iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117682

UUCD1 version

UUC-TaR-00545

Ensembl Protein ID

ENSTRUP00000026187.1

UniProt Accession

H2TND1; H2TND1_TAKRU

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000010399.1	ENSTRUT00000026294.1	ENSTRUP00000026187.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-75	255.6	1468	1793

Active Site

Position(s)	Description	Evidence
1763	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 16   EegldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykl 99
           +e+ + +G+tr ++++ +++  + +  ++lf +  +++ ++ +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k 
   Q: 1468 QENRKRHGSTRSVVDMELDDPDDGEdnAPLFyQPGKRGFYSPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKV 1550
           5667777888888888777777766667788233333666666666554....89******************************** PP
   S: 100  llgkklsledleevdpelykslkeikena...esdieelgldltfsvseei..lgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
           llg+k++++d++ +dp +y+sl ++ ++    e+d   +++dl+f ++ ++     ++++eL++gG n+pVt  N +eYv++++e+r
   Q: 1551 LLGRKVNWHDFAFFDPVMYESLRQLIRHSqagEADAVFAAMDLAFAIDLCKeeGAGQDQVELLSGGVNMPVTPLNVYEYVRKYAEHR 1637
           *********************7777666547766888888888888665443377778888************************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkaf 264
           +    ++ ++a+r+G+ +v+p++ l+ +t+e+++ll++G+ e++v++l ++t+++++  e+  ++    +wFw+++e++s++er+++
   Q: 1638 MLVVAEQPLHAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENADKLlqfkRWFWSIVEKMSMTERQDL 1724
           ******************************************************9999999888888999***************** PP
   S: 265  LqFvTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           + F+T+s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 1725 VYFWTSSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 1793
           ************999******..799999.99**********************************9.99875 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

ESGPSSSDHQ DPVSPPIAPP SWVPDPPPMD PDGDIDFILA PAVGSLTTAS TGTSQGPSTS 60
TIPGPSNESP VVESKDRKAN AHLILKLMCD SVVLRPHLRE LLSAKDARGM TPFMLAVSGR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGTCTGGCC CATCGTCTAG TGACCACCAG GATCCCGTAT CGCCACCAAT TGCCCCGCCA 60
AGTTGGGTTC CTGATCCTCC ACCCATGGAC CCTGGTGAGT GTATCGAGAT AATGACGCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR

Pfam

PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	88.14	0.00e+00	2635.00
IUUC-Apl-004165	Anas platyrhynchos	87.98	0.00e+00	2631.00
IUUC-Aca-004577	Anolis carolinensis	88.03	0.00e+00	2571.00
IUUC-Ame-010702	Astyanax mexicanus	90.03	0.00e+00	2609.00
IUUC-Bta-012313	Bos taurus	88.41	0.00e+00	2637.00
IUUC-Cel-018165	Caenorhabditis elegans	26.68	7.00e-84	306.00
IUUC-Cja-019858	Callithrix jacchus	88.30	0.00e+00	2653.00
IUUC-Cfa-020973	Canis familiaris	88.52	0.00e+00	2641.00
IUUC-Cpo-022065	Cavia porcellus	87.75	0.00e+00	925.00
IUUC-Csa-023985	Chlorocebus sabaeus	88.41	0.00e+00	2655.00
IUUC-Cho-025034	Choloepus hoffmanni	78.39	0.00e+00	910.00
IUUC-Cin-025715	Ciona intestinalis	45.59	0.00e+00	786.00
IUUC-Csv-026131	Ciona savignyi	47.29	0.00e+00	671.00
IUUC-Dre-027730	Danio rerio	94.82	0.00e+00	2774.00
IUUC-Dno-029123	Dasypus novemcinctus	86.12	0.00e+00	2564.00
IUUC-Dor-030757	Dipodomys ordii	89.42	0.00e+00	1248.00
IUUC-Dme-032192	Drosophila melanogaster	52.31	2.00e-173	604.00
IUUC-Ete-032292	Echinops telfairi	84.85	0.00e+00	1641.00
IUUC-Eca-034347	Equus caballus	88.35	0.00e+00	2627.00
IUUC-Eeu-034873	Erinaceus europaeus	82.47	0.00e+00	2438.00
IUUC-Fca-036485	Felis catus	86.16	0.00e+00	2542.00
IUUC-Fal-037071	Ficedula albicollis	88.74	0.00e+00	2641.00
IUUC-Gmo-039589	Gadus morhua	94.39	0.00e+00	2779.00
IUUC-Gga-041195	Gallus gallus	86.86	0.00e+00	2565.00
IUUC-Gac-042538	Gasterosteus aculeatus	95.89	0.00e+00	2825.00
IUUC-Ggo-045351	Gorilla gorilla	87.60	0.00e+00	2660.00
IUUC-Hsa-045941	Homo sapiens	88.35	0.00e+00	2654.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	88.24	0.00e+00	2637.00
IUUC-Lch-050480	Latimeria chalumnae	87.97	0.00e+00	2626.00
IUUC-Loc-052664	Lepisosteus oculatus	90.28	0.00e+00	2673.00
IUUC-Laf-053960	Loxodonta africana	86.78	0.00e+00	1398.00
IUUC-Mcc-054703	Macaca mulatta	88.35	0.00e+00	2654.00
IUUC-Meu-056431	Macropus eugenii	79.94	0.00e+00	729.00
IUUC-Mga-059289	Meleagris gallopavo	88.10	0.00e+00	2676.00
IUUC-Mmr-061737	Microcebus murinus	87.92	0.00e+00	2574.00
IUUC-Mdo-062499	Monodelphis domestica	88.02	0.00e+00	2614.00
IUUC-Mmu-063273	Mus musculus	87.91	0.00e+00	2608.00
IUUC-Mpu-066907	Mustela putorius furo	88.46	0.00e+00	2637.00
IUUC-Mlu-067942	Myotis lucifugus	87.73	0.00e+00	2664.00
IUUC-Nle-069527	Nomascus leucogenys	88.30	0.00e+00	2660.00
IUUC-Opr-070626	Ochotona princeps	83.18	0.00e+00	674.00
IUUC-Ont-071951	Oreochromis niloticus	96.09	0.00e+00	2839.00
IUUC-Oan-072958	Ornithorhynchus anatinus	88.52	0.00e+00	2617.00
IUUC-Ocu-074503	Oryctolagus cuniculus	86.99	0.00e+00	2617.00
IUUC-Ola-086757	Oryzias latipes	94.56	0.00e+00	2803.00
IUUC-Oga-088781	Otolemur garnettii	88.24	0.00e+00	2626.00
IUUC-Oar-089274	Ovis aries	88.41	0.00e+00	2636.00
IUUC-Ptr-090669	Pan troglodytes	88.30	0.00e+00	2652.00
IUUC-Pan-092226	Papio anubis	87.97	0.00e+00	2642.00
IUUC-Psi-093502	Pelodiscus sinensis	87.99	0.00e+00	2618.00
IUUC-Pma-094454	Petromyzon marinus	81.06	0.00e+00	727.00
IUUC-Pfo-096173	Poecilia formosa	95.67	0.00e+00	2861.00
IUUC-Pab-098355	Pongo abelii	89.51	0.00e+00	1556.00
IUUC-Pca-100570	Procavia capensis	88.89	0.00e+00	927.00
IUUC-Pva-102572	Pteropus vampyrus	85.25	0.00e+00	1047.00
IUUC-Rno-104916	Rattus norvegicus	87.96	0.00e+00	2618.00
IUUC-Sha-106653	Sarcophilus harrisii	87.92	0.00e+00	2622.00
IUUC-Sar-113517	Sorex araneus	87.64	0.00e+00	1004.00
IUUC-Ssc-115470	Sus scrofa	88.69	0.00e+00	2286.00
IUUC-Tgu-116932	Taeniopygia guttata	88.41	0.00e+00	2626.00
IUUC-Tsy-119417	Tarsius syrichta	84.81	0.00e+00	2222.00
IUUC-Tni-120442	Tetraodon nigroviridis	93.66	0.00e+00	2640.00
IUUC-Tbe-127456	Tupaia belangeri	75.72	0.00e+00	929.00
IUUC-Ttr-128606	Tursiops truncatus	89.22	0.00e+00	916.00
IUUC-Vpa-130112	Vicugna pacos	84.68	0.00e+00	2460.00
IUUC-Xtr-131929	Xenopus tropicalis	86.90	0.00e+00	2583.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence