iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-070051

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Katanin p80 WD40 repeat-containing subunit B1; p80 katanin

Genbank Nucleotide ID

ADFV01013113

Gene Name

KATNB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000003185.2	ENSNLET00000004044.2	ENSNLEP00000003851.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.40e-44	147.4	145	180
UBD/Beta-Prp	7.70e-60	202.5	15	257

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH+  v+cl+f +d + l+s++dD+t+k+WDl+ g+
   Q: 145  GHSQAVRCLRFsPDgKWLASAADDHTVKLWDLTAGK 180
           8***********999*****************9997 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           ++ +h ++v + v  + +++llatg++d ++ +w++ +++++ sl gh+++v +v+++  ++++v gs+ + i+vwdl++ k+++tl g
   Q: 15   EIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMG 103
           67788888999888899************************************************************************ PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           h+++++sl+f+p+g++++sGs+d  i++wd++ + c+    +gh+++v+c++++pdg+ l+s+++D tv+lWdl  gk++ ++ g ht+
   Q: 104  HKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF-RYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG-HTG 190
           *************************************9.9********************************************9.*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +v+ ++f++n   l+sgs d+t+++wdl++ ++v   +g   +v sv f p++  l+sg +D s+r++
   Q: 191  PVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVMSVLFNPDGCCLYSGCQD-SLRVY 257
           **********************************************************9766.45554 PP

Organism

Nomascus leucogenys

Functional Description
(View)

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Protein Sequence
(Fasta)

MATPVVTKTA WKLQEIVAHA SNVSSLVLGK ASGRLLATGG DDCRVNLWSI NKPNCIMSLT 60
GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT LMGHKANICS LDFHPYGEFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTGTATTG AGCTGAGATG GCTCGAGCCT AACATTCCAT GATCCAGGAT CGTGACAGAT 60
GTGCACAGGC TGCTGCTGTT GCTGCTGTGG GTAATTTGGA ACCACGAGGC ACCCCAGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0008352--C:katanin complex
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000922--C:spindle pole
GO:0008568--F:microtubule-severing ATPase activity
GO:0051301--P:cell division
GO:0051013--P:microtubule severing
GO:0007079--P:mitotic chromosome movement towards spindle pole
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0031117--P:positive regulation of microtubule depolymerization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000954	Aegilops tauschii	48.17	2.00e-86	314.00
IUUC-Aml-002187	Ailuropoda melanoleuca	86.45	0.00e+00	1080.00
IUUC-Atr-002899	Amborella trichopoda	54.11	1.00e-101	364.00
IUUC-Apl-003305	Anas platyrhynchos	75.55	0.00e+00	999.00
IUUC-Aca-004635	Anolis carolinensis	79.11	0.00e+00	952.00
IUUC-Aly-005711	Arabidopsis lyrata	51.16	1.00e-100	360.00
IUUC-Ath-007606	Arabidopsis thaliana	51.16	2.00e-100	360.00
IUUC-Ame-010870	Astyanax mexicanus	55.73	8.00e-95	340.00
IUUC-Bta-012527	Bos taurus	93.07	0.00e+00	1153.00
IUUC-Bdi-014652	Brachypodium distachyon	53.18	9.00e-103	368.00
IUUC-Bol-015242	Brassica oleracea	50.17	8.00e-99	354.00
IUUC-Bra-017390	Brassica rapa	50.50	3.00e-99	356.00
IUUC-Cja-019706	Callithrix jacchus	94.68	0.00e+00	1082.00
IUUC-Cfa-020139	Canis familiaris	78.10	0.00e+00	731.00
IUUC-Cpo-021710	Cavia porcellus	92.84	0.00e+00	1134.00
IUUC-Cre-022746	Chlamydomonas reinhardtii	41.14	4.00e-68	252.00
IUUC-Csa-023546	Chlorocebus sabaeus	96.19	0.00e+00	1060.00
IUUC-Cin-025156	Ciona intestinalis	41.37	3.00e-153	535.00
IUUC-Csv-025962	Ciona savignyi	49.66	2.00e-89	322.00
IUUC-Dre-028215	Danio rerio	61.98	0.00e+00	847.00
IUUC-Dno-029314	Dasypus novemcinctus	91.77	0.00e+00	1108.00
IUUC-Dor-030482	Dipodomys ordii	93.29	0.00e+00	1176.00
IUUC-Dme-032188	Drosophila melanogaster	38.18	6.00e-59	222.00
IUUC-Eca-034143	Equus caballus	93.14	0.00e+00	1154.00
IUUC-Fca-035924	Felis catus	94.07	0.00e+00	1128.00
IUUC-Fal-037387	Ficedula albicollis	76.77	0.00e+00	972.00
IUUC-Gmo-038692	Gadus morhua	64.96	4.00e-154	538.00
IUUC-Gga-040597	Gallus gallus	78.12	0.00e+00	1023.00
IUUC-Gac-042004	Gasterosteus aculeatus	60.94	0.00e+00	818.00
IUUC-Gma-044134	Glycine max	52.49	7.00e-100	358.00
IUUC-Ggo-044761	Gorilla gorilla	96.65	0.00e+00	1100.00
IUUC-Hsa-045698	Homo sapiens	96.34	0.00e+00	1133.00
IUUC-Hvu-047649	Hordeum vulgare	52.92	6.00e-103	369.00
IUUC-Itr-048697	Ictidomys tridecemlineatus	92.68	0.00e+00	1112.00
IUUC-Lch-049674	Latimeria chalumnae	65.67	0.00e+00	905.00
IUUC-Lpe-051554	Leersia perrieri	52.22	2.00e-105	377.00
IUUC-Loc-052623	Lepisosteus oculatus	65.71	0.00e+00	892.00
IUUC-Laf-054587	Loxodonta africana	94.38	0.00e+00	1160.00
IUUC-Mcc-055851	Macaca mulatta	96.49	0.00e+00	1100.00
IUUC-Meu-056704	Macropus eugenii	87.86	0.00e+00	1146.00
IUUC-Mtr-058053	Medicago truncatula	52.16	2.00e-103	370.00
IUUC-Mga-059608	Meleagris gallopavo	77.88	0.00e+00	1013.00
IUUC-Mmr-061154	Microcebus murinus	95.59	0.00e+00	1137.00
IUUC-Mdo-062365	Monodelphis domestica	83.93	0.00e+00	1077.00
IUUC-Mmu-063754	Mus musculus	92.44	0.00e+00	1122.00
IUUC-Mac-064667	Musa acuminata	52.04	1.00e-99	357.00
IUUC-Mpu-066245	Mustela putorius furo	94.05	0.00e+00	1100.00
IUUC-Mlu-067692	Myotis lucifugus	93.37	0.00e+00	1108.00
IUUC-Opr-070855	Ochotona princeps	93.45	0.00e+00	1138.00
IUUC-Ont-071883	Oreochromis niloticus	58.51	0.00e+00	813.00
IUUC-Oan-073293	Ornithorhynchus anatinus	87.60	0.00e+00	1008.00
IUUC-Ocu-074644	Oryctolagus cuniculus	94.66	0.00e+00	1156.00
IUUC-Oba-075448	Oryza barthii	54.52	1.00e-105	377.00
IUUC-Obr-076385	Oryza brachyantha	51.58	1.00e-104	374.00
IUUC-Ogl-077427	Oryza glaberrima	52.53	5.00e-106	379.00
IUUC-Ogu-079022	Oryza glumaepatula	48.56	5.00e-97	348.00
IUUC-Oin-079811	Oryza indica	50.30	5.00e-103	369.00
IUUC-Olo-080245	Oryza longistaminata	50.30	6.00e-103	368.00
IUUC-Ome-081239	Oryza meridionalis	51.94	1.00e-102	367.00
IUUC-Oni-082640	Oryza nivara	54.52	1.00e-105	377.00
IUUC-Opu-083748	Oryza punctata	51.22	4.00e-106	379.00
IUUC-Oru-084609	Oryza rufipogon	54.52	1.00e-105	377.00
IUUC-Osa-086267	Oryza sativa	48.56	4.00e-97	349.00
IUUC-Ola-087483	Oryzias latipes	57.87	0.00e+00	654.00
IUUC-Oga-087964	Otolemur garnettii	93.45	0.00e+00	1158.00
IUUC-Oar-089483	Ovis aries	91.72	0.00e+00	1113.00
IUUC-Ptr-091387	Pan troglodytes	96.49	0.00e+00	1135.00
IUUC-Pan-092623	Papio anubis	96.49	0.00e+00	1100.00
IUUC-Psi-093830	Pelodiscus sinensis	80.39	0.00e+00	1031.00
IUUC-Pma-094135	Petromyzon marinus	45.50	3.00e-38	151.00
IUUC-Ppa-095379	Physcomitrella patens	54.45	8.00e-97	348.00
IUUC-Pfo-096755	Poecilia formosa	57.62	0.00e+00	796.00
IUUC-Pab-097564	Pongo abelii	94.86	0.00e+00	966.00
IUUC-Pop-099149	Populus trichocarpa	52.16	3.00e-103	369.00
IUUC-Pca-100357	Procavia capensis	99.52	6.00e-126	444.00
IUUC-Ppe-101237	Prunus persica	52.16	6.00e-103	368.00
IUUC-Pva-102397	Pteropus vampyrus	89.79	0.00e+00	1047.00
IUUC-Rno-105349	Rattus norvegicus	92.53	0.00e+00	1158.00
IUUC-Smo-109379	Selaginella moellendorffii	53.92	2.00e-100	360.00
IUUC-Sit-110360	Setaria italica	52.53	1.00e-105	377.00
IUUC-Sly-111307	Solanum lycopersicum	52.84	2.00e-98	353.00
IUUC-Stu-112462	Solanum tuberosum	52.05	9.00e-95	340.00
IUUC-Sar-112953	Sorex araneus	81.58	6.00e-108	384.00
IUUC-Sbi-114389	Sorghum bicolor	46.64	2.00e-93	336.00
IUUC-Ssc-115949	Sus scrofa	90.61	0.00e+00	843.00
IUUC-Tgu-117461	Taeniopygia guttata	75.97	0.00e+00	1004.00
IUUC-Tru-117865	Takifugu rubripes	58.35	0.00e+00	790.00
IUUC-Tsy-119036	Tarsius syrichta	80.00	4.00e-81	295.00
IUUC-Tni-120903	Tetraodon nigroviridis	61.61	0.00e+00	781.00
IUUC-Tca-121185	Theobroma cacao	51.16	4.00e-100	359.00
IUUC-Tae-125263	Triticum aestivum	53.25	2.00e-103	370.00
IUUC-Tur-126181	Triticum urartu	47.62	2.00e-93	337.00
IUUC-Tbe-127518	Tupaia belangeri	79.02	1.00e-178	619.00
IUUC-Ttr-128172	Tursiops truncatus	93.90	0.00e+00	1113.00
IUUC-Vvi-131489	Vitis vinifera	52.82	1.00e-103	370.00
IUUC-Xtr-132915	Xenopus tropicalis	72.58	0.00e+00	952.00
IUUC-Xma-134133	Xiphophorus maculatus	57.33	0.00e+00	783.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence