iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073695

UUCD1 version

UUC-OrA-00843

Ensembl Protein ID

ENSOANP00000004672.1

UniProt Accession

F7A9J4; F7A9J4_ORNAN

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP33

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000002941.1	ENSOANT00000004673.1	ENSOANP00000004672.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.50e-90	302.2	153	640

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tGlkN+gNtCYmN++LQ+Lsn+p+l++++l+     +    ++++k +++ks+ kl++elw ks+ ++v p++l++ +k++++ f+gy+
   Q: 153  TGLKNIGNTCYMNAALQALSNCPPLTQFFLD-----CGGLVRTDKKPAICKSYLKLMTELWhKSRPGSVVPTNLFQGIKTVNPAFRGYS 236
           7******************************.....999999*******************99************************** PP
   S: 89   qqDaqEflaflldqleeelkk.........eknkpkeeeeeedkselsde....................................... 129
           qqDaqEfl++l+d l+eelk+             + ee++eedks+   +                                       
   Q: 237  QQDAQEFLRCLMDLLHEELKEqvmeleenvP-AVTPEESMEEDKSQ---Sdadfqscescsssdkaenesgsrgftedhaettmliqde 321
           *******************888887766532.22222333333333...1334789999999999************************ PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 322  ennpvlskdwqkekicnklnqinseedmekdidtmadpaefsnnqetvkvqihsrfseyitdahlnepstpqtppsneginlrlstspp 410
           ***************************************************************************************** PP
   S: 130  .....................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke............ 185
                                 ++kk+kk++s+isd+F+g++ s+++cl+cd+vs++ e+f+dlslp+pgke+ +k+            
   Q: 411  ksgslwsglapahkkapsapsPKKKKHKKYRSVISDVFDGTIVSSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLhssshptsivka 499
           ********************98899999********************************************99888************ PP
   S: 186  .....................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRf 237
                                                +lqdcL++f++++el+g+n+y+cekckk+++ +k +k++k+Pe+L++hLkRf
   Q: 500  gscgeayapqgwiaffmeyfkrfvvscvpswfwgpvvTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQKFPEILCIHLKRF 588
           ***************************************************************************************** PP
   S: 238  sfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslss 292
             ++e ++++ki+++v+fple Ldl++f+++++ +q   ++Y+L++ ++H+G++ss
   Q: 589  --RHELMFSTKISTHVSFPLEgLDLQSFLAKDSPAQ--IVTYDLLSAICHHGTASS 640
           ..9999*************************88777..9*************9875 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MSALSSYCPH LESVGEITKE ELIQKSHGTC QDCKVRGPNL WACLENGCSY VGCGESYVDH 60
STIHSQDTKH CLTVNLTTLR VWCYACSKEV FLDRKLGTQS PLPSARQLQQ VQENVQDFKI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCAGCCC TCAGCAGTTA CTGTCCTCAT TTGGAATCGG TTGGGGAAAT AACAAAGGAA 60
GAGTTGATTC AGAAATCTCA TGTGAGCACT CTAGTTCTTT TTCCTCTCTG CCATAAAATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005776--C:autophagosome
GO:0044297--C:cell body
GO:0005813--C:centrosome
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0007411--P:axon guidance
GO:0016477--P:cell migration
GO:0009267--P:cellular response to starvation
GO:0051298--P:centrosome duplication
GO:0032091--P:negative regulation of protein binding
GO:0032092--P:positive regulation of protein binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001742	Ailuropoda melanoleuca	85.87	0.00e+00	1077.00
IUUC-Apl-003987	Anas platyrhynchos	82.87	0.00e+00	1027.00
IUUC-Aca-004713	Anolis carolinensis	76.56	0.00e+00	944.00
IUUC-Bta-013132	Bos taurus	85.67	0.00e+00	1072.00
IUUC-Cja-018811	Callithrix jacchus	85.80	0.00e+00	1082.00
IUUC-Cfa-021158	Canis familiaris	86.02	0.00e+00	1077.00
IUUC-Cpo-021910	Cavia porcellus	83.76	0.00e+00	928.00
IUUC-Csa-023130	Chlorocebus sabaeus	86.27	0.00e+00	1082.00
IUUC-Cho-024383	Choloepus hoffmanni	69.25	5.00e-160	557.00
IUUC-Dno-029416	Dasypus novemcinctus	86.92	0.00e+00	1052.00
IUUC-Ete-032994	Echinops telfairi	71.86	0.00e+00	755.00
IUUC-Eca-034248	Equus caballus	85.67	0.00e+00	1073.00
IUUC-Eeu-035357	Erinaceus europaeus	70.05	0.00e+00	796.00
IUUC-Fca-036013	Felis catus	82.09	0.00e+00	1015.00
IUUC-Fal-037509	Ficedula albicollis	81.12	0.00e+00	994.00
IUUC-Gga-040647	Gallus gallus	79.60	0.00e+00	993.00
IUUC-Ggo-044689	Gorilla gorilla	76.48	0.00e+00	852.00
IUUC-Hsa-045694	Homo sapiens	85.02	0.00e+00	1064.00
IUUC-Itr-049041	Ictidomys tridecemlineatus	85.20	0.00e+00	1048.00
IUUC-Laf-053493	Loxodonta africana	85.51	0.00e+00	1074.00
IUUC-Mcc-055542	Macaca mulatta	86.27	0.00e+00	1085.00
IUUC-Meu-056645	Macropus eugenii	74.14	0.00e+00	884.00
IUUC-Mmr-061241	Microcebus murinus	82.53	0.00e+00	1049.00
IUUC-Mmu-063786	Mus musculus	82.53	0.00e+00	1006.00
IUUC-Mpu-065772	Mustela putorius furo	86.40	0.00e+00	824.00
IUUC-Mlu-067732	Myotis lucifugus	84.67	0.00e+00	1056.00
IUUC-Nle-069528	Nomascus leucogenys	85.02	0.00e+00	1085.00
IUUC-Opr-070606	Ochotona princeps	80.66	0.00e+00	948.00
IUUC-Ocu-074457	Oryctolagus cuniculus	81.66	0.00e+00	1043.00
IUUC-Oga-088720	Otolemur garnettii	86.41	0.00e+00	1084.00
IUUC-Oar-089921	Ovis aries	85.67	0.00e+00	1075.00
IUUC-Ptr-090526	Pan troglodytes	85.34	0.00e+00	1068.00
IUUC-Pan-092396	Papio anubis	86.00	0.00e+00	1081.00
IUUC-Psi-092971	Pelodiscus sinensis	83.64	0.00e+00	1073.00
IUUC-Pab-098740	Pongo abelii	85.80	0.00e+00	1097.00
IUUC-Pva-102820	Pteropus vampyrus	81.78	0.00e+00	1026.00
IUUC-Rno-104894	Rattus norvegicus	82.09	0.00e+00	1008.00
IUUC-Sha-107244	Sarcophilus harrisii	78.29	0.00e+00	946.00
IUUC-Sar-113665	Sorex araneus	82.24	0.00e+00	1063.00
IUUC-Ssc-115793	Sus scrofa	84.58	0.00e+00	1045.00
IUUC-Tgu-117487	Taeniopygia guttata	82.87	0.00e+00	1011.00
IUUC-Tsy-119598	Tarsius syrichta	76.60	0.00e+00	916.00
IUUC-Tbe-128125	Tupaia belangeri	77.41	4.00e-97	348.00
IUUC-Ttr-128269	Tursiops truncatus	82.50	0.00e+00	1012.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence