iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028089

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

WD repeat and SOCS box-containing protein 1

Genbank Nucleotide ID

BC054567

Gene Name

wsb1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000021343.4	ENSDART00000008854.4	ENSDARP00000005989.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	2.20e-13	50.8	377	421
E3 adaptor/Cullin RING/DCX/DWD	7.70e-33	112.0	170	204
UBD/Beta-Prp	7.50e-49	167.4	135	379

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
            +w  +++  SLqhLCR++ rr +++q++    +LP+P s++dYL y+
   Q: 377  HFWASPRSIASLQHLCRMTLRRVMPTQQV---YTLPIPFSMQDYLAYK 421
           6999**********************999...**************98 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtg 33
           Htd v++l f +d    lvs+s+D+t++vWDl+++
   Q: 170  HTDIVRDLTFaPDgsLVLVSASRDKTLRVWDLKDD 204
           ***********8864558*************9887 PP

UBD/Beta-Prp

   S: 16   vkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsf 102
            kf +d+ llatg  +g+ik+wdv tgkll  l +h++ v++++f pdg+ +lv++s+D+t++vwdl+ +g +v +l+gh++ v++ +f
   Q: 135  FKFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLMDHTDIVRDLTFAPDGSlVLVSASRDKTLRVWDLKdDGNMVKVLRGHQNWVYCSAF 223
           68899999******************************************99***************989******************* PP
   S: 103  spsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl............tggh 179
           sp++++l s ++ + + +wd+++++ ++  l+gh+  v c +++pdg ll+++s+D+ v +Wd  t+++l +l             g++
   Q: 224  SPDSSVLCSVGAGKAVFLWDMDKYTLIR-KLEGHHNDVVCCEFSPDGALLATASYDTRVIVWDPHTATVLLELghlfpppspifaGGAN 311
           ****************************.9******************************************************9888* PP
   S: 180  tdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           ++ v+s++f ++g++++s+ +d+ v++w++ +++   + +g  +n ++ +fs ++  l  gs Dgs+ +W
   Q: 312  DRWVRSVAFCHDGRHIASVTDDRLVRFWSIDEKS--PQAIGPLTNGLCCAFSTDGSVLSAGSRDGSVHFW 379
           ******************************9995..8999****************************** PP

Organism

Danio rerio

Functional Description
(View)

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MASFPDCVNE NEIGKAKFIG ELIPPVAPFD QKSGRETWTV AFAPDGSYFA WSQGHRIVRL 60
VPWKKCLASF SVRKEDRSSG AGPRRLSRQN SEGSLLPGEP REHTIDCGDI VWGLAFGSSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATCGTTTGG ACGTTTACAG CCATTACAAT ACACAGAATC CACGCAGAGA GCACCGCTGT 60
TTGAGGAAGC CGGAATATTT ACATCCTAAT TTAAGTTTAA AATTAGTTTC AATTAAACTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR011045--N2O_reductase_N
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

dre:323226

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001635	Ailuropoda melanoleuca	75.53	0.00e+00	665.00
IUUC-Apl-003903	Anas platyrhynchos	75.25	0.00e+00	660.00
IUUC-Aca-005214	Anolis carolinensis	65.73	6.00e-171	593.00
IUUC-Ame-011740	Astyanax mexicanus	90.07	0.00e+00	801.00
IUUC-Bta-013475	Bos taurus	75.12	0.00e+00	667.00
IUUC-Cja-019053	Callithrix jacchus	74.88	0.00e+00	678.00
IUUC-Cfa-020103	Canis familiaris	75.30	0.00e+00	665.00
IUUC-Cpo-022438	Cavia porcellus	74.58	0.00e+00	674.00
IUUC-Csa-024062	Chlorocebus sabaeus	75.06	0.00e+00	681.00
IUUC-Cho-024334	Choloepus hoffmanni	68.01	2.00e-165	575.00
IUUC-Cin-025590	Ciona intestinalis	41.06	3.00e-77	282.00
IUUC-Csv-026023	Ciona savignyi	42.17	6.00e-79	287.00
IUUC-Dno-029436	Dasypus novemcinctus	78.95	1.00e-161	562.00
IUUC-Dor-031107	Dipodomys ordii	70.31	5.00e-173	600.00
IUUC-Ete-032326	Echinops telfairi	75.37	0.00e+00	643.00
IUUC-Eca-033401	Equus caballus	75.53	0.00e+00	666.00
IUUC-Eeu-034520	Erinaceus europaeus	73.87	0.00e+00	670.00
IUUC-Fca-036386	Felis catus	75.06	0.00e+00	666.00
IUUC-Fal-036616	Ficedula albicollis	74.26	0.00e+00	650.00
IUUC-Gmo-039335	Gadus morhua	80.93	0.00e+00	673.00
IUUC-Gga-040856	Gallus gallus	75.77	0.00e+00	683.00
IUUC-Gac-042140	Gasterosteus aculeatus	84.31	0.00e+00	750.00
IUUC-Ggo-044619	Gorilla gorilla	74.88	0.00e+00	682.00
IUUC-Hsa-046300	Homo sapiens	75.06	0.00e+00	680.00
IUUC-Itr-048830	Ictidomys tridecemlineatus	75.06	0.00e+00	676.00
IUUC-Lch-049550	Latimeria chalumnae	75.29	2.00e-158	551.00
IUUC-Loc-051769	Lepisosteus oculatus	86.46	0.00e+00	743.00
IUUC-Laf-054576	Loxodonta africana	76.25	0.00e+00	665.00
IUUC-Mcc-054666	Macaca mulatta	77.01	1.00e-125	442.00
IUUC-Meu-055989	Macropus eugenii	76.79	6.00e-159	553.00
IUUC-Mga-059722	Meleagris gallopavo	74.64	0.00e+00	671.00
IUUC-Mmr-060970	Microcebus murinus	75.30	0.00e+00	666.00
IUUC-Mdo-062249	Monodelphis domestica	64.00	5.00e-152	530.00
IUUC-Mmu-063742	Mus musculus	72.68	0.00e+00	655.00
IUUC-Mpu-066518	Mustela putorius furo	75.53	0.00e+00	684.00
IUUC-Mlu-068063	Myotis lucifugus	75.53	0.00e+00	660.00
IUUC-Nle-069561	Nomascus leucogenys	75.30	0.00e+00	682.00
IUUC-Opr-071158	Ochotona princeps	71.56	0.00e+00	648.00
IUUC-Ont-072542	Oreochromis niloticus	82.90	0.00e+00	729.00
IUUC-Oan-073217	Ornithorhynchus anatinus	75.36	0.00e+00	679.00
IUUC-Ocu-074251	Oryctolagus cuniculus	74.69	0.00e+00	648.00
IUUC-Ola-086549	Oryzias latipes	80.09	0.00e+00	718.00
IUUC-Oga-088382	Otolemur garnettii	74.82	0.00e+00	663.00
IUUC-Oar-090263	Ovis aries	74.35	0.00e+00	667.00
IUUC-Ptr-090922	Pan troglodytes	75.06	0.00e+00	681.00
IUUC-Pan-092518	Papio anubis	75.06	0.00e+00	681.00
IUUC-Psi-093512	Pelodiscus sinensis	75.30	0.00e+00	676.00
IUUC-Pma-094324	Petromyzon marinus	58.66	3.00e-138	485.00
IUUC-Pfo-096264	Poecilia formosa	82.67	0.00e+00	744.00
IUUC-Pab-098018	Pongo abelii	73.63	0.00e+00	667.00
IUUC-Pca-101034	Procavia capensis	74.45	2.00e-178	618.00
IUUC-Pva-102862	Pteropus vampyrus	73.16	1.00e-176	612.00
IUUC-Rno-106116	Rattus norvegicus	73.70	0.00e+00	669.00
IUUC-Sha-106952	Sarcophilus harrisii	73.46	0.00e+00	627.00
IUUC-Sar-113211	Sorex araneus	67.40	6.00e-121	427.00
IUUC-Ssc-116440	Sus scrofa	75.77	0.00e+00	668.00
IUUC-Tgu-116675	Taeniopygia guttata	74.02	0.00e+00	646.00
IUUC-Tru-118295	Takifugu rubripes	79.63	0.00e+00	699.00
IUUC-Tsy-118916	Tarsius syrichta	64.13	4.00e-158	551.00
IUUC-Tni-120302	Tetraodon nigroviridis	79.39	0.00e+00	694.00
IUUC-Tbe-127416	Tupaia belangeri	63.64	5.00e-153	533.00
IUUC-Ttr-128185	Tursiops truncatus	75.36	0.00e+00	667.00
IUUC-Xtr-132465	Xenopus tropicalis	74.70	0.00e+00	678.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence