iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118579

UUCD1 version

UUC-TaR-00031

Ensembl Protein ID

ENSTRUP00000001228.1

UniProt Accession

H2RM65; H2RM65_TAKRU

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000000517.1	ENSTRUT00000001232.1	ENSTRUP00000001227.1
ENSTRUG00000000517.1	ENSTRUT00000001233.1	ENSTRUP00000001228.1
ENSTRUG00000000517.1	ENSTRUT00000001234.1	ENSTRUP00000001229.1
ENSTRUG00000000517.1	ENSTRUT00000001235.1	ENSTRUP00000001230.1
ENSTRUG00000000517.1	ENSTRUT00000001236.1	ENSTRUP00000001231.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.30e-06	29.3	373	412

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd  ++ pCgH+++++Cl +w    ++s ++  CP Cr
   Q: 373  CKICAENDKD-IKIEPCGHLMCTSCLTAW----QESDGQ-GCPFCR 412
           99********.******************....555555.5****8 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MAAALNGRNP GGRGPNRSKG RILGIIDAIQ DAVGPPKQPA ADRRTVEKTW KLMDKVVRLC 60
QNPRLQLKNS PPYILDILPD AYQHLRLILG KYEENQRLTQ LSENEYFKIY IDSLMKKSKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGAGTAACA TCAGATCACT TGGAAGCAAT AACACAACCA GCACAGGTAG AAAAACACGG 60
AGGAAAGCAG AGACTTATCT TAAACTCTGC TCGAGTGTAA TCTGATTACA TGTGATTTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0006508--P:proteolysis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001412	Ailuropoda melanoleuca	62.17	0.00e+00	941.00
IUUC-Apl-004148	Anas platyrhynchos	61.35	0.00e+00	962.00
IUUC-Aca-005204	Anolis carolinensis	63.12	0.00e+00	964.00
IUUC-Ame-011919	Astyanax mexicanus	63.57	0.00e+00	982.00
IUUC-Bta-013044	Bos taurus	86.26	0.00e+00	882.00
IUUC-Cja-018813	Callithrix jacchus	85.74	0.00e+00	870.00
IUUC-Cfa-021054	Canis familiaris	62.41	0.00e+00	969.00
IUUC-Cpo-022514	Cavia porcellus	61.70	0.00e+00	969.00
IUUC-Csa-024110	Chlorocebus sabaeus	86.07	0.00e+00	879.00
IUUC-Cho-024886	Choloepus hoffmanni	69.12	2.00e-173	602.00
IUUC-Dre-027480	Danio rerio	65.73	0.00e+00	1056.00
IUUC-Dno-028923	Dasypus novemcinctus	62.61	0.00e+00	955.00
IUUC-Dor-031040	Dipodomys ordii	79.69	0.00e+00	722.00
IUUC-Ete-032406	Echinops telfairi	85.96	0.00e+00	792.00
IUUC-Eca-033849	Equus caballus	62.41	0.00e+00	958.00
IUUC-Fca-036224	Felis catus	62.44	0.00e+00	952.00
IUUC-Fal-036860	Ficedula albicollis	84.89	0.00e+00	874.00
IUUC-Gga-040159	Gallus gallus	62.44	0.00e+00	974.00
IUUC-Gac-042312	Gasterosteus aculeatus	66.83	0.00e+00	1097.00
IUUC-Ggo-045175	Gorilla gorilla	86.45	0.00e+00	876.00
IUUC-Hsa-046306	Homo sapiens	86.07	0.00e+00	880.00
IUUC-Loc-052524	Lepisosteus oculatus	67.10	0.00e+00	1007.00
IUUC-Laf-053635	Loxodonta africana	59.17	0.00e+00	878.00
IUUC-Mcc-055536	Macaca mulatta	86.07	0.00e+00	880.00
IUUC-Meu-056045	Macropus eugenii	70.99	0.00e+00	674.00
IUUC-Mga-060177	Meleagris gallopavo	85.28	0.00e+00	801.00
IUUC-Mmr-061088	Microcebus murinus	62.41	0.00e+00	951.00
IUUC-Mdo-062020	Monodelphis domestica	85.88	0.00e+00	877.00
IUUC-Mmu-063114	Mus musculus	86.07	0.00e+00	880.00
IUUC-Mpu-066632	Mustela putorius furo	62.92	0.00e+00	970.00
IUUC-Mlu-067145	Myotis lucifugus	62.31	0.00e+00	949.00
IUUC-Ont-072323	Oreochromis niloticus	81.09	0.00e+00	1041.00
IUUC-Oan-073165	Ornithorhynchus anatinus	63.24	0.00e+00	981.00
IUUC-Ocu-074723	Oryctolagus cuniculus	62.03	0.00e+00	955.00
IUUC-Oga-088021	Otolemur garnettii	86.26	0.00e+00	880.00
IUUC-Oar-089809	Ovis aries	86.07	0.00e+00	880.00
IUUC-Ptr-090834	Pan troglodytes	86.07	0.00e+00	880.00
IUUC-Pan-092225	Papio anubis	86.07	0.00e+00	880.00
IUUC-Psi-093317	Pelodiscus sinensis	63.47	0.00e+00	978.00
IUUC-Pab-097595	Pongo abelii	86.07	0.00e+00	880.00
IUUC-Pca-100844	Procavia capensis	72.14	0.00e+00	679.00
IUUC-Pva-103216	Pteropus vampyrus	86.25	0.00e+00	876.00
IUUC-Pyt-104640	Pyrenophora triticirepentis	30.30	1.00e-05	43.10
IUUC-Rno-105381	Rattus norvegicus	62.13	0.00e+00	956.00
IUUC-Sha-107574	Sarcophilus harrisii	61.08	0.00e+00	937.00
IUUC-Tgu-116866	Taeniopygia guttata	61.71	0.00e+00	950.00
IUUC-Tsy-119167	Tarsius syrichta	74.24	0.00e+00	715.00
IUUC-Tni-120788	Tetraodon nigroviridis	81.95	0.00e+00	1421.00
IUUC-Tbe-127830	Tupaia belangeri	80.92	0.00e+00	806.00
IUUC-Ttr-128631	Tursiops truncatus	62.72	0.00e+00	959.00
IUUC-Vpa-130713	Vicugna pacos	65.61	0.00e+00	878.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence