ENST00000554146.1 ENSP00000451921.1
ENSG00000006432.15 ENST00000611979.4 ENSP00000480011.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Drug and target
TTDDrugBankGRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtPHOSIDA
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.70e-15 58.3 58 112
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 7    qvlydyeaqnddeLtlkkGdvvlvi...ekeeqdegWlkgvkelegkrGlfPenFve 60
            + ++yea+ +deLtl+ Gdvv+v+   ++ + degW+ g  +l+++ G+fP+n+v+
   Q: 58   TAVFEYEAAGEDELTLRLGDVVEVLskdSQVSGDEGWWTG--QLNQRVGIFPSNYVT 112
           689**********************76666777*******..8************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
 Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Protein Sequence
(Fasta)
MEPSRALLGC LASAAAAAPP GEDGAGAGAE EEEEEEEEAA AAVGPGELGC DAPLPYWTAV 60
FEYEAAGEDE LTLRLGDVVE VLSKDSQVSG DEGWWTGQLN QRVGIFPSNY VTPRSAFSSR 120
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Protein Fasta Sequence


>IUUC-Hsa-045938|UBD,SH3|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGGGGCGGGG CACGGCACGG CGCGGAGAGG AGAGCGGCGG CCGGCTGGCA GCGGCGGGCA 60
CCGGCTGCGC GAGCAGGTAC CGGCGGCAGA GGTGACGAGG CCGCCCCCGG GGGGGCGAGC 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-045938|UBD,SH3|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0728--SH3 domain
KW-0346--Stress response
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
Interpro

IPR011009--Kinase-like_dom
IPR016231--MLK1/MLK2/MLK4
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008271--Ser/Thr_kinase_AS
IPR001452--SH3_domain
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50002--SH3
Pfam

PF00069--Pkinase
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
PR00109--TYRKINASE
SMART

SM00220--S_TKc
SM00326--SH3
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0004706--F:JUN kinase kinase kinase activity
GO:0004708--F:MAP kinase kinase activity
GO:0042803--F:protein homodimerization activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0007257--P:activation of JUN kinase activity
GO:0006915--P:apoptotic process
GO:0043065--P:positive regulation of apoptotic process
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:4293
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001439 Ailuropoda melanoleuca 95.34 0.00e+00 1825.00
IUUC-Aca-004389 Anolis carolinensis 74.10 0.00e+00 1340.00
IUUC-Bta-012675 Bos taurus 92.54 0.00e+00 1709.00
IUUC-Cel-018266 Caenorhabditis elegans 31.66 1.00e-51 198.00
IUUC-Cja-018922 Callithrix jacchus 97.39 0.00e+00 1840.00
IUUC-Cpo-021603 Cavia porcellus 93.73 0.00e+00 1757.00
IUUC-Csa-023806 Chlorocebus sabaeus 99.21 0.00e+00 1196.00
IUUC-Cho-025023 Choloepus hoffmanni 97.56 4.00e-94 338.00
IUUC-Csv-026102 Ciona savignyi 58.46 2.00e-163 568.00
IUUC-Dre-028642 Danio rerio 58.05 0.00e+00 954.00
IUUC-Dno-029040 Dasypus novemcinctus 95.34 0.00e+00 1792.00
IUUC-Dme-032210 Drosophila melanogaster 47.48 2.00e-140 493.00
IUUC-Fal-036753 Ficedula albicollis 78.95 0.00e+00 1317.00
IUUC-Gga-040283 Gallus gallus 79.23 0.00e+00 1426.00
IUUC-Gac-041536 Gasterosteus aculeatus 57.27 0.00e+00 904.00
IUUC-Ggo-045285 Gorilla gorilla 99.41 0.00e+00 1038.00
IUUC-Lch-049935 Latimeria chalumnae 59.23 0.00e+00 970.00
IUUC-Loc-051860 Lepisosteus oculatus 62.80 0.00e+00 994.00
IUUC-Laf-053926 Loxodonta africana 93.38 0.00e+00 1746.00
IUUC-Mcc-055636 Macaca mulatta 99.07 0.00e+00 1867.00
IUUC-Mmr-061210 Microcebus murinus 95.69 0.00e+00 1730.00
IUUC-Mdo-062056 Monodelphis domestica 89.96 0.00e+00 1694.00
IUUC-Mmu-063275 Mus musculus 91.99 0.00e+00 1685.00
IUUC-Mac-064532 Musa acuminata 33.93 5.00e-23 103.00
IUUC-Mlu-067856 Myotis lucifugus 92.26 0.00e+00 1637.00
IUUC-Nle-068969 Nomascus leucogenys 97.11 0.00e+00 1795.00
IUUC-Ont-071908 Oreochromis niloticus 68.87 0.00e+00 813.00
IUUC-Ola-087339 Oryzias latipes 58.09 0.00e+00 907.00
IUUC-Oga-088123 Otolemur garnettii 90.50 0.00e+00 1722.00
IUUC-Ptr-091156 Pan troglodytes 97.76 0.00e+00 1839.00
IUUC-Pan-091971 Papio anubis 97.57 0.00e+00 1835.00
IUUC-Pma-094398 Petromyzon marinus 64.65 0.00e+00 699.00
IUUC-Pfo-096513 Poecilia formosa 56.12 0.00e+00 904.00
IUUC-Pab-097753 Pongo abelii 97.48 0.00e+00 1831.00
IUUC-Pca-100945 Procavia capensis 89.56 0.00e+00 1658.00
IUUC-Pva-102748 Pteropus vampyrus 92.34 0.00e+00 1738.00
IUUC-Rno-105729 Rattus norvegicus 93.85 0.00e+00 1734.00
IUUC-Sit-109929 Setaria italica 31.20 3.00e-23 104.00
IUUC-Tru-117541 Takifugu rubripes 57.14 0.00e+00 883.00
IUUC-Tni-119938 Tetraodon nigroviridis 70.60 0.00e+00 770.00
IUUC-Tbe-128153 Tupaia belangeri 91.28 0.00e+00 1652.00
IUUC-Ttr-128341 Tursiops truncatus 91.88 0.00e+00 1641.00
IUUC-Xtr-131880 Xenopus tropicalis 67.78 0.00e+00 1209.00
Created Date 25-Jun-2017

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