iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012750

Ensembl Protein ID

ENSBTAP00000041904.3

UniProt Accession

F1MBM6; F1MBM6_BOVIN

Genbank Protein ID

ENSBTAP00000041904

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

DAAA02002676

Gene Name

SIAH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000023445.4	ENSBTAT00000044404.3	ENSBTAP00000041904.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	99.61	3.00e-152	535.00	IUUC-Hsa-046179
E3 activity/RING/RING	99.61	1.00e-151	533.00	IUUC-Mmu-063206
E3 activity/RING/RING	99.61	8.00e-152	533.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSRPSSTGPS ANKPCSKQPP PQPQHAPSPA APPAAATISA AGPGSSAVPA AAAVISGPGG 60
GGGGGGGGGG GAGPVSPQHH ELTSLFECPV CFDYVLPPIL QCQAGHLVCN QCRQKLSCCP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCCGCC CGTCCTCCAC CGGCCCCAGC GCTAACAAAC CCTGCAGCAA GCAGCCGCCG 60
CCGCAGCCAC AGCACGCTCC GTCCCCGGCT GCGCCCCCGG CCGCCGCCAC CATCTCGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

bta:785659

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	99.61	3.00e-156	543.00
IUUC-Ame-011678	Astyanax mexicanus	91.70	4.00e-141	493.00
IUUC-Cja-019800	Callithrix jacchus	99.61	1.00e-153	535.00
IUUC-Cfa-020505	Canis familiaris	99.22	4.00e-154	537.00
IUUC-Cpo-021394	Cavia porcellus	98.84	2.00e-153	535.00
IUUC-Csa-023374	Chlorocebus sabaeus	99.61	1.00e-153	535.00
IUUC-Cho-024933	Choloepus hoffmanni	99.61	1.00e-154	538.00
IUUC-Dre-027711	Danio rerio	91.30	8.00e-141	493.00
IUUC-Dno-029260	Dasypus novemcinctus	99.59	1.00e-147	515.00
IUUC-Dor-030489	Dipodomys ordii	95.68	2.00e-107	381.00
IUUC-Ete-032946	Echinops telfairi	98.84	6.00e-155	539.00
IUUC-Eca-033546	Equus caballus	99.22	1.00e-155	541.00
IUUC-Eeu-034861	Erinaceus europaeus	95.74	3.00e-148	517.00
IUUC-Fal-037160	Ficedula albicollis	88.05	1.00e-132	465.00
IUUC-Gmo-039091	Gadus morhua	89.33	5.00e-139	486.00
IUUC-Gga-040252	Gallus gallus	97.67	4.00e-152	530.00
IUUC-Gac-041673	Gasterosteus aculeatus	89.33	3.00e-139	487.00
IUUC-Ggo-044618	Gorilla gorilla	99.61	1.00e-153	535.00
IUUC-Hsa-046179	Homo sapiens	99.61	1.00e-153	535.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	98.06	4.00e-154	536.00
IUUC-Lch-049496	Latimeria chalumnae	79.76	7.00e-151	526.00
IUUC-Loc-052107	Lepisosteus oculatus	92.40	3.00e-141	494.00
IUUC-Laf-054257	Loxodonta africana	99.22	2.00e-153	534.00
IUUC-Mcc-055023	Macaca mulatta	99.61	1.00e-153	535.00
IUUC-Meu-055922	Macropus eugenii	96.86	3.00e-149	520.00
IUUC-Mga-060070	Meleagris gallopavo	96.11	3.00e-148	517.00
IUUC-Mmr-061494	Microcebus murinus	99.61	1.00e-153	535.00
IUUC-Mdo-061971	Monodelphis domestica	98.43	2.00e-153	534.00
IUUC-Mmu-063206	Mus musculus	99.61	5.00e-153	533.00
IUUC-Mpu-066597	Mustela putorius furo	99.61	1.00e-153	535.00
IUUC-Mlu-067199	Myotis lucifugus	99.22	5.00e-154	536.00
IUUC-Nle-069342	Nomascus leucogenys	99.61	1.00e-153	535.00
IUUC-Opr-070341	Ochotona princeps	56.86	3.00e-50	191.00
IUUC-Ont-071906	Oreochromis niloticus	89.72	3.00e-140	491.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	4.00e-50	191.00
IUUC-Ocu-073950	Oryctolagus cuniculus	100.00	3.00e-157	547.00
IUUC-Oga-089154	Otolemur garnettii	99.61	1.00e-153	535.00
IUUC-Oar-089446	Ovis aries	99.23	2.00e-157	547.00
IUUC-Ptr-091088	Pan troglodytes	99.61	1.00e-153	535.00
IUUC-Psi-093079	Pelodiscus sinensis	98.86	8.00e-159	552.00
IUUC-Pfo-097007	Poecilia formosa	84.98	6.00e-133	466.00
IUUC-Pab-098092	Pongo abelii	99.61	1.00e-153	535.00
IUUC-Pca-100328	Procavia capensis	97.25	7.00e-149	519.00
IUUC-Pva-102368	Pteropus vampyrus	99.11	5.00e-64	237.00
IUUC-Rno-105477	Rattus norvegicus	99.61	5.00e-153	533.00
IUUC-Sha-107630	Sarcophilus harrisii	98.48	2.00e-158	550.00
IUUC-Ssc-116441	Sus scrofa	100.00	6.00e-154	536.00
IUUC-Tru-118004	Takifugu rubripes	86.96	1.00e-134	472.00
IUUC-Tsy-119548	Tarsius syrichta	88.72	2.00e-67	248.00
IUUC-Tni-120846	Tetraodon nigroviridis	88.54	6.00e-137	479.00
IUUC-Vpa-130799	Vicugna pacos	100.00	2.00e-104	370.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence