iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049550

Ensembl Protein ID

ENSLACP00000019777.1

UniProt Accession

H3BD06; H3BD06_LATCH

Genbank Protein ID

ENSLACP00000019777

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01008463

Gene Name

WSB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000017388.1	ENSLACT00000019915.1	ENSLACP00000019777.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.30e-31	106.2	99	133
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	2.20e-16	59.7	305	350
UBD/Beta-Prp	9.00e-47	159.9	63	313

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtg 33
           Ht+ v++l f +d   +lvs+s+D+t++vWDl+++
   Q: 99   HTEVVRDLTFaPDgsLILVSASRDKTLRVWDLKDD 133
           9**********8865668*************9987 PP

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           +++w ++s++ SLqhLCR+aIrr + ++++   +kLP+P+++ d+L y+
   Q: 305  VYFWATPSNVASLQHLCRMAIRRVIATTQV---KKLPIPPKMVDFLTYQ 350
           589************************999...**************98 PP

UBD/Beta-Prp

   S: 15   cvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlsls 101
             kf +d+ llatg  +g+ik+wdv tgkll  l +h++ v++++f pdg+ ilv++s+D+t++vwdl+ +g +  +lkgh++ v+s+s
   Q: 63   RFKFGQDQLLLATGLNSGRIKIWDVYTGKLLLNLMDHTEVVRDLTFAPDGSlILVSASRDKTLRVWDLKdDGNMAKVLKGHQSWVYSCS 151
           56889999************************************************************989****************** PP
   S: 102  fspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl............tgg 178
           fsp+++ l s ++ + + +w++++++ ++  l+gh+  v + +++pdg llv++s+D+ v +Wd  tg++lr l             g+
   Q: 152  FSPDSSILCSVGAGKAVFLWNMDKYTMIR-KLEGHHNDVVSCEFSPDGGLLVTASYDTRVIVWDPYTGSILRVLghlfppptpifaGGA 239
           *****************************.999999999999*******************************************9888 PP
   S: 179  htdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW....d 250
           +++ v+s+sf+++g +++s+++d+ v++w + +g  v+   +  +  ++  fs ++  l+ g+ Dg +++W    +
   Q: 240  NDRWVRSVSFSHDGLHVASIADDKMVRFWRIDNGAPVEV--ASLSKGLCCVFSIDGGVLAAGTRDGNVYFWatpsN 313
           **********************************88775..55556666788889****************44443 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

LPNCKKNFNN TVERRLSRQN SDGNQKSVLQ EHALDCGDIV WSLAFGSSVS EKQSCCVDVE 60
WHRFKFGQDQ LLLATGLNSG RIKIWDVYTG KLLLNLMDHT EVVRDLTFAP DGSLILVSAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATTGACAGG CACGTTGGGG ATCCGTGGAA AATTTGCAGA GCATTGAAAA AGTGACTGTA 60
ATTCTTCAAG TAAGACCGAA TTTGCCAGTA GCTCTGCTAT GTATTTGTTT TATAAGAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001635	Ailuropoda melanoleuca	80.06	3.00e-164	571.00
IUUC-Apl-003903	Anas platyrhynchos	81.79	1.00e-171	595.00
IUUC-Aca-005214	Anolis carolinensis	68.66	2.00e-145	508.00
IUUC-Ame-011740	Astyanax mexicanus	73.54	1.00e-158	552.00
IUUC-Bta-013475	Bos taurus	80.64	7.00e-166	576.00
IUUC-Cja-019053	Callithrix jacchus	80.00	7.00e-170	589.00
IUUC-Cfa-020103	Canis familiaris	80.35	6.00e-165	573.00
IUUC-Cpo-022438	Cavia porcellus	79.48	1.00e-168	585.00
IUUC-Csa-024062	Chlorocebus sabaeus	79.48	7.00e-170	589.00
IUUC-Cho-024334	Choloepus hoffmanni	70.30	7.00e-137	479.00
IUUC-Cin-025590	Ciona intestinalis	43.21	5.00e-73	268.00
IUUC-Csv-026023	Ciona savignyi	47.39	2.00e-73	269.00
IUUC-Dre-028089	Danio rerio	75.29	2.00e-158	551.00
IUUC-Dno-029436	Dasypus novemcinctus	78.63	1.00e-164	572.00
IUUC-Dor-031107	Dipodomys ordii	73.64	2.00e-145	508.00
IUUC-Ete-032326	Echinops telfairi	80.23	1.00e-165	575.00
IUUC-Eca-033401	Equus caballus	80.64	2.00e-165	575.00
IUUC-Eeu-034520	Erinaceus europaeus	78.03	4.00e-167	580.00
IUUC-Fca-036386	Felis catus	80.06	6.00e-165	573.00
IUUC-Fal-036616	Ficedula albicollis	79.19	3.00e-166	577.00
IUUC-Gmo-039335	Gadus morhua	77.57	2.00e-152	531.00
IUUC-Gga-040856	Gallus gallus	81.79	9.00e-173	599.00
IUUC-Gac-042140	Gasterosteus aculeatus	73.28	2.00e-157	548.00
IUUC-Ggo-044619	Gorilla gorilla	80.35	3.00e-170	590.00
IUUC-Hsa-046300	Homo sapiens	80.06	3.00e-170	590.00
IUUC-Itr-048830	Ictidomys tridecemlineatus	79.48	5.00e-170	590.00
IUUC-Loc-051769	Lepisosteus oculatus	77.84	2.00e-162	565.00
IUUC-Laf-054576	Loxodonta africana	80.92	5.00e-167	580.00
IUUC-Mcc-054666	Macaca mulatta	80.53	4.00e-130	456.00
IUUC-Meu-055989	Macropus eugenii	78.84	9.00e-165	572.00
IUUC-Mga-059722	Meleagris gallopavo	82.08	2.00e-173	602.00
IUUC-Mmr-060970	Microcebus murinus	81.21	4.00e-165	573.00
IUUC-Mdo-062249	Monodelphis domestica	69.36	8.00e-131	459.00
IUUC-Mmu-063742	Mus musculus	77.39	3.00e-164	571.00
IUUC-Mpu-066518	Mustela putorius furo	80.64	1.00e-170	592.00
IUUC-Mlu-068063	Myotis lucifugus	80.06	2.00e-164	571.00
IUUC-Nle-069561	Nomascus leucogenys	80.06	3.00e-170	590.00
IUUC-Opr-071158	Ochotona princeps	77.68	5.00e-164	570.00
IUUC-Ont-072542	Oreochromis niloticus	73.58	4.00e-155	540.00
IUUC-Oan-073217	Ornithorhynchus anatinus	82.57	2.00e-175	607.00
IUUC-Ocu-074251	Oryctolagus cuniculus	79.19	7.00e-166	576.00
IUUC-Ola-086549	Oryzias latipes	75.07	1.00e-155	542.00
IUUC-Oga-088382	Otolemur garnettii	79.48	7.00e-165	573.00
IUUC-Oar-090263	Ovis aries	79.48	5.00e-167	580.00
IUUC-Ptr-090922	Pan troglodytes	80.06	2.00e-170	592.00
IUUC-Pan-092518	Papio anubis	79.48	7.00e-170	589.00
IUUC-Psi-093512	Pelodiscus sinensis	80.92	2.00e-170	591.00
IUUC-Pma-094324	Petromyzon marinus	64.38	2.00e-121	429.00
IUUC-Pfo-096264	Poecilia formosa	74.72	2.00e-158	551.00
IUUC-Pab-098018	Pongo abelii	80.06	4.00e-170	590.00
IUUC-Pca-101034	Procavia capensis	78.32	5.00e-157	546.00
IUUC-Pva-102862	Pteropus vampyrus	77.58	3.00e-156	544.00
IUUC-Rno-106116	Rattus norvegicus	78.03	8.00e-166	576.00
IUUC-Sha-106952	Sarcophilus harrisii	81.46	1.00e-163	568.00
IUUC-Sar-113211	Sorex araneus	73.15	3.00e-103	368.00
IUUC-Ssc-116440	Sus scrofa	80.35	5.00e-165	573.00
IUUC-Tgu-116675	Taeniopygia guttata	80.64	5.00e-168	583.00
IUUC-Tru-118295	Takifugu rubripes	72.13	1.00e-148	519.00
IUUC-Tsy-118916	Tarsius syrichta	67.88	3.00e-131	461.00
IUUC-Tni-120302	Tetraodon nigroviridis	72.41	1.00e-148	519.00
IUUC-Tbe-127416	Tupaia belangeri	67.32	5.00e-133	467.00
IUUC-Ttr-128185	Tursiops truncatus	80.92	8.00e-166	576.00
IUUC-Xtr-132465	Xenopus tropicalis	79.83	3.00e-168	584.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence